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nanoporetech / dorado

Oxford Nanopore's Basecaller
https://nanoporetech.com/
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Is possible to do the joint modification calling of DNA 6mA and CpG methylation on the same time? #827

Closed DexinYang1998 closed 1 month ago

DexinYang1998 commented 1 month ago

Hi,

Thanks so much for your wonderful tools for analyzing nanopore data. I am wondering whether there is a way to do the joint modification calling of DNA 6mA and CpG methylation rather than calling separately. Or, whether it is possible to merge the two types of modification information into the same read.

Thanks.

HalfPhoton commented 1 month ago

Hi @DexinYang1998, thank you for the kind words! You should be able to basecall both mods at the same time.

Try the model complex hac,6mA,5mCG_5hmCG and dorado should automatically find the newest models for you.

DexinYang1998 commented 1 month ago

Thank you!