sagehrke
commented
3 days ago Dear @nklsbckmnn, Thank you for reaching out to the Mondo Disease Ontology, part of the Monarch Initiative!
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"Cancer" is logically defined as "neoplasm and ('has characteristic' some 'neoplastic, malignant')". "Brain cancer" is textually defined as "A primary or metastatic malignant neoplasm affecting the brain."
But since "secondary neoplasms" are distinct from "neoplasms" and "metastatic malignant neoplasms" are "secondary neoplasms", brain cancers cannot logically include "metastatic malignant neoplasms".
One option would be to broaden the definition of cancer to include "secondary neoplasms". This would also be descriptively adequate insofar as it conforms to language use of physicians and scientists.
I just noticed that "metastatic malignant neoplasm in the lymph nodes" is logically defined as "'lymph node cancer' and ('has characteristic' some 'neoplastic, metastatic')". There are other "metastatic malignant neoplasm in the x" that are defined as "metastatic malignant neoplasm in the "'metastatic malignant neoplasm' and ('disease has location' some 'x')". This is inconsistent.