The age of Earth is about 4.54 billion years. Evidence suggests that life on Earth has existed for at least 3.5 billion years, with the oldest physical traces of life dating back 3.7 billion years; however, some hypotheses, such as Late Heavy Bombardment, suggest that life on Earth may have started even earlier, as early as 4.1–4.4 billion years ago, and the chemistry leading to life may have begun shortly after the Big Bang, 13.8 billion years ago, during an epoch when the universe was only 10–17 million years old. Time estimates from molecular clocks, as summarized in TimeTree, generally place the origin of life around 4.0 billion years ago or earlier. More than 99% of all species of life forms, amounting to over five billion species, that ever lived on Earth are estimated to be extinct. Although the number of Earth's catalogued species of lifeforms is between 1.2 million and 2 million, the total number of species in the planet is uncertain. Estimates range from 8 million to 100 million, with a more narrow range between 10 and 14 million, but it may be as high as 1 trillion (with only one-thousandth of one per cent of the species described) according to studies realised in May 2016. The total number of related DNA base pairs on Earth is estimated at 5.0 x 1037 and weighs 50 billion tonnes. In comparison, the total mass of the biosphere has been estimated to be as much as 4 TtC (trillion tons of carbon). In July 2016, scientists reported identifying a set of 355 genes from the Last Universal Common Ancestor (LUCA) of all organisms living on Earth. All known life forms share fundamental molecular mechanisms, reflecting their common descent; based on these observations, hypotheses on the origin of life attempt to find a mechanism explaining the formation of a universal common ancestor, from simple organic molecules via pre-cellular life to protocells and metabolism. Models have been divided into "genes-first" and "metabolism-first" categories, but a recent trend is the emergence of hybrid models that combine both categories. There is no current scientific consensus as to how life originated. However, most accepted scientific models build on the Miller–Urey experiment and the work of Sidney Fox, which show that conditions on the primitive Earth favoured chemical reactions that synthesize amino acids and other organic compounds from inorganic precursors, and phospholipids spontaneously form lipid bilayers, the basic structure of a cell membrane. Living organisms synthesize proteins, which are polymers of amino acids using instructions encoded by deoxyribonucleic acid (DNA). Protein synthesis entails intermediary ribonucleic acid (RNA) polymers. One possibility for how life began is that genes originated first, followed by proteins; the alternative being that proteins came first and then genes. However, because genes and proteins are both required to produce the other, the problem of considering which came first is like that of the chicken or the egg. Most scientists have adopted the hypothesis that because of this, it is unlikely that genes and proteins arose independently. Therefore, a possibility, first suggested by Francis Crick, is that the first life was based on RNA, which has the DNA-like properties of information storage and the catalytic properties of some proteins. This is called the RNA world hypothesis, and it is supported by the observation that many of the most critical components of cells (those that evolve the slowest) are composed mostly or entirely of RNA. Also, many critical cofactors (ATP, Acetyl-CoA, NADH, etc.) are either nucleotides or substances clearly related to them. The catalytic properties of RNA had not yet been demonstrated when the hypothesis was first proposed, but they were confirmed by Thomas Cech in 1986. One issue with the RNA world hypothesis is that synthesis of RNA from simple inorganic precursors is more difficult than for other organic molecules. One reason for this is that RNA precursors are very stable and react with each other very slowly under ambient conditions, and it has also been proposed that living organisms consisted of other molecules before RNA. However, the successful synthesis of certain RNA molecules under the conditions that existed prior to life on Earth has been achieved by adding alternative precursors in a specified order with the precursor phosphate present throughout the reaction. This study makes the RNA world hypothesis more plausible. Geological findings in 2013 showed that reactive phosphorus species (like phosphite) were in abundance in the ocean before 3.5 Ga, and that Schreibersite easily reacts with aqueous glycerol to generate phosphite and glycerol 3-phosphate. It is hypothesized that Schreibersite-containing meteorites from the Late Heavy Bombardment could have provided early reduced phosphorus, which could react with prebiotic organic molecules to form phosphorylated biomolecules, like RNA. In 2009, experiments demonstrated Darwinian evolution of a two-component system of RNA enzymes (ribozymes) in vitro. The work was performed in the laboratory of Gerald Joyce, who stated "This is the first example, outside of biology, of evolutionary adaptation in a molecular genetic system." Prebiotic compounds may have originated extraterrestrially. NASA findings in 2011, based on studies with meteorites found on Earth, suggest DNA and RNA components (adenine, guanine and related organic molecules) may be formed in outer space. In March 2015, NASA scientists reported that, for the first time, complex DNA and RNA organic compounds of life, including uracil, cytosine and thymine, have been formed in the laboratory under outer space conditions, using starting chemicals, such as pyrimidine, found in meteorites. Pyrimidine, like polycyclic aromatic hydrocarbons (PAHs), the most carbon-rich chemical found in the universe, may have been formed in red giants or in interstellar dust and gas clouds, according to the scientists. According to the panspermia hypothesis, microscopic life—distributed by meteoroids, asteroids and other small Solar System bodies—may exist throughout the universe.
The output would be this
The age of Earth is about 4.54 billion years. Evidence suggests that life on Earth has existed 4 at least 3.5 billion years, with the oldest physical traces of life d8ɪŋ back 3.7 billion years; however, some hypotheses, such as Late Heavy Bombardment, suggest that life on Earth may have started even earlier, as early as 4.1–4.4 billion years ago, and the chemistry leading 2 life may have begun shortly after the Big Bang, 13.8 billion years ago, during an epoch when the universe was only 10–17 million years old. Time ɛstəˌm8s from molecular clocks, as summarized in TimeTree, generally place the origin of life around 4.0 billion years ago or earlier. More than 99% of all species of life forms, amounting 2 over 5 billion species, that ever lived on Earth are ɛstəˌm8əd 2 be extinct. Although the number of Earth's catalogued species of lifeforms is between 1.2 million and 2 million, the total number of species in the planet is uncertain. Estimates range from 8 million 2 100 million, with a more narrow range between 10 and 14 million, but it may be as high as 1 trillion (with only one-thousandth of 1 per cent of the species described) according 2 studies realised in May 2016. The total number of /ˌɹiˈɫ8ɪd/ DNA base pairs on Earth is ɛstəˌm8əd at 5.0 x 1037 and weighs 50 billion tonnes. In comparison, the total mass of the biosphere has been ɛstəˌm8əd 2 be as much as 4 TtC (trillion tons of carbon). In July 2016, scientists reported identifying a set of 355 genes from the Last Universal Common Ancestor (LUCA) of all organisms living on Earth. All known life 4mz share fundamental molecular mechanisms, reflecting their common descent; based on these observations, hypotheses on the origin of life attempt 2 find a mechanism explaining the /4ˈmeɪʃən/ of a universal common ancestor, from simple organic molecules via pre-cellular life 2 protocells and metabolism. Models have been divided ɪn2 "genes-first" and "metabolism-first" categories, but a recent trend is the emergence of hybrid models that combine both categories. There is no current scientific consensus as 2 how life originated. However, most accepted scientific models build on the Miller–Urey experiment and the work of Sidney Fox, which show that conditions on the primitive Earth favoured chemical reactions that synthesize amino acids and other organic compounds from inorganic precursors, and phospholipids spontaneously 4m lipid bilayers, the basic structure of a cell membrane. Living organisms synthesize proteins, which are polymers of amino acids using instructions encoded by deoxyribonucleic acid (DNA). Protein synthesis entails intermediary ribonucleic acid (RNA) polymers. One possibility 4 how life began is that genes /ɝˈɪdʒəˌn8əd/ first, followed by proteins; the alternative being that proteins came first and then genes. However, because genes and proteins are both required 2 produce the other, the problem of considering which came first is like that of the chicken or the egg. Most scientists have adopted the hypothesis that because of this, it is unlikely that genes and proteins arose independently. Therefore, a possibility, first suggested by Francis Crick, is that the first life was based on RNA, which has the DNA-like properties of information storage and the catalytic properties of some proteins. This is called the RNA world hypothesis, and it is supported by the observation that many of the most critical components of cells (those that evolve the slowest) are composed mostly or entirely of RNA. Also, many critical cofactors (ATP, Acetyl-CoA, NADH, etc.) are either nucleotides or substances clearly /ˌɹiˈɫ8ɪd/ 2 them. The catalytic properties of RNA had not yet been dɛmənˌstɹ8ɪd when the hypothesis was first proposed, but they were confirmed by Thomas Cech in 1986. One issue with the RNA world hypothesis is that synthesis of RNA from simple inorganic precursors is more difficult than 4 other organic molecules. One reason 4 this is that RNA precursors are very stable and react with each other very slowly under ambient conditions, and it has also been proposed that living organisms consisted of other molecules /ˌbiˈ4/ RNA. However, the successful synthesis of certain RNA molecules under the conditions that existed prior 2 life on Earth has been achieved by adding alternative precursors in a specified order with the precursor fɑsf8 present throughout the reaction. This study makes the RNA world hypothesis more plausible. Geological findings in 2013 showed that reactive phosphorus species (like phosphite) were in abundance in the ocean /ˌbiˈ4/ 3.5 Ga, and that Schreibersite easily reacts with aqueous glycerol 2 dʒɛnɝˌ8 phosphite and glycerol 3-phosphate. It is hypothesized that Schreibersite-containing meteorites from the Late Heavy Bombardment could have provided early reduced phosphorus, which could react with prebiotic organic molecules 2 4m phosphorylated biomolecules, like RNA. In 2009, experiments dɛmənˌstɹ8ɪd Darwinian evolution of a two-component system of RNA enzymes (ribozymes) in vitro. The work was /pɝˈ4md/ in the laboratory of Gerald Joyce, who st8ɪd "This is the first example, outside of biology, of evolutionary adaptation in a molecular genetic system." Prebiotic compounds may have /ɝˈɪdʒəˌn8əd/ extraterrestrially. NASA findings in 2011, based on studies with meteorites found on Earth, suggest DNA and RNA components (adenine, guanine and /ˌɹiˈɫ8ɪd/ organic molecules) may be 4md in outer space. In March 2015, NASA scientists reported that, 4 the first time, complex DNA and RNA organic compounds of life, including uracil, cytosine and thymine, have been 4md in the laboratory under outer space conditions, using starting chemicals, such as pyrimidine, found in meteorites. Pyrimidine, like polycyclic aromatic hydrocarbons (PAHs), the most carbon-rich chemical found in the universe, may have been 4md in red giants or in interstellar dust and gas clouds, according 2 the scientists. According 2 the panspermia hypothesis, microscopic life—distributed by meteoroids, asteroids and other small Solar System bodies—may exist throughout the universe.
the output contains words like /ˌbiˈ4/ which should be converted into b4 and many more words like this.
If you use this as an input
The output would be this
the output contains words like
/ˌbiˈ4/
which should be converted intob4
and many more words like this.