How does PhyloWGS handle polyclonal seeding?

morrislab / phylowgs

Application for inferring subclonal composition and evolution from whole-genome sequencing data.

GNU General Public License v3.0

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How does PhyloWGS handle polyclonal seeding? #124

Open bioinfograd opened 4 years ago

bioinfograd commented 4 years ago

I am analyzing 8 tumors and based on CCF and unsupervised heirchal clustering I'm expecting one of my tumors to have been seeded by two separate tumors. How does PhyloWGS handle this? Would this show up in the output?

adhisadi commented 2 months ago

I was able to get polyclonal trees with --include-multiprimary --max-multiprimary 1 when running the write_results.py script.