Typically useful combined with PSCBS::findLargeGaps (e.g. to find centromeres).
Probably also useful for exome sequencing, where one expects a lot of such gaps.
This is particularly relevant because the segmentation methods implemented in the package are not aware of genome position and treat all loci as equally spaced.
Both RBS and DP are naturally able to handle this.
Typically useful combined with PSCBS::findLargeGaps (e.g. to find centromeres). Probably also useful for exome sequencing, where one expects a lot of such gaps. This is particularly relevant because the segmentation methods implemented in the package are not aware of genome position and treat all loci as equally spaced.
Both RBS and DP are naturally able to handle this.