Open gaberudy opened 4 years ago
Mutalyzer makes its protein description by comparing the reference protein sequence to the observed sequence. This is the only way to make two variants that result in the same protein have the same description.
We realise that this is not completely in line with the current HGVS recommendations, but pending a fixed set of rules to resolve this issue, we have no way of dealing with this in a structured way.
The following variant: NM_001123385.1:c.2574_2575insGTTCCTTAGGAG introduces a stop codon and according to the updated HGVS spec I believe should be represented as p.E858_L859insValProTer)
Currently: https://mutalyzer.nl/name-checker?description=NM_001123385.1%3Ac.2574_2575insGTTCCTTAGGAG
It produces NM_001123385.1(BCOR_i001):p.(Leu859_Trp1755delinsValPro)
The updated HGVS page describes this case with an example: https://varnomen.hgvs.org/recommendations/protein/variant/insertion/
This is definitely an edge case, but I do think the new HGVS recommendation