mskcc / facets

Algorithm to implement Fraction and Copy number Estimate from Tumor/normal Sequencing.
139 stars 65 forks source link

Comparing FACETS to results from callers that calculate a relative copy number only #158

Open popicka opened 3 years ago

popicka commented 3 years ago

Hi,

We are working on comparison between several callers and we have some questions regarding ploidy estimates. In FACETS output ploidy of the sample is 3. For other callers, example: GATK, ploidy is not set and we assume it is 2.

How to compare those results? Should we adjust results from FACETS to 3, meaning that result >3 would be gain, ==3 would be neutral, and <3 would be loss, or in which way to compare those results to other callers, for example GATK or FREEC?

Thank you in advance