morrislab / phylowgs

Application for inferring subclonal composition and evolution from whole-genome sequencing data.
GNU General Public License v3.0
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Questions about the Integrating of copy number variation #136

Closed HushWay closed 1 year ago

HushWay commented 3 years ago

Hi,

If I'm not mistaken, your algorithm adjusted the mutation copy number influenced by the copy number variation described in the published article. Because I am not very familiar with Python, so I am confused about the followed questions:

  1. Is the adjustment of mutation copy number conducted after the inferring of the subclonal tree with MCMC sampling?
  2. Where is the code for the adjustment?
  3. Whether there is a CCF or cellular prevalence value for each mutation?

Thanks, Liuwei