Easiest would be to use the "experimental wow64 support", but that at least seems to have issues running i686 msys2 (not that that's horribly relevant anymore, but may be indicative of more issues, hence the "experimental" moniker). Could also do it the old-fashioned way and build a full i386 wine and x86_64 wine and hook them together with the proper configure arguments.
Easiest would be to use the "experimental wow64 support", but that at least seems to have issues running i686 msys2 (not that that's horribly relevant anymore, but may be indicative of more issues, hence the "experimental" moniker). Could also do it the old-fashioned way and build a full i386 wine and x86_64 wine and hook them together with the proper configure arguments.