At the moment Slick is tightly coupled with MooTools, which is a heavy burden if you're environment supports QSA.
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I made a start https://gist.github.com/1629934.
The mootools specs don't pass yet for some cases, and .getParent() and other methods that use reversed combinators will be a bit harder too.
At the moment Slick is tightly coupled with MooTools, which is a heavy burden if you're environment supports QSA.