Closed ugeigenmuller closed 8 years ago
Hi @ugeigenmuller, thanks for the report!
I think I know what is going on here. Using the JSON webservice, arguments are passed as HTTP query string parameters and therefore need to be encoded as such. Amongst the reserved characters in the query string is +
, and this is probably the reason some of your variant descriptions are being misinterpreted.
For example, the request you show should be:
https://mutalyzer.nl/json/numberConversion?build=hg19&variant=NM_000388.3%3Ac.1732%2B16T%3EC
Depending on the programming language you are using, there's probably a library which you can use for this. Here's an interface to do it directly from your browser.
We'll update the text on the website to mention this, I think it's a very unfortunate pitfall.
Thanks so much for your quick help!
From: Martijn Vermaat [mailto:notifications@github.com] Sent: Thursday, April 28, 2016 3:49 PM To: mutalyzer/mutalyzer Cc: Geigenmuller, Ute; Mention Subject: Re: [mutalyzer/mutalyzer] wrong position returned by position converter via https/json (#362)
Hi @ugeigenmullerhttps://github.com/ugeigenmuller, thanks for the report!
I think I know what is going on here. Using the JSON webservice, arguments are passed as HTTP query string parameters and therefore need to be encodedhttps://en.wikipedia.org/wiki/Query_string#URL_encoding as such. Amongst the reserved characters in the query string is +, and this is probably the reason some of your variant descriptions are being misinterpreted.
For example, the request you show should be:
https://mutalyzer.nl/json/numberConversion?build=hg19&variant=NM_000388.3%3Ac.1732%2B16T%3EC
Depending on the programming language you are using, there's probably a library which you can use for this. Here's an interfacehttp://meyerweb.com/eric/tools/dencoder/ to do it directly from your browser.
We'll update the text on the website to mention this, I think it's a very unfortunate pitfall.
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Variant: NM_000388.3:c.1732+16T>C
manual use of website NC_000003.11:g.122001099T>C
https://mutalyzer.nl/json/numberConversion?build=hg19&variant=NM_000388.3:c.1732+16T>C ["NC_000003.11:g.122174017T>C"]
This happened for about 10% of about 4000 variants tested.