[x] description of key tumour model parameters, how related to each other
(paper and functional documentation)
[x] discussion and guidance how user should determine key model
parameters
[x] Summary, second paragraph, third sentence: This sentence is a little unclear to me. Does it mean that CancerSim can reproduce multi-region sequencing/profiling data? If so, I'd recommend re-wording a bit to make this more clear.
[x] Summary, second paragraph, fourth sentence: I'd recommend listing a few examples to help make the point more clearly.
[x] Summary, first paragraph, third sentence: please change "existence tumour" to "existence a tumour".
[x] Summary, third paragraph, first sentence: I think a comma after "neoplasm type" is a little easier to read.
[x] Summary, third paragraph, second sentence: I'd suggest rewriting "It resembles the most to superficially" as "It most closely resembles superficially"
[x] Summary, fourth paragraph, sentence three: Please replace "mutation cell" with "mutation the cell".
[x] Summary, paragraph five, sentence three: Can the division probabilities change during the course of a simulation in response to a cell acquiring a specific mutation? Or are the division probabilities just fixed at the beginning in a way that models beneficial or deleterious effects?
[x] discussion in broader context of modeling methods and how casim relates to
them (paper, state of the field)
from #11:
[x] general: description of model parameters missing, applicability in
theoretical modelling to be more detailed
[x] enhance summary for non-specialists (explain expert level terms)
from #16:
from #11: