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mrc-ide / malariasimulation

The malaria model
https://mrc-ide.github.io/malariasimulation
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Model ATSB #21

Open giovannic opened 4 years ago

giovannic commented 4 years ago

Bait for mosquitos. Increases daily mortality in mosquitos. Modelled by @KeithJF82

KeithJF82 commented 4 years ago

Just saw this. What are you looking for?

giovannic commented 4 years ago

Thanks Kieth! Is there a paper or a codebase I could look at to learn how ATSB is modelled?

We're thinking of integrating it into this new malaria IBM.

KeithJF82 commented 4 years ago

Incorporating it into an existing malaria model is fairly simple using the method I use, which is based on Marshall et al 2013 ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765557/ ). A factor currently referred to as the bait killing rate is added to the natural mosquito death rate when modelling the mosquito population. The Marshall paper has a rate at which the mosquitoes feed on the ATSB and a mortality rate for those which have fed on it, but the outcome there was that the death rate after feeding on the bait is extremely high, so I simplified it to a feeding rate, with feeding assumed to lead to effectively instant death. (Work carried out since the Marshall paper was published indicates that the feeding rate obtained using dyed bait and the death rate obtained from looking at the mosquito numbers are not necessarily the same, but this is probably not because the bait does not kill the mosquitoes quickly - the bait efficacy can be verified by lab tests.)

If you want to see a malaria model with the ATSB model incorporated, you can look at my vectorpower R package: https://github.com/KeithJF82/vectorpower . The main malaria model is in the file src/mainpop.cpp. I can also send you further details on how the vectorpower package works and the malaria model used in it if need be.

giovannic commented 4 years ago

Thank you so much!