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mscastillo / GRNVBEM

AR1MA1 - VBEM reverse engineering GRNs method
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Question #2

Open ShellyCoder opened 5 years ago

ShellyCoder commented 5 years ago
  1. Must i select differential genes in required input?
  2. In other word, it'll work well if i select differential genes.
mscastillo commented 5 years ago

Hi 1746252547,

You don't have to filter and include only genes that are deferentially expressed . However, housekeeping or genes with a flat expression pattern on time shouldn't contribute to explain the dynamic of others. It would make sense to me to filter out those "flat" genes, but this will depends on your data and the type of regulatory event you are interested to capture.

Thanks for your question!