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mrc-ide / hypatia

Individual-based COVID transmission model
https://mrc-ide.github.io/hypatia
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Revaccination #22

Open giovannic opened 4 years ago

giovannic commented 4 years ago

Contingent on #20

Vaccinating an individual with a vaccine different to their initial vaccine.

pwinskill commented 3 years ago

We are defining re-vaccination as vaccination with a new vaccine type following an original vaccination.

We will need to decide how impacts of multiple vaccines (with potentially different characteristics) interact. To date, there is no information (for COVID19) to parameterise these interactions and the best approach may be to get expert opionion from immunologists.

abhogan commented 3 years ago

The simplest approach might be to assume that the individual is protected according to the characteristics of the most recent vaccine that they received.

We will also need to decide how to deal with correlation - i.e. individuals who have been vaccinated previously are more likely to get vaccinated again, and some people will never get any vaccine.

pwinskill commented 3 years ago

Good point on correlation. I've just reviewed Giovanni's correlation implementation for the malaria model which we could use for inspiration if needed?