Closed Tiezhengyuan closed 5 years ago
Please check if racon is running properly on your system. If not, please compile the latest version from source.
the racon is v1.3.1 . It works very well on pinfish/polish_clusters/test_data/sirv_e0_sorted.bam. But racon failed when I worked on my data.
[superuser@A4]$ racon --v v1.3.1 [superuser@A4]$ racon -t 40 -q -1 /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reads.fq /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/alignments.sam /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reference.fq > /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/consensus.fq [racon::Polisher::initialize] loaded target sequences [bioparser::FastqParser] error: invalid file format!
Could you please paste here the head of reads.fq and reference.fq?
The first coupe lines of reads.fq:
@f82a9341-d2cc-46dd-b19b-c71bb35304c6
+
@361d0257-1be3-44ae-a1b1-5186a01ca67a
+
@25ada1a3-4b67-4d63-991a-e8ce5bf17199 TTGTTGTACTTCGTTCCAGTTGCGTATTGCACAGCACCACAACACACACACCATATCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCCAACCCACTTCACTAACAACACAGTAAGCGCTCTGTGCAGGTAGAAACAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCAAGTATCACATACACACGGTTTAGCCTCATCCACGTTCAGCTGCTTCGCTACTAGCAGAATCATTAAATTTATTTTTCTCACCTCCTGCAGGTACTAAAGATGCTGCTTCCCCACGTACTTAACCCCCACACTGACTATGAATTCATCAGCAGGTACCTACCATAACGGCAGGCGGGTTTCCCCCATTCGGACATCCTGGATCAACGCTCAATTGACAACTCCCCGGGCTTAACGCAGCCTTACGCGTCCTTCATCGGCCCAGCATACCAAGGCATCCACCATGCGCCCTTAAATAAACACACACCCCAACCAACACACAATCAGCTGTGGGGTGACAACCATATTCAAAATACTAAATACACACCAACCAAAGTTGGTATGCGACGTTCTCACCAGAAAAAATAAGAAAAATTACACACACCACACAAAACACTTCAAAAAGCACTCGTGTGGGTAGGATGCTCCGCTTTGCGTCTTCTGCCACAGTTCTCCACACCAACACTACACCACCAACCACACACCCCTTTGCAAACAAAGCGTTTAGTGCGTGTTTCGTGATGCAAGCACGGGACCAGCCCACATAAAGTGGATTGCTGTCCCAGACACCCAACAACCAGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAGCCTCTATAACTGCCGGGGTATGTTTTCCCACTCCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCACCAACACCCACTTTACAACCGTGTGACAGCAAAGATGTTTTAATTTAAAAGCTCGCCCAGAAGGAGTGATCAGCCGCACCTTCCGGTACGGCTACCTTGATACGACTTCGTCCCAATCGCCGATCCACCGACGGCTCCTAACAAGTTTAGGCCACTGGCTTCCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGGAACGTATTCACCGCATTTGCCTGATCTTGCGTTACTGGCGACTCCGGCCATGGGGTCGAGTTGCCGGAGCCAATCGAACTAAGGCCGACTTTCAGGATTCGCTCCACGATGTCGCTGCCCATTTGTATCACGACCATTTGTAGCGTAATGTGAAGCCACGGACATAGAGCATGATGATTTGACGTATCCCCCACCTTCCTCGAGTTAACCTACGCCCAGTTTCTCGCATGAGTCCCCACCATCACGTGCTGGCAGCATAAGACAGAGGTTGCGCTCGTTGGGATAACCCAACATCTCACGACACGAGCTGACGACAACCATGCACCACCCTGTATACAGACCACAAAGGGACGAACTATCTCTAGCCCCAATCCTGTATATGTAAGCCCAGGTAAGGTTCTTCGCGTTGCGTGAATTAATCCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGGAGTTTTAGCCGCGCAGCCCGTACTCAGGCAGGGCGCTTAATACGTTAGCTACGGGCACAGAAGACTGTTGATGGAAGCCCCTACACCTGGCGCCCTCGTTTACGGCATGGACTACTGGGTATCGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCTACACCGGGAGTTCAGTCTCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCGCCCGAAGTTAAGCCCGGAGTTTCACAGACGACGCGACCCGACCACCTACGAGCTCTTTACGCCCAGTAATTCCGGACAACGCTTGCACCCTACGTATTACACCGCGGCTGCTGGCACGTAGTTAGCCGGTGCTTCTTATCTACCGTCACCACCCAAGGTGAAGCTTCGTCGATAGCGAAAGGAGTTTACAGCGAGGCCGTCATCCCCACGCGGCGTCGCTGCATCGGGCTTGCGCCCGGTATTGCAATATTCCCCACTGCTGCCTCCGTAGGGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCCGTACCACTCGGGCCGGATACCCCGTCGCCGCCTTGGTAGGCCACCCCGCAACAAGCTGATAGGCCGCGGAAACATCCCACCGCAAAAGCTTTCCCACCCACAACATCAAGAAGTGGTCCTATATGGTGAAGTAGACCCAGTTTCCCGGGCTTATCCATAGTGGGAACTCACTTGCGTGTTTGCTGCGTTCGCCGCTCAGGTACTGCGGTACGAACGTTCCGACGTGAAATTTGGCGCGCGGCGTTTAAATGCAAAACCGGATCAAACTCTCTAAAAAAAGGCTGTGAAAAGCCCAGAACCTAACCAAAAGACAAACAACACAAAACATCTCTACTAAGTGTGAAGCTGACCAAAGGAGTACTACATAAAGAAATCAACAAATAGCCAACCAAGTAAAAAATGCCAGTTGAGTAAGGTAAAGTGTTTTAACCTGCATCAGCAGACAACAATTACATTCATTCAATATGTACCGTTACAGTATTTAACTATTTTCAATGCCACCCATAACGACAAGTGACATCCGGTACACACCAACAACAAACAAACAACAGTTCATTCAGCCCAACATAATTCTCATCCACACAACACAGACAAAAATAAAAATCTGGTACATTTGGCACACTGGTAGGTTCTCAGACAACAACCACACCCGCAACCCATTACCACATACAGGGCGAAGATAAGTGAATGAAAAGTCTAGAAATAGAGTTTGCTTTACATCAACGGCTGTTTCCCTACCATACTCACCAGAACCCTTGGCTCATGCGGGGGCGTTGTCGGTCTCCTTGGCTATAAAGTTACACCAACCAGAAACAACACAAATCCCCAGCACAAAACCACATTTTCGTTGATCTTGATTGAACTTGGTTTCAGCTCATCGCGACACTGGTGCCATTCCGAACCAACACGCGAGCCCACCAGGGTAGATATTGGTCTTACGAGCCATGCTCAGAGCAACAATGCCAGCGCTATGTATCCACCAAGCGCGGCCAATACTGGAAGCAGGAAGCCACAGGCAATACCGATCATAACATAGACTTCGAGTGCTGCTGCGACGGCGACTACGGGGATGGTTACGGTCCAGCTCAGACGGGTGGTTAGTCCAAATGGTCGATGGCTAGCGGTAGGACAAGGTAGGCGGCGAGGGCACTGAGGTAGTTCCGCGGTACGCCGGCACCTAGGACCACGAGTAGTCCGGGAACGCTGAGTTGATTGACTCGTTAGTTGCGCCCAAAGTTTTGCGCGTTCGCCGAAAGCTACATATTCACGCAACGGCGTCGTAGCTGATGTCTTCATAAACAATGAAGACGATGGGCTGACGGCTTAACCGGTATGAAGGAATAGCCTGAAGCCCAGTGGTTTATTAAACAGGGGCGCTGATTATCAATAGAGCAGGAGACTAGCGCGGCTACGCTGACGATATACATGGCACCAGCGACTTGGGGTCTCATGACGAGCTGGCCTTCGATGGTCACGGGAAATTGGCCGTCATCGGTTCTACCGCTTGTTCCTGCCAAAGGTCGCCCTTCCTAGAGCGATCACTCCTTGGTATACGGGGATTGCGTGCCTAAGTGCCGCGATAACTAGGTAGCCGACGATAAAACCACAATGAAGATCGATTGGTCAGTACAGTAGCCGAAGGCGGTATTGGGGCGGCCGAGACGGCGATTTCACTCCGGCGTTGCAGATTTAATAATCTCGCCTACCAAGTCAGTCGCCGGAACCCAAAGGATCACCGGCGGGTGCCGTCAGCGGATACCGGCCAAGACAGGGAGGTAGAGGTACTGCGAATTTACTTCCCGTGGACAGGCCAGCTGCCAAGACCGCAAAGACGGGCCGAATTGCCCACCGGGGAGTTTATCAACGAGTTCCCGCTGGCTGCGGATTCATGCCGGTCCTTCTCACCGAGCGCTATAGGACTGCTTTCCAGGTTAACCTTCGCTGGCGCGCGAAGGTCGAGAGACACTCGCGGCATCAAAGACATTGTCCGCTCCGGCGCAATCGCATCTACTATGACGCGGTCACCTAAGGCGGTTGGGTTACGGCAGGGTGTTATCTTGCAATCGGTTGAGTGACGGTCAATGTTTTCTGGGTGGCCGGTGACCTCCAAGATTCCATCGATAAGCTCTGCTACCACCCGTGCTTCATGCCATTGAGCATCAGCACGGTATCGAAGATGCCGGATAATTCGTTGAGGTGGGTGGAATAACTATGGTTCGAGCGTGCTCTTCACGCAGCACGTCGCCAGAAACGGCGCTTTTCTGCGTCGGGCCGAGATAGGGTTCATCGAAGCATGGGCTCACAACCTGAAGCTACTGCCATGATGATGCCGCAGCGGTTTGCCCCCGTGATAGAGCAGAGTGGTTCTTGGACGGTAAGCTCAGTCTGCTGCGGCTACTCGGCGCGTGCGCTTCCACGTTGACCAGCGAGCGCACTGCCCAGACGCATGGGCTAGCAATACGTAACTGA + $&%%&')-57:85766'&)4,#),--30*,'&'/1110,(3)((-..0/.+///4:4('$$%',752231//3559676-7-)&/0''+1,(.&/1)$'(5,15,.582+-'')(0&'(..542//%'#0('(')0))0//7-+,''037&-'(%#)+,,1//154748456:4+'+)01)-23)-+..9862/,3878896.,-,140%'+++.//-./265.,+,,.,./456:67:6::..9<<.471((0,),-./1/--1698)+,&$&%.32386+.(2)$)'0)29:7-(-..-223,1,7)+5)22,&1)&1)++0()0:86;:11.-%.0/<9-9;;,,0;85:787:67303.055381122188/..--9.-/44.2,.0202012/,((%##%#',+75073325),42)(+-/3.5,'&-10631'2,9814116)((467.3..67645)6,-'/-42434,0,.+6..,2333,0.-$'+-01)+))+),$057('(067:1#&'-/386+0(77--0101.+(-,04(08143&+&&&498;;0950'17:/3831%.,-0''''1:70,#&$$'+152#/1/3.20,((.(.-/023+1)#%&)&-,-22/2040/.+237,+(&+&*&)%(#)'')016+4245792201,57-)074)11994)5,+,/29/-))'$+/5).61/1%$,&0,1665'+$/5+441:.-037,1.,,1-3340--3:2----1&)#2(2/..71.6,30823:99969;955586786/'"-&.7124630),+-182,()(-2/0287)4+,/224:;/,0)&,5*+5846:+001%7619323778912+++%1+,1997374+-',(2,,,6)('((''(-458/866462,0/393),..6:9$2)7-23/%()'('''.++--',$&&(146%(3(,46:72:'4()$/330%3(%+)),./02724:.462/54:-,,+-$%&))-)(,':(&+-50,/0::-59:8120+/)%'+)+/)+()%%.30
reference.fq (There are only 4 lines) :
@71f61652-7fc8-4901-a511-a16d2ff8f3ff
+
alignments.sam:
@SQ SN:71f61652-7fc8-4901-a511-a16d2ff8f3ff LN:0 @PG ID:minimap2 PN:minimap2 VN:2.12-r829-dirty CL:minimap2 -ax map-ont -t 40 -k14 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq f82a9341-d2cc-46dd-b19b-c71bb35304c6 4 0 0 0 0 361d0257-1be3-44ae-a1b1-5186a01ca67a 4 0 0 0 0 25ada1a3-4b67-4d63-991a-e8ce5bf17199 4 0 0 0 0 TTGTTGTACTTCGTTCCAGTTGCGTATTGCACAGCACCACAACACACACACCATATCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCCAACCCACTTCACTAACAACACAGTAAGCGCTCTGTGCAGGTAGAAACAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCAAGTATCACATACACACGGTTTAGCCTCATCCACGTTCAGCTGCTTCGCTACTAGCAGAATCATTAAATTTATTTTTCTCACCTCCTGCAGGTACTAAAGATGCTGCTTCCCCACGTACTTAACCCCCACACTGACTATGAATTCATCAGCAGGTACCTACCATAACGGCAGGCGGGTTTCCCCCATTCGGACATCCTGGATCAACGCTCAATTGACAACTCCCCGGGCTTAACGCAGCCTTACGCGTCCTTCATCGGCCCAGCATACCAAGGCATCCACCATGCGCCCTTAAATAAACACACACCCCAACCAACACACAATCAGCTGTGGGGTGACAACCATATTCAAAATACTAAATACACACCAACCAAAGTTGGTATGCGACGTTCTCACCAGAAAAAATAAGAAAAATTACACACACCACACAAAACACTTCAAAAAGCACTCGTGTGGGTAGGATGCTCCGCTTTGCGTCTTCTGCCACAGTTCTCCACACCAACACTACACCACCAACCACACACCCCTTTGCAAACAAAGCGTTTAGTGCGTGTTTCGTGATGCAAGCACGGGACCAGCCCACATAAAGTGGATTGCTGTCCCAGACACCCAACAACCAGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAGCCTCTATAACTGCCGGGGTATGTTTTCCCACTCCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCACCAACACCCACTTTACAACCGTGTGACAGCAAAGATGTTTTAATTTAAAAGCTCGCCCAGAAGGAGTGATCAGCCGCACCTTCCGGTACGGCTACCTTGATACGACTTCGTCCCAATCGCCGATCCACCGACGGCTCCTAACAAGTTTAGGCCACTGGCTTCCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGGAACGTATTCACCGCATTTGCCTGATCTTGCGTTACTGGCGACTCCGGCCATGGGGTCGAGTTGCCGGAGCCAATCGAACTAAGGCCGACTTTCAGGATTCGCTCCACGATGTCGCTGCCCATTTGTATCACGACCATTTGTAGCGTAATGTGAAGCCACGGACATAGAGCATGATGATTTGACGTATCCCCCACCTTCCTCGAGTTAACCTACGCCCAGTTTCTCGCATGAGTCCCCACCATCACGTGCTGGCAGCATAAGACAGAGGTTGCGCTCGTTGGGATAACCCAACATCTCACGACACGAGCTGACGACAACCATGCACCACCCTGTATACAGACCACAAAGGGACGAACTATCTCTAGCCCCAATCCTGTATATGTAAGCCCAGGTAAGGTTCTTCGCGTTGCGTGAATTAATCCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGGAGTTTTAGCCGCGCAGCCCGTACTCAGGCAGGGCGCTTAATACGTTAGCTACGGGCACAGAAGACTGTTGATGGAAGCCCCTACACCTGGCGCCCTCGTTTACGGCATGGACTACTGGGTATCGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCTACACCGGGAGTTCAGTCTCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCGCCCGAAGTTAAGCCCGGAGTTTCACAGACGACGCGACCCGACCACCTACGAGCTCTTTACGCCCAGTAATTCCGGACAACGCTTGCACCCTACGTATTACACCGCGGCTGCTGGCACGTAGTTAGCCGGTGCTTCTTATCTACCGTCACCACCCAAGGTGAAGCTTCGTCGATAGCGAAAGGAGTTTACAGCGAGGCCGTCATCCCCACGCGGCGTCGCTGCATCGGGCTTGCGCCCGGTATTGCAATATTCCCCACTGCTGCCTCCGTAGGGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCCGTACCACTCGGGCCGGATACCCCGTCGCCGCCTTGGTAGGCCACCCCGCAACAAGCTGATAGGCCGCGGAAACATCCCACCGCAAAAGCTTTCCCACCCACAACATCAAGAAGTGGTCCTATATGGTGAAGTAGACCCAGTTTCCCGGGCTTATCCATAGTGGGAACTCACTTGCGTGTTTGCTGCGTTCGCCGCTCAGGTACTGCGGTACGAACGTTCCGACGTGAAATTTGGCGCGCGGCGTTTAAATGCAAAACCGGATCAAACTCTCTAAAAAAAGGCTGTGAAAAGCCCAGAACCTAACCAAAAGACAAACAACACAAAACATCTCTACTAAGTGTGAAGCTGACCAAAGGAGTACTACATAAAGAAATCAACAAATAGCCAACCAAGTAAAAAATGCCAGTTGAGTAAGGTAAAGTGTTTTAACCTGCATCAGCAGACAACAATTACATTCATTCAATATGTACCGTTACAGTATTTAACTATTTTCAATGCCACCCATAACGACAAGTGACATCCGGTACACACCAACAACAAACAAACAACAGTTCATTCAGCCCAACATAATTCTCATCCACACAACACAGACAAAAATAAAAATCTGGTACATTTGGCACACTGGTAGGTTCTCAGACAACAACCACACCCGCAACCCATTACCACATACAGGGCGAAGATAAGTGAATGAAAAGTCTAGAAATAGAGTTTGCTTTACATCAACGGCTGTTTCCCTACCATACTCACCAGAACCCTTGGCTCATGCGGGGGCGTTGTCGGTCTCCTTGGCTATAAAGTTACACCAACCAGAAACAACACAAATCCCCAGCACAAAACCACATTTTCGTTGATCTTGATTGAACTTGGTTTCAGCTCATCGCGACACTGGTGCCATTCCGAACCAACACGCGAGCCCACCAGGGTAGATATTGGTCTTACGAGCCATGCTCAGAGCAACAATGCCAGCGCTATGTATCCACCAAGCGCGGCCAATACTGGAAGCAGGAAGCCACAGGCAATACCGATCATAACATAGACTTCGAGTGCTGCTGCGACGGCGACTACGGGGATGGTTACGGTCCAGCTCAGACGGGTGGTTAGTCCAAATGGTCGATGGCTAGCGGTAGGACAAGGTAGGCGGCGAGGGCACTGAGGTAGTTCCGCGGTACGCCGGCACCTAGGACCACGAGTAGTCCGGGAACGCTGAGTTGATTGACTCGTTAGTTGCGCCCAAAGTTTTGCGCGTTCGCCGAAAGCTACATATTCACGCAACGGCGTCGTAGCTGATGTCTTCATAAACAATGAAGACGATGGGCTGACGGCTTAACCGGTATGAAGGAATAGCCTGAAGCCCAGTGGTTTATTAAACAGGGGCGCTGATTATCAATAGAGCAGGAGACTAGCGCGGCTACGCTGACGATATACATGGCACCAGCGACTTGGGGTCTCATGACGAGCTGGCCTTCGATGGTCACGGGAAATTGGCCGTCATCGGTTCTACCGCTTGTTCCTGCCAAAGGTCGCCCTTCCTAGAGCGATCACTCCTTGGTATACGGGGATTGCGTGCCTAAGTGCCGCGATAACTAGGTAGCCGACGATAAAACCACAATGAAGATCGATTGGTCAGTACAGTAGCCGAAGGCGGTATTGGGGCGGCCGAGACGGCGATTTCACTCCGGCGTTGCAGATTTAATAATCTCGCCTACCAAGTCAGTCGCCGGAACCCAAAGGATCACCGGCGGGTGCCGTCAGCGGATACCGGCCAAGACAGGGAGGTAGAGGTACTGCGAATTTACTTCCCGTGGACAGGCCAGCTGCCAAGACCGCAAAGACGGGCCGAATTGCCCACCGGGGAGTTTATCAACGAGTTCCCGCTGGCTGCGGATTCATGCCGGTCCTTCTCACCGAGCGCTATAGGACTGCTTTCCAGGTTAACCTTCGCTGGCGCGCGAAGGTCGAGAGACACTCGCGGCATCAAAGACATTGTCCGCTCCGGCGCAATCGCATCTACTATGACGCGGTCACCTAAGGCGGTTGGGTTACGGCAGGGTGTTATCTTGCAATCGGTTGAGTGACGGTCAATGTTTTCTGGGTGGCCGGTGACCTCCAAGATTCCATCGATAAGCTCTGCTACCACCCGTGCTTCATGCCATTGAGCATCAGCACGGTATCGAAGATGCCGGATAATTCGTTGAGGTGGGTGGAATAACTATGGTTCGAGCGTGCTCTTCACGCAGCACGTCGCCAGAAACGGCGCTTTTCTGCGTCGGGCCGAGATAGGGTTCATCGAAGCATGGGCTCACAACCTGAAGCTACTGCCATGATGATGCCGCAGCGGTTTGCCCCCGTGATAGAGCAGAGTGGTTCTTGGACGGTAAGCTCAGTCTGCTGCGGCTACTCGGCGCGTGCGCTTCCACGTTGACCAGCGAGCGCACTGCCCAGACGCATGGGCTAGCAATACGTAACTGA $&%%&')-57:85766'&)4,#),--30,'&'/1110,(3)((-..0/.+///4:4('$$%',752231//3559676-7-)&/0''+1,(.&/1)$'(5,15,.582+-'')(0&'(..542//%'#0('(')0))0//7-+,''037&-'(%#)+,,1//154748456:4+'+)01)-23)-+..9862/,3878896.,-,140%'+++.//-./265.,+,,.,./456:67:6::..9<<.471((0,),-./1/--1698)+,&$&%.32386+.(2)$)'0)29:7-(-..-223,1,7)+5)22,&1)&1)++0()0:86;:11.-%.0/<9-9;;,,0;85:787:67303.055381122188/..--9.-/44.2,.0202012/,((%##%#',+75073325),42)(+-/3.5,'&-10631'2,9814116)((467.3..67645)6,-'/-42434,0,.+6..,2333,0.-$'+-01)+))+),$057('(067:1#&'-/386+0(77--0101.+(-,04(08143&+&&&498;;0950'17:/3831%.,-0''''1:70,#&$$'+152#/1/3.20,((.(.-/023+1)#%&)&-,-22/2040/.+237,+(&+&*&)%(#)'')016+4245792201,57-)074)11994)5,+,/29/-))'$+/5).61/1%$,&0,1665'+$/5+441:.-037,1.,,1-3340--3:2----1&)#2(2/..71.6,30823:99969;955586786/'"-&.7124630),+-182,()(-2/0287)4+,/224:;/,0)&,5*+5846:+001%7619323778912+++%1+,1997374+-',(2,,,6)('((''(-458/866462,0/393),..6:9$2)7-23/%()'('''.++--',$&&(146%(3(,46:72:'4()$/330%3(%+)),./02724:.462/54:-,,+-$%&))-)(,':(&+-50,/0::-59:8120+/)%'+)+/)+()%%.30/).6,.489987737:8::22300542051.06-',+.('-/+.03;5122'&$''',$"&+)%&%'(3:431%/&($+5'/'+,+0,,8624204(&.&%.,.,/(17703/-197817;3-(..(+/957420)).0,455533/750.&(',',+,742095-.'./),+(+-7424++(085864.$&%+/,+---78;3+)('()/63.((-5/8/')/232/5.,)$"%'+'&'-0;9,11)#&&#),03),4/893515/130610$4017:554,--)77794862..(),-12,0.266760%'),,+-&%0.//247422)(856.1128/+0(,,2200513587,,+7'-5-773054778888622/66-,12224-00-.'''+')/1#()(.+//1:9650/236,%)$'&)//066-,..-1/2313:5-4-,,48-0+)241'(-+2.82-+11+%',:;,3/0($&)(#(8.))1,'/%+/6'965,)&&$)$,.01-)-+),,'&%#$&$)'%/,((%$%-0+3,)/96,')-'3+$))'.-%'&'.82'()-3459822,#(.),%'%#'#'%--7017666;/,-&24./.-3-125741++,070+2.,,,,)&&&&))+-..86476378786,0,.47.)),-(,,-584/-+,-,:33057).732/0303/&%,1-,++,+/(&%()+/0-10)+511&37.,16769:;++)),)'.)1210)/1-(&),:8,+0./69.)+(',6&&)12820/,&)$$$'/2094-.3--)(.0898150615061/5,216/,,203152((#(///-,+-701/),.065/9---2)/1/019/040114457453237,0--0'0+''$'-656.(++101/-5&0(+2:,+,$()(34969:8.9::-&)+/4001311/-1123'(%2,302,)%%'(./-+)&81936,(++''(,2/39,/3(0&%(+02::6+'--/026+'//8---2110,1')$(+%&&$%5.7/;095-:60((),:79212221))'&$%)1/+&,)2,34+,)++&315/(,/,++%&&&(/($)),-58+'%(10(6.+.4-$)),/5596%)(&+-110.,+-.,-0-'$$%(,..701'++:&)%#&1.4361.24')&/1,'"#$+.(()&&%($/($&&%'&)-''),+024&)'$$$"$((%%%+)&%&%&-'&%"$$%&#""%+(+)&('&)1),+,($$$'&').0.1$+-./504...00)%)/481)),++,,+1-)&&-,&&).,-#(109361&(74:51.-,&-)67-+,+/185587:5115621,-+/,,%$./0'%&'-.011./18,(,3')/3,8:3%'$'(/-+-'"%&-/42113:8090,)+,38(11:-85.9;2--01,,--,.&$#%335439922(,42/.:0,4///8898:215)+-000/;+,+39;;0.093251,12-+146/.,-.3-0029681.0+--.)++.+/*6(8:0.9:9968778;9760-'%()'+5543/(+,52753,,+//201/2,--6;9629<:90,,&$(./,/'++)'/--/,,,%$798880140+%,+4,4.101)##$$).%%'9843457/$-10--0-163,1/,6&,1/+)10)($,%00))#&(&##$###%%.0/'0(356524+,%##)+7642.-+,'+),266&-,/./,$&&+274--206,/(,'(()*$%'0%%+/9+/1./24.7/794/174031,-.0:7)3.'#'(,,+2:-&11/00.5;2.&1/%&..6///610+-)-/823+(--.687-.+,/8877677896850'(5:74771/0,-+.,5'#&$,,%(&,(,+5373131....13:58)333$,(%'165763/2&)+'(+/0.,./07,1,1)+,-/667.3.-/114.3,($0()(#%&&($49811+,--,)$$133()..05,-,)(-)027445557/-%+,+.//++&'1-77+647..83:')-//&,.431++5.7.,+/3+145-&&#%%)/1)#$&((./.(2+//5.422/00)10($0-+$+(-+,..890+',243522509465:4,36/4-)(&$&'(426%.51'.%$'#$)%$/073.+#')/.+))1),(.2)15+,3;:9000-.,.&-,&)-)(-516%-40/797210/0+103.(%&'$'&'(,-775/046-2+/,,/--,))&$$,((%#$###%%((/1198897.317,9/-5694909./62.235737'&0'253,#,5675011011;21+,,),--(25'+)%()/40//266544.2--.(''$(&'#$#$&('&&)+.8;6,325/00362154181500,)103-,(,-0$'%+(--.1/56671'-++:,03732.1'-7&%$')/60(2+853/)(('$,,,.//,)))+$%#),-/3-)360-9-/.8)14)(%+'-,1,-.,,%))(4-./).1/..-251+,$)&3)-.1-.000&...7/8)/(/%))(),(&%')+'&)#$$&+6+,(02-/024)6-'#).(&#%&0)',.).'(%'-'&'&.*,45306.,+&%%'(%$(&#(%$'&)-,2,-/34589;381,4.,/004:2(4287797829/0,+)+%+2+%($($))(-45,+($),+).//29(:9:5/%+0.-&+,,513/,+/0500,/+*'%$-3,',1,)90&1,1:6,#',-(%-.4040./0/91(%#+.//07,&6)5+4.3-()%&(,,.48,+()%%'%444440+184)0-(,)0''%+,8781.-&%'&(),'/'((&'$)$0'.-0-/4//6717(-0+5,)++,.08$(+0221310(+/35135121/267293/)1+&$&/1/3:)6&+)24&)'''-,/-+&--0)&%&)'&'109/.&'#'#+.530.).,,7:.(-05//3211,1./027,/&&&'+(--10+/,-+,62159+6$'+++0.126356368%/&')02214004574:986:+.+&$,-/21.66:7;9/9/,+#,&)460*0/,)&*).5+('/04535:.+.'/-./--23$%&((.2,),(&))02,%%-/35)2685/(217,7796;6/10+(',..0,-0111225852.+,++/-201/+)-+-.-05367+/+(2+6+/,6;8-),,,,/.00),%/33,1.292:54(()+0#$&(-1)'$%&(&*&&+--6..-1250))())(&((,30000,/.'##'(+.)2,)+34945%+'$-,++%$#''65/$#'#$# c1deb4b3-dd60-47a2-94b4-5a79a2f7422e 4 0 0 0 0 59faddaf-7594-403e-884f-fd02031db2d3 4 0 0 0 0 eb63ca70-84ea-4298-8053-ebd427fa2aaf 4 0 0 0 0 6c3acb49-10fe-4c99-bdf5-21dd1fbb340e 4 0 0 0 0 69b8d75f-68c4-41a3-932f-4765c05a4f03 4 0 0 0 0 326b545d-a316-4858-b724-928598aa5f2f 4 0 0 0 0 be67d78a-0d8d-46d0-ae44-58a10c1a7f51 4 0 0 0 0 TTCGTGCTTCCGTTCAGTTACGTATTGCTAGGGCTCTCACCTTCTACGGCTGGACATTCAACCCACTTCACCCTAACAACCTGGCGCTCTGTCACGGTAGAAACAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCAAGTATCACATACACACGGTTTACAGCCTCATCCACGTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAAGATGTTTCACTTCCCATTATAACCCCACTGACTATGAATTCATCAGCGGGTACCTACCCATAACGGCAGGCGGGTTTCCCCATTGGACATCCTCGGATCAACGCTCAATTGGCGGCCACAGGGCGCTGGCCTTACACGTCCTTCATCGGCCCAGCATAGAGGCATCCACCATGCGCCCTTAAATAACAAACACACACACCCCACACACCACAAAATAAGCAGGGTGAACAACCATAACTAAAATACTAAACCACACACCAACCAAAGTTGGTAGTAAACGTTCTCACAGAAAAAATAAGAAAAATTACACACACCACACAAACACTTCAAAAGCACTCGTGTGGTGGATGCTCGCGGTCACTATACAGTTCTCACACAACACCCCACACCACCAACCACACACCCACTTCCCGTCTTCGTTTGAGTGCGTGTTTCGTGATGCAAACACGGGGACCAACCCATAACGTGGTGCTGTCAGACACCCAACGGTCTACCAATGTCTAAACCCAGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAAAGCCTCTATAACTGCCGGTGTGTTTCCACTCCGATTCAAACTCAGGCGGCATTACACTCGGGTCATCAACCACCAACACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAGGTTTAAAAGCTCCTTAGAAAGGGAGGTGATCCAGCCGCACCTTCCGGTACAGCTTCTGATACGACTTCGTCCCAATCACCGATCCACCTTCGACAAAGCTCCCTAACAAGTTTAGGCCACTGGCTTCAGGTGTTACCAACTTTCATGACTGACGGGCGGTATGTACAAAGGCCGGGAACGTATTCACCGCAGCATTGCTGATCTGCGATTACTAGCGACTCCGACTTCGCTGGGGTCGAGTTGCAGACAATCGAACTAAGGCCGACTTTCAGGGGATTCGCTCCACCTCACGATGTCGCTGCCGTGGCATGAACCATTGTAGCATGTGTGAAGCCCTGGACATAAGGCGCGGTGACGGCTGATCATCCCACCTTCCTCCGAGTTAACCCGGCAGTTTTCTCATGAGTCCCCACCATCACGTGCGCTGGCAACGCCAGACAAGGGTTGCGCTCGTTGCGGGATAACCCAACATCTCGGCGAGCTGACGGCAACCATGCACCACCTGTACAGACCACAAGGGACGAGCTATCTCCTGGCGTCGCTATGTCAAAGCCAGTGAGTTCTTCGCGTTGCATCGAATTATGCTCCGCCGCTTTGTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCGGCCGTACTCCCCAGGCGGGGCGCTTAATGCGTTAGCTACGGCACGAAGACGTGGAAGCCCACCTAGCGCCCTCGTTTTGGCATGGACTACCAGGGTATCTAATCCTGTTCGCTACCCGTAGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGGACCTGCCAGCGCCGCCATCCCGGTGTTCACTCCTGATATCTGCGCATTTCACCGCTACACGGGAATTCCAGTCTCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCCGGAGTTTCACAGACTGACGCGACAAACCACCTACGAGCTCTTTACGCCCGAAGTAATTCCGGACAACGCTTGCACCCTACGTATTACCGCGGCTGCTGGCGTGGTTAACCGGTGCTTCTTATCTACCTACCGTCACCTGGGCCGTCGATAGCGAAGGTTTAGCCAGGCCGTCATCACCACGCGGCGTGCGCATGGAGCTTGCGCCCGTATTGCAATATTCCCCACTGCTGCCTCCGTAGGAGTCTGGGCCGTATCCTCGGTCCAATGTGATGTGCACCCTCTCAGGGCCGGATGCGTCGCCGCCCCGG (%"$&$%%-&%(/590,8-,-78040-.1-.,)).0/043:0))-(%$#'(-+/,+-+052),/60513))-664,-##%%&##'&(-./&$0-,%++)-&59.13.0/3254(',/13038,0-33.-..88:87124651-0064333389751438593'#'(+,.-20()1673778.12466783,,,)+5,-/52-293/091-+1324:449068556768.-/-69--02./94(+())5124-214566581.1094435//4-/'))69420:5,+372/76-+0#(,3,+51,&#%%+'5,85(-13./51)2,2674,7%&##$#"""$$)+&$$%#')((()+-.-/128;9,)&))'&(#%%"%)43-2129385103:4,41;;766988232,(((,./75(')(',2,/-6-'%&%%%'&#,(18/(,5--51/1;;:,+(%69784121234612-2.:7+2,2+/%#&')2/(,5.30-.,++.424/./*'/638,-0+,.10001.+*(020',.'.4-5-+..0.2121)-/+262243%+'"),-2898701084,,')0086-840&((-5-.6+2.7)++--4:.,-4')&$"#$&()-:2$$&,+.1422;44-4...1289'-/0/.)111/,-+&"#&$&'..04367801%',$+11,11'-("#&+1/4767369306('+-:979841601:7554131-.164578.5(#.'7,425-6+%)+&&(+.130...1,523.)054763:413'1/++,2:5581322$($%)('&%&)')-,73.-,01027.))+1,/-83+.00.2---,.-)-3757/,-494)+,-4.&'&+-,('-()+0:1.1,,+)-(&'%''///&')/9-2238105'+))$'$#$#"(-)-//196473:/,++&"$&'-.0/)//1:.((#&)(&)+,3)',1,22+:2.1::;460.'')1/)/4..-:/06+-(0-,/430)$''05+/0$##$&(,-5.4273,.),//52481368.,.333:666887774657080101//./22732/330.##%(49.-.-//05/1%&+/%+'/&'0778:+9870/0-:90&0.(8,937563,0323/2132+'('$%',$2%(&,$'(05.70,+'-,,/12++)06;202925%$(,/-)&'%%"#'#'$%$'(./-54+.33::271&'',,1/-,.-(310197:+446$$).+237()/,-/4-/32,0$(.72+3%%$2+03',&,1+6/2256889954.4'(%'-))(,,.+.&&(#$),,.)/*%/2116,,143664:9+))''./860-(.2##&'(1332.1%&&$#%#'&+)0/.1,3&%(,%)($+)6/7;:8806806474$%)$''++20/3++,1-)/-1+6)61)%$%,)(&/%%,'&&(+68))3+/3)107591,++3::4/599.98542.0,/.-,.,)2,+-.),,6,-.-)+03.,'&'$'')%,30#''(//"$),/,%'(5246941/+.-+0$#.'-.71;117578;8677373-#%"#%)-+'(,146,))+(.-2013./1507+&(((&&'&##"((,-4111('13339+$((-.-,.10*14.4;8+111+(%+/)1-1,4.0+))++02-+-,.0++-/-,+..-06799;:589,/2./.-4/'),:/,3/+%''5-&(,)+.-+,,2,,/0248579247-.1++/44408-&)&,&%%)(&&.362739133/22010++-7+)((&).71474/4.//86,6++%)(1/536552.0$&6)7.5..''$&%&$&2)16--4'.('$/+3510,$%&&(&(&1)$('%$(%,3277844%'&),.1911+$#%'$(%'%(+.4/.+52))%,/-,&(('.21%)(()%'+-04/+/-+$'():;:321/250.'+-)/)(&'&&$(&$&$("'%20.,4$.3),-/046)2++(-04(-+%$$# 52ca506f-7d10-4b79-af84-64947719c186 4 0 0 0 0 b3f17dcd-949d-4181-bb49-2b8ddb17d824 4 0 0 0 0 c9a5ba6d-9514-487b-9ec6-ebd642ef0ff9 4 0 0 0 0 TTGTGCCTTCGTTCAGTTACGTATTGCTAGGCTTAACGCGGCGCGTGCTATGGCTGACGCGAGGCATCCACCGGCTGCGCCCTTAAATAACAAACACACACCCCACACACCACAAAATGCATGGGGGTGAACAGCCATAACTAAAAATGCTAAACCACACACCAACCAAAGTTGGTATGCGACGTTCTCACAGAAAGAAAAATTACACACACCACAAACGCCCCAGCCTCGTGTGTGAGGGTGGATGCTCCGCGTCCACTATACGGATTCTCACACAACACCCCACACCACCAACCACACACACCCACTTTGCAAACCAAAGCGTTTGAGTGCGTGTTTCGTGATGCAAGCACCGGGACCAACCCACATAACGTGAATTGCTGTCCCAGACACCCAACAGTGCACCAATATCCTAAACTGATTTCATCTTGCCTGTGTTTATGTGTCTCAGAATTCGTGTTAACGTACCTCTATAACTGCCGGTGTATTTCCACTCCGATTCAAACTCAATTGTGACCGCTCGGGTCATCAACCACCAACCACCCGCGCCACAACCGTGTGTTAGCAAAGATGTTTAAAGCTCCTTAGAAAGGAGGTGATCCAGCCGCACCTTCCGGTACAGCTACCTTGTTGACTTCGTCCCAATCGCCGATCCACCTTCGACGGCTCCCTAACAAGTTTAGGCCACTGGCTTCAGGTGTTACCAACTTTCATGACGTAGTGACGGGCGGTGTGCAGGCCGGGAACGTATTCACCACGCTTGTGCTGTCTGCGATTACTAGCGACTCCGACTTCATGGGGTCGGGTTGAACCCCAATCGAACTAAGGCCGACTTTCAGGGGATTCGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTGTAGCGTATGTGAGCCACGGACGCCAAGGGGCATGATGATTTGACGTCATCACGCTTCCTCCCCAGTTAACCCCGGCAGTTTTCTCGCGGTCCCCACCATCACGTGCTGGCAACATAAGACAAGGTTGCGCTCGTTTGCGGGACTTAACCCAACATCTCGACACAGGCTGACTGACAACCATGCACCACCTGTATACAGACCACAGGGACGAACTATCTCCTAGCCCAATCCGCAGCATATAGTAAGCCGGGTAAAGGTTCTTCGCGTTGCATCGAATTAATCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCGGCCGTACTCCCCGGGCAGGGCGCTTAATGCACGTTAGCTACGGCACAGAAGACGTGGAAGCCCCCTGCCTAGCGCCTGGTTTACGGCATGGATTTCAGGGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCAGAGACCTGCCTTCATCGGTGTTCCTCCTGATATCTTAGAACACTTGCCGCTACACCAGAATTCCCAGTCTCCCCTACAGCACTCAGGATTATGCCCGTATCTGCACGCCCGAAGTTAAGCCCCGGGATTTCACAGACGGCGCGACAAACCACCTACAGGCTCTTTACGCCCGAAGTAATTTCGGACAGCAGCACCCTACGTATTACCGCGGCTGCTGGCGTGGTTAACCGGTGCTTCGCCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGGAGTTTACAACCCGGGCCGTCATCCCCCACGCGGCGTCAGCTGCATCAGGCTTGCGCCCGTATTGCAATATTCCCCACTGCTGCCTCCGTAGTCTGAATACCTCAGGTCTACATCCGTACACCCTCTCGGGCGGATACCCGTCGCCGCCTTGGTAGGCCATTACCCCACCAACAAGCTGATGGGTACAGGCTCATCCCACACCGCAAAGCACCACCACAACGCATCAAGTGGTCACCATATGGTATTAGACCCAGTTTCCCAAGCATCCCATAGTGCCAGGGGGCAGATCCTTACGTGTTACTCGCCCGTTCGCCACTCGGGGTGCCTTATTGCAGCCTGAGGCCTTTCCGTTCGACTTGCATGTATTTAAGCACGCCGCCAGCATTCATCCTGAGCGGATCAAACTCTCCACAAAAGGCTGAAAAGCCCCGACCTAACCAAAAGACAAACCTTACCTAAACATCACTGCAATGTGTGTGAAGCTGGCCAAAATTACACTACATAAAGAAATCAACGGCCCAACCAAACAAAATGCCAGTTGAGTAGGGTAAAGTGTTTTAACCTGCATCGGCGAATAACAATTACATTCATTCAATATGTACCGTTAAAATATTTAACTATTTTCAATGCATAACGACAAGTGACATCCGGTACACACCAACAACCAAACACACCCGAAGGAATGCTCAGTCAACGCAAATTCCCATCCACACAACACGAACAAAAATATAAAATCTAATTACATTGGTACACTATTGAGTTCTCAGACAACAACCACACCACCACAACCAACCCGCATTACACACGGGAGGCAGAATAAGTGAATGAAAAGTACAAATAAATTTTGCTTGTCAACGGCTGTTTCCTACCGCCAGCCTCACACCAGAACCCTTGGCTCTGTGCGGGGCGTTGTCGGTCTCGCTGACTCACATGAAGTTACACACCAACCAGAGCAACACAAATCCCCAGCACAAGCTACATTTCTGCGATTCGTACTGGGGTTCATTTTTGATGATGTGAAGTTGATGAACGATTTCCTCTTGTCCGCGCTCAATCGGTAGCACCAAGCGCACGGAGGTTTGAAGTGCAATTCACCGGTCAGTATGGAAGACATCATGCACAGTGGATTTGCGCTTCATCAGCGCAAAATGCGGAGAGCACCAATCCTGCACCCGCACGGATATCGGATGACCAAACGTGCGTGGAGAGCTTCTCTTGCCCACGAAGAACAACATGGTGGCCATCGACTTGAGCGTCTGCACCGAGGTCAAGCATCTCGTCAACAAAGCGGAAGCGCGACTCAAAAGACATTCTCTGTAATGACGGCAGTTCCTTCAGCTATTGCAGAGAGCCCAATAGCCATTGGCTGCAGGTCAGTAGGAAAGCCCGGAAATGGCAGAGTTTACGATAATCCACTGGCTTTGGTCGACCGTCATGCGAGCACGGAATCGGGTGCCAGGTCTCAATGTCTGCACCGGCAGAACGCAGCTTCGATAGCGGAAGGTGCAAGTGCCGTGGAGCAATACGCTAACCGTGATGTCACCTTGGGTCATCACCGCAGCATAAGCCAAGTGCCTGCAACAATGCGGTCGCCGATAACTTCATGGTTAGTGGGATAGAGCTTGTCACATTGATAGTGATAGTTGACGTGCCAGCACCGGAGATATCTGCACCCATCTCCGAGAGCATGCTGCACAGATCAACAATTTCTGGCTCGCGCAGCATTATGGTAGAATGCATTAGCATGGCCCAACACTGCGGCGGTCAAAATATTTTCGGTAGCTCCCACGGATGGAAAAATCGAGCTTAATCTTTGCGCCAGCAAGCTCGGAGGCTTCGGTTACTACCGCGCCATGCTCAATGTGGGTTGTTGCGCAAGCTTTTCTGAAAGATTTTGGTGCATGTCCAGAGGGCGGGAGCCAATGGCGTCACCGCACGGAAGGTACACGGGCTTTGCCACAACGTGCAGTTAGCGGACCCAAGACACAAACGGATGCGCGGAATTGACGAACAGCATCAAAGTCATACTTCAGGCACCGCTGGGGTGTCAATGGTGACGGTCGGCGCAATCAATGTCCCACCGTGCAGCCAGTCCCTCGAGTACCTTTGCATCAAAGGGACATCGGATCTCTGGGCAATTAGTTAGCGTTGTAGCAGATCCTTCCCGGCCAGCAATGCGGCGGCCATCGGATTTAGAACCGAGTTCTTGGCGCCGTCTACTTTCACAGCGCCTTGCAGGCGCTCCACCAGAAACAGTAAATAGATCTTTCGCCTAACTTTATCTTGCAATGCACCAATTCGGCGCGCAGCGTTAACCGCCTCATGCTTAGTATGTGCTCCAAGCATTACGAGCGAAATACGGTGACAGTCTCGCGCCGATACCCCATTTCTTCTACCCTTCCCACATTGTAGCCCAATACGGCCTGCAACTCAGCACATCCAATTCTCGTGCCGACAACTTCGTAGGTGCCCGGCGAACTGGTAAAGACCATCTGATCGCAAAGGCCTTCCGCTCCTTGCGCAAAATTCATCTTCGGCACGGTGCCAAGCATGCGCAGCTTTTGAGTACGTGGGGAACATGCCTCCCCTCGCGCCGACCATTACGTAACCCGCGGCCAGCACCAGCAGTACCATCGCTGCAACGAAAATTTACCGCAGTCCTGTTTCAGGAACGCAATCCTCCTTCAATCTTTATCGCAAGCAAACTAGTAGCTATAAATAACTCCATTCGCATTACTATCCAGAGCAATCAAATACAATCCTTCATCTTAAATATATTCTCATGCGAATCATATTCGCACAAAATATAATCCAAACACACCAACTGCAACAAGTAAAACTACGCATCCACCTCTTTAACAATAAGGTATTCTACAGTACCGAAATACATACTTCAACCCACTGCATAATTGCAACAATTATCCAGCAACAAATTCCATACGCAAAGCTAACCAGAATACCTGCCATCTTCAACGCAGCCTGAACCTTCATCATCATCTTTATCAATGCAATCCATGCTTAAACTCGCGCAAAACCCGTAAACAAAGTATTCCACAATTATCCACAGATTTAACCATTATCCGTATCCTAACCTGCACTACAGAAACTCAATCCCCAGCTCATCGAGATTCCACTAAATCTAAGACACCCGAGCAAATTGCCCCCACTTACCTGCTCTTACCCACCCACCCCACCCATCTCTTAACCTTTCAGTCACAGAATAAATATACCATCCAGTCTATGTCGTAGTATACACTAGCGTGGAACAACAAAATTGTCTACAAAAGAAAGAGCCATATCCATAGCTAAGATTCACGATTCAATTCTGACACCATCAGCAGAACCCCACTGGTTCGACTCAACAACCAAGGATCTCGCGCAGAGTCACAGTTAGATAAAGTCCTTCAACCAACTAACTCAGTCCAAACCGCATCAGTAAAACAATCATCGACACCGCCGAGCATCTAGCGAAAGCTCAAGCCAAGCAGCACCATCGCCAAAGCCACCTCGAGCATACCAGTATCACTGCTTGTTGGCGCATCCCGTAGCTAAAAGGGTTAGCGTAGCCATACCGAAAACCGCATATCTGCTGGCGCGCCGCATCTTACTGCGCACGCCACGGGTACAGAAATAAATGCGGCCCAGAGCACTGCACAGCATACGAGCGCTGTCGGCAAAACAAATAGAGTTCTGGCGCAGCAGAGACAACGCAGTCACCCGCCCGTCAGATTTCTCCAACGAAACGACTGCGCAGATCCACTACGAACCACTGGTCACAGAGACCTGGAAGAACTCCGGCGAGCAATGGACGCATTCGTCGCTGAGTAGTAGGCACGAAGCGGCACTGTCACCGCGCTGGCCGCTACCTGAAAGAAAGAACGCCGACCTGCACACAATTTAACAGCCGAGCCTGCTGATTCCCCAGTACTGACCGAAGGCAAGGCTGGCCCACAGGTAGAGCCTTGGCGCCAACTTCATTCCTGAGGTTCTAGATCGCGAAGCTTCTCGATGGTTCTTACCGCAGCAACGATCCATCGCTATGGCCCGCAAGCGCTGGCTACCGATGAGGGCCTACTGGTTCAGTATCTCCTCCGGTGCAAACGTCGCAGCAGCGAAGCTTGCTGAGCGTAGGGAATTCAAGGAACTTAAGACCATCGTCGTTGTTAGCAATACGTAACG #"$#%&%%-$$&2.#,3--.984260113.1++(4-6)')&$%#%##&"%$%%$'#%%+&&&#"%),.*.)$%',+.2+,(39:0202.73.()''&+30+&)().,-5;:5-/0/1,5:8-().,+'.+,)2.0-:962.*1(,488521///24.5/7.:/.+8-4-5+))4146540/0,+46+'5781/94311..../++,/)"$$%#%#$()+3/3,+-)'&'',,0$$$$$(),01,-,24,3,43246733134651516+).24()+/276,,,+-+,55(),50$+0452'.)-22:8)#&(,,5875;0/-))))(-1%)+-(/5/(0/.91//124,65703)6()6)+/')33&'(&+'1/15/.&%(+&),'(%#&'))'-("&((5.-3622266;;3437476677014362/.)'$'#$$$#'2.034+.#&-()3381//',5204,..5()(00/:8572'#5%$%%&+(()-/$22.01::0+/8,3)-/&)093&+)+(+4160631&&&')42:--+(-69/9()129+/-('/2'(%++'().+4,&-(,2466)7-4-4&334&1&&'$('&&+205832/501,-5-..282383./)(()((+2().:71&'(.:43:8:576-8,,75$2+,/:-.7.-)+4--166540)'(,/889;:557/,%$&%+53,.+,)''((,;7647($#""$&%+&#$(-1-+/2./+21101197-+-10288-34/+'0,4)$+)681)1-8,/66531446910229:6'()(,$5'&%'++,015733022)00'%''06-,7---2478482390/)+,,-,&'##%&)+5:77%%%5-)(1.,,5../.(,1,),/0047)#&"#"$-')+49+&'(-+(+00++0-.-852+0+,&&(3+745('.7186.112365495518026:67716)4-:26477:/70+,0282-(+//,,''/41721$&(--/3%(00',+%(:7%4.--5:79;372455554736781,,,-8627417'(.22,5''',20++,-1("$#$&-.01&$&&'),2(2+/+.).-3;;:;:6942955489.+0--.-).+012553/-01.0.5-//747-5881,.9498:745:82351<<.(-&)(%$&'(,77302458-268':9886234050/.''())')+',.++1%%-(&-+3342-3+,8:6,((.0+).247:3,/.61.131234/,.'#()'%")-.-/901.,,1;54651391-03+4;+,1025836+,-/,10//4/015//,-..9976/,--+/582.3-.045)-2-,.000.+%#$(('%)&&&(-04+/-/4/,),3+'(236+83+(,))'()$()+%+%1)357031,-0,)%)),+,20+++'1,4,237034,1:/../01761%1)+,-:<99:4691-1')),-:0;9-/-32,(+-)#+-59(/8-90)0$#%#',''(+)2+-,,4...23+.1/-(&(%,+364:921+'$'%(%(1/011,141/..5-+,/732-/419:/...++..&&+$(4;8356502(($'&1,478:29<:+'105%0/.13$&')+-+,8,23/19.32.7'&&&'(/,,3-339/,223$&'+10'(-...2$%$#'$'-'',/,%$)+-1,../+054////%21)')$#'/8.0623+'%#%%03./37.1.,079-+022-.0+,))0/)(8,.59988.58'++./&..&&&%+6-78'(3.-/13..,%'+6+.##"%(-161-6&-/5/,-.;6/--,$#%-.&&+1.44.2(#-457,0-/641%&)/03007.///"#$&'1886780324'.)-&(,&-&#&%"%%%('##&'+-.77-4.03-,%)%%&$%($+#,/%(($%)235879:210#,5.01/0)&&',).0,4//,-.-)((-65,'0(,,')--()/2'%&&)++3/0,86+)97253(&$%#$##('(&'*+$&%(.1320.-++,,-.3/7.-/4,'0)$'())../14,).4602/,&&%))-/,/-12/1;;../6;//50)+))0+-2:8,5408;8-85-..01050+&%++/2/00..)))(,$#)((.1./29899;68:6;;:337;404.1369;43/:20...174/-+')&+44+431430.3'-,073,234$$)/-)))#%,+)+3(($'(,011+-36)6"#(.)372:435780.--.0-++'(837;;:-2206998/.)$.('+7/:-6/24157.5.,+339567%&4+%%()(,,193562113-2,7,:100-.+.+,+,)+2$')&%')26+22087+11'1,15;<9:;:2;:7./6/9:1+0/63406;7+)/4&$$$&%&'(&).0./14%)$&'23377974(79744,9+,-0621.55-.,,,10,-.0#),3.+..-321,02++,(,06/334;9./78++,+)/-'-.0+7;2.699668:7/605868:547841;75)''((),,0./4,,/(#'&$()-20;4..01.900021423782:64++,++'.+-/411..,3++)'%%('''%$"#%&&)5-0925,(02362+...),4--/-,+,/1/$0(&+&(002666034563951,+/.&'(+,3//6.10-++'04+//16265695;8855,+1:893856654.+()$&'-7964:024+(()-.)')%%&).&-,-,7.650,+,)/1)*+3566761',&))'+-00//-01/606:').(.'(*,,++,8486-/01;4211124900/0&42.299:79;61344,8-,,6,,&$(10'0*--%+,$+&,(*18-6822//0+5.64+-61.,+3,+485/,+,.7,,,,'0--802/3/,,+3.54438./1+(2+$.---(()/%.)&%'(3,8593(''%$'(.30454352/,,-/3:5540+,-1/4-03.-/6635798/.1(&(,+9-.0-358882,/,.00;9:,9+78-../36237-/,+,'&((,),+6351)06.9879895954()31--)..8360/-$&'6588.&1109+,(#$&),('++'2+,-.-5+++-..)&-011609/011,76774.37.,551&$$%#--2:877/.'&%$5541)6605:0&',221&&%$%'))03),%$##$$#&$.#.&%%)$)$++.(%.-0148585$42295/155;;54-7-,+--/82,.1337964814)'(/1.,.-:9--22)#',2,-.)+,'(.-061/62902.(2)(579:79132,/++-,140;+20,+%)(('()-/4'+0&#'$,(%%(&(-/-9&%-#0/13&//(,,%+,:641-+,2+-+,,+(%%#$#%&-&11/,-0+.,)0/./562607--..5/6('&#('-3/-%./742-+,)0%--/.'%,.072+4449+:4/20)'#%%,+$,')571551%0-/04/12./4022/(.-///.'-(&(.('$+.43,/7176-,+1-)/.5.+&$%(/6+59)-,-23&-1869745''(.+'&,),/'2(%(3$(&)5,,'(%-03667-1(%'2)210/4/-.1+0)7.-/0,5+36'''-4/30.3/:080203,2/-11.),,5-((),.-,.)&+,52+0+0-)+,()&&&/016'%&'-/,19.-)0-+-.&&&''1,4+%)&'&%(#/%')0)),+,43-+,,(-+)((+.1..(/%%$%&(()(&&$((5(0#%$&%(-'')'$++,,,.))'',&%+)'''&)/'$,(/(,)'(.')4:322060/.58+(,)/)&$$&)-,2,(''#"$##)()./)%))%+0&-',,102-2'2/+%+--+2-9.2$)$)/''%)$$&/148./-(%0-1581(%+'26,'))&'2)%$'-/-)-,,$3&-')&.),0160)&++.1-&(%,,',53531-)'''(&&%(+)10625+''&).&)%%+-%&(&&,.'"$(#)&"$$#"%..(#'('5,()(+)&$&$&(%/7/14)0130$$)$+,)./+.70+%$$2+&'$""$$##""%%&()(()""$$"(&%&'("%(&(#''*''$%#&%&$$$%$&$'$$'#$').%))/)'$&')&##'"&&'),-2/)''.+.+),)(+(&#%(#"###(.,).+3))/-.)/-/4.$'$)))'%',+.-1-.26.--)%1%$$"%%$%&$$&'(/.//45,2-/-(%'%)#%%$#&()(+(&%)'/+((%%(+%%%%&()/&##%'&&+(#%%$))+)+,%++)+&'&)'+1(,$++-,.33/62..0,/"%'%#%%$'&,)((06433)%$%0)&$#&,.)%%%&(/4.'(300-2,+,'(/,(--%+(#%&&&()$&#&'+,/'&(#($'&('&.+(0+,'(+($&&'&)$$()(+%()())((3+($$&%,-&($"##'()($*(*'%)%-/23(&'+(++(,')&%&$)/+$)%$/-15)&(#-$%'0-)01.0.%&$..)'%.&.799+#$%$%+0&#'&(&%&,,$%&%%054&)++,)&$"&%)&2))(./-$#$$(.'/9.,-++.0+,3%',,+'""%))1)&'&$&*)*'&'(&&',+3160'//'+655656.($('#&),0((,4/2(,,+(&$(,+++..),///)%%'+22887"#$")',,58//3(.-5.())+-(,)/).'2/'')6,+)(&$&%%%&))##$(+(#$$%$()+0-,3-2(.&'(++,0,/5&/0&.-/+.))+4.'),784+2+++2/($,36-2)&&+3%"%'%%&$$-5'.(-/$$%)+./14-.-%"')'(-3+.3+3#&(.&$)-6+222)($&#"%'')/&'+2657+-/0-,+')%&(&)%"#&'&(%0,-,+-.$$$('.-&&%(&'(###%%'.5(2$2,/#+,&0)--014-&((&%%$"%#)'&$$()%%-)((,+)(#,./$$%+,-/))#%&(&.-03)'3487'-%%##'%'//63))0-&+),+'%($10/-#-(%/0'.*)$+--%)/))%2+-,36'3(/$),)%$&$$%&')+/454-)-/&',,.)+/21.+(+(&3%&$%&$$'/050/42%%(($%')./2,1-01(,.745/$&'&$%%(&%&$'&&-)-)%(&%-+&/''(+,,)/--00/..(%&,%%(.+&+61.0+%040--+''((25)()+,-2-)%,.-13-+)0.7('#($$$)/5/0-%)-#&%)))+'+)(&(%)%($%#,+)/(+://+.00458,-)).5&$(),01,,(#%"$+0//-$'(,,4/8/,.)'-,0.).)+--,'(&'0&)2,0)&)+,',,+(+,+&',+1(,/)$&%),%%$'(-145523)+((&4.24/064/1'&%%#%'%&+,&(,,('.''%&&$%-).-&(,+)'+&-/.54+,,,:+'-%#&(+2/01($$""" 1821e6ad-ff47-46a1-998a-ccbe741790f4 4 0 0 0 0 8ffe151c-4b3b-4801-8fee-0d43e7ec6b6d 4 0 0 0 0 7d7301f8-df66-4679-94e3-b37b5934d83c 4 0 0 0 0 4bfabea3-fb07-4bb6-bea6-bc426cd1f3e7 4 0 0 0 0 2aeb18f2-4045-4c6f-b07e-3fa15ec86328 4 0 0 0 0 872ecaaf-7b05-4576-891c-42c13568628e 4 0 0 0 0 bc417d2a-7773-4046-950c-e5acc4b82d7c 4 0 0 0 0 TTGGTATGCGCTTCGTTCAGTTACGTATTGCTCCTCACCTTCTATAAGCCGGGCATTTCCAGCCCATACCTAACAGCACAATGCGCGCTCTGTCACGAGTAGAGCAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCATTATCACGCCACACGAGTTTTAGCCTCATCCACGTTCGCTCCTTACGCTACCGCCAGAATCGGTATTTGGCCTGCTCCTCCTGCGGAGTACTAAGATGTTTCACTTCCCCACGCTATAACCCCCACCTGGATTCATCAGCGGTACCTACCCATAACGGCAGGCGGAAGGTTTCCCCATTCGGACATCCTCGGATCAGCGCTCAATTGACAACTCCCCGAGGCCAACGCAGGCGCCACGTCCTTCATCAGCAGCATACCAAGGCATCCACCACCTTGCGCCCAGCAAATAACAAACACACACGAAATGCATGGGGGTGAACAACCATAACTAAAATACTAAACCACCAACCAAAGTTGAGTATACGACGTTCTCACAGAAAAATAAGAAAATTACACCACACAAACGCCAAAGCACTCGTGTAGTGGATGCTCGCGTCCACTTCTCACAGTTCTCACACAACTTTTACACCACCAACCACACACCCACTTTTTACCAAATAAAGCCCATTTTAGTACGTGTTTCGTAGGTATTCACAAACACCGGGCCAGCCACGCAACGTAGATTATCCCCAGACACTTAGTGCACCAATGCTCTAAACCCAGATTTAATCTTGCCTGTGTTTATGTCTCAGAATTCATTATTTGTAGCCCTCTATAACTGCCAGTGTGTTTTCACTCAGTTCAAACTCAGTAGCGCCTTGACCACCTCAGGTCATCAACCACCAGCACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTAGCTCCTTAGCAGAAAGGAAGTGATCCAGCCGCACCTTCCAGTACGGCTGCATGACTTCACGTCCCGATAGCGATCCACCTTCGACTGGCTCCTACAACAGTTTAGGCCACTGGCTTCAGGTGTACCTGTAGCTTTCATGACGTGACAGGCGGTGTACAGGCCGGGGAACGTATTCACCGCAACGTGCTGATCTGCGATTACTAGCGACTCCGACTTCATGAGGTCGGGTTACGGATACGAAATCGAACTAAGGCGACTTTCAGAGTTCCTCCACCTCACGATGCTCGCTGCCATTGCTTAGTCGACCATTGTAGCATGTATGAAGCCTGGACGCAGAGCATGATGATTTGACGTCATCCCCACCTTCCTCCGGAATTCACTGGCAGTTTCTCGCGGAGTCCCCACCATCGCATTACTTTGGCAACATAAGACCAAAGGTTGCGCTCGTTGCGGAACCAGCAACATCTCACATTGAGCTGGCGAGCAACCATGCACCACCTGTATACAGACCACAAGGGACCCAGACTATCTCTGGCCAATCCTGTATATATCAAGCCCAGTGGAGTTCTTCGCGTTGCATCAGATTAATCCACATGCTCCGCCATGTGCAGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCAGCCCATGCTCCCGGGCAGAGCAATGCGTGCTTCTGGCGCAGAAGACGTGCGGCCCCACACCTATAGCGCCCGCCGTTTACAGCATGGACACGGGGTATCTAATCCTGTTTCGCCTACGTAGCTTTCGCTCCTCCAGCGTCAGTTTTACTTGAGACCACTGCCTTCGCCATCGGTGTTTCCTCCTGATATCTACGCATTTCACCCGCTGCAGGAATTTCCAGTCTCCTACAGCGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCCGGAGTTTCACAGACGGCGCGACCGACCACCTACAGGCTCTTTACGCCCAGTAATTCCCGGACAACGCCTACGTATTACCGCGGCTGCTGGCGCGTAGTTAGCGGTGCTTCTTCTACCTGCAAATCACCTAGAGTAAGCTTCGTCGATAGCAGAAAGGAGTTTGTAGCCGAAGATACCGTCATCCCCGCGCGGCGTCGCTGCATCAGGCTTGCGCCCGTCCAGTAGTATTCCCCCACTGCTGCCTCCCGTAGGAGTCTGGTACGTATCTCAGTCCCAGTGTGTCCATACGCTCAGGGCCGGATACCCGTCGCGCCGCCTTGGTAGGCCGTACCCCACCAACAAGCTGATGGGCCCGCAGGCTCATCACACCGCAAAGCTTTCCACCCACAGCATCAAGAAGTGGTCCTATAGTAGTCAATGGGCCAGTTCCCAAGCTTATCCCATAGTGCAGGGCCAGATCACCCGTATTTACTCACTTACGTTCGCCCACTCGAGGTACTGTACAAATTTTGGGCCTTTCCGTTCGACTTGCATGTATTGGCGCCGCCAGCGTTCATCCGGGCGGATCAGAACTCTCTCCACCGAGGCTGTGAAAAGCTAAAACCAACCAAAAGAGACAAACCTTTTTACAAAACATCACTTATTAGCCAGGCTGACCAAAGGTACTGCATAGAATCAACAAACCCAACCAACCAAAGTTAGCCAGGTAAGGTAAAAGTGTTTTAACTGCATCAGCAGACAACAATTACATTCAATATGCACCGTTACAGTATTGCTTCTTTTTCAATGCCACCCATAACGACGGTGACATCAGCGGTACGCAACAGCCAAACACACCCCGAAGGAATGCTCAGTCCAACATAATTCCTCATCCACACACAGCACAGACAAAATAAAAAATCTAATTACATTTGGCACTGTGGGTTTCTCAGACGCGGCTTCACACAAGATGAATTCGGCTTCGCCCGGCTGTTTTTAAGCTCTCGGCGCGGAGTTTCTACTATAGACAAACTGTTTGACGTTTGTCAACCGGTAACTTTTATGCCGCACGCTCTCTCGCGGCGGCTTCGATAAAGTTACACAGGACCCAGATCTTTGAAATGATCGCCAGGTAAATCCACGGTTTTAAGATCGGGCAAACAGAGCCCGCGAGCTTTCATTTAAAGACTGCGCTAATGCAAGGTTAATTGCTCAAAGCGCGGACTTCCGATGGAAACTGGCAGAGATGGAAGCCTATGACCTATCTAGGCCTTGGTGCGATGAACGCCGGCGAAGTTAACAACGCGGCGCATCACAAGCCATGCACCGTGGAAGTCATCTTCGGCGGGGTCCAATCATCAGACTCGCTGGTGTGGCGTACGCGCCGCCCAGCTAACTGTAATCGTGCGGCAGGCTGCACCCGCGCCGGAATCAGCGGGCCAGAAGCAGCAGGCAGGTCAACGATTCCGAAAGTCATCATCGCCAAGCTCTGCCACGTTGGTCTCCGACAATGCGCCTTACAAGTCTTTTCATCAGATCCTTTAAGTTCAAGCGCGACCGAAAAGTGCCTGCGCGGCAAGCTCTACTGCACAGGTGGCCTCGTTGCATGTACCCAGAGTTGGTCATCTCTTGCGCGGAAGGACGGCGCTTCGTCAGCGCGAAGGCTCTTCTTCGGCGGCAGCCTTGGCGTACTCAGCGATTTCTTCTGGTTCAAGAAGGTAAGCCAGCGCGGTGATCGATGACCACGGGAGTCACCAGCGTTGAGGAAGTACTGGTACCGGGAATAGGCCGAGGTCTTGTCGGATCCAGCCACGGCTTGCCGCCGCAGTGGACTTGCCAGAGCTTTTGTCCTGCGCGTCGGTCACCCAATGGACAGGTCAGCGCGTGCGCTGGCTACTTCATCAGCACGACGGTTGGGATCACGGAACGATGTACTTACTGATCGCCGCCGCAACCTGCAAGACGCAGTCGATACTTGCGCTGCAGCTGCACAGGTCGGTGGCCTGCAGGAGCATGTAGAAGGGAATTCCGTGTAGGAGATGCCGTCGAGTTTCCAGGCAGCCCGGCGGTATCGCCAGTCCAGCGCTGGTGAGCAACGGAAGTTCTTGCCAACATCCGCGCAAGAGAATCAGCCGGCGGACGCTATTCATCGTCCGATGGCATTGTGTGGCCCGTATGATGGCTGGAGTTTGTCGCCATCAAGTCCACGGGTGGCGGAAGCTGCTTCTTACGATCGCCTCCCGGGTTATTATCGATCTCGTCTTGGCTGGGCATGGAGGCGCTCCCCACATCGTGGTCATCGTCGCCAGTTGCGCCACCCGCCAGTGCAAGTATGGCTGTGCCCCGGCTTCTTGGAAGCGACGCAACATAATCATCGGCACCAAATGCCGGCGTGCGAGAGTCATGGTAGGGAGTCAGAATAACGTAGGGAAGTAATAAGGACTTTCGCCGGCTACACGCCTTGGGGCGTCGATATCAGTGGACTGGTTAATAGAAAGCCCGCGCCATTGCAGTTCATCGATAATGTTCATAGTTTCCTCGTTTAGATTCTAGAAGGGTGCTGAGTAAAAATTTTGGCCGCTGAAATTCAGCTGCGCAGGAGCTTACTGGGCCTTCAGCCATGGCAGCGTCATCCACCAACGTGGCCAGATTCCATCTTCCAATACGGCAATCCCGGGCGCTCGGTGGCTAGGACTTGTTCATCTTTCCAGATAGGCTCAATATTTGTCCTGCGGGCACACAAGTTTCTACTGGCGGGATCTAAACTCATGGTTTCTTATCGTACCTTCTCGCCGGAGTCTCTTCTGCTCCTTGACCCCAGAACTATCACCGCTTGCGCCTTCCTCCATTTTTGGACGAAAGACTGGCGCGGTAAAGTTATGGAAGTAAAGCTACAGACTATACCTGCTGGAAGAGTGTATCAGCTACTGGCGACGACGGGCGACCATTGGGATCTTGCAGGTCCGTAGCACCGGAATTGCCTTATGTGACTGGGTCAGCAGAAGCTAGACCAGCAGCGAATCGGCTGGAACGCCCGCGCTGCTGTAGAGGAACTCCTCATATTCCGCTGGGGTTTGGTTCACGTATTCCACATCCTTTGCCCAGCCGCCGGCCAATCTGCGCCGCAATATCCGGATGGAGTCAGGGCTGGCTGGCGCCGGCGAGCTCAGCTGGAGCCTTTCCGGCATGTCCGTCGGCCCGGTGGTAGCGACAACAGCGGCCGCCTCAGCAAAGTCCGCACGCAGCGCCAGGGGAAACCTTAAGCTTCACCAGCAGCAGAAAGAGACTTGCAGGGACTTACCTGTCTCGGGCCGGAGGCATGGTTGCCAGCCGTTGCGCAGCCTTGCGTGCTCGATGCCGCTATCAGCCAGCAGCTTTTTCCCGTCGCCACGTGTTCAGGGCCAAAACAGTTCTGAGGTCCAGGTTCAACAAGCTGGTGTATATGCAATCCTAGGCAACACCAGCAGATTTCGCCGCATTGACGATATTAGTGTACTGTGAATCAATGCGCTTGCCCACCTCACTGTGGAGACAGACTAGGCCGGTCCACACCATCAAACGCTTTCCTTAACTTGCTGATTCATCTTCATAGGCAGCAGCAGCGTCTTAGTCCCCCTCTTCGCTAGGTCCATAATACCTTTTCTTCATTTGCAGACAACAGCAGCGATATCGGATGGGGGCAGCATGTGAGCGAGCAGCCGATAGTTAGTCCATGAATGACCCGTTACCAGTAACAACTAATGCATGTAAGAACTCCTTGAAGTAAGTGATTGTTGTACTTACACCAGAGCCTAGCGCCTGGAAATAGTTAGTGCAATACTTTCATTAAGTAGCACTCACGGTCTAAAAGGTAGAAAGAACATATCCACCTCTCTCAAGAAAAGTCACTTAAGAATCTTCCCCACGCTGCCGATGTCTTTTTCCGCCCTGTACTCATCCCGGGGCGCTTCAGCACCTCACGGGCCGTTGAGGATCGTTGACCATAGGTGGCGCTGTTAGAAGCTTAATTACTCCCCTACGCTTTGCGGAACTACATCGAAAAAATAGAAGGCATTAGTGACCGGATGATGTCGCAGACTTTGGTAGGATTAAGGCGCGACAGCATGTGGTCAAACTGCGAGGTCCACTGAATCCATTCCCCGCACGTGGACTACTCGCCTCGCTGGGAATCAAGGTTGCCCGACCACCTGCAGACGGTGGCCGGATCAATTTGAGTCACAGTTGGATGGGGTCATCGCGTCGCAAGGGCTTTACGATGCCAACTGGAGCAATAAATGAGAAAAATGCTCTTATCCCACATTCGGGGATAAGAGCATTTTTACTATCGGCTTGAAGTTCTTAGTTCTTAGCTATATCGCACTGGCGTATTTGCCCACGCGCGGGGGAAATCGTCGGTGGAAAAACTATTGTGAGATATACTGTTCAGCCGCGCGCGTACTTGGCAATTGCCGCCCTTGGTGGAACGAGATGCCACCCGCACCATCGATGAGTAGGCACATCTTTGCAGCTGGCTTGGAGCGACTGTCACGTTCTGGGAGTTCTTCATCAGTGGGAGTCTACAGATCCGCACCCACGAGATTCCGCCAAGCGAACGCATTCGCCCGGATGCCTCATGAGCCTCGCGGGAAGGAACGCGCAACTACAGCGCACCATCCACTCTGCCAAGTCAGTAGCGTAAAGCCCTGCGAAGTGTCGAAAGCTCGCGCATGCATCTCAGTGTGGAATTCCAAGGTAGGGGAGACCAGACCCGCATCATAGCCGGTAGCAGCAAGTTGAGCTGCGCGACCAGATCCACGATGGGTTCTTTATCTTCTTGCGGAGTCACGGTTATAGGCCAAGGGCTGTGCCTTTAATGTTGCGAGCAAGCCGACAAGGTTGCCAATAGGGCGTCAGCGGTTTGCACCGCCAGGTCCAGCTCAGCGGCATCAGGTTTTCTTCTGCGGCATGATGGACGAACCTTATCGACCAGGCATCACTGGGGTGACGCCAGATTCAGGTACGCAGTAGATGATTTCTTCGGCAAAGCGCGACATATCCACGGCGATTTGCGCCAAGACGGAATGCCTCGGGGCGAATCACGCGAAGCCCGTGGCATCGAGGGAGTTTTCTGCCTGCGGCATCAAAGCCCGAAGCTCATCGGCGATGGCCTCTGGGTTCAGGCTGCAGGAAAACTACCAGCGCACACCCAGGCCATATGGAGAAATATGAAACGCTTGTCCGAGGTCCTTGGGGCGATCGATATCCTTTGCAGCAAGGGCTGGGCATGAAGCCGAGCAGCGAATGTGCCAGCAAGATCGGCTGTACCCGCTTGGGAGTGCGTCTTGCCCGGCAGTGGCATCCAGGATGCTTTTCAGCCTGGCCGGAGATAAGCTTCGACGGGTCGCTGACCTGCAGCGCAATATAGGGTAGCGCTAGCGCACCCACATACGAAATAAGCGTGGCCACCTGGTCATTGCAGGAACGACCAGCGCGCAGGCGCCCGCCTACTTCAGTCCGACGATGTCAGATTGGCCCACGTTCCATTGCGCCGTGGACATCTTCATCGCTGGCTGCGGGGCCGGTCACCGAAGCCACCCCTGGCGCCAGGCTCGTCAGGGCCATCGAGGCATAGTCTGCAGGTCAGCATCAGAGCAATCAGCGCTGTACAATACCTTGGCGTGGTACCAGCACGTCATAAAGGCCAGCGCAATCAGAAGTGCGTGGATGCAGCAACGCAGCCATGGCCTCTGACGGTCCATGAGAAAAGCGTCCGCCCACAGTGCGCCTTCATTCGTCTTATGTAGGCTGCATATTTAGCTGCTATCCTCCGTTATTTTTTGGACTATATACATTGCGTTATTATCGCGTATAGTCAGCGTACTTACTTACGTTTACTGGCCATTTTCGCTGGATTTAGAGCCGCCATCACGGTCACACGCTGGTTTGGGGGATCTGGGTGGACAGACCAGCTACGAAACGAAGCCCATGGCCGCAGTTTGCGGTCAGAAAGCATCACCAGTGTCGTAGGTGGCCAAGGAGAAATTATACAGCGACTGGCGAACGACGGCCGGGTGACGATGATCTGGCCAGCCTGCAGCGCAAGCCCGGATATCGCCAGTGACATGCTCACGGGACTCAGCCGGTAGAAAGTCCAAGAACGCCTTCAATGGCGAGTACCACAGGCCGTCGTGACCTCTTCGGACCAGCAGGCATCCGTCAAACGCGCCTTGGCGTGCGGGTTCGCGCGCGCTCCATGGTGACATCTTCCAGGCAGCACTGTGTGCGCAGATCAACGTGGTTACTGCGGGTGCCATGAATCTCACGGGACTTAATTCCTGCAGGGCGGTCCTCGACCATATCCAAGTAGCCAATACCTGGGCGCTACACCTGCGACGGTTGAGCTCTTCGGTAAGCTTCAAGCACGCTTACCGGCTTGCCGTCGGAGAGTAGCAACAGGCTTGCCTTATCAGAAGGAGATGACGGCCTCATCGGGAACTTGTGCCCAACGCTGGATCCTCAGTGCTTAAGATGCGGCATCTAAGCTTTGTCAGTGGGTTCCACAGGTCTTCCAAGGAGTAGCCGGTTTTCTACCGCGCACTGACCCCCAGACGTTTTTAGTCAGTAATAGAAAAACGGGTAGGACGCCGACTGCTCAATCAACCCAAGTCGATTTCTTCCGCAAACGCAATGGCCTTATCACTTGGAGTCAGGCGTAGTCACGTACCGCTGATGATGTCAAGATGGATCCAGCGCGCGGAAGGAGACCTCAAAACATTACCTGGTCATTGCCATACCGGTGCAGCCGTAGGGGAGACGTAGGTGCCGCCAGATTCCTGTACGCAGCCTGAACCCGGAGCAGTAATCAGCGGAGCGAGAGTTGCAGAGACCAGTAGGTACTGCTTCATGCGCATGCCGTTGGCCTGGATGGTCGGCAGACAGTACTCGTCCGCGGAATTCATCGCACAGCATCAAGCTGACGATAGATTCCACGGCGCCGCAGTCCAGTGCACGCTGACGTACAGATTCCATATCCTCATACCGCGCCTGAGCACAAGTCGGGGACTGCGACAACGTCACCTCCGGTCATCTTTTGCCAGGTAAGGGATGGCAGCCGAAGTGTATCAGGCCGCCGGAGTAAGCCAGAAGCACAACGCGTGCGTTCATAGTTTTCTCCTCTCCTCTGTCTTAACGTTTTGCTCATTCGCGTA "'3&-+-((#%)&++-62&),-&,#0#0-,01010/)$%+"($%'&#&%)3774-51+,&(.("$"'%)+,,+',,-/8411./-0230.-.))%#&*0+,$).480,,##'.-58-)+&(.(%,%(#()(,&3,/5.,-+$&'),.-&'(()',$'35()5/77654&')'()#$'0%#$"&$%3#$$%',+.0/.&'0,-2,')++)$((356640-)/%'(/0214)+)./,'(,1,477)')##$$"%)75/(),(&$%'39668,)))&%$(&$%&10--35284$'+)#($$&+70,34+-,33%1-3,453/433311/'-+..5*)'))$((,)++&)&'%,%'&)+$&((+($%#%&-000070+%($&(&(')'$&'))'),-,#,+(,(((1)&"$(,/-//0.)(&&$&#%$)*&))-*'.2.'('(,12%/.32/,,,77211410+)/%,$+'((,,&%%'%"#((21695.-##('/0375-0.&++,++)(()-1&(#$%&&'$%#))&%'"&'-$4$%#+-'2/.)&((.,,1-&%(+,-"#%)/6624&(&&&'%$%$$%()+.,.2-3-0))()'/2+(,21-%$))/-($$(#"%%"+55'$,'+./109+-3%$(&"%'&#$%-''(.%&(#$$%"4)%&#$'+,(,#)#'&&(728,,,$$##'('.-+,+-,.4$-30-,.2:9080-1+274/6186()#)'+0)&('1)$&%&5-)'+--6'(+-'$'3//6820.1(/13+)&)),#((&%+//0./$,&()())'(&')-&(.%8762,7'(2$&&(#+--12/035+-+,1,78/1%$%%&))50)4&-.(%)*,%&%&(+#$#'%(&'++'(&&$(%()00('$'&$(+.2360+&,,-++,,'&$"###&)$$%'-)##&&#$%&$%-(&'%&'&&)&$&++&-+&%#)+($#+2#(,./')+,+.-,%-)'%%"%$$%#&"(-540(+-//'''+&26/'&'&&+.749%-3--126224.+,5&'$+$/&'.///0-,++0+%,'(%&#%%.--/081$$$#+'&(%0)1%($))+),)+,/(,()52-+()&#'(/824('&&+%&&,3'/-2()+%+-,/-/)-2%$&%&(((+1,,14'('((+/.&#%#'&-2.,..5%'&(((''(+0.9('#+755626:/,41:6///+),')%.+$'"'(1#')54./4-)$%&088/,5067)3'-()+%(+),%%)0+-'.(+'')(.')(&()'0)('()))%/'++12444--&+.)+,0%(++-%$(.%,,%($,,2)..0133433-23+(('3'53-&'&)(+-0.-..--32(-.0100/4665.0)+)')++$'(#$#&6:122))+-25//022))$(3,2((((),,3854-$&#($,$/,/792/45149:4&()&'%)89.),20-5.+&/(')&+.5++1,,%%#%%+1.1120,+)(%"$&&%(+./$(#$%%-11#((.('$&((31+##-/.62(($)++2)%'&(,')014/3.0541,59())%%',%(%#$%),+/0132-3'&&'(76+(/-%%$&#$&((&&"%$#&'+,/2-..'+2&)3.-00.4.-.11120'/.1+14/).//,$%+"($((),-''&&(/(&(&&((++%,)..2/()..+#+(%../2%%%%&(%))+(&(+(2+7+-03).&$(/(#$&&3,2-'--0.%%&-5112%$(''/(('+2-(/0.2'%$&(648,.'('(&""$#&''),,/,/-+141.4...1/./%##4.306,))&&(,)+++(&)14/-33940/04.$%$'(($$%'(,,0322.%)$%.)'%+,8+%%%'.%'($&)&,&/16.478-$++--51134/0.0.+,$,'#$%$&)(&#%)+(++#((./+42-#&%&($&('&-93/14%+$',1,-,)&&&-/(#,./$$&$'%((,.%)&(#%%&(424/0((&.24.15/0,,1--1'0--0+%)',44"%&($0/2)01-//'2110'$)++4047636&'',$)(20+,/.0'.)-/'333.,&#$%$%('+(&"%$#$&()'()(-+)))%',4'+&-'&'---/63),+/.(,%+0..'&(32,#(+%'(,6-)14++--),+4:42566%()&&&+%+%%(%,/'.%$%&%&%&(+0+-4.-,,++,+.)+'+'$%$%&''48/01+-.+/#',()48153)&-$)+++/+&'#$%,+321-1&$&$+-++%)'.-/67+#'((//02+'(),,&)28:1.-,-#$$$&'%##"'&%%&+)/(4/&+'/+.1'3,.0('+''(%%$$))+'(')%./34./.+)0-.22531.07;-,0+,04)(%),,.01-0(,022'/0-.-,-78:506/-/00&1)'(%()4(2)$%+&$026/02.2)/1062(+/14/-('%%#.+#)'(/-()$('2.,$'+,2')'(41,)/1/1+2,),(,(,/-0(/)+-,-2'-,53444,-('(($++0,,04(20-)/8861(-%)+,*--2.'''+('-$(,8-+/5'(+)#"##%%)''(-+/-/0.+431/-.'$#''/0)'(%/5782+2"$$&+/+2,)),(/:4.-++$$($&(*-)+./96--///86+/+-#+$'$/)'&+131..34...00286/,&)()&++/0194,+2/2-&&.'('($12/)'(+,)12&#'%&,.0&/+&).-18(-5,$(+%50&))'+/%30.+,2--)+).60())%((+161$+/--5.()/1233+6-..10-1.:0-//,17+1')+-1,2.20/-+')+/,(#%&$%&#$&%#*&''(%(('--50000-%+&&""$)0-,,,,$%1401-,.,+(&-'$#$$#'%$%&$$%'(.++(#%#%&&)&,4-3(&(%%(,,.66:.+..-)22-4)0,66205'&+-,/041.,--++%(&(.+.3+,2/-%(&$%(---(1-./76&-.,,-)41&(''$)((103)&(&,.,7++)$2,,4(&21#$+,.0-2-$/%%##,.)+,.,48592%%#,'),-65690(9.616572335341(2/)/'##&+)--,,/169%(++$$)&0,18:82$%().',81082-'5-2766720%0.,.+-14212,+)+.,(&%)3++&%%$%##%0,)&('8+(++,3353.9-/()+&(',)(')'-(&%%((#&%&''(.+2+-0494596/&/%((,/5/8182358899-3671-970161-.106/-3%(+-/03-%3,,)-+'1%$&+++,21,/(-##$&(-10-..+,)(,%&%%'43.+,+.3%4.193(0-0.''.+-19,/2(2,07&(&&&%'',+1/76,.5%0$,,3;6416-2-'(%$(,485+.04,.444/4306:6.2)'#$)(/+(+-0+%++-42'%')()%%""$&$(2/-')#&'()%))+)(+*(,$'&1+91,,0+4+))'(),,,,-/149+/(461-/&+&0)++/4.,,+(+././/34'.%$%($&%$%%&()('.&(##"%'(--%'-/'&)''',)$%+.-(&),.+&'&-2)&++%$%+8)(('()%'#$+),++),-5')%&(420,,-'#%$(&%%(-*$(%&.50/..02././0/%$'(0.1&$%,+0+,#%$&%1+51-(%'&(-&.+10+/&%%(&)),/2/,)%%&"'%#&&(((,)764-.032$)*49;965%'&'+-.1+)$($$$,(%'''&+$%###&&-./66.7)&.1-0+'())-1000022/55////+,,)++-704&(++31/./'&%'&+(#&--0%$('$#$%%-/1901('-01-0004++&#)'()$#$%*'+0,'$&$$'#(()($(,-/237-3%$.605+.//,&.(10,($$%'&$&&#(''$%'''(('%$)$'%%$%%$%()()+#&(%&&$(-/.%1($$$&$#"'$%#%$$%%),'()360234/..../4,.25:/0-'+(./.-&*)%12(+/49,7,(,.12:,/6/,-13(-%..-%)$)72,().05;9,&(+38631%.,-06'"%'-:30-,4;-/,-+-./.13/29//#%(/0$3%%)+,+2/../-'%&&'9-%-5/5./%&$)+)303478+.22&&&$'&.,,('/1/.07664-%-+&('"&&.,,-&'%$&+12/&-*++297/4.()(&(/*+'+&')98%(&&++',)(-4-&1/),')11/(%((,,9/.4.//+,"(,/1.)&%'--1(1)20:7/,++5,7-4459744('%($#$,))'(,-21&')'&5/%%#(&%"&1-2&%&)'''01/94.0692/;;;-/5/.)&*&'$%$$.0+'&&,%&7-.,')"',21+,202-43-.'.2/0134+(%$')(''(+)+----+&'138684711233/$#+--5--((+.61)-%&()%%&(9))$-&&)'$(&++-+)0())'&&#%()&(31450.-$)'('0))&.)127/741333-/),,+++&)($#'().,0/+,001536//03-9+.88,,31153425:(6/0/13/)-(-(&&',$$(&)%+5482.((/36-)'',0-.28+'&(+,.75)(')('$'&$&++&42'#)(&'%%(('(#76.76,.&/.+./566442)++))'.-,))))/1456(2-./)42614:4.,%.00,-/5+&&&#(%'%,51'%%#,((%,&,,-),)'(%('./.'($141$3(%)+')/-,140422/1,7654,3,1..0&+)&"(2,(16/3730.2,+,)%2+-..,11022%$&(++&&%&&'%.-0224'.+99577-/./,494-00+)-20(002:5'%('(,.-1/::2+20&)',/)+(++08091&&66:.0..,5)+,/41;92067-+.,)()'(*+/3'&.#.-)%%(%%+360%0..-4-6,'+./,0/1',-+.'%'%+).#&&,(++54''+.46122680+&'085-%'$'%()&(%,-./8746-8,,.000-(&&&%(+,1&),++,,--(+1')/1008/0,')$$%-2/5742921,+.()3&%9./$,(,+%+,..075;78015+(,('++()'%#/1+)++'%%(')-#&).-.40.&'''102424$%'$%&%'+../%(%0)/%)&'&,.3,02300%('&('(&)&&)/71$44+--0-,.('$'$%$26.0-/,11%'++-+-&-.7.+3)/-10%.+27003533.2.++--..(464.13)')(++,32(#-,.78587)27,-))).+($('+,+.)%$),++5942/,+,.#'$(*+0////,653645,-,+-0,*,%,,-729.+&)-&%#$&'&().//0,&(+885/2(&%4513.&./)),2/2#&(&)($$(%-.%)(%&&(&,&&')-96+(./(,,)2/820-0')&'&8997.3,)-).43)1)&$+(75868667332)+$--+78(#$$%'$1'0&('%'-+-&%%$%&+&-/3+)(&#&('&0&+)"##&'1.5,-7444.%('((83841,&#$$$(()0')/34,1+-,0/429+35,03+&($##'"-'/%#'($&('&'-$$-('+),,-+/20:/8/7(&)0+006757565(')%'(%$%'%$((+,43/',--,%%&+,%&-&#%%..))))++7,,,5%&'-5/.,2-,-..()(+)1122%../34$###$+('08133//3:4/)(#%+%&%').5144,4-..51:1*,.-&./1,4((&&)')+.,$$-(/+,-.'&'&.(($$#&',+)($/.)#"$#%&-.-23-+(0'().($)$$,1-14.)/'+.88:70)1.35%+2,(.+39.//..5'##%'0,,','-,-,%$$++1.9//64/%))1401+)#&'-;86,6'&(6;77:7659(01).+().--/#(-+-.$+2.'(-+,.,/70..1942-20152010097681+,4.:656((#'($'(/-34720%')('&'&)%$#&"##$'&((1,770.&(.05482%')+.0((&'&--92(,73./4%&)$%#%##'('&(/+//044-,#%#%&%/1.',/+2+4(-'-+++-&)((),0203+5,'#$$,-.4.-//.)())#')4-34'$012.,),-2),165-)))0-.246,1/-+1037/)(.&()*13/4.5--+/1/41/&10',)03482121)2)(&%,/261322764..17--5.4.$-/+,35.$)&&'-$&,4/-/'+++-/550)1%,/224(/-6::+63921).--)),-111853-+20(('&'7668:385529733+(')+)'%%#$)$%0052#)&(832..//-02-$-1'(02((.+.-+$'(01+112375-+,+5/0,095,./.5+-,/2&)%&"&&%&)'$%'%&,45-+)&'('(.+/)),/-&2+)/;:6.,()%%-.5667/&)&''$$#$,248:8+4.++,(.7/98.2)&',)%&111%,%.),+2&%%)'$./1.+,),&)).12;67000-+(&'()/1+))(('(-))..,)%-+-10/006:6****/00$,&'+&&))+)&+03.516+-0-'$#"&(+-'&75210/,-)(+1/030/0%&#'&(%$#"#,3&&(21/,9+4/''&%'/585-16%(.7/5441;:8+++3,-3)69-3242&$#&,400%+",3..'+,+,/7/44-././/.+'$&$#&%,$"#$'-+(-/%'(/)&0*(0-+-/51838//4/,0/0)4*0&70512444.$%'54551832041,11.2553$4072-),&%&)/'%'-'+(-/-&().,-)&,,+.068/3065637//0-.0024/3520,)$-731)$$'##&$%)()25(1.-(-+),.&)14&56%1:84:664&$'&')6-355403//2-',-//&&'$%-0.-&()%(-01+/(()%(//1%0-*)&$$$)(&&'$/8/00/)(*4/'(.+9,1+.&$($&(44+3&+.3#1+#'%'%$,'(.8/5,87820/123$-,//(+*()...%(#4464.94((,,/1477897.26(+30051)'&#$"#$#'&(&&+$##%&#&+.84+59/391/9:7/,/30-/,-.,.1'1+,1/8,,7/-,./.289./0-$&((+&&$$('$0/99,15371,%/67;056640663(((%)./28/..$+$-01..(-+/-&0/83.-&&'+-1.5').8473687,&#"$&('++$###$),2.%(&,-/()%./:8-/)313%$+)++,0).+(112237/5--/719/5(+)('%$,&')-54/.,'')(((/,530/-.,)(('&.)-641031/-/&1-+,9-511../&1((&'%&(84:96461:.,&,#&#&(,)./991-,,#(+''(.%&(+&%(.'3)(/81,.'3,3.-4:7%#')).-%'&$(/5.)%%)&)6++4:65:976111(667994566,(,.''%%%%'))8(2,,(/.-+++0115-.+))+,.%3-2+%%")($%&'%%#"%%))+)2')-6/.&--3&&0+))),&/.)&&%%('3551.)-&/77/8/2/2929226,,1+-27454/23343'(&,+-$$#.(((+6.'%)20%$##%#(',.,--437(%),09.,'((0(&%&%++&,,,.2+-+(--2-()+1)&%$&#'$$#&')/2.3,(+-)30/1()-/,'(,25-3%(/412633$)(&(&&(+-/1,,%+(-/4:212103(.0/-//0$'%&%###$)'++)$%&)'--0,4+-)-4/,,),'((744(+)).%%&&017)/78:,43446))$%"$#$"---''%&86--:89.%+-0#((.+)(-21.+/'-)),('(1241//-),.3:55/+,)%'()+.1//;1-0-3(%'07.+)).+)'('(,7555),)++')+%+2246626+%(')&'$$#$&2331-)2(-/''&'.2+,,23153-/(/'&('74:6375,((%(&-41.-/0066.03(.&)&%'+.-.19,4(+3.+()+76:80420082/5)+,.///+(-')"$$)-22.0:39-,&$)$.)6,,)/(/%#'$#$%$(-*,00,-/+.(()+.4/.07...8.)2($%+.1-86.9.%')()+035.,&03-0//',+,./.78/./.))',,+.,$%&%$'()87'$#%)6//0..35860++/.--1.())1)$)/1455/./-+/+.1+,,6,5604465,/0(/,/2)$*)$%#%,#$$',.4-0-0%,,+-,.3201/047180-'+-37695917,,,701931,0:54351./2-+&,''(+)$-(3,45:,5#(40'*%)%'''),/1&3014769377*.20665'&'$%'())+0-0)-(6)4-587-&46627'&#$""$ 475d420c-02cf-4b03-a32a-4b73fd1460c4 4 0 0 0 0 e61d7f34-bc86-401f-9584-30510dd2602f 4 0 0 0 0 eebd36e4-4247-4775-b3b4-6dcfad451958 4 0 0 0 0 fdec0c4f-ca65-455c-bf1a-3dd9b75e0d15 4 0 0 0 0 f71e1c6d-9a06-4403-ae09-021f99f4b2bb 4 0 0 0 0 fb03098f-0be5-4c8d-b3c4-801a9df64997 4 0 0 0 0 24cca5b2-76b5-4ed0-ab8d-f7637bc16a29 4 0 0 0 0 89fb2203-f2df-4586-8246-c49a014257c4 4 0 0 0 0 140bb280-51fe-4e2e-bf49-a4281be91870 4 0 0 0 0 2f796d08-6ecc-4220-922f-d161eb12a371 4 0 0 0 0 ab595d9d-b414-4f96-b63c-d85c5c1ae92a 4 0 0 0 0 05721ef8-9a23-45a0-907b-c135ac302891 4 0 0 0 0 d9cc9d0a-b673-4312-aaab-184ac556b421 4 0 0 0 0 c2f6fb1b-73bb-4813-8834-0ffef270721f 4 0 0 0 0 8df1d6aa-390b-4914-8b99-3cf8b5eec0c8 4 0 0 0 0 2b73a55d-3bbe-4b3e-923e-a7cd2b137f6b 4 0 0 0 0 798e29d8-635c-4608-bdd9-199972d274bc 4 0 0 0 0 ea3085d7-ec01-4edb-986e-5508af4c5c18 4 0 0 0 0 3b3e6290-741f-4cd8-a8ec-bc7d4949ca01 4 0 0 0 0 TTACTTGTACTCGTTCAGTTACGTATTGCTCACAACAAGGGGCTCTGACGGATTGTAGACACATGGTTTCGGGAATATTTCCTCCCCCTCGGGGTACTTTTCACCATTCCCTCGGTACTCCTTACACTATCGGTCACACTGAGTGTTAGGCTTGGGTGGTCACAAGCAGATTCAGCAGATTCCACGAGCCGCTTTCTCAGGCACCACAACACACACCATGTTTGTCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCAACCCACTTCACTAACAACACAATGCGCGCTCTGTCACGGTAGAAACAGAAAATCATGGCCCCACAACCACCGCATGCACAACCTCTACCAAGTAGCTTATCCCGCATACACGGTTTAGCCTCATCCTTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAGATGTTTCACTTCCCCACGTATAACCCCACACTGACTGAATTCATCAGCAGGTACCTACCCATAACGGCAGGCGGGTTTCCCCATTCGGACATCGATCAGCGCTCAATTGACAACTCCCCGAGGAAACGCGCGGCCTTACACGTCCTTCATCGGCCCCATACCAAGGCATCCACCATGCGCCCTTAAATAACAAACACACACCCCACACACCACAAAATGCGCTGGGGGTGAACAACCATAACTAAAATGCTAAACACCCACACACCAGCTTCGGATTGGTATGCGACGTTCTCACAGAAAAAATAAGAAAAATTACACACCACACAAACACTTCCAAAAGCACTCGTGGATGCTCGCGTCCACTATGCAGTTCTCACACAACACCCCACACCACCAACCACACACCCGCGCAAACAAAGCGTTTTAGTGCGTGTTTCGTGATGCAAGCTTTACGGGACCAACCCACATAACGTGATTGCTGTCCCAGACGCAACAGTGCACCAATGTCTAAACCCGTTGGCTGCCTGTGTTTATGTGTCTCAAAATTCGTGTTAGCAGCCTCTATAGCTGCCGGTGTGTTTCCACTCCGATTCAAACTCGGTGGCGCTGACCACACTCCAGGTCATCAACCACCAACACCCGCGCCACACAACCGTGCTTGACAGCAGATGTTTAATTACAAAGCTCCTTAGAGGAGGTGATCAGCCGCACCTTCCGGTACGGCTACCTTGTTACGACTTCGTCCCAATCGCCGATCCCGCAGCTACGACAGCTCTAACAAGTTTGAGCCCACTGGCTTCAGGTGTTACCAACTTTCGCTGACGTGACGGGCGGTGTGTACAAGGCCGGGAACGTATTATTCACCACACAGCATTGCTGATCTGCGATTACTAACCGACTGCATGGGGTCAGGTTGCAATTAATCCGAACTGAGCCGACTTTCGGGGATTCGCTCCACTCACGATGTCGCTGCCCATTGTATCGACCATTGTAGCATGTGTAAACCCTGGACATAAGAGGCATGATGGTTGACATCATCCCACCTTCCTCCGAGTTAGCCACAAGTTTCTCATGAGTCCCCACCATCACGTGCTGGCAACGCCAAGACAAGGGTTGCGCTCGTTGCGGGACTTAACCAACATCTCACGACACGAGGCTGACGACAACCATGCACCACCTGTATACGGGCTGGGGTTGAGCCTTATCTCGCCCAATCCTGTATGTAAAGCCCGGGTAAGGTTCTTCGCGTTGCATCGGGTAATCCCATGCTCCGCCGCTTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCGGCACTCCCCAGGGCAGGGGGCGCTTAATGCGTTAGCTACGGCACAGAAGAAGACGTGGAAACCCCTACACCTAAGCGCCTGGGTTTACGGCATGGACTACCGGGGTATCTAATCCTGTTATTCGCTTCCCCATGCTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCCGCTACACCGGGAATTCCAGTCTCCCTACCAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCGGGATTTCACAGACGACGCGACAAACCACCTACGATGCCTTTACGCCCAGTAATTCGGACAACTTGCACCCCTGCGTATTACCGCGGCTGCTGGCACGTAGTTAACCGGTGCTTCTTATCTACTGCCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGAGTTTACAACCCGAGGCCGTCATCCCCACTGCGGCGTCGCTGCATGGAGCTTGCGCCAGTATTGCAATATTCCCCACTGCCTCCCGTGTGAGTCTGGGCCGTATCTCAGTCCAATGTGTCCGTACACCCTCTCGGAGCCGGATGCCGTCGCGCCGCCTTGGTAGACCATTACCCCCACCAACAAGCTGATGGGCCGCAGGCTCATCCCACACCATAAAGCTTTCCGCCACAACATCCAAAAGTGGTCATAATTATTAGACCCAGTTTCCCAAGCTTATCCCCGCCAATTGCAGGGCGGATCACTTGTGGCATGCCCGTTCGCCACTCGGAGTACCTGTGTACAAGTACAGGCCTTTCCGTTCGACTTTGCATGTGTTAAGCACGCCGCCAGCGATTCATCCTGAGCCGGATCAAACTCTCACAAAACAGCGAAACCCAAGAACCTAACCAAAAGACAAACAACACACAAACATCCTGCAATGTGTGAAGCTGACCAAAGTACTACATGAAATTCAGCAAACCCAACCAACCAAAGTTAGCCGGTAGGTAAAAGTGTTTTAACTGCATCAGCGGACAAACAATTACATTCAATATGCACCGTTACAGTATTTAACTATTTTTCAATGCCACCCATAACGACAAGTGACATCCAGTACGCAACAGCCAAACACACCCGAAGGAATGAAGTCAACATAATTCTCATCCACACAACACAGACAAAATAAAAATCTAGTACATTGGCACACTATTGAGTTCTCAGACAACAATCGCACACTTGATTGGAGCTTTTACATCTTTAGCCCCGCCGCCAAGCGGCTTTATTGAACTTACGCTATCGATTCGGCCGTGTCAAATCCTTGCTTTGAAGTTCTTCGTTGTCGCTTTGCGTTACGCGGCAACCTCTCGGCGACGGCATCCGCCGTCATTCGTCATCCATCTATATCCCATCTTTCGCGTGCTCGGCATACCGCAGCATGGGTGATAATAAATTACCGTTTCAAATGATAGTACGGCGAAACTGCTCAACGCTTCTTTCAGAAATGCCCTCATTTCCACCGAAGTATTACGTGTCCGGGTATTTAATAGCTCATCCAAAAGTACATAGTCTGTTTCCTGACATAGCACCCATGGCGACATAGGCACGTTAGCGCTGGCCGCGAGATTGATCAAGTAGCGGTCTTCCAAGGCCCCAGTGAAGGAAGTCGATATGCGAAATAATCTCTTCGTCTTCATCGGTCAGACGACCCTTGGAATGAGGAAAGCGACCGAAGCCTACGAGCTGACGGACGGTAGCTTGGTAATGAAAGTAGTTCTCGGCGGAGGACGGAAATTATCTTTGCCAAGTCTTTGGACTTGGGTCGCAATATCCATTTCGGCGACGCGGTTTCGCCACAGCATCCATGCCGAGCAAGCGACCGACCATCGTCAGCATCGACTTGCTACAGCACCGTAGAACCAATCAGCGCGGTATTACCGCCAGCTGGGATTTCAAAGTTGACGGGACCAATTTTCAGTTTCTGATGAATACGCCTTTGTGACGTCAGTCAGAGTAATCACAGTCGTCCCTAGCAAGATGACATTGCAGGAACACAGAACCGCCTACTAGCACTCAAGCTGTATTAGTGCGACGCCCTGTGCATAAAACACGTGCCGCATGATGAAGTATGCGCCGGTAAAGGCACCGTAAAGCCAGTTACCGCGGCCATCAGGAAGAGATAGCGGTGGTCATAAGTATCAGCAAATTGATAAGCCAAGGTGGCAACGAGAAGCCCGGGAGGTCATCGGACCGACAAGTGCGTCGTTATTTGCCATTAAAATGGAGACCAAACCAAGGTGTATATCGCATTGACTGCCTTGGATTTAACACCAAGCTGATCGGGCATCCCGCCCGAGCGCCAGCACATTGAGGCGGCGCGAGTTTAGATCCCCATCAACACCGTGGCACCGATGATGGACGGAATGGCGATGGGATGAGTACTCCAGTATCGGCATTGGTAACCGAACCGAAAAGCCGAGCGGTTAAGACATCGAATTTCACTGGGGTCGGCAGACGCTGCATAAACGTCGAGATGGAGCCTAGTCCGCCACCGATGACGATGCCGACGAGCAACATGGCGATGCATGTTTTTGCTTCCGGTGAGCGGCAGTGCAGCAGCGACGAGAGAAAGACCATGAGGACAGGCTGCGACGAACATCTCACGGTGCGGGCATTGTTCAGACTACTACGCGCCGAAGAAATAATTGGCGTGAATTACTCGATAGAGCGATTCGAAGCCCATGATTGGCAACGTCAAAATTCGAACGTGGTTACCGTTTGAAATGCCACGGTGGCCACGGCGGCAGACTGCCACCAAGGCCATGGCGATTACCCCCATCGAGGCGACGATTGGCGATGAGCCAAAAGCCGCGGGTGCCAAATTGCATCCGGGTTTTCATGGGTGCAAGACCGAAGGAAAATAGCGCCGCCAAAATGGACGCTATGGCGATAATCGCGATCGGTATTTGCGGGTACTGTCGCCGACTGGAAAGCGCCGACGTGGCGCGGGTATCTTTCATCAGACCTGCCACTGCAGCGCGTTCTTTATTTGCCACGAGAGTCGACCTCACAATCAAACTTGAAGACGATGGCTCCGGCGATTCCCCAAAATAACCGACACCGGCATTTCAAATGGGGAAATAATCCGCGGCTGGCAGGTCACAGACGGTGACATTAGCGTGCCGAGCAGCAAGACCCACACGGCAGGTTGGAGCCGCAGGTCATCACCGCGGAACATGCGGCAAATGTAGGGGGACGGAAATCAAAGCTAAAAAGTAAGCCAGAGGCCAAACGGCCACGGTAGCCACACCAGTGGCGATGGACACAGATGCAGTTCCCAGCAGCAAACTTTCTGGTTGTAGTTCAAACCAATGGCCAGGTGGCGATATCTTCGCCCAATCCTGCATTGTGAGCTTATCCGCGAAGAAAAGACGGCGATTACGACAACAGGCACAACCCACAGAACTTCGTGGCCTTTGGCCGGAAGTAAACGAACCGCCAGACCAGATGCCAGCTGTTGCAGCGAATCTGTAGCCGAAAATGCAAAGAAGGAAGAATGCAGGCAATGACTGCGCCGAGCATGATGCCGACGATGGGCACGACCATGGACGAGCGCAGTGTTACTCGGCGTAGGAAGAAGAAGATCATGGTGCCGATGAAGGAAAAATCACGCGGCAACAATCATCTTGACCAGTACTGATGACTGCGAGACGGATCAAACACATCAACAGCGAGCCCGGCCCACTCGGTGGTACCGGTGGTGGTCGGTTCGGCAGAAGCGGTTTGCGTCAGCTGCATGGCCGGGCCTGCAAATAGCCATGGCGGCACCGGCGAGAACCCAGTGCGATGGTGCGCGGAACGCGGGTGATCCCGAACATTTCCCATCCGAAGTCATCGGAAAGAATGCTGTATTCGCCTACGGACAACGGCGCAATCAATAATAAGATAGCGACGCGGTAGCTAAGCTTCCAGTTCCATAACGCGGGATCGGCGCTGGTGTCGCCAACTCAGAACGCTCAGCATATGCGCCGTAGGCATCGAGTTCGAAGTTGTCCGTAATCACTTATTCTTTCAAACCAGGCTCAGTTGAGGCCTTGAGGTCTCTCATTCCCCAAGGTCAACCGGCGTTCGTAAAGCACTGTGCACCTAGCTTTTATCTTGCAAAGTGTACATCCTGGCTAAGTATTCTGTGCCTCAAATGCGTCAGCGATGAGGTTGAGAATCTCGGTGTAGGTCACGATGTTCTCATTGGA %%"##"%$$()+17:60.5///.22+)+0--.0/61.-.4../4667626246/0((.00.07784:84'/.$&)))99))+:992&*.-++-/-/16989825.-%)&()),$&$(.%-.30.402-1-01/%(,$$$%%)'+))')+44$&%'$(+.+/+),-,,/-4,+''%#'+&"#%')),2%1,-,/,)02+()()+//43-+)%"&().,-695663664+),..-252;60/0417:6:972605(/.83'+.4326(385'/00-+0-/.-+--3443/'&(0,)((,+.,(,045+-,3./121,&'(.,'%--0:+)()%2'(,.3,$%'%#%%&(+30+%../00&0'+14''%+/-1,10%"#&'/034#$&'-221////4:872/9'+5.)09;3/377344889018-,+)))+/983;7/*-..186.,..033++)/0/&(#%&)'('-4..3.'+-+././6''-))"%&+).950166/:32:3+793().,+/786,)$%')'++1292223/,00+(-46&'&,+&'$&"#"#%/.-.-,+$&(/7&(0,-,8'-+-1,)+-260(2.5780*%&%$&,,/&)'698.0'029764..-,,42.,++).((7::7,))&%(-5/4(,-556/&04144:666;;9.)0226-)"'&'%',016.$,,1-(&)0+5+.()+4,21004332.09:;9;-0/+-213+/2//))(---.+,/1.%,4/1343/&,01&)&()14213546057545488(723./+(,+(/),-/1.'))/1,132458220264,%)&)(3827:3/1,29:$''--,5;7/14122/125'$#$$%0)1-/2/3(24-+/38677-2-.151*237475.536984&3&3)755825;649-'/,$#"$$(.--/.064+-'%-456-3&.':+01/.(()(-5.1.)'&#)..1/.2,.135;7.4.2/8#-'&'14798/3-$'())()(,+')()),'%)%,+077.88.4//0+57,+316:3212223:1/,')+-+&(&+'())/(++.'&+/,&--6''+('(&(,)--.(&.+),+/10.5'1)/--.-++#()&%%(+155526580-//328-,-,%")$#$##%'(1+01/4',135254:.('38:(+8652//30'-/.105019.2,-60-),--/2-.186784%+-%%%%$-,020.).,+-.8-)*&&25023+%(%&-,,50112211.-.--,4-'$%$%/)+,#&"(&'.0/2%&+)4%)"#&)/+,%%)/..((-:855:72(.('4+/')+,6$'',+)+$./0131182--1+,+..-44893;10//,.3-0%(004:4/0:986/6%%('026-.+-(11,)()+,--2)%/-52%&'&($)-'&$'(((%+,76+()%('#%'+39.-57:4./.-.115:130%%#0+44+,','2,)545989;55.91,()(,#.$0(0+(%&'+&).%+(2)+%55365&55%)&'#+.52441112(.',&%$+,-3//,2()'($"#',10275413.)&'(')0-+1''(&+5946:5/40/944179.6+,+,(3-)+,+2256-03+,&&&$+66.75,.6/236644:902,6;;+)+1)4.,(()%"('.42'%111%+/0.631/4.3'()/-,,./60/1-+.)3+'+-+74).&(&'-0("#&&1+()()./7,(,#/,+'+&/+8:041230++(,3/14.0,+&(+(022-($$&..62/.)5)15660/0-/5438556:#)#$'))'&))-(%/.4)$#$#(&+++.95,-.-,--00/422210//:30''$-1./,-(0)0,)'+(+.,,0/+,+*'),'%()&-,'/#&'('''+410,.3375/20-,/'((3;751')%53+/1,+584.1&-/31240.7/4+(''#&(+/,43+-50%(((+1/2-84522,+)+-0/6,+%,$'&&,.+0..-2..144,/%$(+2/,5#&$+/.4798.:.+)$))&+'-((&'(13-3/-/2654413/,$#$$'.))+&(-4+))2...%$'))66+-:7.762*$/0136594++,++(),/+(253533/%(+-0&()3.,-469.&-+/,/7(%($&&(9:644/2745./&0.1(-+50,+,/0,60004:5,,.#1#'.8-7./)61-:1/.(-2/11/000213)785.9..799)$(,/.(,('',,11'262,''#')))6+:7+%)&($$/6.+)09.24,%+0/3-.7&4))(')-43)$-(-.,&+'))6615++;707+4+--.1.-.()'&')&%,'',4861.0//-'%$&$#$$)%)))+.73)),(,/$+%)),.:71/'+-25/-/033659+1.)-)((-),-0.8,-0/7564/705+-)-026683.//.(110986.,/3)5,0,///.-53422-$%%'(%&#'(%''03)-+$-')$$'3-./73+).26:997120.),('+$'-,&#$&+000..,)+0&()+.-.($$$'/...$$&)'%'$%#"%/$00+/4271'.'256+3-)(,''''&)-8:1(./1::6.5//,//+1&(,.(,02',55/7-.(450010///8.40,..,5-.::/5/1/47::,2,).)-,-66006.7655/&+,56670''3+,,25-1%2+34+-,+/1-(1,,'")((..2/4,+,$31//2/236-.+,%%'(+9:7::3-2:;:,.0+,.06069(4.1/./)/,++46879:01696531410,2-,()-0-/0930$(,781&$(,98;-)-85)+7/%'*-4(6..8811512520-+,,-34442-221/&34197784:3.1.()'(+.//,1856:8.2-,6++(,3./(,%"%$&',033310-0/30-),($'),.)"$$"#"""""""""""""###"""#&-,%(&(/&&#$##"$%').+)))'$&#)0,,-,('-'((*')&()%#%&(%##"%$)0+%,&)')+'.-./.&$'+-1,398)#'&'&$.,'(-06.+'+&')&%%)#-'''3))1()299)+(%),-,,+,,35-)+01+'%-+&%7(-%#$$+()+33$#"%%&)),/0+,.1('%0(#',,+-'1)%$%$$#6')3/%$&))(())'(+/.,),'(+&'#&2)/)'')%(''&)#$%'&)+,'/-1103295)567994770720&&.0-$/8..3132+&#),.+,+,1-+,..,63.1.,&'''))-35835,,$%$%&1-4/-,1-)#+)6063:50/2%./)((').),4:0,2/5.01.5:+-+,..2+.(%&%-)8-65:945;:4)44536(&'#-70./23(('$(,-1602-))('-/)'''%$,-+368,26533,%+$)+'+*+#$$#&#')((1%++-)04$6(650+.(+(,-.//-1/-00)222-3,+1;91+4$,+4'%%"06/33)))27.+(2.9610010-/456:782.64.0227435/113-,*,/7654744775994((&$%'-&+,444(-+.,010,,-1/2518947:737$()112,'&((%$&'&&)91.,,-,094--/,,-,02.+,+-.//7.&((,-./))&'(44747-8,+,&,&&'0&$1+03),0$)-''3:12,/26.15%2734+-+'()676:76-/63/1468+//.020+)))((%()303,,70/061(&'&$/30/4'(-,.4994:79531853-2,2/+'12%/)'(3770:.;;9,.)*((9,,&)#-.+')0223645%3%%'+'())+'))-:3-51&4))%$%&122,++-+139))),5,'()+,0-,//1+6)((-7(62234/13:6%(#%&00(&8650.-4+/.2-.//+0-00-)%#')),,,9.-+/)10+,)+--006'&&,,.25:7420-%...0835998''&'&(31255-/2021049788'-(4772.1+-.3.1$97368726755-..839788756799:--.84/266258827063.1,,+,%'#&'0&$,-.(21-7/.-%(////36;5-##")%+8011884:2&+,&/+&+#,+%1-,('&',./926413:27$%4560/.,.///.-65/,#&,85:8/4.+,,430+)---)&'&#&(+0-++#((+)(7(/-)('&+,3*-.2032')(*-5766%'0'.5)'++1131/,///07;:2373-#%&$)&))9(,8708+)-1.+(/5-.(()+00+.2++'4.44:87772,02.699:790:0,)-/-696(/3(-/,5610#-+-9100223,7(7:;(2635$'&'%&,+$,($',-3,,5/4:78++%.%#%1(,,/,-+.+047./,('/53060:98223$%'(#$)&()./321+&$&'.%3051;2,,--($"(,630/1,286+.%%&$&#))0166:8883'''((07/(067&1'..06791101+$+++335;96;;+56+(361.,'&%')117878/)-2-7225'$$%2+(-,)+))()2')$.-/732:9)-8:9-1.3.-$'',3.8654;:43;60282').5-33,+-.741)/0),2.++/#'+0%/0-.-'(&#&(()-62214..0123569.))&)+2153713./$&)&(%22//$00/04+30878..'($%%$)('4'.82,-3-)/)'++0'%&#(.+&$%%%&'##%$%(1%)$(,+&'',)&#$%#%)+/,/16:9212/5,,'+'+-/8'689290--/,,/))-%$,,-0809.//46;236.7:18....-))+$(./7699999821,)),/225-.3"1##&''(',#(+'&,.-&%,4.+)%..6..,.,(,.3+.%#&50/0067:,(+%-0-0:(&%&&+&'+-.-.,)'&$$%27())%&11&'%'&75--,01/.0/&(-7924%(.687664-),/+').02-.18&$,&&)''$'##&)12&7,//10/7716)'/4,,.05566500/,6,+,./256,33:89&$,+,8)642.7-./92:44417))&''%(+()/1197:336934443645-99:.,/%&'(0367.42:6744-(),,38./,,,+,--.0/1/+%++$+,,8277.--.156)6%32/.235-.0,,(&-.35:76200144566565977%75943(6)&-')13627.(+-51-/.04).'$+,14753'#,'01313891412.-++3.79-,)+))$$&.999458(./-20217/862./,&&)*//00%',///:7-63,-2(((1$(,1-22)-3501..125-+),)$$&-2295+5/(.%)(,+4.3)-46288,2332&%%#$#..0('),/4.+,0;/'),&(%("(,30+%'&$&&+-+$0537-8,++2-)'-21715$#%"%')/50295935:6'++)028/$'%&.0+14&%&,703//03059,87,./96,-(+(--'(//&)335333&$+1,,,.+/+1,1154--//0.84505//))''51&/.14594706-%(---:;1/+'#$(1,4).,-,'%(2($"%()+6((','%$+(1.-5:://./24(/(&(#(/04/,,&011979%2442-++,1----#7:/58023&$" 0fd2b78c-4d7e-4a10-9852-ac515399af05 4 0 0 0 0 d586333d-dcf7-4e6f-9daf-deb324169694 4 0 0 * 0 0 ACTTATCGGTAGCCTTCGATTTGCATTATTGCTGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAGCCTCTCTATAACTTTGCCGGTGTGTTTCCCTCCGATTCAAACTCGGTGCTTTACTCGGTCATCAACCACCAACACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTGCAAAGCTCCTTAGAGGAGGTGATCCAGCCGCACCTTCCGGTACGGCTACCTTATTACGACTTCGTCCCAATCGCCGATCCACCTTCGACAGCTCCCTAACAAGTTTAGGCCACTGGCTTCGAGATTATTTACCAACTCATGACGTGATGACGGGCGGTGTGTACAAGGCCGGGAACGTATTCACCGCAGCATTGCTACGATCTGCGATTACTATAGCGACTCCGACTTCATGGGGTCGAGTTGCAGACCCCAATGGCCAATCCGAACTAAGGCCGACTTTTCGGGATTCAGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTGTAGCGTAATGTGAAGCCCTGGACGCAAGAGGCATGATGATTTGACGTCATCCCCACACCTTCCTCCAGGTTAACCACAGAAGAGTTTCTCATGAGTCCCCACCATCACGTGCTGGCAACATAAGACAAGGGTTGCGCTCGTTTGCGGGACTTAACCCAACATCACGACACGAGCTGACGACAGCCATGCACCACCTGTATACAGACCACAAGGGACGAACTATCTCTAGCCCAATCCTGTATATGTCAAGCCCGGGTAAGGTTCTTCGCGTTGCATCGAATTAATCCACATGCTCCGCCCGCTTGTGCGGGCCCCGTCGAAAATTCCTTTGAGTTTAGCCTTGCGGCCGTACTCCCCAGGCAGGGGCGCTTAATGCGTTAGCTACGGCACAGAAGACGTGGAAGCCCTACACCTAGCGCCCCTGCGTTTTACGGCATGGACTACCAGGGGTATCTAATCCTGTTCGCTACCCATGCTGGCTCCTCAGCGTGATTACTGCCCAGAGACCTGCCTTCGCCATCGGGTGATTTCCTCCTGATATCTGCGCATTTCACCGCTACACGGGAATTCCAGTCTCCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCGCCCGAAGTTAAGCCCGAGTTCTGAACGACGCGACAAACCACCTACGAGCTCTTTACGCCCAGTAATTCGGACAACGCTTGCACCCTACGTATTACCGCGGCTGCTGGCACGTAGTTAGCCGGTGCTTCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGAGTTTACAACCCGAAGGCCGTCATCCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCCATCAGTGCAATATTCCCCACTGCTGCCTCCCGTAGGAGTCTGGGCCATCTCAGTCCCAATGTGTCCGTACACCCTCAGGCCGGATACCGTCGCCGCAGGCCATTACCCCACCAACAAGCTGATAGGCCGCAGGCTCATCCCACACCACAAAGCTTTCCACCACAACATCAAGAAGTGGTCCTATATGGTATTAGACCCAGTTTCCCAAGCTTATCCCATAGTGCAGGGCGGATCACTTACGATGTTACTCACCCGTTCGCCACTCGGTACCTGTACAAATTACAGGCCTTTCCGTTCGACTTGCATGTATTTAAGCACGCCGCCAGCGATTCATCCTGAGCCGGGATCAAACTCTCCACAAAAGGCTGTAGAAGAAGCCCAAAACCTAACCAAAAGACAAACAACGCACAAACTATCACTGCAATGTGAAGCTGACCAAAATTACTACATAAAGAAATCAAACTAAACCCAACCAACCAAAGTTAGCCCGGGTAAAAGTGTTTTAACTGCATCAGCAGACAACAATTACATTCAATATGCACCGTTACAGTATTTAACTATTTTCAGTACACCCTCAACGACAAAAGTGACATCGGTACACACACCAACAACCAAACACACCCGAAGGAATGCTCAGTCAACATAATTCTCATCCACACAACACAGACAAAATAAAAATCTAGTACATTGGCACACTATTGGGTTCTCAGACAACAACCACACAAGATGAATTCGAAGCACAACCCAGAAGCTGTTTTTCGCTCTCGGCTGGGTTCTACCTTAGACAAACTGTTTTGACGTTTGTCAGCCAGGTCAGTAACTTTTTGTGCGCACGCTCTCTCGCGGCGACTTCGATAAAGGATTACACGGGACCCAGATCTTTTGACAAATCGCCAGGTAAATCACGGTTTTAAAGATCGGGCAAACAACAGAGCCCCGCGAGCTTTCATTTAAGAAGACTGCGCTAATGCAAAGTTAATTGCTCCAGCGCGGACTTCCGATGGAAGCTAGCAGAGGTAAACCTATATTATCTAGGCCTTGGTGCGATGAACGCCGGCAGAAGTTCTTCTTGCTGCGGCGCATCACAAGCCATGCACCGTGGAGGAAGTCATCTTCGGCGGGGTCAATCATCAGACTCGATGCGCTGGTTATTGACGTACGCGCCGCTAACAATCGTGCGGCGGGCTGCACCCCGCTGGAATCAGCAGTACGAAGCAACGAGCAGGTCAACGATTCGAAGTCGTCATCGCCAAGCTCTGCCGGTCTCCGACAATGCGCCTTCAGGTCTTTTCATCCAGATCGCTAAGTTCAGCGCGACCGAAAAGTGCCTGCGCGGCAAGCTCTACTGCCTGGGTGGCCTCGTTGCCGTAGCACCAAGTTGGTCATCTCTTGCGCGAGACGGCGCTGGGCGGCACGCGAAGGCTCTTCTTCGACGGCCTTGGCGTACTCGGCGATTTCTTCACGGTTCAAGAGGTAAACCAGCGCGGGTAGTCGATGACCACGGAGTCACCAGCGTTGAGGAAGTACTGGTGCCGGAATAGGCCGAGGTCTTGTCGGATCAGCCACAGCTTGCCGCCACCGGTGGACTTGCCAAACTTTGTCCTGCGCGTCGGTCACCAATGGACGGAGTCAGCGCGTGCGCTTTGGCGCCATCAGCACGACGGTTGGGATCCGCACCGGAACGATATTGCCCACTGATCGCCGCCACCAACCGCAAGACGCAGTCGTGCTTGCGCTGCAGCTGCACAAAGTCATTGGCCTGCAGGAGCATGTGAGAAAATTCCGTGTAGGAGATGCCGTCGGTTTCCAAACGGCGCTTGACGGTATCGCGGTCCAGCATGGTGTTCAGCAGAAGTTCTTGCCAACATCACGCAAGAAATCAATGACGGACATCGTCCAGTCGGCATTGTTGACCATGATGGCTGGGTTGTCGCCAGCCAGTCCACGAATTGGCAGAGGCACCAGCTGATCGCCTCGGGTTGATATCTCGTCTTGGCTGAGCATGGGCGCTCCCCACATCCTGGGTCGCGATAAAACCAGTTGCGCCACCCGCCAGTGCAAGTGGCTTGTGCTAGCTATGGAAGCGACGCAACATAATCATCGGCGCAAGTGTCCGGCGTGCAAGAGTCGCCGGTGGGGTCGAAGCCAGCGTAGAGAGTAATGGGCTGCTCACAAGCTTCACGCAGGGCGTCGATATCAGTGGACTGGTTAATAAGCCCGCGCCATTGCAGTTCATCGATAATGTTCATGGTTTCCTCGTTTAGATTCTAGAAGGGGTGCTGGGTAAAATTTTGGCCGCTGAAAATTCAGCTGCGCAGGAGCTTACTGAGCCTTCGGCCATGGCAGCGTCATCCACCAACGCGACCGGAATTCCATCTTCAATAGGATAGGCAATCCCAGGGCGCTCATTGACTGGACTTGTTCATCTTCAGATAGCTCAATGGCCCCTTGTCCTTACTGGGCACACAGGATTTCTACTAGCGCAGGATCTAGAAGGTTTCTTATCGTACCTTCTCATGTGGTCTCTTCTTCTCTGCTCGCACTGACCCCAGAAACAACTCACCGCGCGCCTTCCTCCATTTTGGACGAAAAAGACGCGCGGTAAAGTTGTAGGTAAAGCCACAGACTATGCCTGCTGGAAAGTGTCAACTACGGCGACGACGGGCGACCGATGAGGATCTTGCAGGTCCGTGCTTTCGGAGTACAGTGCACTGCTGCTCAATGACTGGGTCAGCAGAAGCTAGACCAGCAGCGGGAAATCGGCTGGGAACGCCCGCGCGCTGCTGCAGAGACTCCTCGCTATTCCGCTGGGGTTTGGTTCGCATTCACATCCTTGCCCAGCACTTGACCAATCTGCGCCGCAATATCCGGATAGGTCAGGGGCTGGCGCGCCGGCGAGCTCATAGACCTTTTCCGGCATGTCCGTCGGTGGTAGCGACAACAGCGGCCGCCTCAGCAAAGTCCGCACGCGCGGCGCCAGAAACCTTAAGCTACACCAGCGGCAGAAAGAACTTACCCGGGACACCTGTCTCGGGCCGGGCATAGTTTTTCCCAGTACCAACCGTTGCGCAGCAGTGCTCGATGCCGCTATCAGCCAGCAGCTTTTCCGTCGCCACGTGTTCCAGGGCCAAAACAGTTCTGGGAGTCCGGGTTCAACAAGCTGGTGTATGCAATCTGGGCAACGCAAGCAGATTTCGCCACATTGACGATATTGGGTATTAGCGGTCGTACGCTTGCCCACCTCACTGGCGGAGACAAAGATTCGACGGTCCACACCGTAAACGCTTTCGCCAACGCTGATTCTCTTCGCCAGGCAGCAACGGCGATATTGATCCCCCTGCTTCGCTAGGTCCTGTGCCTTTTCTTCATTGCGAACAACGGCAGCGATATCGGATGGGGCAACATCGCGAGCGAGCAGCTTGTCGATGATTAGTCGCCCAGATGACCCGTTGCACCGGTAACAGCAATACGCGTATAGGAAGCCAGGGATGATTGTTGTACTTACACGCAAACCCTAGCGCACTTACAAATAGTTAATTCGCAATACTTTCATTGTCGCGCTCACACGTCTAAGGTAAACATGTATCCACCTCTCAAGAAAAGTCGCAGAATCTTCCCGCTGCCGATGTCTTTTCCGCCCTGTGCTCATCCGGGGCCTTCAACCTCACGGGCCGTTGGGGATGTTGACCATGGTGGCGCTGTTAAAGCAGTACTCCCCTACGCTTTGCGGAACTTCGTCAGAAAAATAGAAGGCATTAGTGACCGGATGATGTCGCAGACTTTGGGCCGGATTAGGCGCGACGGCATGGTCAAACGCGAAGTCCTGGATCCATTCCCCGCACGTGGACTACTCGCTTACTCCGCTGGGAATCAAGGTTGCCCGACCACTGCAGACATTGACCGGGATCATTTGAGTCACAGTTGGATGAGGTCATCGCGTCATAAGAGCTACGATGCCAACACGGAGCAATAAATAGAAAAATGCTCTTATCCACATTCAGGGATAAGAGCATTTTCTATCGAAACGAAGTTCTTAGTTCTTAGCTTCTCTCGCACTGGCGTATTTGCCCACGCGCGGGAAATCGTCGTTGAGCTTATTGACGGTCTCGCGCTGTTCAGTAACGCGTGCCAGCGGTACCGCCCTTGGTGGAACGAGATGCCACCGCACCATCGATAGTGAGCACGTCGCGCACGGCTGGCTTGAGGCGACTGTCCACGTTCTGGAGTTCTTCATCGGTGAGGTCTGCAAGATCCGCACCACGAGATTCCGCCAAGCGGAACGCATTCGCCGGATGCCTCGTGAGCCTCGCGGAAAGGAACGCCTTCGCGCACCATCCACTCTGCCAAGTCAGTAGCCAGCGTAAAGCCCTGCGGGGTAAGCTCGCGCATGCGCTTCTCGTTAATGGAATTCCAGGTAGAGACCAGACCCGTCGCAGCCGGTAGCAGCAAGTTGAGCTGCGCGACCGAATCCACGATGGGTTCTTTATCTTCTTGCAGGTCACGGTTATAGGCCAAGGGCTGTGCCTTTAATGTTGCGAGCAAGCCGTGGGTTGCCAATGAGGCGTCGGTTTTACCGCGGGTCAGCTCGGCAACATCCGGGTTTTTCTTCTGCGGCGCGATGGACGAACTGTCGACCGGGCATCACTGAGGGGTGAAGCGTAGCCGAATTCCGGAGTACACCAGTAGATGATTTCTTCGGCAAAGCGCGACATATCCACGGCGATTTGCGCCAAGACGAATGCTACCGTCTCGGAGGCGAAATCACGCGAAGCCGTGGCATCGAGGAGTTTTTCTGCTGCGGCATCAAAGCCCAGCTCATCGGCGATGGCCTCTGGGTTGAGCTGCAAGGAAGAACCTGCCAGCGCACAGAGCCATATGGAGGAAATAGCCAAACCTTGTCGAGGTCAGCAGGGCGATCGATATCGCGCAGCAGGGCTGGGCATGAGCGAAGCAGCCCGAATGTGCCAACAAGATCGGCTGTGTGCCGCTTGGGAGTGCGTCTTGCCCGGCATGATGGCATCGGGATGCTTTTCAGCCTGGCCGGAGATAGCTTCGACGGGGTCGCTGACCTGCAGCGCAATATCGCCCGATGGCATCGCGCACCCACATGCGAAATAGCGTGGCTTTTTGGTCATTGCGGAACGACCAGCAGGCGCCCGCCTACTTCGGTCCGACGATGTCGAATTAGCCCACGTTCCATTGCGCCGTGGACATCTTCATCGCTGGCTGCGGGGCCAAATTCACCCGAAGCCACCCTGGCGCCGAAGCTCGTCGAGGGCCATCGAGCTATGGTCTGCAGGTCGGCATCGGAAAGCAATCCGGCGCTGTGCAATGCCTTGGCGTGCGCTTTCCGTGCCAGCACGTGGAGCCAGCGCAATCGAAGTGCGTGGATGCGGCAACGCAGCCATGGCCTCTGACAGTCCGCCAGAAAAGCGTCCGCCCCACAGTGCGCCTTCATTCGTCTTATGTGGCTGCATATTGGCTAACTATCCTCCGTTATTTTGGACTATACGTGCGTTATTATCGCGTATAGTCGCGTACTTACTTTTACTGGCCGTTTTCGCTGGTTGGGAAACCGCCATCACGGTCACACTGGTTGGAGATCTGTTGGACAGACCATGCAGCTGCACGAAGCCCTTGGCCGCAGTTTGGTCGAAAGCATCACCCGGTGTCGTAGGTGGCCGGGAGAAGTCATACTGGCGACTGTGGCGAGCGACCGTTGACGATGATCTGACCAGCCTGCGGCACCAAGCGGATATCGCCAGTGACATGCTCACGGGACTCGGCGATGAAGCGTCAAGAACGCTTCAATGGCGAGTACCACAAGCCCGTCGTAGACCTCTTCGGACCAACGAGCATCCGTCAAACGCTTGTAGCGTGCGAGTTCGCGCTCCATGGTGACATCTTCAGGCGCGCTTCGTGTGCTGAATCAACGTGATTGCACCAGGTGCTTCATAGATCTCACGGGACTTAATTCCTACGGGCGGTCCTCGGCCATGTCAAGCGGCCAATACCTGAGCGCCTGCACGACGGTTAGGCTCTTCGATAGCTTCAAGCACGCTACCGGCTTGCCGTCGATAGCAACAGGCTTGCCCATCGAAGGAGATGACGCGACGACCTCATCGGGAGCATTGCCCAACGCTGGATCCTCGGTGTAGGGTAAACGTCAGCTGTCGGTGGGTTCCACAGATTCAGGGTAGCAGTTTCTACCGCGCGCGGCCCCGAACGTTTTGGTCAATAGAAAAACGGTGGGGACGCCGACTGCTCAATCGGCAAGTCGATTTCTTCCGCAAACGCAATGGCCTTATCGGGTCAGGCGTAGTCACGTGCCGGCGCGATGATGTCCAAAGATGGATCCAGCGCGCGGAGACCTCAAAACGTACCTGGTCATTTGCCCTTACCGGTGCAATACCGTGGGAGACGTGGGTGCCGCCGAATTCCTGTGCAGCCTGAACCAGGTCTTGGTAATCAGCGGGCGAGATTTGCGAGACCAGTGGGTACTGCTTCATGTACATACCGTTGGCCTGGATGGTCGGCAGACGGTATGTCCGCGAATTCATCTTTGGCATCAATGACGATAGATTCACGGCGCCGCAGTCAGTGCACGCTGACGTACAGATTCCATATCCTCGCCGCCCTGACCTAGGTCCGGGGAGACTGCGACAACGTCCTCCGGTCATCTTTGCCCGGGTAAGGGATGGCAGCCGGTATCAGGCGCCGGAGTAAGCCGAAGCGCAACGCGTGCGTTCATAGTTTCCTCTGTCTTAACGTTTCTCATTGCTTGACATTTTATTTCCACAGCTGTACGTCAGGCCTATTGGAAATATACACGAAGTTACGCAATATACAAACTCGTCGTGCATAATCTGAGCTGTGTTTATTCAATCTCACCTCGACGCGAGCCAGCTGAGGCGTTCGGCCAGCTCTGCCCAGTAATTGATTCGCGACTGGCACAAAAATCATAAGTCCGCGGCAATACGGCCATATCTTCCAAGCCCACGCGATCAGTGAAGCTGGCAAGATACTGCGCGGCACCGGCTGGGGTGCGCAACAGCGATATTGCCGGAGCTATCCACAGAGACCACCAATTCATCAATCATTCGGCGCAGCTTCTCGTGGACCATTGACGGTCAACGGGCGATCCATTTCACCGACGGAGATAAAAAGGACCGCCCACCATCACGCCCGGCCTTTTTGGCACCGGGACATCTAAGTCGCGACAAGGTCGCTTGGGTGATATCGATGCCTTCATCAAGCAGCAAATCAAGCTGCACACGGCTGGTCACGCGGGTTTTTCCTAAAATTTCCAAGATTTTCGCTTGGGCATTGCGAGTCTTAGGCATGGTCATAGTATTTACCTTAAACCCAGCATACTTGCCCAGCCTCAGCTGCCTTATGCCGCTAACCGCACCCATCAAAGCCTTCTGCCGCGTGCGGGCGGTTTTTCAGCTTCGTCAAATGGGCAGGAGCCGTCGGTAACTTCCGCAGTAACTTCACGTGCCGCCGGTAGGCCGGCAGGCGGTGCGAAGATGCGTTCACCATAGGCGCAGCCGCCATCGAATCTGGTTGACCTGGCGCGGCATAAAGGGCGTGCGACGGTCTTTGCCGTCATCTTTGCTTGGCCCCATAGATACCCAGGTATCAGTGATGATGATGTCAGCCCCATCAACCACACTCGTATCATCTGTGATTGTAATGGGTGGCACCGGTGTGTTCAGCGCGGTCAGCGCACGGTCGACAAAGTGCTGCTCCGGCTGGGAAATCATCAGGCGCGCAGATGGCAATATCTACCGGCGGTATGAAGCCGATGAGGTAAGAATTGGCCATATTATTAGCACCATCGCGCCCAAAATGGAGCAGCCTTTTTGCGCTGGCTTGTCGATGCCCCAAATTCCTCCGCGCAGGTGAGCAAATCCGCCAAATCGGCACGGATGCAAATCATCCGTGGCGAATTCGATAATCAATTTACGGTCGACGTCTGCCATCAATGAGGTTTTGGTGCCTTGTGAAAGGTACGCCAGATGATCATTTCGGTAAACCGTGACAACACCGCCGCGGTATCCTGCAAGCTTTCGCCTTTGCCCAACTTTGGGAGCTTTGATCCGTGGACATGATGGCGCATCATCCGTCGCCGCGATACCGGCTGAAAACCGGGTACGTGTGGACGTCTTCGAAAACAACAACGCCACCGACGGGCCCTTCAGCGGGCGGTATACAAGGTTCTTTCTTTGGCTCGAGTGCCAGCGCTAGAACTTCCTGCTGTTCTTTCGGGGGTAGGATCATCGTCAGCTAAGAATGCCGGATGCCGCCAGACCTACTTCTAGCTTGTGAGGAATGGACACCAACTTCGCGGGTGGGTTGGCCACTCATGTGCAAGTTTCGCCAATTGTCGGTCTTAGTGACCCAGTGGCAAGACGGTGGTGATTTTTCTCAATCGCCGCATCGATATCTTCTTCGGTGATAACCAGTGGTGAACCAATACGCACAACATCGGCGCTTGGTGCGTTGACAATGAGCCCATTGTTTAAGCCCTCAGCAACTGCTTCCTTAGCAACGGGCTGGTTGAGCACAACGCCAAGGAGCAGGCCCTGACCGCGCATGATCCACCAACGACAGCTTGTTGAGCTCCGCGGCGAACTTCTCACCCTTGGGCGCACACCAGCGATAAATTCATCATCGATGACATCTAGCACCGCATTGGCTGCGGCGCATACGGGACAGCTGCCGCCAAGGTGGTGCCGTGGCTGCCGGTTCAAAAAGCTCTGCCTTGCCGGTACCAATGCACGCACCGATGGGAAGACCGCGGGCCGCTGGCCATGGTGATGACATCCGGGAGTAATTCAGCCTTTTTAAAGGCAAAGAACGTTCGGTACGCCCCACGGTTTGGACTTCATCCACCACCACATCAAAATCGTACTCATCGCACGGTGCGCGGATGTCTTGGAGGAACTTCTTGCGTGGCTGGGATAACGCCGGTTTCACCTGGGATGGGCTCGAGGAAAATAGCCGCAGTGTCGATGGGATTAACTTCTACAAGCTTGCGCGGTAGTGTCATCATATAGGGATAAACTCCACGCCCCGGGCAGCGGGGCAAGATCGCGTTTGGAAGGCTGGCCTGTCAGCGCTAAAGGCCATGGTGCGGCCATAGAGTATGGTCGGCTGCGAGGTATCCGGCGGCGCCCAGTCAAGCGTGCCGGCAGGCTACTTCATTTGCCTCCGCGCCGGGTTGGAAAAGATGGCGCGTGCGGAGTCATCGCCGACTTTTCTTGCAAACGCTGCGCGAGTTTCACCGCGGGTGGCGATGCAAAAAGTTTTCACGTGGCTCAGCGTCGATACTTGCGTTGACGGCCTTCACCACAGCAAATTTGGTTGGTGCCCAAAATTCGCACGATTCCGGCCAAAGGTCCGGTACTCGGTGCCGTGTTCATCAACCAAGTAGGCCCCGTGCTGGGAGACGGTCCCGAAGGTGCCATAGTTATTCATCATGGCTGATTGCAGGAACTGGTTAGTGATGTTTGTGGTGCTCACTGTGAATCGTCCTTCCTAAGAGCAGATTGCCTTCGGGGTAGCGGGAACGCTCAAAATTATCGGGCAAGACCATGATTGCCAATACCGCCCATGGTCAACAAGCTCAAACAAGACGAGTGCGCTAAGCGGCCATCGATAACATGGGATGCTGCACCGCAGCGTGACGGCGTTGAGGGCAGATTCCATCTTCAGGGATCATACCGGCATCTAATTGCCAACATCGCTTCAAGCTGCGTTGCTTCAATCTTGGACACCAAAGATTCCTTGTTTGGCCAATCGGTGTAGAGACCTTCCACGGTAGTCAACGCGGCCAAGAAGCGTTCAGCACCTAAGGAAGCGAGCTAAAGCACGGCGCAGTCGGCGTTAATGTTATAGACCTCGCCATCAGTGCCAGGGGCAATGCCGGAGACCAGGGATGCGGCCAGCTTCGATAATACATCACGGCTGAAGGGTTGACGTCAGTAATATCGCCAACCAGGCCAATATCAGTCAGTTCGCCGTGACGTTGACCATGCGCTTGGTGGCAGTAAAAGCCCAGCGTCTTCCCCGGAGGTGCCCACCGCATATGGACCATGGGAATTGATGAGATTGGCCCGAGGTCGCGGCCAACAGCCAGAGCACCATTCGAACGACGTCCGCCGATCTCAGGGCTGGTTACCCGAAAACCACCTTTAAATTCGCCTTCGATGCCAATTTTGCCCAGCATTTCATTAATCTGCGGTCCGCCGCCGTGCACGACAACGGGCTTCGCACCGACGGTGCGCAAAGATCAGCGGCAAAGCGCGCTTGGTCTTCATCAACCATGGCGTTCCGCCATATTTCACCACCACAATTTTGTTGCGGTAGTGCTGCAGCCAGCGCCTCGGCGATATGGCGCGGTCATGTTCGACGTCGTATACGTATCACAAGGCTGCCGCGGTGTTTCACGGTCAGGCGTTTTGAAATGCCGCGTACGCGTTGCTGATGCCGGCATCAGCGTAAGGTACGTTAAACATGGGGCGGGGCGCCAGAGTTGGTTCACCGTTTGCGCTTTGGTCGTGAAAGGTCGTGGATTACGTATGGGCATGGGCGCGCAGCGGCTGGTTTGGATCAGGGCGGCGGCTGGCGGTTATTAAGATTTCAAAACGTTGGGGCGTCGTCGGGCCGGGTGCGGCAGCGTTGCATTACTCCGGCATCGAAGCGGGCGATCAAGCTGGGATAAACGGTGCTGGATGACATGGCTCGTCCTGTGAGGTTCGATGCCCGGGCACCATTGGCTAATGCGATGACGGTGTCATTAGTCGGTAGAGCCATCAACATCAAAGTATTAAGGTGATCGCGGGCCTTGCGCAAGGCTTCATCAAGGCGGCAGGGCTTGCTTGAGGCATCAGTAGTAATGCATGCAACATGGTGGTAACGTGGCGCCATCGTACTTACGCATAGCCTGCCCATGCCACCGACAGACCAGCCTTGCCCGTGCACAGCGGTTTAGCCCAGCAACGGTATCGGTCGTCATGATCGCTCGCGCTTCAGCGCCGTGGTCAGGTCGGATCCTGGAGTCTTTCGCTGAAGCTTGTCGATGCCCCCATGCACCTGCTCCATCATCAACTCCCCGATAAGCCCCGTGGGCACACAGCGATCTGGTCGCATCGAGACCGAGCGCAAGGCGGTATCTTCCGCCATCTTTTGCGCATCGGTCATTCCTTGACACCATTGCAGGGCAGTAGCATTGCCGGCGTTATTCACTACGCGGTGGGTTGGGCTCACCGTTTTTCCAGGGCGGCCTGGGTAATTTTACCGGTGCTGCGACAACGCGGTTGCGGGTAAACACCGCTGCCGCGTCAAAGTTCAAGACTGGTTTGTTGACCGGGGCCATATCAGGATGCCGGGCTTAATGCCAGCGATGGTCGATGCCGCAAGAAGCCCTGCGGAACAGTGCACCACTGGCTGGAGTTCGGACGTTGTCATGGCTTGTATCCTTCTTTCCGTGCGAGTTTATGGTGCGACTGCGGCCTGTGGCAGGCCAGCGGTTTCGTCAGACCTAAGGCTAGGTTCATGCACTGTACGGCAGCGCCGCGGGGTGCCCATGGTCCGGAATTGTCTAAGGCGGGAAGTGATCCGCGACTGTGTGCTCCAGCGTCCACGTGGGCTTGAATCTGGCACATATTAGATCCACCACGTGCTGGGTTTGTGGCTGCTGTCGCTACTACTGGCGGCACCCCGGCAAAATGGCTCGTCGGCGTAAAGTTTTGGAAGACTTTGGTGACCTGATGCTTGCGTCACTTTCAGCGGTGCCGTAATCGTGGCGAGGATACTGAGGCATCGGGTACCAACGCGGCGTGACTGACGACGGCGGGTGGTTGCCAAACGGGCTGAGGGTTTTTGTACCGCTTCTGGGGTGTGGCCGGTGGGTACCACACGGTGAATAGGCTTTCACGCTGCCCGCATGGTCTCAGCTCCAGCAGCAGGTGCGGCGGCCTTCTTTGCCGGCACCTGCGACCACCGGTAGCTGCCACAACAGACAAATCGGGCTCAATTAGTTTGCCATGCAGTGCTGGCGAGGCACTTCAGCGTCATGGTGGTTGGGAAGCAACCAGGTACCGCTACCCTTTTCGCGCCTTGGAGTTCTTCGCGGTTGCCGGGTAACAGAATGCCATAGGGCCAGCTTCCGGCATGTTCTGGAGCCATAGAAGTTTTCCCAGTCCTTGGAATCTTTCAAACGGAAATCCGCGGCGCAGTCAATAACGACGACATCATGGTGCCTTAGCGATGGGACCCGAATACTGTGTAGCGAAGTCAAGGAAGACCACGTCATGGCCGAATTATCCACGGTGGTATCGATGGTGCGGCCTGCCGGTTGGTAGCGGAATTATGCGGCAGCTCTGCTACGGTGCGGCGTTGGAGTGGCCGGTGAGTGCGCCAATTTCTAAGTCGCCAGGAGCGCCCAATGCCCGA $(,%$$&%+&%&&#$'$#-1(#0'5(03($#"%561082+5-&+96798/4/-0+/0402,$().00031/6(+'$+2-81(1111,)/0,(2339489/3;-13,3322582./)/0-%+)),.((0,15029:5)6724-0,,1:5).-13/.-,,%,+'-',/20/018;,+.369;;.082/"$-11-.,-/.))'(%)&+++&+-5,/+#'$%%&(+'..-/)2))+&''&'&&(')+4,57868./--0/0--,-,)'+-040..2+12512&(.'3--/1(%'--/-.--1++6,/%(#-''2,')--,'(&$&,-087,%(/064353()+''&)+1)016396+701::9;4328).--0&--,,-+,//-/52-4.++,,+,.//68674368;4((&-75./-(),'-$%0.53('%$#")','(58864:-8.6458.39.0%-'%-+6&'+043).0.100#(*-,+)/9.,29-,,./179947:-,+,&8%&')(&),'5&%+6,/'%3&&'(-.5/00096+')+.0028-69-&)'.52;6/12+)+$).++'&(,+/,#('5;268/..,0980/49567///01::1;-..-5674,,.-((/+7157878528++.):,+$%#&,'-,,,-',,.1-/)-3098598560173701/1916568++/+....45-,-157-61-74433324+,.+7+++-43,./,-./(,18-39&((,)1..038::97951400/49&'+1,,7-.-,,/1051691/;)01402/105-09:/,16%+./+592').-+++7;.(/,17-2131553)4.,%%+,3&)43,+-+-+-/../016///0+,&)'+)-+../4--,,).7+(-./18)(',101))$().5;+245:/---9750.('''$.'+7)(',-1281+01.0:3,.-.&),+/+.(())('&42/16/5-))(++,986,737::99;8751&')#50+266734567648..22413;7.,/+#'(++-3-&,5+++.768.-+++/--.-/34&&'/03+2-(1299667'.,-52),*).;/8/01$'.1($%&10))/-0104:;7::688,'&+-/45176,/+)+)%&()1.))),970.(%%%$$%%)-)/259729,./,-28778::09'$(()/0.6...7-15-..5(()1/,-7123879979-+,80)/(((+008:2///+-.(-(()&)2:70144362(.(4(:637324/8;4('/-3276579/4645-0586214/1+39-./'&(./-./4705$&&'.--06065')).()+67:6475(*32,'()1//+,--03204255.-(&&(.0/5.5((..,-410(&($$(06.4/.3:75(-1517803.-//-766/+,'()(00+:6+%+.)$)-4/',661-.55/0/64211(%'&'(3,6)$*'&'),,,.)*0.+/.<-45.0+(()),)/3)),/78773323/0343-0(##$#&14/038.190)+;9578-,,($()%+.255).-'+)()-.,54:834/27677(,&&&#(#,#,6).,$(&/1978((('%,+5897833681+--.9927852334+,-591'+2/55+&%.+$((',0.,,,2,65692,1:3+(556:50.+-$+(111&$'&(++-,+,/,&,'&+(%+,..01;5/-1..1895474-$(,5-,$'%%&,5(26,55572-00+6-))4+,+(&'&$$'680,0,7;:-/,,,11138'),')662168-:,,,:6:4293340///9-6.,,&'-).9403.4249;0+'$'-2336,+&(123774++%(/755',$&(,,&//145254006013102/.-,4.8-7/,+)+/479)7)%(-+---76899,++(1)+0''))0;;:/9;;;3423+4+/058.5)()+02)&'+,9688--5,0)+2(/())/21-/..4251./&)&$&$#&$%'"#'(29:;7013335+7000/(86528.7.--7:/1/242998+,,./0;/./-.%/'+'$'%##3.1+&'))&'+%,+--//15822/1)3..-2350856753,'/&--++.-7;534-+1714;9-/00:;867699/1..5;50.&(,(5;;)18))/23)841758)+-()$45/(.$&0-79++.6;:+'#','1099:611-+-1403&('600.1,-./,''),4151363/.,)1-.)('$&(&,'''%&)')'%&%''%0+-/0.()+,+034.////;:8:;/60$$'(+178;-8,%)&)+-4356231-01827:6931015,.410(()/87::8;07//.(4+).,+648(,+++)+.42231211$$%$/+..--.6.0,-,'/,,,4:6638537./256.73-$%'-)/51/,'#'$&,%%+&(/1'&,165444+21053(#%$$*+7988:;96:6)):9&&&%((,2651.,+.(213840+$&0-.::936.8+(3465073717:/.,/-7)(3)-68-)-,.1.7533+-0,(&'+/."$+-414))..1/082.:+/6.-&(+/2/6+22)),01655041-,./'''-/7/.04.302+'*&'%&)''%',3:866231947770667335/12108771;;104-))'$%(+'&),0,4;83:-)-'/'-+-.4771020149162+'()++8,++/.0,'&-(,/'+,/-+.'-(+')+.01498/++/+0-,,6)6.72)/1/,/+-+0,-9;89;286698654,8,,22170.083-,60':888996;,+%($'&.1768%.$&(.-2115-0+/+,-2--/./38792.,+--/24324((-.132$-(0,+,.442451/9/-95,122231676993340(3&)--,3888155(0%'$$(.0/252/34,,)()+(,-..1.37227+.-(+0532$$%)139090&%,/219--./0868996/9;--//99737212/8/009:9956463:4.&'+.''&&(+3++&$%))(+7/7.-124,612202-2//%'2+))0)+,9:7+'(%%)3./&).994964.8.,7/00:55//1,:///:629.12140+"$%&%,,-&(%"$('-2.&'%&'('-(,%%%%&0224744(&),/)'./+-+,,23-7)6),-034575+)+)--5:;...,"$+7/-,'//03;5'-%14-.5:64;9137032234/-/4:80800/4(($',%%).,0+,/35466524437223987-+$..%&&+13247462$'+,%')-449;-:9759800-,2+,.,$)*2,$$&&%&/42&049:9980-./1$++6-/200,3567576011118.245:6623737.6--2018.,.4:;0:/)-"+$'''(0)+.4.016<++++:,:4/2242186+')5,1///1&(25+..399::+09510787,5.4+/2127975:8++,:89562'++-.--2557::7;:6;6:-3/2.,/,.78:::46830-$%)-.3,0,4161669::6040..3742#$.$+,1("&0)+++/42-++'4),08/0;6487668-.27&'%',0;00;1<6*/9211-,)%,48322.-))(092/250-,/00/'22/2110,-++,;1/39555(6(,4150&'',%-100.'&(/41644,-)%('#%%&/64#$+2+,1+--6316374648::9:7467.3;<7-:79/-476-(+/(//,4/097+5,+0+1,7;5)($%&'51121&6763455-.(-656445+0&((/899891757683.),,.--6,4-),$0%4735..-77//-(&(%.),/-("&&(455658.9.,,002;7+)++'&/'()3/398:333$--#.+-1-)-)0&&%'+/++.89//.//./0/$''%$%$558957),29;963))8:62;:6:963)%.2('('(1,2,/(((-/%(##)$/318455::7:5/33:55.5-,.023679(172,,.48654-49587(%(-)($'$$%,.+36+283;410/.++,-0187+%&''01288..,--.517,2797.(03114300-+.-/2,2))"$*&'(4.-('%%&'$%&3:022%4//-23/&'3,.:./0)'2-('(6515619-77.8'.3..6656<;9,320-+/%,0003338:15/0,+#&('-2,+,,)73457669,)-0%0--'.708-03379798+,,,2958&%663+'/3,++%34,&$')73698<:8143),.024202557494-,0-/12#3)7/0,00.::0.1-'+,3012--.-,6.+($%%"###%&&',,3)(+)'69.,470/+.,1.,0)%&)'+(+&#)&#'#+'5348.2-59578892)).3,()6+0123899777)-:2()+'*+-&/22/748810.%,/+.0-:80)0,/090204'3652201358/3;:2-;6855957.+-+,$)$35447235437-9276:;:.95778966.'44/..-+,+0.,,35456589-,/2%(,'()01--/70//--10+-,/24-1/-,'#&&(&/'&'(&$#)'%%&%#$%#0&,6)++0/.%%(/3444:'%$#$$&"&&%)).3-$)/-/60:&+30,,-8709)&%"&+-1//+#$$(%','0)(-%$)+0+-1.,46444//(,02.)+)#%&(03./02.9-/75:92332276;;6--57;6310-'$,4/7./64(&&.0,..4,-,/.5434012.27,+74070129788631821/2+3,0'+%((0../)44/((*5./.95-.-)0++162776%$1368-0+&+,,41)5,+-8435.486:555447.,%&756;979-1,%(%/(+&,.+++.7/,/69374-26.+'()(1"$(/54747-0:9,2-///19677034.().'"%%1.018:2041335/72:057,.798-.--22769)4'('1((%(,1.+(4&%%0,//51564612(',+/09979788'&-.()%#(-1555630'2'/$+-0612;:3''.89:0121420;2.21)+.275-5;9/4/-((),5277-()())#$'&%('+6,3-,,4;637.')1(+)6464454;979:0;7+,-+)1/-./,0'(.+,5478-4-'314:5693./,.55734''-/491'0080212139.6,.(($&(182472184:4968623.2356994691345636..'+))++0033578889632-3...35(&&')+3-3989884'')/98999+-/:630&,,622-$3.,.0$3.0/5152'--.1(-(-+-623,/18355-%)(+3425:879;6:9:8887853)&-2102211.+.,%'+5477:6;651+235:69:7.030.&&('',,0/2202691550103,%/95238'%)%$(,-:47664657/-'%%')1-2,&+104/8/6+,11)+./8211/71.17)1172682324+./.3/6.-,')+-2,-0.17'&6.-'++(-,948;;22.4914967/4744370''%(3052,3((((1177977;:08101:53-/8899$77-(/41:227,6+&02/597)031;/,4/1%2)+"&-.0996/7672-.0/-8;<046850050.0%,.12:862++,,(/24.30+453-..-.60-+,*&%'($(,.0-*2''+4,/..,&('+,'6&$'-)+'6;..70/(098:0+--11,3-//53,++.33550;:/0+4+,+5355/.2&$#&.738857-/)+.+.+,).1743403(06(2&++-,-'/,).9:;28787889;:89966./064,+-78793384291+.00.46270+1,+-/57+6),--1-/7.93320---.//2)--178:9:::)&),1.0.3/29.1((2,,(0(,'(((,4512323.444485779657'/14+0'+043541'5(+$&(+/..+651656;92875-5774-,)*)))50.,/+06.)0063)5)(20(1:52412,/-++24%7://,-138+/+,.6.6:6/-'%(,/2'+6/869+),++&$&)%-81974565222/-00()'%),10..2973,-,50*-/3381-$3102&.-.142,,0.0..7./+4(3//5:.-))#(.86472139524696)2252/./.01153++)-.,.-70&-8<;:164.+-/2.79;7679868:99;7804))%&#'593,/153440/30.&1,.7013.++6-,,-())),/5682+('&$#'').+,).6:71.12',2122;7-33,7,3,+/.:.00+0-,/2287,4()%/'%$$/34997-56,+&%75))#(,#$#(71////11+,()(,+3399991'$1117610.))(4+553544252-.-+.525-/44011.,)0997759:0),&,%).)466:8359548+441.6/0.21//24031212..0448477..:3/;;8-:95664/1/11807/.04//0(,.3587495,)((/),281.39/919/2<<9+7896:19.&%*(/;488732/.,021+,)./115608/0125,2',/917/.6798;85033474+'$%$1+4'%(-/-29;;264.(+1,)0776467((32-,--,(.+)49)$),('+(++/542(%&)./78310532)).(()+0835..--,334./13-2,448&0.'/)2,29597988856:0/---,21130).$111688397111,-/,,290,('-7.--9.;/7-,82/,,,.+,-66279+-;9-1'(.1555:1&/(7006/)56388/12557%,)2)))%+,821+'+09723-160///++++3188:59%%370&).-434+''((.,-08.767-1-+-102&-()+18:3-/..15342.09.,,4-6.8170+)1%)2+7/00#%%$%7,7561,4%%/.2(/.//8,)..45522$&)011-+$&$$&(7:6661,//3879:1636'-'.0(/).,&96::4453.239489;757,47,++,'(,03.,1.-+)('(#&)+/67938:2;5(,-(1-+2400216599844-+,,8..,+((,8111/,)),+,.-(),647:4/,-$/&/./''.++-$%%056)(,%%(+.-/./1,3-+%%)17/8;:.143030/((030.-,$),),41):;9563,+),,0-0'//1214436/;://;3++7949344:64:64.7---.326)-51-&%&'))0&."'.,2/).135667739'/33(,/9:530/--/33665-+-)5235+:913%,'*:88893))4''.1$$(#('))4&&'2-,-401%,+&(,0+.+-15988:-(,01/()+.6/--5/,+,777026/&'-//1988/)-'04(+)'$$-%"##%,-09002271.)/5/1282)3+(((%+'5;7/8,1+.5:8;:644-147997.31/+&()756-.,0-:582145/61236-3+----,,)./33.$%),/030.0/216%,)+.2412212+5%6/--/7-6)/56865501.127,'(271&-/%36/)$--011053342.11',35265.,.(42(-3('),,.%134103/,-'21.(&'+&&..35/0(-+%-)%#&&'%,,75566000.154##&(,,.,16886/5,0,-.88+/'$('%"$#'$$##$''&,1201....33)$"%%&$%)(243)/6+()(%(2%.-./((1-+,(),6.//887::377787.8/001104674/-,/4,8:5/1;:6:861424689-)()0137,+)#4(/:;9+1'($%'(,+%0((&/2,+.0,./.-&$'$%$#$&')/6884+,$'$&#(&%&&%(($)%+,,$"&%$&%')).60%)(-//2/)&&'(0+)2,,0/-.3176666.(+)%(*,712-3/,.).12-)&'./6293369,+++2236.-.())+98103,$.644:-8,+),100+610%)).5.+-'',769:41+)%&&2.:..3.3,-++79169','+11,&)%.45:7+(.-125347-(0/44201-//,,//9-::9.3,,,2*)/4/5885+*'+-%%$$&),515.+-+.3.-.26688888576598568-/3+&%&+37,1./0++)(#&+)+.00.())/'.)::8+5()1:91.;/+/.,/0;<;2/.(((-+7041+(%&((+4++1/..+++352-4,28,/.8-86011'#$%'+(),&(23)(+3/440++)())+($,'#%(+).+$%#(&$#-)95.)*).()'%',028$3.-0'-:;1.-+(').)11()&%%&$$"('&%.,,.+()-+/2.%$'%(.2-.5.&&%)%'(#($'"%#).5.:80/4/-)'#$#&%%(%#&$(##')((#&'%%&$,+)+,-+')&+/-'0)++,/043/#%/0851269'23:650///-3683-((&")(',,-/+(&&#$'-8.56./3/-//(4-+'.,..67)..+++(++-.10$/76511344,46,4.246/13795752/0--3..,0/-/1''))(%1*4.44344;0..//:899/$%%'43400,,*$.0)77950/0-/03/455+04,-2:;37966658..88.6.0//--(-1:282(320)),-.0/01/$',%&$(&,-3.:275360.4+))((++,,+&).,,47+.2,&(-2229;8..1+-0)/+5.0,($.)4.&%%)/0.00-./28&221..4489:24;64;3:8)(&&)-/,.(.%%$')2388//164(-,/'(.3722&(-++%).86533434)''%%')-5//6),4-)+0,.1%"#%&-.7)-),.84/0$)+2-133;64'857:17:-6-/1.3...;579440710151(+003(-/92146-/:8-1.)'%',*,.1&)+2:0,--28234;85$#%')45/#'*#,0/,%&(.267561800.)-()./.2+$5.))(-.2455877)+02,+7.6-118+7+,)%-03+180(,,5::/.,(#$#&,()+79+)(88:&3051.(*,./2'10/37.4480090:89::::<+9;0+/662'(#(--1939934/')++),1.00'.+,-120()&$%$174')))+,+.(''&'%$'+.)+.,.-02595704,,&(+9,'.&--0593/((,2+-;61#$#-2.7-/-10/,2.&+)&&3-$(+)0-.-,(/)3//-0;;:999%(()0($('-+++%.).:5498555-./.58;111.+')%$+&-(333#-$%&%$(++-.0/401+,,46565181(#&+43/0945<:67-5:0/1./2/-+&%&((1&'&,.515/9:667919-+/1,01844480/($'))4653(/08;821/,+++.'&)'.5+-,,),3+-)$&()-&)1'($%)()1,/7201'%,512.2/.,.)),()+9;8;88::7:92222277650+'),414-//.1-/0+1,++/-,&+'(/),$&'$%(423:52'.+,511261435+)')#%(171/;4/+)''$$--5.380954456676/,/+-039())74.)'''&''),,)#%0(7.6,4121/00003/14&.60%%(58641/-1.0553.4)/(1)-()+2037:4.865652996$',,97.6.)(&'')/()1427/,(,12888(,.+-(3344:;5302.4/..547422/01.41-)7+-4,))(03015988789;8450&0//508.;07427((2,-;763-',,'',2/.)03402.4774+#$(+72/0,.)'.().2---5/..0,,+%$)')(#&###(./7:86758/(-0.2495''+'((,,$222/(2)./-+20/931806295547574655(-+%)+-()--15+,54.,..58--'('"$&(579:0323211+)',,078393/910,0,()-0+40747789/6(&%%"('-4/74-83./9655,++/.+(*93/183-'.'-23413++#%()9:99;:5/,/766.17,//8:2032442+%$(98334.+,)-)+-0--./.34;1+(/.431,$'(+1:45565889.---+00:-/&&++227472:5035/)('(#$$+'#-3/(05/,66-272"#""$')025.0.-5(+'-/+/&$&)),...02-/05;:9:82()..3+/-..256,0164,0,,"'''))'-.(((+-4,,4:)-%-4//9;9130),%.,..9.+/',56:74.),()+,,/+99+('/8.--$&'/0)668468914+(%&'&(-1((,,+.8785&)-')#'&%313410123-4''%-,/01999::47::65%#.+1.5.5553240'%'#,26.)%&"#&&)%',.(+&%%'$&(,769020229239./00895658949657+)'.'"(&)&+/1644002.,39-8,--9-4-2887:938(+;:.1028854/1157-9,).'.12,,,5,0'(56227,)/'-2.,5,3,:961706'+285306/1;200.2/304+3..-/+-.//78860$%'++(/10'+$$-%/4/$((/)0730/1017505$+#'')''01321/((-%)'&%$&&.+77)9':&''3)%('&,02.//19628).978.4:9047;85880.'%%%)%.5))/78/828.0//-,),'#&&,02)'-)(+3-,42-7...226-.//61229402121/47:9:06...32489247;6527$2&(67;212;08886-4,3,4/6/'+2087,$%./-/10/260;78+16./0/./91,07261//005343++()))//1660,,(+%()'($(%),.25362.,).(-(--7:54:3'+674'51113')'&--+('2:652,&()'-0'26/796873:441-'-,0,---3(0,0;7181--33053+)+62;3+()))417824:49:590.-..2-3*-6/26;6.15976956510##15-)+,.12400+'%$%'2/-4-12-.1:8620'(,.262354802/1877-08')-&',%'(3-;;:15:61/.,+-777725+*,-$))-02))%'""#$%'$%'$"$#%'%+'("%)+("#"##'#%%&$#%(&%&((&''$#(%+%(.($""$$'&&%%$&(&&$"%($&"&%$$"'$'%&&()#$&$$$"&%%$%#%&$$""##"$#%"#%%(+,(%&&$&'%#%+'%"%%$$#$))%',('"%#)'+($&&&(+-3(($&%&#%$&##'$&"'%%'(',%,+)%("$#%$$"""#####%&&+()++-.%&#&&%$'###$%&&''$)#$$&#$$&$&'""""#&'(-%%#$""%#&%"&#%&$%#"##""((',"%#(%$%),//40.10$$$&''((('#(''(%%$&'&+(##"#&%%##&)),&&&%'#$$&)/25/-('(+,-0'$'('80),)-.06298100-.7+%)()0//3223/3432.,(+(%$&$),+169:;52,+'&(#&(/5-0-$(&'))172-.-'(#"&&/-1493237,4065.33/9994-.'%'&)(++,0/)+)),-2002,.1./4.495..&9/+'''/:692(+()'$%$((&)$%&-76./552)/0066+158;)('&(#%,-+2/010132128)&&0.)+.3865:7767+4(%,#&')++&&++('(%'(,+,.02:588;86(,+2.51)+('#)3338;324,'&$')0,-.1221/7960-20415:22446745.)(.-93-588.204652089-+22-,2,''.2//+$)'32-3153(.176+0005/2'())2-.49:;+2++78:/4;:/0610/01%545/887-+)'),48+4,)+(223/%%+))--.403,4-++11)-(#&'$+))+'"&,-25287355-/++1;69/.,,0985.6272:7.-/-+17/-2908/46778889362238814)((00-6;910173563698:988./,+,3'&''885324('$),+(/7.183879:1.,+'0602662404.026,+4497511114---10$()'.664388.97106((&-)#''-.2134$()..'0+66,;,--66/8..4113464,30/78272761'.+75-.1:98:89987646594651851156:434435;:-248-/;338;36021/96;681..-.25801&1-+.//97)(%)(2,)21%$'#.-1('-%#,+-/19:20/$('%$(&)),/)&)+$'&'&(.3'$%%(00501.327/+3++7::999;4////-0-((10.-(.+//27:99:78:9,3+4//0;:995%&/(''''%&()'-.)+%'&),-+8;:12&')1/46113+,1,)+,25/8.2/-/0/51/-'(/+"$%,+,2.11,&')7,'&'''/+,00./1//295610%10+#'#&)+3,6893-+')%&$&##)&('((&#(#((&%&%%()(%%%')&')4987755780+8-.;;8+55561$-/,1//8:2////50,).,-4+/.28--&&'.'()3321410:8+&."./67#++.444./-0101&%).)&%%(&+$((.2,,0..8/6/'%+-231'+'#%'($)&%)4.83%%()'('(/,214988;:01986,,%'&),,59/19597:53879728.-#)&)$))(%$)+35714739896:060'0(+-37/(+-874423:50::803321)(&"&385:;867595:,'++'#$#&&%$&006867,4170+))(0522+3145678/$(-'%7:661)(($)-)'176+01))./051)08).((,')).,',%(&2,/0)/00*/),%.00++,)#%#$&'&,),--/02;90-,-++56+$##$%'))&%)),))&(&(94244450-2'&#$#'-,,./)')/53286-,%%%)3934.-.0.0569.,.+)((-(+'%'$%')++-'%(')..247076:9787973.6.1%'(+5.+-3/1-120/$$#/&29)662/2355:+/$(-)%%'$%&'$$# af03a9c3-4a86-40be-952e-32c5ecd3aec1 4 0 0 0 0 5d81df1d-c415-4562-a915-cf226080a3d3 4 0 0 0 0 82ddfd10-73f5-4992-bd43-9189cbf58c7a 4 0 0 0 0 a49506e2-9bac-4672-94c5-922729605659 4 0 0 0 0 08f4ba5d-b293-472f-8fb1-935a7b74847b 4 0 0 0 0 549d42c2-eaa1-4b8e-90e9-4e181b2f2fb7 4 0 0 * 0 0 TTGATGTGCTTCGTTCAGTTACGTATTGCTATCACCCACACACAACCAGGGGCTCTGATTGTAGACACATGGTTTCAGGAACTGGCCCTCCCCTCCCGGGGTACTTTTCACCATTCCTCACGGTACTCATACACTATCGGTCACACTGGGTATTTGGAAACACCAGGGTGGTCAGAAGCAGATTCACAGCAGATTCCACGAGCCACTTTGCTACTCGGGCACCACAACACACACACCATCTTATCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCCAGCCCACTTCACTAACAACACAATGCGCGCTCTGTCACGGTAGAAACAGAAAATCATGGCCCCTGACACCGCATGCACAACCTCTACCAGAGTATCACATACACACGGTTTAGCCTCATCCACGTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAAGTCACTTCCCCACGTATAACCCCCCACACTGACTATGAATTCATCAGCAGGTACCTACCGCCAACGGCAGGCGGGTTTCCCCATTCCGGACATCCCTCGGATCAACGCTCAATTGACAGCTCCCCGGGAAGCAACGCGGCCCAACTTACACGTCCTTCATCGGCCCAGCATACCCAAGGCACATCCACCATGCGCCCTTAAATAACAAACACACACCCCACACACCTACGGAAATGCATGGGGTGAACAACCATAACTAAAATGCTAAACCACACACCAACCAAAGTTGGTATGCGACGTTCTCACAGAAAATAAGAAATTACACACACCACAAACACTTCAAAAGCACTCGTGTGGTGGATTATACGTCCACTATACTCACACAACACCACACCACCAACCACACACCCACTTTTGCAAACCAGCGTTTAGTGCGTGTTTCGTGATGCAAGCACCGGGACCAACCCACATAATGAATTGCTGTCCCAGACGCAACAGTGCACAATGTCTAAACCCAGTTTAATCTTGCCTGTGTTTTATGTGTCTCAGAATTCGTGTTAGCAGCCTCTATAACTGCGGTGTGTTTCACTCCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCAGCACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTAAAAGCTCCTTAGAGGTGATCAGCCGCACCTTCAGTACGGCTACCTTATTACGACTTCGTCCCAATCGCCGATCCACCTTCGACTCCTAACAAGTTTACAGGCCACTGGCTTCGATTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGAACGTATTCACCGCAGCGCGGTTGCTGATCTGCGATTACTAGCGACTCCGACTTCATAGGGTCGAGTTGCAGACCCCAATCGAACTAAGATGGCCGACTTTCAGGGATTCGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTTGTAGCGTAATGTGAAGCCACGGACGCCAAGGGCATGATGATTTGACGTCATCCCACCTTCCTCCCAGTTAACCCCAGCGGTTTCTCGCGGTCCCCACCATCACGTGCTGGCAACGCCAAGACAAGGGTTGCGCTCGTTGCGGGACAACCCAACATCTCGGCGAGCTGACGGCTAGCCGCCACCACCTGTATACAGACCACAAGGGACGAACTATCTCTAGCCCAATCCTGTATATGTCAAGCCCGGTGGGTTCTTCGCGTTGCATCAGGTGAATCCACATGCTCCGCCGCTTGTGCGGCCCCGTCAATTCCTTTGAGGTTTTAGCCTTGCGGCCGTACTCCCCGGGCGGGCGCTTAATGCGTTAGCTACGGCGCAGGGCAGTGGAAGCCCCTACACCTAGCGCCTGCGTTTACGGCATGGACTACGGTATCTAATCCTGTTCGCTGCCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTTCCTCCTGATATCTGCGCATTTCACCGCTACACGGAATTCAGTCTCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCCCGGAGTTTTCACAGACGACGCGACAAACCACCTACAGGCTCTTTACGCCCAGTAATTCGGACAACGCTTGCACCCTACGTATTACCGCGGCTGCTGGCGTAGTTAGCCAGTGCTTCTTATCTACCTACCGTCGTCACACAAAATTGAAGCCGTCGATAGCGAAAGAGTTTACAACCCGAAGGCCGTCATCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCGTATTGCAATATTCCCCTGCTGCCTCCCGTAGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCCGTATTACACCCTCTCAGGCCGGATACCCGTCGCCGCCTTGGTAGGCCATTACCCCACCAACAAGCTGATGGGCCGCAGGCTCATCCCACACCACAAAAGCTTTCCACCACAACATCCAGAAGTGGTCCTGCAATTAGACCCAGTTTCCCAAGCATCCCATAGTGCAGGGCAGATCACCCACGTGTTACTCACCCGTTCGCCACTCGGGGTACCTTGTGCAAGCACAAGGCCTTTCCGTTCTTGCATGTGTTAAGCGCACCGCCAGCGTTCATCCCTGAGCGGGATCAAATATCCACAAAAGGCTGTAGAGCCCAAACCTAACCAAAAGACAAACAACACACAAACATCACTGCAATGTGTGAAGCTGGCCAAAAATTACTACGCAAAGAAATCAACAAACCCAACCAAACAATGCCAGTTGGTAAGGTAAAAGTGTTTTAACCTGCATCAGCAGACAACAATTATTCATTCAATATGTACCGTTAAAATATTTGGCTTCCTTTTCCAGTACCACCCATAACGATGAAGTGACATCCGGTACACCAACAACCAAACACACGCGAAGAATGCTCAGTCCAACATGAATTCCCATCCGCACAACACAGAACTAAAAATATAAAATCTATTACATTGGTACTGAGTTCTCAGACGTAGCCACACCACCACAACCAACCCGCATTACACGAGGCAGAAGATAGGTGAATGAAAAGTCACAAATAAATTTTTGCTTGTCAACGGCTGTTTTCCTACCGCCATACTCACCCAGAACCACGCCAGCTCTGTGCGGGGCGTTGTCGGTCTCGCTGACTCACATAAAGTTACACACCAACCAGAAACAACACCGTCTACGGCACCCAAACTACGTTTCTGCGATTCGTACTGGGGTTCATTTTTTCGATGATGTGAAGTTATTGGACGATTTCCTCTTGTCCGCGCTCAATCGTGGCACCAAGCGCACGGGTTTTCCACGAGATTCTCGGGTATCCGCAGTCAATATGGAAGACATCATGCACAGTGGTTGCTTCGCGCAAAATGCGGGAGGCACTAAATCCTGCACCCGCACGGATATCGGATGACCAAACGTGCGTGGAGGAAAGCTTCTCTTGCCCACGAAGAACAACATGGTGGCCATCGGCTTGAGCGTCTGCACCGAGTCAGAAGCATCTCGTCAACAAAGGCAGGCGCGGCTCAAGGCATTCTCTGTAATGGCAGCAGTTCCTTCAGCGCTGGCTGCAGAGGCCCAATAGCCATTGGCTGCAGGTCAGTAGGAAAGCCGATAGCAGGATTTGATAATCCACTGACTTTTGGTCGGCCGTCCATGCGAACACGGAATCCGTTTCATGGGTCTCAATGTCTGCACCGGCAGAGCAGCTTCGATAGCCCGGAAGGTGCAAGTGCCGTGAGCAACCACCGCTAGTGATGTCACCTTGGGTCATCACCGCGGCTTATAAGCCAGTGCCTGCAACAATGCGGTCGCCGATAACTTCATGGTTAGTGGGATGAGAGCTTGTCCACACCATTATTAGTGATAGTTACATTTAGCGCGGAGATATCACCCATCTCAAGAGCATGCGCTGAATCCAGCAATTTCTGGCTCGCGCGCAGCATTACATCAAACACGGTCGTGCCCGCCCGGCCAGCACTGCGGCGGTCAAAATATTTTCCGGTAGCTCCACGGATGGAAAATCCGAGGCTTAATCTTTGCATAACAAGCTCCGGAGGCTTCGGTTACTACCGCGCGCCATGCTCAATGTGGGTTGTTGCGCAAGCACTGCAATCAGACTGGTGCATGTCAGAGGGCGGGAGCCAATGGCGTCACCGCACGGAAGGGCTACGGGCTTTGCCACAGCGACGCAGTTAGCGGACCCAAGACACAAACGGATGCGCGGAGATTGACGAACAGCATCAAAGTCAGCATCACTTCGGGGCACCGCTGGGGTGTCAATGGTGACGGTCGTACCGTCAATGTCCACCGATGCAGCCGTCCCTCGGTACCTTTTGCATCAAAGGGACATCGAGGATCTCTAGACAATTAGTTAGCGTTGTAGATCCTTCAGCCAGCAATGCGTATCGGTTAAGAACCGAGTTCTTTAGCGCCGTCTACTTTCACAGCGCCTTGCAGGCGCGCTCCACCGAAACAGTAAATAGATCTTTTTCACGCCTAACTATCTTACGGCAATGCACCAATTCGGCTGGCGATAACCGCCTCATGGCAGTATGTGCTCCCAAAGCTTGCGCATTACGAGGCAGAAGATACGATTTGACGGTCTCGGCTGCGCCGATGCCCATTTCTTCTGCCGCTTCCACATTTTGTGTGGCCCAATGCGACGCAGCTCAGCACGTCAATTCTCGTGCCGACAACTTCGCGTAGATTATGACACGAACTGGTGAGACCATCTGATCATAAAGTGCGCTACAAGCTCCGCGCGCAGATTCATCTTCGACACGGTTAGCAAGCATGCGCATAGAACGTGCGCCCCTCCGCGCCGTTCATTACGTGACCGCGACCGGCACCAGCGGGTGCCATCGCTGCGACGGCGCAAGTTACGCAGTCCTATTCCGACTGCGCGCAATCATCGTGACTTCTTCAATCACTTTGTCGCCGAGGCGGGCAGGTGGAGTGCACTCCAACACCAGATGACTCCACGAATTTCGCGTTGCACAATCCCGGGAACTTACGATCAGATGCAGTCCTTCATCTTGAATGCCAGCGGTCATTCTCGTGCGAGGATCGTATTCGCGCGAATATAGTCAGACACGCCAACTGCGGCGGGTAGAACTACGCGTCCACCAACACCAACACGGTTTAACGTTGAGATTCTGCGGTGCCGGGTACGTAAGCCGACCCACTGCGTAATTTGCGGTTATCCGGCAACAGAGTTCGTACATGGTGACCCGGAATGCCTGTAGCCGACTTCAAAAGAGACTAACGCGGTACGGACGGCTTCATCGTCGTCTTTTATCCGATGCGAGTCCATTAGCCGACTCCTTAAAGCCCGTAAAACAGGGGTATTCCAACACGGTTATCCACAGTTTAACCGTTATTCGGGGGTAATCTAACCCACTGCTACGGAAACTCCAATCTGACATCGGGTTCCGTAAATCTAGGGACGCGAACAGGTGCCCCGCTTACTGCAACAACGCGCACCCACCCCAAATCTGCCAACCTTTCGGTCTAGAATAAATATACCGTCGGTCTAAATTGTCGTAGTACACTAGCGATGAACCAACAAGTTGTCTACAAAGGAATATATCGCGGCTAAAAGATTCACGATTAAATTCTTGACACCATCGGTAGATTTACTGGTTCGACTCAACTTAGCTGACCAGGATCTCGGCGCAGGAGTCACGGTTAGGTCGAAGTCCTTCAACCCAGCTAACTCGGTCAAAGACCGCATCGGTAGGCAATCGTGGGCGCGCCGGGGCATCCTGGCGAGCTCAAGCCAGGCGGCACCATCGTAGAGGCCACCTCAGGCAACACCGGTATCGCACTGGCTGACGAAAGGCGCATCCCGTGGCTACAAAGGTTGTGACCATGGGAAACCATGTCTGCTGAGCGCCGCGTCTTGCTGCCGCGCATACGGTGCGGAAATCGTCTTGACCCGGGTGCTGCTGGCATGCAGGGCGCTGTCGACAAGGCAAATGAGGGTTCTGGCGCAGCAGGACAAACGCGTCCTTGCCCGTCAGTTCTCCAACAGAAACCGACGCAGATCCACTACAGGACCACTGGTCCGCAGAGACCTGGGAAGACTCCGGCGAGAACGTGGGCGCATTCGTCGCTGGTGTGGGCACAGGCGGCACTGTCACGCGCTGGCCGCTACCTGAAGGAAAGAACGCCGACCTGCACCTGGTTACCATCGAGGCCTGCTGATTCCCAGTACTGACCGAAGGCAAGGCTGGCCCACACAAAGATTCAGGACCTTGGCGCCAGCTTCCTGTGAGGTTCTGGATCGCGAGCTTCTCGATGAGGTTCTTACCGCAACCAGCAGAAGATCCATCGCTATGGCCTGTGGCTACCGATGAGGGCCTACTGGTTGGTATCTCATCTCCGGTGCAAACGTCCGCTGGCGCTGGCGCTGAGCTTGCTGAGCGTGGGGAATTCAAGGCGAATGCATCGTCGTTGTTGCTCCAGACTTTTGGTAGGCGCTACGTCTCCACTGTCTCTTCGAAGACATCCGCGACTAATTAATTCTCGGCTGCGCGAAGACTTTAATTCATCAGCGTCATTCCCGGCTATCAATGTTGTTGGGCAGCCGGGTCTTTATAATTGGCGACTTAAAGGTTTAACGGTAGAATCCGGGGGCATGAACCTTTCTGATAATCATTTCTCGGATTCGGGAAGACTAGCCGCCCAATGCTCGCATGATCCTGCTGCTCGTGGCGAAAATGCGGTCATTTACTCCGGATTGCACGCCATTTGGGTCCACCGCATTTGCCACTGGCACAATGGGCCGCAACATTAAAAAGGACCGGCGCGGATTTTATCCCAATTAAACCGCTTCCTTACCGGCATTTGAAATCCACCACAATTTTTGGTCGCCGGTTCTTTATCGACCACGGCATAGGCATCGTTATTGGCGAAACCGCCGAGATTGGCGACAGCGTCATGCTTTATCACGGCGTGACTTTGCCAGGTTCTGGCCCCAACTAAGCGCCACCCACGCTCAAAGACAACGTCGTGGTTGGTGCGGGTGCTAAGAATGCTAGTCCCATCACCATCGGCGAAGGCTCCGCTGTAGGGGCGAATGCTGTAGTAACCAAGACGTTCCTGATACACCGCGACGGCATTCCGGCTAAAATCGCCCTGCCAAAAAGGACCAGCAAATCAAACTGGTCGACCCTGATTATTTTATTTAATTGCCTACTAATTACTCAACGAAGTCGCTGCACAATGTCATTTTGTGTGCAGCGACTTTACGGATTTAGAACAGTGAGACTAGCTTTCTCGGAATCGTCTTTCTTTGACGTCGGAGGCACGGCGATGATGTCGCCTTAGTCGCCGGTAAGTACGCGCAATTTACGCACTGCAGGACACGTGGCAACGACTTTGACCCCCATCGTCCGCGATTGGTCCAAGGCGCTAGTAATCAACGGTTTAGATAGCCCTTGGCCGCGCGGAATGCATCATCAACGACTGGTGAAATTCGCGCACACCATCAACCCAATATTGAGGGTAATGCGATGCCCCAGCTTCGTCGCCATCGACGGTTCATTTTATATTTAAGGTTTCAGGATCATGCGTGACTTGAATGTCTTTATCTTCTGAGCTCATCTTCTTCTCCTTCAACGCATCTGCTCATTCCCCGGTGGTTGTGGCATCAGCTTGAGGGAATGGACAGATCGTGCAGGCTTTTTGCTTATCGACGAATGAGGATCTTCGTATTCTGGATTCTTGTTCACAAAGTGCTGTACAGCCCGGAGCTGAGGCAACTGCCTTGAGCCCGACTTCACAGTATCATCAACTGCCTTCACCAATGGTGAGGACAGGCCTTGTCCTGAAATCTGGGTTAATAACCGTGTGGTTGAAGTCTACGGACATCCTCAGTGACGTAGTCAACCGCAAATCCAGCAGGTTCGCCATCGACGAGTGAGGACGAAACGCTTGCGGTCAGTGTTATTGAGTTACTTCATTAGTCATGGTTCCCAGTCTACGCGGGAACAACAAAGCCCCTAATGTTTTTCACACTAGGAGCTTTATGGTATGTAGAGCGGGGATCGAACTACGGCGACCCCCACACTTTCAGGCGTGTACTCCACCGACTGGGCTATCTATTAAAAGATTGCCGCAAGGACAATCTTGCGACCCTAAGGACTTGAACCTGACCTCCGCCGTGACAGGGCGGCGCGCTAATAACTGCATGGGCCTTATTTAATTTATCTGTGCCTTAGGCACGATATGTTACTTTACATAACGCGCGCTCAGCAATACAAATCCGCAGTTCAAGCGCCAGTTTAGCCGACCTTTGCCCGAGCTTCTCCTCGCAAGTACTTAGCAGCAGCTTAGAAAAGAAGCCCGAAAAGATTAGGCGCGAGACGAATCAGCGGTCATCTTACTGCTTGTTACGCAGCCGCAGCACGATGACCACAGCAGCCGCCAGAAGCCCCAGTACCACGTGCCTACCACTTTTTAGACAGCGCCGTTGGATACACCGTTGGACTTACTTTACGCCGCCGCGTTGGAGACATCTGTACGGTCGCCTGCATCTTCGGGGGCGGTCTCCACCGCCGATGGTATTACCACTTCGGCTCAAGGTCGTGTAGCGAATCCGGGCTCCGGACCTGGTTCACGTACGTCGGACGCCGTCGCTTGCCTTCATCAGGCCCGTTGACATCTACCGCGAGCTCATGAAATCCTGGTCGTGTTTCTCAGACTCTTCATCCCACGGCACCGCCAGTAATACCGCAATGGAAATGATCACCGGCAATGGAAACGCGCTCATCACCCGCGTTCACATTCCTGTTGTCGTGGCAGCCTGTCCACCATAAGCTGGGACATTTTGAGCTTTCTGAGTCTCTGCTGGAGACGAATGCGTATCATCCACAGATTTCACGGGATTGACCAGTGGAAGTGACAACCAAGCGGAATCAATATTTTCGTTCAGTCGGTTTGCGGATGGCCATCTCAGGAACTGGCCCCACTCGACGGGAATCTTGCTTAGTAATGAGTTTCGCCAGCCACGATGGAGTTCTTAAAGGTTCTGGCTCAATCTCAGGCGCGCCAGTAGCTGTGTTCAAATATGGGCATTTTCAAACTTCACCGGGAGACTCCTGCGCCAAAGACCGGGGTCGCCCTCTTCATGAATTGCATTTCCGGAGGAACTGGCTTATGGCAGATGTTGACTTCTACGCCAAGCTCTTCACCAACAAGTTCTCGATCCCATCCCGGCGGTAAAGGTGTGTCCGACAATCCACTCTTCCATGTCGCAATTGCCCTTCTTCCCGTGATGAAAGATGTCCTTTCATGGGTTCAGTGGGAAAAGATTCCTCATGTCGACTTTTCCTTTCCACACCGTCGGTGACTCATCCGCCCGGCAGTCAGACCCGTAAGCGCGATTTGACACCTCCAGCAGCATCTACTTGCACGCTGCCATCGCTTCCTGAAGCTACGCTTCCGGTTAGTCTCGCAGTGCTGTTCGGTTGCAGGATCATCGCGTTGTGCAGGGACAGCTACGCGGAAGTAATTGATGTCGCTCTCGGTACCGGACGCATGACTGGGTCTGGTACTTGGCCTCGTCGAGCCATTTGGCGTCGTCGATATTGTCGGCGTATTCAAATTCAGTTACCGCTCATGTCGTAGCCGACGGTGTCACGCTGAACCGGGGAACTCAGGCTGGTTGCCCAGTTCCTCAGCGTTTTCGGCTTCAACGTAGGTACCGCCACAAGGGCTCAGGATACATTCCAACTCCGCCTGTGCGGCTTCATCACTTTAAACCCACGGTGTGGATGCGGCGAGGAGTCGAAACCGTCGCGAGTTCTTCCGCCACCTCACAGACCGGTGGCGGTGCGCACATATCAATGCCATCAGGACCAAGATGATGGAGCGGTCCCCTCCTGCCCAGTTCATCGGCAGCGCTGGCCTGCCATTTTCCCATCGGGGTATAACCCTGCGCGCCTCCAAGGCACCAATCTCACTTTGAGCTCTTCTTTGTCAATACGCTCAACCGGTGCCAGCGTCGATGTCTGGCACCCTCGCTCCCGGTTGTGGGCATTGGACTCCGCAGGGCCCCGTAGGCCAAGCATGCCCATCACGGCTGTCTCCGGAGGAATTCACAAGCTGATTAGCCGCCTGCTTCGCTGCATCCAGTCGCGTTTCCCCATCAACGTCTTCGGCGAGCATCGAATCCGAGGCATCCATGATGAGCGCAGCGCGCGAGTCCACCACCGAATTTTCGGCGCTTCCCGGG "''%'%(.7334:8,-1/+/787.:../3575194,+*)+1730.494122',#)&##$$//0+)-4:05'',%'"##$$$$'06(-+()$#&-,9:1('+11956+-1+43149866776776894:7.(),2-)&(+.:6/1.2'002/%$&%.(0'+%"%('(//2/4,+'')(),1/.7++'',4-'%%,'(5-+'0'583106)-)4,.+-,--1396,$+)(118;6424/./159:68651+,+.710&.(1-4'3,./9;/-,)+2-(+/0.4//2221,+,560,+,,//039311.,$),'%+,0,/.++)70+&#"&)),01324-..+0,8-2,%#'$+$&%(+42/5676//.+.286--4.2599.()(.+&'&),-21111-32--/--296-&/6//::11::7357845766:/463)20%$&%',3,778-,..07526087:3-)+++..2887932395:669)'&"%$)#0.%%+($'&31/,(+(.41(926;8/8;5,183&4,2333.7+,017001,)+(),10./.'&%$(5+)(,/#"%',643.,-0)($$%'#&(').1256204:45,:-))33205/(.0033,&)124/16197;566(+.;:339:9;863''&,23.-13142%&$$%.))-.)-&)1+/--366078885:411;;8.%&+/51734342467+6,8:5-/9-7--)+*,3/&6(()5609:,)2*$,*)/-,..-/11+32.,.132397-.1.115421/%/0230.&%#$#&1434.-((+/()&'))))/)$&'.4'*'/./701-113:.,)43+'/04874(++.04;;579774765;955://..,14'-/1-17513,6+/,4--+&$%'(4(+83-48.),49)./21,.,+$,-924.+$)/+(2($(09298779679879/9::-.01,1204+'+,40;8:74-+))-.7/9531/1,1)-&2+1265;83$')01''1)650-15)3-..76899-'((.'-500.572058+,1%+/187-.67-504041:.67859:03/091.314;:4;9<:094((,-;.//+)'(01&(+72-18505%,,344421-/,-&+1+-.024713353304/6&),00.77)-+6843/.+/,(+36662466$%(//,++()()+5-%/&(29-/)/++,8,,.755434306(,3343+,001144627430%1),0-712;6./5,+)))-'$/'...,..048800,),30001/35484..,1.11%22-,.-1,3-'-121/3-),-./.19:92-&)'&(-4,/1.641()(	:88147)/..3,./112645-00+89512343366.77()4-,--142//),&'44,,,668&''/(.6,(-.+,../6;3//258764/52),6/9853.62,,2774199.#+-%53;711/$#'+287-./9297/102333276677)(#0()7523'+,+5+++07,(),40)%.'-,+016-,)%1..)0./04211,/$.(('''/0615412,,---892--.1'4.88501112111001..7+.1631234304459510690.3+,2-9/0:868113//179,2&3#2))41---1,,--5579.-(1&$$&$#"#$&&6586:9.03)%('1:;+,4,13+.23641821/727)),/,+/-(%'+,./1/1,,0+-,4393#,&(-/-$./'&)'(,80+*-.)/4'$%&'.(&"%%4:7/11:62369.,,)-)0)-111/4.//./1:21143+-.11.::,./0455,++++::4314..-,,.''',+-70015:87458113%/-,,-12.....2234/+,/62--,,0/2042,%%-&++357-83'++'-/,44517-6.-.207,.2:98%%#$%((,,-6(),4)1+1+/.-/(,%&08/(//0.178728784568;76:2481/0&%/3327:7.322/-$#+(5+96$0,31(2&$#%&'),)',133505,/6..)4,,-7/:+-)..3-(.+%..&11-7//.8227;768:,,+'*/((&&+-/'*(1,$%$&&(121)/.&&2+%'.940132310+/.04:47::,9::2')+(,+,1.1260101125876813/42&&'(#$2&()9,86//0029,68'(:6)'()-:9;3484588114127681,2-673445)/)+,.57'513+10/1)01+),2/24613/.75/8.7/,279-;,,153.).226+/,...,')260'+&+,3-.((.1)'--//-2<:))++66/303.,-329672&,&(')/:99'&%$%$.%#'&10)(+,<2383-)$&()+,-%,-1554564()/10()#'()3/02.,+61//;:59:3563'')'()1334//-3(++,2/42102,,4-&%'-$(&%&"%$&&(&&#$#'&00051-/+,32-.,2%%'(10.94201((#"$-+))576-(1-54)&$'#..,,03)..430-/82)(/17-0,&-.,-./70(+1037.-.+/++))+1-.+5,.++963,10,.,)+(01%/--7757;006+1,25383-,1((2,.++(-+(0-..95)/10;90+)--.//007$/-02682./(('(),4269:61/,,,(.'/70031;;78,81)$$%%%$#(.2++&+$.%'-,)),,/.,'(&-(+-,1360/(,)%'),.6456-/.1::341-$(''.''.,,-1,-+2'6):)('-+4/66-0339,..,-(("$$'&.,-3;97,..0/476/1-()(%(+2/)4)+,(,7310'/$)$"&#,6-1/16-/&(+-3250$06.&,(1-('((&%2,1().)()84$,,-.:,,54/,//'&''/(.492;;:,/-8,/183)1/302339:7----1:578/-'+,,//+).(.+5%&$()&&),/86614%36/02-9-,/3326.1+-)+-.86232.3:0,01--(/,.55.16&)33,,7/()%$&)%'%$&$(+-11440.$(-,0345,+&0,)/7.0465,260.'$&++..3+)&&/$,(/+46570;8+24031010,+.-1796:88%/(4,.-5001&)''(')/;:4/%%&'%$"'$''(+--+,(,,+-%7860633464,((++/..7.-,),673612%'%/$%&))19:-142.8(',+))/%,3-65-0554;8).-01:9:899074001-/;:7532212591,.0,''(-,,6,+2:((-2'',-34397/091:/64.%'&()()45555320.(&,).,'$(%'767,-,,-166:6,&++%/))-+0'1(.)&+192214,127.0,)#)()02:9417(')""%$#&++0(&)))24*/+(2(&).+/3365261/,,--//+3&.(''/'11&'#2:6,--.8679../,+-7:11:75.,683247,//6..40576:3:569/6;;-66$27.--5283559860/06+3/'&#)%&+-0443,+/$(+2+0/0171$''++,-/,0/1)')/9/1+((+.//00+,-+0,433//24372(-)+%#$&.0%'%%$)%)))#'+.:68001.7///994-24,-5,5999491+3.4/+/'&&')+.80007/.-/2.2-)-'(900.(&2(&$"$%""$'$3'+%$./3,+#%,((-.7:',(),/77()"##%&))6%&'0,7.:3+#$&)-&3.$4(%-(),0143%,-1-975')')//%()).+.+,',-.66:/://7-,1323/67;<12,.01,0121+-099:9/0+.((('())),(3-5/53/((%',8173'119$,,(1./87(+6.,1-/(,,-+..571879/;///55.17.2&$%&()(%$"$)&)-403$-$'$'+),/653:++0440-8-+5722./1//45.,.&'),.--)&$$&#')5:109.-1('(&+-(%'-''00.,/-1/2,((+-.%.+23,0413003+/)&/.-'-&%,/-/223405),--,-.,.0)+,-/)+-+,-08+/36584..01511797689-8115)/-//2.7/--3+)4'-&3((,7)0275244.8:1+/01285(52/00./..--+))(,-31402,0('$%%(144%$+./5769-.04+.-.31+('$#%&+%1.()56991'.2,0-5,%/-15288777,:9,,2-..,//1/+-/15/-/-.45-''&&(,,++,0811--./-.7:.0--/,.81/72229+;++3.+--%,&&.//3:+1(($(+)(&&&-).&(-#1#.,,+1/0$/&'+/4%12,&%'&')23-4-)-$")'+($())-1/5/$/1)(.-)-,+()##%$&)..+..+2+'&,3,,12($#-,%(3+52',08:,)-)&'37(3')%8/-,++,,.,0('(#&':+95;886065771-,&&&+./'+&.'-$-$"$$().037/.')('((),;:40,+,-/++7:02-(''-'),((,35&%%.-,++%))2/13578743623.+,+&++0./-4./$'%'%(&1)(+#&&(-/),071447:5:63$+(--$+-/0039826212..&'#&&+&(1--3),,/430-$&&%%$$)%%&%(&-/(&/12.*-.0454-0#++121,%(/1843214243)'16'#..3992'114'&".#('$%&$%'(3-250//&+$$#(:9555453(+$3%3;1//2/08/.-..68,&')16-5('%$(&(+-,++7000,+133/0.%%(#'+##"%()(,,0.47).3040.&).766:::<94434/+:765//23#$8547425/./0-,,((26-,+%'&,..3363.,&3+,3.%%""$)&,('-))%,+#+(5/-/,-,)+%,)$''--:630142:8;3,,/9724306&'&'.,0.2,-'-+((+.06'(1.%%)&),4(59030.72362--./%"')21464%$&$&%.1/05&,)'&,207.33264%'""#$%-3/0((+5..+.'('+(06/,3%,)+/02-,-152+,1/,+,,()&',2).-7/9'6)4554)8,)(6($))04:9586:65:44:8/550),.822035396$,+,,+31-+0.,-52+0/+#%&(../'--(0(%()3-,,##,6018+5+++,2041,3++'-,3-/1::7,8,6'%&#%%'(')443+660/-&$".43/:6-/0//10307548-)#$$'.'7-52.0%+&&)--1%&()13,,%%,)(2/505068)800033547((%&%&)-64+'172223+(&(203'+,.0&+0)6+.741656856,'$"%#$--+-.47-87578833&..,+.'.315.888:2:321..+')+()'/+1)'/+.-,&(.086;:97+73'(++,/+,05757'3)-8552.02&301+5.364521+'&(%,+5+)--+215:+,392+++),5$&(/253394943595::64+'&)0.-010835;968555.4---46-.),($$$(&,'(&#''//5499--43;880758(.+,7('',6,2(%$++2.56988:::9854445863433+1,,423'34/1-7537553&++'&1141,++,,'.2,,44021052$#&.842789898807.'(,,.;21,&,/,-0$#&(+,.)1272.+-''%)&')5621:833978:;9.:+1)3&'4,'$&('.&,.15724522$)'(760101:5.%#&)&$'4-668-+,+2744450/)+0853.0.(44269/./.-3)''1387/-./98/'+,0+(%(('&),)4/908826450.,-+3--21))(17:752.292+1-9)-$,0,,032931534477584,+00(--227401/30692742-4-5++-.0/&$',0//4$3116/71318)%),,-+//&/)41471'%',$+%&')+,9688100,&21235260210197:;7'5''42241157998203++)'('1./,87/01/+/54/4.+../8591('),/--#+,/2859545,,)14$$&$&())%$$''',-,%#$'//142043782&.'(250.487,++,+..0145259;57723/8.,.43079&&1)-.4985())8374).0318126:8-,%((.18;5.///./.1+/),.56981;111;:1/1.,.0397,608/-,''),-/33,8)1++-4/:'9,/-9)/651,/2//1202378,'$&1(+-11-,+/+,10:778555323.9.1+0:99534.,01-/7-((&#"))./3-82-*3+-+:-9-:8,+('&&&%%'&#+'))776+-0313121&'+,+./32%'$$$/3---/,5+%063-./.-,/.-:---30160465(110/4/06)0,04,/85650."#&&'+'&'(,/553081:6-',.77+&('%&/8/1;:95/28,0+503830,$(,,96/7118/30+0/&$,0))36,06/1$$&$$%')00328527984284-,045641119975#%22.11/03+(2.51//731:78853..-5+51548,3323:89637;7+10/..,+////75-).+/196:.)),3/&1+(%.'()+-2)&&$++175592.46653665726692245(-).3764('$%##%#(04:7,37779595342%'2)1.2266)-+,,19643//8+())(',9:6966.-2'+9+)),,&*'+442/5315.40)1303:;6/1.01)&&,.972()-7:659:9;:..+*&'&*%&)23:))+.4,,/:;.+3:.++01-/.-(144+51&.172%.,((,1-4500003)4(.2-79;..1/)11%0/**0+')'+#'(&(&$%&(%,)/10445;:437,5-636595587/)&,01487900+/(&$#'&)+2/)+),2'(%$$)/4499475+%%'(436.63+/0,,.1.01-2,+873+-/-#('01/#$$)'4::3))-.,...0/,3.0/5.)/,063334&..08452-4,32921-/521090,5+5,2/44612+.-+-/027::4550.00/2(+.50/2:700/-,24:77.-$,&')4,..9.,.5(-0/-+3.011,727,-13988521454;:878'0,)%%%%)+-.5:.0-031;5./786742,)+))5+'$$&52&((5-21899447789989859017179:5;:8-4///.2/-3//7+5:6).3/,08;(+183340.,($&,#/1,+:7688.'%&139886101/5;0+)/+-8555%--01+/666;7554687988+.4.3611++45+.02598950//1')+.,&'$(,3041./(.(-)%$$#$$#%,.,&%$$////++,),)-::7;877;7:8564+)370337:760-',-)&).7),9:<:.9+:,.71:066446490/3-,(%"&)/8998:42(#$&(.0766168))+(%(.38-7)(&(")#'%"#%&'+2753&#%(/.03+&&.2+-227163:7:025813%/()65:067;50/+1(##),,(/),-878863+)1+4+,&'#$$%/0-($&402/<;5-201-03+-,$&(45&(''.%)(-+,,-'&,+)64..3/'%&)+3311986,')''+-),,575321+,.-.)+1-4552&.124564&(%1/3)&)-/,880422.1177:4,1.#,+,/:+'##),5./().762/06:9:6689475+(/26.+0+--5060.15/.(&(,/.00/901;5020:,,,7856,4..-,.5+&,.54676:0+''+,/++%&-2479306152-27<502:(1--2:;864546;587;'(49992791+0))'((,.34.0--1,1/+,(/,,)'-,++,-00.$%'13'&,//'(+)406444+#.+/%%975%.+22349+2*1014/308/00-,2-23/),+-././411311+))0/,7+(('(160+/+3,''')340%--'++..$%$/2$(2311'%%(#%%,5.136:/&&%#$$%#"&'++27450/523&)3133(&%$&+/0875.,$+.284*693.10200174-0505+)'%,&'&"%$"&(&(0,.+.+(,(,+-(%%(+(-,..&-3/04(5-47925652''$2/,12(/+4)&%(-)))&&264::99;+318/''')+/-072.6712(-++-')$/+(),055/(+&,::/08),..88;:7/;8,)010.+2-,,($'%%"$')$.+715'',,)567547:110+&((%)$$#$$$%%&'('),.+057441.-/60/-/34025).%&''+/908843&&&&*/.(+63+,#$'')($,69,++/,(+++%').35'-//,667;::9:95-%%'%/)3;+-./8;10.)'')$.'(+('+-07433:42.00306461820289:2%787134624:-76:1649474750,)),++$.&233-)+,10481-&,(,64.)%&'#)##&&((5/75893222&'%'790+.76/3/19530:4)(,+++'.+,540/5433/0-&$(%(('#-/70(0##&%,.1/-49,.)5722&%57..46:72/01+-,.&.:%481..08;31'#&'',./+4&'#,1,-*3/'(++410+'$&#'(+&'.00.0.--8<976:6533,+-.98;9719/(/31-4,+,)()2)+96(3756:6270(/,/0456,/&4143781241294/.2,11+,$(').82)23.792&$%+&'/-(,-536'&'''+-'053984354:872,(.,50//2305-0,..99645/;6.-,+15-50$$)+--42+'&-/.(0/..31.)+5+%(&&&&')+(-3,()+)/++&&')./-1832030,,,.-5478942/%'.)9:..7....1..12/0,313))(')1%13$',/)()($#,))02553436:0636$07.,/(544-/($)&(&')/.1/-//4697875///.'/.122.+,"(%&'(+/2.32764)%$#)&.+,.49-/34745:(4)66390//,,.++-+/.,3--/88;80$++.-#,/'%493573-1,+,'&'&'&%(.66877512/./3.-20).8-8131$1,8957/+-+$')//413+,.0149-,+)(0,1664-+/)('(4-/'#'+'+/.-,+%+2189836-.-'..::46576844,/-.89871#%&.018'3:4),.76677;84-(('&)&+(%(2&'2+3(&%#$&%')(788;7104:56662++.13$.,-//.33-.23/,((-3291.2:777++/-0(267710443+,-1:-83/()/3.+.;3247)--,+'&#)',+&(+%"&-//,65--/0780-3112:6220.-&+2-6.&0.23/6/9+0(-'-+*&'+367:;19;1-723$##)(+/8768967(+-0/(,%')6852/-'2.+/5((7332/2-+)2)''&.03/,)&+--4)"$$&')-8601402/)--007)9;,+21.0/71+++,3+1&%,'(/,,,43.../342-,01/579567:455)50/6%'(,7()59'1::3.47425,,+2,75986477577/'7-5%')38513.-/0.0000655-+-,+222--/1-19566'%%',,4-110')+4(1'&%# 5fb325bc-2666-4958-892b-711be3745fc0 4 0 0 0 0 0266a999-7b90-4851-9384-6fca5ef6b306 4 0 0 0 0 00ad07fa-fd16-4892-abcf-2fc2dd29b782 4 0 0 0 0 6d4e0da6-7ede-4ff9-b7d4-ae09ee96260f 4 0 0 0 0 2457fcf9-c206-4bc9-ba50-1878ef3b9f30 4 0 0 0 0 ed23ba5c-e8d0-4be0-a673-53a9592ab83c 4 0 0 0 0 fd444e67-274a-4be3-b844-d83a72e5d26f 4 0 0 0 0 b9dd0de8-2f21-428e-9074-ed26fc89a963 4 0 0 0 0 19ffabb9-4618-4299-8c3b-d11fdfc8a13f 4 0 0 0 0 f69208a5-d1eb-4c0d-b3ab-b85f6f2dfb4e 4 0 0 0 0 TTCGGTATGCTTCGTTCAGTTGCATACCACAGCTCAGCCAGTATTAAATGACATCACCGCAGTGGGTCCCCTTCTTCCGAAGTTACGGGGCAATTTGCCGAATTCCTTAACCACAGTTATCCCGAACGCCTTAGTATTTTCAACCTGACTACCTGTGTCGGTTTTAGGGTACAGGCCATATACACATCGCTAGAGGCTTTCTCGGCAATTTACCAGGATCACCAACTTCACCAAAGGGCTCCGCATCACGCCTTAACCATATGGTGACGGATTTACCTATCACTCGAGCACACGCTTACACCAACAATCCACTAAGTGGCATGGCTACCTCCCTGTATCACCCCATCGGACCACATTTCAGATTTACGCACGCACACACAATCACATCATCCGAAAGAATCAATAGCCATTAACTTGTGGGTGGTTTAAGTATCAATCACTTTACCACGGGCGCGCCACGGGTACCAGAATATCAACTGGTTATCCATCGACTACGCCTGTCGGCCTCGCCTTAGGTCGACTCACCTGGGAGAGACAGACTTGACCCGGGGAACCCCTTAGTCATCCGGACGATTCTCACTGTCAATTCGTTACTCATGCCTGCATTCTCTCCCGCTCGCACACAGTCCGACTCCTTACAGTACCGCCATACCATTTTGACGCTCCCCTGCAATACGCAAAATATATTTGCCGCGGCTTCGGCGGTGTAGCAGGCCCACTACATTGTCGGCGCCGTTTCACTCGACCAGTGAGCTATTACGCACTCTTTCAGGATGGCTGCTTCTAAGCCAACCTCACGGCTATCTTCGCGATCTTACATCCTTTTCACTTAGCACACCCTTAGGGGCCTTAACCGGCTTGATCTGGGCTGTTTCCTCTCGACTATAGGCTTATCCCCACAGACTGCTGCGTAGAACACAATTGAAGTGGCATTCGGAGTTTGGCTGATGTTGCTAAGATGATGGTCCGCTCAACCAACCAGTAAATACCTCCACCAAGCCTACTACGACGCTGCACCTAAATGCATTTCGGGAGAACCAGCTATCACGGAGTTTGGTGGCCTTTCACCCCTACCCACAACTCATCCTGATTTTCAACCTACGTGGGTTCGCGCCTCCCACGACGTCTTACCATCGCTTCACACTGGCCATGGGTGAATCACCCCCGCTTCCGGGACGTACCACTACCACCCTCGTTGGGATTCGGTTTCCCTACGGCTACCCCACGCGGGTTAACCTCGCGACATGCCGCTGACTCGCAGGCTCATTCTTCAAAAGGCGCGCCATCACCCACAACAAGGGGCTCTGACGGATTGTAGACACATGGTTTCAGGGTTTCTTCACTCTCCCCTCCAGGGTGCTTTCACCATTCCCTCACGGTACTCATACACTATCGGTCACTGAGTATTTGGAAGCACCGGGTGGTCTGCGGCAGATTCACAGCAGATTCCACAGGCCCGCTGCTACTCGGGCACCACAACACACACCATGTTATCTTCACCTGGGGCTCTCACCTTCTACGGCCGGGTTGTTCCAGCCCCACTTCACCTAACAACACAATGCGCGCTCTCTTGGTAGAAACAGAAAATCCATGGCCCCACAACACCGCGTACACAACCTCTACCAAGTATCACATACACACAGTTTAGCCTCATCCACATTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAGATGTTTCACTTCCCCACGTATAACCCCACACTGACTATGAATTCATCAGCAGGTACCTACCCATAACAGCGAGCGGGTTTCCCCATTCGGACATCCCTCGGATCAACGCTCAGTGAGCGCTCCCCGAGGCTTAACGCAGCCTTACACGTCCTTCATCGGCCCAGCAGCAAGGCATCCACCATGCGCCCGCCAAATAACAAACACACACCCCACACACCACAAAATGCATGGGGTGAACAGCCATAACTAAAAATACTAAACCACACACCAACCAAAGTTGGTATGCGACGTTCTCACAGAAAAAATAAGAAAAATTACGCACACCACACAAACACTTCAAAAGCACTCGTGTGGTGGATGCTCGCGTCCACTAACCACAGTTCTCACACAACACCCCACACCACCAACCCACACACCCACTTTTGCAAAAGTAAGCGTTTGGTGTTTCGTGATGCAAGCACCGGGACCAACCCACATAACGTGAATTGCTGTCCCAGACGCAACAGTGCACCAATGTCTAAACCCAGATTTAATCACGCACCCAATGTTTATGTCTCCAAGAATTCGTGTTAGCAGCCTCTATAACTGCCAGTGTGTTTCCACTCCGATTCAAACTCGGTGGCGCGGCCACACTCGGGTCATCAACCACCAACACCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTAGCTCGCGCCAGAAGGTGATCAGCCGCACCTTCCGAGGTACGGCCTACCTTATTACGACTTCGTCCCAATCGCCGATCCACCTTCGACAGCTCCCCTGCTCAAGTTTAGGCCACTGGCTTCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGAACGTATTCACCGCAGCATTGCTGATCTGCGATTACTAGCGACTCCGACTTCATGGGGTCGAGTTGCAGATTAATCGAACTAAGGCCGACTTTGAGTTCGCTCCACCTCACGATGTCGCTGCCATTGTATCGACCATTGTAGCGTAATGGCGAAGCCCTGGACGCGGGCATGATGATTTGACGTCATCCCACCTCCGGGAAGTTAACCCCGGCAGTTTCTCATGGAGTCCCCACCATCACGTGCTGGCAGCATAAGACAAGGAGTTGCGCTCGTTTGCAGGACTTAACCAACATCTCACGACACGAGCTGACGACAACCATACCACCTGTATACAGACCACAAGGGACGAACTATCTCTAGCCCAATCCTGTATATATCAAGCCCAGGTAAGGTTCTTGCGTTGCATCCAGATTAATCCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCACTTGCGTATTACTCCCAGGGCAGGGGCGCTTGGCCGTTAGCTACGGCACAGAAGGCAGTGGAAGCCTACACCTAGCGCCCTGCGGCATGGACTACCAAGTGCTCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTGTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCTACACGAGGAATTCCAGTCTCCCACAGCACTCAAGTTATGCTGCCCCGTATCGCCTGCACGCCCGAAGTTAAGCCCGGGTTCACAGACTTGACGCGACAAACCACCTACAGAGCTCTTTACGCCCAAGTAATTCCGGACAACACTACGTATTACCGCGGCTGCTGGCGTGGTTAGCCAGTGCTTCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGTTTACAACCCGAAGGCCGTCATCCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCCATTGGCTGGCAATATTCCCCACTGCTGCCTCCCGTAGAGGTCTGGGCCGTATCTCAGTCAATGTGTCCGTACACCCCTCAGGGCCGGATACCCGTCGCCGCCTTGGTAGGCCATTACCCCACCAACAAGCTGATAGGGCCGCAGGCTCATCCACACCGCAAAGCTTTCCCACCACAACATCAAGAGTGGTCCTATATGATGTGAACCCAGTTTTCCCAAGCTTATCCCATAGCGTGCAGGGCTACTTACGTGTTTACTCACCCGTTCGCCACTCGGGGTACCTGGCGCAGTACAGGCCTTTTCCCGTTCGACTTGCATGTGGTGAACGCCGCCAGCGAATTCATCCTGAGCGGATCAAACTCTCCACAAAAGGCTGCAGAAAGAAGCCCAAACCTAACCAAAAGACAAACAACACACAAACATCCTGCAATGTGTGAAGCTGACCAAAATTACTACATAAAGAAATCAACAAACCCAACCAACCAAAGTTAGCCAGGTAAGGTAAAAGTGTTTTAACTGCATCCAGCAGACGCTCATTCATTCAATATGCACCGTTACAGTATTTAACTATTTTCAATTACCACCCACTTAACGACAAGTGACATCCGAGGTACACACAACAACCAAACACACCCAGAAGATGCTCAGTCAACATAATTCCTCATCCACACAACACAGACAAAAATAAAAATCTAGGTACATTGGCACACTATTGAGTTCTCAGACAGCAGCCACACAAGATGGGTCGGCTTCCTTAGAGCTGTTTTCGCTCTCGGCTGGAGTTTCTACCTTAAGACAAACTGTTTGACGTTTGTCAACCAGGTCGGTAACTTTTATTGCCGCACGCTCTCTCGCGGCGACTTCGATAAGTTACACGGGACCCAGATCTTTGACAAATCGCCAAGGTAAATCACGGTTTTAAAGATCGGGCAAACAGAACCCCGCGAGCTTTCATTTTAAAGACTGCGCTAATGCAAGGTTAATTGCTCAAAGCGCGGACTTCCGGTGGAAGCTAGCGGGGTAAAATATGACCTATCTAGGCCTTGGTGCGATGAACGCCGGCGAAGTTCTTCTTGCCGCGCGGCGCATCACAAACCATGCACCGTGGAGGAAGTCATCTTCGGCGGGGTCAATCATCGCTCGATGCGCTGGTTATTGACGTACGCGCCTTCTTTAATCGTGCGGCGGGGCTGCACCCCTTGGAATCAGCGAGGCCGAAGCAACGAAGGCAGGTCAACATTCCGAAAGAGTCGTCATCGCCAAGCTCTGCCACGTTGGTCTCCGACAATGCGCCTTCTAGGGTCTTTTCATCCGGAATCCTTTAAGTTCAGCGCGACCGAAAGTGCCTGCGGCGGCTCTACTGCCTGGAATTGGCCTCATTTGCCGTGTACCAAGTTGGTCATCTCTTGCGCGAGACGGCGCTGGGCGGCACAGCGAAGAGCTCTTCTTCGACGGCCTTAGCGTACTCAGCGATTTCTTCACGGTTCAAAGAAGGTAAACCAGCGCAGGTAGTCGATGACCACGGAGTCACCAGCGTTGAGGAAGTACTGGTACCAGGAATAGGCCGGAGTCTTGTCCGGATCCAGCCACGGCGCGCCACCGGTGGACGCAAACTTTTGTCCCTGCGCGTCGGTCACCAATGGACCGGCGGTGCTTTGTGCGCTTTGACGCCATCAGCGACGGTTGAGATCCACACCAGGAATGTCATTTGCCCCCACTGATCGCCGCCACCAACCTGCAAGACGCAGTCGTACTTGCGCTACAGCTGCACAGAAATCATTGGCCTGCAGGGCATGTAGGGAGAAAATTCCGTGGGAGGAGATGCCGTCGGTTTCCGGCGTAACTGA ("",%(%&#'+/0,../(+.7&%"%#+0-/+-///01381//,41721..00/5668.$(+/+27/,/966.3.(,3/0(-/1-67.82++3.+3163')-%+,)++-/:0,03-+.1.&),$)%()8::.0,1+-,-./.37112-134+:;.,()$.,/3833/30.31145525+,()&),43,28134/%/$$&(377870/-0--407(2(//&())84+,023$)())(+-08:867+,058.3(,9/,30),-+((('##$()-,+/+)$,&298;89924882&3'6+321650.+++.6-./0%01-878,-,1).(0/02/:51$#%##&)02011.,-+.02985/0159793)).3+',236(91%3-,0%$%.')49230/52-+)-+(%$'')%'.-01884)''%$$(-3+)(/',8549:-2-.-+-(''967982111&,%%#&&55/7/605.,)'&1-,+&$&,.)27-19)($%(,2((')%%((14)/59).+171(220258589,,/'&(&+:.88232209+:4;:,9,)/,+%#+2/5659;642))(&#%-0,1-,$,'&''(637.2/--)**-:89505+.)$%#$$'(...-285,(#-%(,-&%&..',-0182))-/))2-,-10/5,,+')$&&%%+03-+++),3(+)+()'-)%$%'.%'.+)%+'()+$),1)-,-.1,-..-991.44.0043303-8-../2#)())#$'-).-66977.0+10+'''&-3--.--,(&)%$%&$)04.-+,46,(0(5)8,.))())'+07:856/5;,1,)+./,34766')'(+//,398+(0&+%(+#')+/00.//53/0.2(''&&),+)038%0#'-5-)&',/+,1;368326'3214,.1755/505.7'&&'$($+/24.$+'+)+%%%/056310(-237233/3://.702:0-(3,)))%++--..78/..(.%'58..%0&3)001--4+))$&(7.+.%-+1178.)'$585,+''(,'#'()7985;31/--2,51'%((()((()).8163,51523145697;6940''$%+++.-784+,-3)()/5+0#)(,1-,-/7./8,-0+5+$12.161466;-16'(--.,++)872,(.$..7809094967552....+5900.--.0;2641239.48/23/,//''.(/)-869:4331+.023/.,766-32$'%)18,1-,+2(+,44458:8;962/.((,)+897$&%)')46,(0&"%#)#')0,+--2++2280+*)+.71./23%%&)(*,.20))(.%)040$(&%$&++),$((9-.&%&%%/4,,+(-&(312%(#%))1)1142/---'8+)1((&)'+))%&&,748102.+,/9.778568652/4(-25040-0+6)-&+)(&&#+5,+',21)&,.//,,3,450&///678562/(&'#'')+,./-)-/)+&$.1(&&#(&'.55)(,.',,//&.'-+303-/.9/663/8.,$,'-.4520,0&+).(-/:91128475676,'.:76848),6///..+(#&'((50044:1/96,/;;31743/1()53090//63;-.333:14+-/2326-/098772:4/$)'-161111//0131658')+)/,++8941/5+''0$3-03%#2-'00.:)2:;1.382,7163517')-//3/-%+(+7&.'%%')(.2-&%$0/,0+1-.+++--0.+('(')15486738.12&&&#%#&+.,.570-3-:96501.+$&$.2744788;81-,),).12/)++--1/++19:,-.3220871,/28-/%1),,28766;;:0.114(1,(&)).4.$,,-)&'-2.45523201/,634233-,557520%.35.,2,$0.0/32()))/951),131188,')/.-,1,++1344010+/1,00555)&%"()+,'./7222.,-./9872;5)--20%+'2.78'(./+14+().03/(/,.-#%)/,0039:5541:40+,--.2042(,/.))2+..5-%&,(100488750$#&'+-48418.)00-5+(0235+,%))5+00330680.6+&--::/8+,')1.01(*&*-3/#((-/(/-&)/,;,141-,(&&()96()+8837467$,-2771;3.,%(+64//1716:9443$'+')#$'/6.3.05%652248895784/+//,.17,.338)+,.17&)&#',,,-49/-/)09603/#$%+2%$"&&+&()%)/0+)$1+00&-)(*.-&&'%)&').+%&&+'&)$&&%'1341/,:.+3,/.14()+5-51;865512.-2/)('&""$/+/08+(,407-100+'$($&).(.-71293/.0892+,,,/22789-6010/+.,,.03/$0,)%)&''(,.-,5..4.02//6.,+,--23663023-0(&+/119675..0060''(5:)--14;36-,',,-+-+086525,/.650(//(%%'+1/.02492470.))+&,,,/3.24'.+.233-+1102)%&'&%'(+/%$#'%$/0%"%.#''((1)((),,+.5(((-),02.94',0-2/+1-''),/1-(%)%'(,-+0/&((&,/7:-.2165$+%0,2309--$..78614*,(%'27/6789:7.:(33%98/,.,)-')(212651-..1655-,0(-./065884993-%-+5/2+.)00898:970./%,,2-0,-),(()0,,(('1-2./.--04433%53.(''/.+--'2&37,,((0.80115:&%&$.'.,54+),+-.,-&&1602/8-+%,)551664)+8786:6+38,+1-9;;(*#%"%%&&(%&%)+./7.%&-')%(-62-')$#$%%'-30-.3,.&0)).+/,-+..0&+'('.#&+0170.,.+68+&#''/1357;46+,10'%)$%,-2102./.1:43665.:-,-*307740248:/-*,.98++)'+)&(%$''):92./$&&"),-3:699'2+,%-05+/7((///62/+/15;82"$%&(()+(')((,)/*3--.7/2&%%(-&().)./62/,)&%,,,(),,-34765/%.+/6'&,,(/,4-066++0143.'&$#&&%&,8373683;:74173,+,'&$',,108/.,0,(#$&+,4,01-)%(&()).-..6./40/)''..4,4100-1.0'&')$(&&+3/,(('().-)$$#&&(-5())0-00756;:88-,,,//++1&++6:3/-11452.0/47776,+058:*(0+//71599/.+**5&)+,.5/2177,#.$$#"##$%(,+(1777)'),,-./286/94-.,,$)(,-/3:57847::85:,-))%)'.200370153+35.,02,7/5;5:69//65)(+1:58//.0//../-+))(.64-.298+898/0,++$$+/+07567764661,66'),4-0--(143(,--2459579/''),..70,+((%%&$.+(#$((&'.046.036//'+.776/44'''((',*-/1%$'&%#'&,--/,25,,234)589:9350&,-.((,&')2+'#%#$($&(+026,'&&$")'&$.)(3-,-$0$--&0)$&)&0.0()(("#))43465,572,4)-844356645((+073.+1.,,$)'--'#&+(3..0+/$)3364;3'(/13418-73533358+'()+,''''$%,(+)(,%'//42029,('(()2,-.-$(,2+2+0/6:6.0-+-/8100208,)-911940:0/,-0/.:7)(.-2:;2-41-,--9,'/+,/2$$$%%)/(%(-,&+0,-,-5.:0//,,-8718377/9884+&0%(6+(02-$(&3(7454/,(-+12-2/,%)').-,(.1735.8/;68770/2((,()(,162(+-1+8.43)1(1/'(,+,4.//013002668705973-6:97++-%)'%(.'.+)(-.74+/,('019676++2+%),%15+/(06123+,%#%2(,4.%%(),')+0298.1-33522,567:8..0<;15898/0.((),081095795./1/5;40576229.&('),14,0880&0)8:'2&014694302041----//40..,/3'+,+.0(69,5.+03656:;...9;2//2350/+0-9:-++.22-:;:03''/+)/-03:831','.79-#&&&(/1:;1/:;;1:0-189687875:3569551716,10+,./.;011163/4680)%)+&)(%)++-,696/44.)'&$$20113+))--(&%).878.,--,:5478/61/,4-.8109+6++6,,,,+71457..(35,(),..2134030.,/+,,+-6+)1,-91/+7510)0044+#%3+./,-..+,.8.,0+(,+..,+(++.-/845344*9,0/0,+-,0775667'.(++.24-,0-0/0,&))(91.)+(%+,$-,+-.,--7(%%0&(+-/3995+/&/87+3335366,+5.7/5497,-.5,+)+(062480.-53+,8:5,/53,,((0/&#(+17.197-1000//19013+)')&#%'&&%()*+731442684,.%')+2514$-4,.76989/:.9/,+:/612+.//0.6,-,/.23475766769783-((%''(.%()&%'/1232..6.6566:9:/6)-+--0143&'4'((;9/0;400,//5524(&)'0+0:::;+'+&+&,,-,0552044588352/()),,59,--./8.-0)-)(022.&'()9).-).,%3769/+&%-/8224'9,12/),+14,.+&'#(&175983:97.++00460/770,-01()23321.2+8,0/1216485&'(%)(%#"##%)(-,(((.-,6;89/,)''(77/7&,/185+0/.#-)&.#%&'0.,,6:5'&)+,-4+-108/-2.202920321/027,+++)'%)--++')%'054+-)(%+,&().5,1)1-367$)(,.230.23')%-437.9.-+.)(()0&&+,8-/7..970<)'($$&&#"&#"" c499d028-472b-4274-9208-95b4523ca5d9 4 0 0 0 0 4d69c521-b119-4a88-b62c-38d4f643485d 4 0 0 0 0 02d43f73-befa-4888-b616-67646fd9d434 4 0 0 0 0 6a185a9f-1b0b-4a28-88ea-dd43e6aa10e4 4 0 0 0 0 db5d9021-7925-4654-8845-b574f9f748fa 4 0 0 0 0 90786119-4789-4e4e-ab3b-8871f4082756 4 0 0 0 0 86c19dd3-d5f2-4487-95ab-b56e13dfb7e6 4 0 0 0 0 1e98192f-6bd5-49e5-a2d3-1db3e57c80a2 4 0 0 0 0 TGGTAATACTTCGTTCAGTTACATTATTGCTAGCTATCACGGAGTTTGATTGGCCTTTCACCCCTACCCCAACTCATCCCGCAGTTTTCAACCTACATTGGGTTCGCGCCTCCACGACGTCTTACCATCGCTTCACACTGGCCATGGGTAGATCACCCCGCTTCGGGTCGGGACATGCCACTACCACCCTCGTTAGGATTCGGTTTCCTACGGCTACCCCACGGGTTAACCTCGCGACATGCCGCTGACTCGCAGGCTCATTCTTCGCGCCATCACCCACACAACAAGGGGCTCTGACGGATTGTAGACACATGGTTTCAGGAACTATTCCTCTCCCCTCCCGGGGTACTTTTCACCATTCCCTCACGGTACTCATACACTATCGGTCACACTACAATTATTTAGGCTTACCGGGTGGTCCCGGCAATTCACAGCAGATTCACGAGCCCGCTGCCTCGGGCACCACAACACACACCATGTTATCTTCACCTACAGAATCTCACCTTCTACGGCCGGGCATTCCAACCACTTCACCTAACAACACAATGCGCGCTCTACAATGCGGTAGAAACAGAAATCGCGGCCCCACAACACCCGCATGCACAACCTCTGCGTATCATACACGGTTTTAGCCTCCACGTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTTCTCCTCCTGCAGGTACTAAGATGTTTCACTTCCCCACGTATAACCCCACGCGACTATGAATTCATCAGCAGGTACCTACCATAACGGCAGGCGGGTTTCCCCATTCCGGACATCCTCGGATCAACGCGCTCAATTGACAACTCCCGAAGCAACGCAGCCTTACGTCCTTCATCGGCCCAGCATACCAAGGCATCCACCATGCGCCCATAAATAACAAACACACACACCGAAATGCATGGGGGTGAACAACCATAACTTAAAAATACTAAACACACACCAACCAAGTTGGTATGCGACGTTCTCCACAGAAAAATAAGAAAAATTACACACACCACACCGACTTACTTCAAAGCACTCGTGTGGTGGATGCGTCCACTATACAGTTCTCACACAACACCCCACACACCACCAACCACACACCCACTTTTGCCAAACCGGCGTTTTAGTGCGTGTTTCGTGATGCAAGCACGGGACCAACCCACATAACGTGGTGCTGTCACAGACGCAACGGTACCAATGTCTAAGCAGATTTAATCTTGCCTGTGTTTATATTGTCTCCAGAATTCGTGTTAGCAGCCTCTATAACTGCCGGTGTGTTTCCTCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCAGCACCGCGCCACACAACCGTGTGACGCTTAAAGATGTTTAATTAAAGCTCCTTAGAAGTGATCCATGCGCACCTTCCGGTGCGGCTACCTTATTACGACTTCGTCCCAATCATACGATCCACCTTCGACAGCTCCTAACAAGTTTAGGCCACTGGCTTCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGAACGTATTCACCGCAGCATTGCTGATCTGCGATTACCTAGCGACTCCGACTTCATGGGGTCGAGTTGCGGGTAATCGAACTAAGGCCGACTTTCAGAGTTCGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTTGTAGCGTAGTGTGAAACTTATTACGGACATAAGGGGCATGATGATTTGACGTCATCCCCACCTTCCTCCGAGTTAACCCGGCAGTTTCTCGCGAGTCCCCACCATCACGTGCTGGCAACGCCAAGACAAGGGTTGCGCTCGTTGCGGGACTTAACCCAACATCTCGACACGGCGGCGGCAACCATACGCCGCACCTGGCCACAGACGGACGAACTATCTCTGGCCAATCCTGTATATGCTTCAGGCGGGTAAGTTCTTCGCGTTGCATCAGATTAATCCATGCTCCGCCGCTGTGCGGGCCCCGTCAATTCCTTTGAGTTTAGCCTTGCGGCCGTACTCCCCGGGCGGGGCGCTTAATGCGTTAAGCTACGGCACAGAAGACGGTCGGAAGCCCCTACACCTGCCGCGCCTGTTTGTGGACTACCAGGGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCTCCTGATATCTGCGCATTTCACCGCTACACCGGGAATTCCAGTCTCCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCAAGCGGGATTTCTGAACGACGACAAACCACCTACGAAGCTCTTTGCGCCCGAAGTAATTCCGGACAACGCGCACCTACGTATTACCGCGGCTGCTGGCGCATGGATATGGTCTTCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGAGTTTACAACCCGAAGGCCGTCATCCCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCCATGTGCAATATTCCCCACTGCCTCCGTGGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCGTACACCTCTCGGGCCGGATACCCGTCGCCGCCTTGGTAGTATTACCCCACCAACAAGCTGATAGGCCGCAGGCTCATCCCCACACCGCAAAAAGCTTTCCACCACAACATCCAAGAAGTGGTCTATATGGTATTAGTTCCCAAGCTTATCCCGCCAATTGCAGGGCGAGATCACTTACGATATTTACTCACCCGTTCTCGCCATCGAGTACCTGTACAAGTACCAGGCCTTTCCGTTCGGCTTGCATGTGGTAAGCACACGCCGCCAGCGTTCATCCCTGTGAGCGGGGATCAAACTCTCACAAAGGCTGTAGAAAGCCCAAAACCACAACCAAAAGACAAACAACACAAACTATCCTGCAATGTGTGGAAGCTGACCAAAATTACTACATAAAGAAATCAACAAACCCAACCAACCAAAGTTAGCGGTAAGGTAAAAGTGTTTTAACTGCATCAGCAGACAACAATTACATTCAATATGCACCGTTACAGTATTTAACTATTTTCAATGCCACCCGCGACAAGTGACATCCGGTACACCACCAACAACCAAACACACCCGAAGGAATGCTCAGTCAACATAATTCTCATCCACAGCACAGACAAAATAAAAATCTAGTACATTGGCACACTATTGAGTTCTCAGACAACAATCGCACACTTGATTTGGAGCTTTTTATCTTTAGCCCACGCCCATGGCTTTATTGAACTTACGCTATCGATTCGACCGTGTCCGTCCTTGCTTTTAGTTCTTCGTTGTGTCGCTTTGCGTTTACCTTGCGGCAACCTCTCGGCGACATCCGCATAAAGGTAGTTGATCTTCGATGAGGAAGGCAAATCGCCATCTTCACCTCCCTATTTCCACCAGGATATCTAGTTTCTGTCCCTCGTTCAACAATCGCGTGGTTTTGTGTTGTCGTGAAAAGACACAACGCCCGCTACGGAAGTTGGTAGCGGGCGTTAATGTGAATCAAGGTAGGTTTCTGGATACTCGCCATTTGCTAGTTAGTGATATAGCAAGCAAGTAGTCCACGGGACCATCAATGGCTTGGATTTGCGTATTAAGATTGGCGACAAGGATTTCTTCCCGCATGATTTCATCTGGAGTACCAGAATGCGACGATTTGTCCATCTTTCACGGCGCAGATGTACTCGGCGTACCGCGCGGCGTAGTTGATGTCGTGCAAAACAACGATGATGGTGCGGCCGAGCTGCTCGGCAGCTTCTTTCAAGATGCCGCATCATTTCCACCGAGTGTGCGATGTCCAGATTGTTTAATGGCTCATCAAGAGGTATGGTCTGTTTCTGACATAGCACCATGGCGGCATAGGCACGTTGGCGCTGACCGCCCGAAAGTTGATCAAGTAGCGGTCAAGGCTAGGTGAAGGAAGTCGATGCTTGGTAATAATCTCTTCGTCTTCATCGGTCAGACGACCTTGGAATAGGGAAAGCGACCAGAAGCCTACGAGCTGACGGACGGTCAGCTTGGTAATAAGTGGTTCTCGGCGGAGGACGGAGATTATCTTTGCCAAGTCTTTGGACGGAGGTCACCTTAATATCCATTTCGGCGACCTTGATTTCGCCAGCATCCATGCCGAGCAAACGGCCGACAACCATCGTCAGCAGCGTCGACTTGCCGGCACCATTGGGGCCAATCAGCGCGGTGATACCGCCAGCTGGGATTTCAGGTTGACGGGACCAATTTCAGTTTCTGATGAATGCGCCTTTGTGACGTCAGTCAGGTAATCACAGTCGTCCTTTCTTAAGATGACGTACAGGAACACAGAACCGCCTACTAACTCAATAATGATAGTCACGACGCCCTGTGCATAAAACACGTGCCGCATGATGAAGTATGCGCCGGTGAGCACCGTAAACCAGTTACCGCGGCCATCGGAAGAGATAGCGGTGGTCATAAGTATCCAGCAATTGATAAGCCAAGGTGGCAACTTGAGAAAGCCGGGAAGGTCATCGGACCGACAAGTGCGGTCGTTATTTACCATTAAAATGGAGACCGTCAAGGTGTATATCGCATTGACCTTGTAGTTAACGCAAGCTGATCGGGCATCCCGCCCGAGCGCCAGCGCACATTGGCGGCGCGAGTTTAGATCATCAACACCACCGTGGCACCGATGATGAGCAGATAGCGATGGGATAGTACTCAGTATCGGCATTGGTAACCGAACCGAAAAGCCGAGCAGTTAAGACATCAGATTCACTGAGGGGTCAGCAGACGCTGCATAAACGTCGAGATGGAGCCTAGTCGCCACCGATGACGATGCCGACGAAACAACGCCAATGTTTTTGGCATTTCCGGTGAGCAGCCGAGAATTGCAGCGGCAGCGGAGAAGACCATGAGGACGAGCTGCACGACGAACATCTCTACGGTGCGGGCATTGTTCAGACCTACCGCGCCGAAAAAGAAATGGTGGCGGTGTGAATTACTCGATAGGCGATTCCGAAGCCCATGATTGGCAGCGTCAAAATTCGGTGTGGTTACCGTTTGAAATGCCACGGTGGCCACGGCTTGGCAGACTGCCACCAAGGCCATGGCGATTACCCCATCGAGGGCGACGTTGGCGATGGGCAAAGCCGCGGAGTGCCAAATTCCATCGGGTTTTCATAGGCCAAAAGACCGAAGGAAAATAGCGCCGCCAAAATGGACATGGCGATAATCATGATCCAGTATTTGCGGGCCGCTGTCGCCGACTGAAGCGCCGACGTGGCGCGAATCTTTTCATCGGGCCTGCCACTGCGGCGCGTTCTTTATTTGCCACGAGTCGACCTCACAATCAAACCAGCTTGAAGACGATGGCTCCGACGATTCCCAAAATAACCGACACACCGGCATTTCAAATGGGAAATAATCACGCGGCCCAACGGGTCACAGACGGTGACGATGGCGATGCCGAGCAGCAAGACCCACGGCAGGTTGGGCCTGAGTCGTCACCGCGGAACATGCTGACGATATTGGGGACAATCAAGCCCAAAATGGCGGGGGCCAACGACCGCAGTGACCACACCAGTGGCGATGGACACCAGTGCGTTTCCCAGCAGCAAACACGGTTGTAGTTCAAACCAATATTGGTGGCGATATCTTCGCCCAATCCTGCGGCTGTGAAGGCTTATCCGCGAAGAAAAAAGGCGGCGATACGACAACAGCGAGCACAACCCACAGAACTTTCGTATTGGCCTTTGTACACGGAAATGAACCATGAACCAGATGCCAAGCTGTTGCAGCGAATCTGTAGCCAATGCAAGAAGGAAGATACTGGGCAATGGCTGCGCCGAGCATGATGCCGACGATGGGCACGACCATGGACGAGCACAGTGTTACTCGGCGTAGGAAGAGGAAGAAGATCTCATGGTGCCGATGAAGGAAAAATGCAGCAACAATCATCTTGGCCAGTACTGATGACTGCGGGAACAAGATCAAACACATCAACAGCGAGGCCAGCCCACTCGGTGGTACCGGTGGTGGTCGGTTCGACGAAGCGGTTTTGCGTCAATAGCTGCATGACCGGTTACAAATAGCCATGGCGGCACCGGCGAGAACCAGTGCGATGGTGGAACGCTGGTGATCCCGAACTTTCCCATCGAAGTCATCGGAAAGAATGCTGTATTCGCCTGGACAACGACGCAATCAATAAGATAAGCGACGCCAAGCGTGGCTAAGCTTCCAGTTCCATAACTTGCCGCGGGATCGGCGCTGGGGTATCATAACTCAGAACCCGCTCCCAGCGCGCATATGCTTGTAGGCGTCGAGTTCGAGGATTGTCGCATCACTTATTCTTTTCAAACCGAAGAACTCGGTTGAGGCCTTAGGGTCTCATTCCCAAGGTCAACCGGCGTTCGTAATCCGGC "$-)%')%.543/296'-0'#)()%0'&%(%'')+/,-+,&(2:5..,.'0+28/.)783)13.'/12348/47,)/,/::7()$3)+)(,(/7497//).,0+'''/1/.1-5.179;:./09./+)%)+5/7)1080-/+-04-499,&30:'57224/*204368./..0862;512213/1:+777/;1-4(,.1612/8.4/&).5.9.9.723221413.0-())/0/-50379998:;94--'++276766-90+16)4/1600//.//4407-.03.2,-126;1:71.37.2//.34.4+-(996+-.&%(-/+06:,+-6+7883710/(((/,.1997824143686&2-/((&,.'')&)&'7<;-1-,07.1)463/0828+,(,+,%&+(+..2/-/150'(&-/5+'.3322/380-.01()/2...)),069(08.0/5;52650(..$%(&+//0549422308/:,773368(3(45'-8/20,'--/,0232;434463785/)0.2.$''((((-1)('%-.,(&&)(-2,('(42557+22610.-(*'*1,')%(+0-..+0,-7;;...+/$&)$').<9:::96::/.-+),,.05476653:209:--7;;/0475238746&-'('111&+,757;;5/001/88)$&'+.,0)2896&))../47472,6/:/784&'+4.--6/+03,.6;99;4345,)41:509920/30&0+68787633,0123501-/49/'4'),,,$-.2+,'&'"&$()./..61+.#&$%'87;969130-8,('./1435.(+,-.11,+1624-12184%$'173.,+08330)(%&$&'"&')'),(('./'&))7,3(9+809/),/9;9-.%.336(+,-021-/%/(60,/5/34404024)452,5+(''-28</805'-.471/321+,('04,,&+(,,),11)194+33677371/--,-3---./314555555$4.8365.,..076-75.-$'&),-,004446-,+,,0/(&'35+)(-+776))*+,,;:0$+*-3022:36410/.'2273544'11./.-3,93,.'(-34)6)')))()-%#('.5,/.-0%+&"))+0--&$,',#'%'(&+--.191173321.07&+5-./617$%)%+10,2+.(-,,.6+0"$%)/.5676050.0+'0.--,)+1732:5665,42/6///..1,'-(,,/-9+,,7997.98//.,%(+4)++1,()'+-288781000/()''.92(+,.96-/,-,5,(+/%#"%%($&$'+.+,/&'##%(1261.001,-/+.()%'$%&%%&)+1923+5-&+((%%%))),1%$(6-'"##)).7'(220,),072.524)/).+()%%&+((.,5(,+-).4-,/7413445796:934921523&3003030&22/4567567669:4-+.9.,,,-.///.+$2)-''(+/--/0/2/.03445867:62')(503($%.'5+:97,+/-/74204;9.++(4948991/-09651//010:978961;5-/9132265552108+,-//%+%$((+),.$%%$#&&%,7.7()+-1,./223553787.//(/43+6/.(073:85530)())+#1.31059<9888--(%+(/52-).40581332367090037))'3+44/5+&)%+,,7::67:14/86++.-(.(++.%220-'"$$'+''(''&((,4+.+,))$"&#(&&$$%&'-,./+)36,+14458531),4/./65(''$%('&$$%$$%()/(#%$%&/&&+(%').1--',3+*0/4-8/060+-/007116&%%'&+-.3/3622+-938/9+))0+(*193'),./+-01//.+--1,/'%'/.&773.-')&.,+)(.)+&$$'%--(&(((%$0($(#,%')'1.)-+1)30'$&$$%'54-.,6''#'-1/472540-.5889;968555:9966+66&')+50,08799,/002457,$/2-.-/+.('&()*8/0/11:;968867824368;35-/,()++,67877740:20#'-,-((&)&((',)-.&()70,/74/+22012-0/31/0,1,+'++),25112/,.+)/5)0-+-&()#0*22(,,010,+5:74736:3+,))'$%((10'#(&.1)$%'$%8834)2-30./.,%&$.,-(-,.7+,1)+/712/5-7(&")",$&(-,-/&.%(6/31//3989:7567100..-,1++)-').-012035+,))-)$'(%(59,,5/47.)-+9969:8938;:3('00339:7965520/.0445::2:11/34#"+&-0.711108592(+%&'%')$%'((102463268545803828,0-,-'+'&%+)/5(+0%06060923&-&&(,,121-1302))+#$%')0+3771)*1,1/6946.-..-6894./,+45778/93.&$'%(.','*(%(0135&-)))/+,.6)-)&()(),134')-((+3/00,))00,(%0'++3.,/5-$%#-+1,,(3#%/%%.20(%#'''&)-83--472182.-4'&),.&((#+&()82337587++(-(),44-/7,)41362,$)+1,1.64532312()'%).02,4,++.,$)-12/6&)-//+13,&((&),-1,,///&)6,2.10,'%&,3,234+/.((.4-)/;8/123::52/--.-)'$''/.'&&)5+)(%'&'$(#$'(+)2+7-++-,.422/029,%*1-+--07-..,-20:1-+,72,.-+.(&',)%,47,,001;;2/66.,,-$-0(25.-//65:5559:00/+)-53147368330452/;(&/,4:;<30;/-.)0)&#&&4442-../5230),-.,(&+'(5,7477%0,2981.+&+)*.)-.40%)',&*33,).25;.0:880,,-,%()///:9518;:8(..(*+/-4)4,+%+21)4+($017665%)43166975,-)+%&&&)'06+--(+,,7:9-,//683$')'$'%+-(,'((&25((+-/1)+(&(.00109)+/:40//.-0,34--//))&&)+)#$&.438::38402112),.7,-2.4;,16.4+-%.20,1-./-+1-,-35683'((/7-),+(,.3.0122:7.//&#..(2679;2/0/442365;644+/4,&,.;;./-,%-/,-+,1')2:.-35573&&//0+/585501/0$14:;00111;.014+77-(+'))+2214;.//0...--'%.(1.--.(/2272:.2-,-1265844(,+0.+7;,+4325-,,-579,49-(01...8./-.('&%###).',1.-./:9/(16174.%&&(()--3+3'.2/-0/61000,&'-'&$#'.12/102:,-;908.+47678;;577921-(()/041&'+/000186483,.126720:/,/2.83/20876/,./-8:86767:675.1%&',,.26/../062420-201)/)(-.+/0.(,''4)44342.',,,/-,/12902;0-/'%#&##$$(+,143;72,-2-)&&+0,2///.5()(.-7+1:9/,,-+2989:/4'$'''(&/11343;50,,-.,/%.001642380)(#$$,$()0.34386787524-3+'-+'&)&)*.+.),,254988+7(3+%%&.0+)&(&&(/-''%%%'+.,-,(-)))&)++688;;5985967-.482),%%#/'20.1,6/)/.+/5252$&(+$4+,,$%20./035:8:2879/$'$#(')/('/%(&0,5/)-+28111-53.++,2-.,-0.(),)#(,/704&$'4(.3,,+)%%+()+5936;9729644712532/;7/.53+3676470019:504271%+(102-0)&))2/356::68/1110941,3.(66*1223:6/8,664,)3:5+)(-,1.,,--07456,4332%+#5&'(+)3/13':8999830;--%/3:(..-03$2#-+*68--1,..(,9(,,-0872111.58426.)8,+-6.8,/'((&+0489070.11,(2-((2185/,0+(-+,)+()&%'&',-+,,39619+07//..,(%$"#')59946/,,,,,(+()+111048474('0--0%016'/30+5++4712,4/:/:)2+1%0))+307:98'(5-$''(:((-2/,.,+/02/3810(/./6--$),())%/&'.174,6,7286684;6987.5/1(-55899/:.+69/%//()08:400()+532(),,0+/.--21196''(,./4,0,+,%302)&$"#&0'+))))*+01/2,63*-41)',/03.)())-+,&'&,'+,../90+-0:4()%'&,,276//.2%()+---,/1.0/,,.-+0,$+/.)45/.01;967/,1-.1.,--1:8;8618/7)/%2),6:722670+-8+&%#$(1)#',/388%%,6-95650%232(+467+0/0---+-')27530146464480-///--.16)5027,0212/..//:8886&$&%&,+.%%$)+-/:;933854/:-1%.'2--26-25/,(+&''$))),$0012844+%,'542.-/3+1%$'),5/,.-.8214868786644(.//07:95207-083)5-8:77543557851972&#),,,/2+0),2/-$%&.))+,-122+,+7:69&'-)3:+100%+13:96;:7/962,0%,%0/'-867;:,0/,+.44//+0+(--/,1-+0+7.94788:::.-.-,..48/0/761,3,/'('+-2.-5)883.(,+,+-.,.(+4'5.&6-0)/#(+.)4:93917003+/0/;;517876422083+)348000,,-0442'&)-8/(276446888814100686854),,,-(4)70;7--%,6-2/019;8588+,11-/0$')+15894959566+.-'-23-)+/0&4+.0,/2+-)(+&')+987:14:3,30+%/3--,)1++,8.2.146233:8:63')&&)+4+-,,,10.///.&05689074(69;.-)+1..100+361-,-0-3,:/-66,'0/+-:94)+-,2,5+&.$1+++.2/079.53147222/::54556;643542737254:8.14:71-.5.5.++$%%#,-,-//-7:03)5-0-033766430..(,'(184.65:6621/,2(,/.,)32%()206000131'1#010034//..40236:7//0.2583654&1%..'2/)(')+//5+(2+-/..+--/58626:29;3730-5/5+3--/0009:;9.62,1/77024020.,,,((#$&(/,-/&&''(($)/361&4)011/.05')+52-&-'$'&&,,05039('(+310(.()28318.7/,.60.51/'-.+-)%%"$,-&(,0872((6825361112239+3,0431:87850+,+1-0187)3+-1/3.&&%$'-/+7.+%,*',+.6/)104644344:97.---)75--../89075:930+*')'.2,7,++7558766630.+&$')).%)+'-/-/,106.0.2,+,/.1/,'+-,%('0..26/60:-,-/)5'&#)677986/.-./3734+9///.+,)+/7:9544347/$20-.&%)'&&()+($-/,%-)(/+/386;423/+++&+/80652)+/((.+;;9+01111091/-1311-.--/.)-&,,1693424:25.84-73141+1))(/657+1/,,,-.8681600$$#'((/110/((((+32-5+-19'%+(+,3667475&)'/+'('-+232$#%#,8291)010465744/3-.55,,6/&(+..962412+-/,6,+')%&(3-'%(0:4-,+3-(.+.,.,987951843+&&'+,%()#$(51110&--62-80(#%&&(&&')&#$#$'"(-+&(+,8/.('+#-+-+,%'2.((.(&1((1.2+//:9954/-$,'&()508.+))/+1/.15-3146995:,,%)01255,++++795')'))))&&" f6eec407-71f7-46a8-b7ff-94dbb3970353 4 0 0 0 0 b2906001-8b8f-4186-a388-2d05a9ea87a4 4 0 0 0 0 1babd196-9ff1-4563-9b73-44661a9bfd23 4 0 0 0 0 dc75275d-f254-45f1-81c1-ef9ea43d2b00 4 0 0 0 0 31cae1c1-e10c-4fb1-9af9-ec6707a8eada 4 0 0 0 0 223b4e3a-005f-46e6-bc7a-5c6bef9f80e3 4 0 0 0 0 9e3822ea-7fca-4f83-9703-98b235e63cc3 4 0 0 0 0 17970e66-6f8c-4f28-8fad-934b22014ec4 4 0 0 0 0 *
There are the lines of the three files for racon: [superuser@A]$ wc -l /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/* 75 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/alignments.sam 0 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/consensus.fq 292 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq 4 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq 371 total
Hi Botond, The attached files are the temporary files generated by polish_clusters.
[superuser@ALCAZIDCQ01 2018_fastq]$ /mnt/rdedata12/yuan/github/pinfish/polish_clusters/polish_clusters -a cluster.tsv -c 50 -o consensus_transcripts.fas -t 40 aln_filter_sorted.bam polish_clusters: 17:33:46 Polishing cluster 71f61652-7fc8-4901-a511-a16d2ff8f3ff of size 73 polish_clusters: 17:33:46 Failed running command: racon -t 40 -q -1 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/alignments.sam /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq > /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/consensus.fq - exit status 1 [superuser@ALCAZIDCQ01 2018_fastq]$ racon -t 40 -q -1 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/alignments.sam /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq > /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/consensus.fq [bioparser::FastqParser] error: invalid file format!
发件人: Botond Sipos notifications@github.com 发送时间: 2019年3月26日 0:08 收件人: nanoporetech/pinfish 抄送: Tiezhengyuan; Author 主题: Re: [nanoporetech/pinfish] errors from polish_clusters (#5)
Could you please paste here the head of reads.fq and reference.fq?
― You are receiving this because you authored the thread. Reply to this email directly, view it on GitHubhttps://github.com/nanoporetech/pinfish/issues/5#issuecomment-476266508, or mute the threadhttps://github.com/notifications/unsubscribe-auth/Afh5RlumGAy7qg8Dy7XBuTnLGof6X6JNks5vaPRxgaJpZM4cG2IA.
The problem is that you did not filter out the secondary and supplementary alignments. Please run pinfish using the pipeline, which will do that for you.
Hi @bsipos ,
I also running polish_cluster with my own data (spliced_bam2gff and cluster_gff worked fine): and I am getting the following error which has something to do with the wrong input format for racon. Besides commands, I am also including pieces of input/ output files.
1) Splice bam2gf spliced_bam2gff -M Pool4_merged_trimmed_BC.bam -t 24 > Pool4_merged_trimmed_BC_raw_transcripts.gff
2) cluster_gff cluster_gff -t 24 -a Pool4_merged_trimmed_BC_raw_transcripts_clusters.tsv Pool4_merged_trimmed_BC_raw_transcripts.gff > Pool4_merged_trimmed_BC_raw_transcripts_clustered_transcripts.gff
3) My command polish_clusters line: (pinfish) martin.tesicky@turbacz:~/Medaka_parrots/Pool4/pinfish$ polish_clusters -a Pool4_merged_trimmed_BC_raw_transcripts_clusters.tsv -c 50 -o Pool4_merged_t_rimmed_BCconsensus_transcripts.fas -t 24 Pool4_merged_trimmed_BC.bam polish_clusters: 15:55:52 Polishing cluster 02e3c0c0-b1b5-4f5f-8bf5-05f83f97fbd3 of size 330 polish_clusters: 15:55:53 Polishing cluster c7a0033e-8bd3-4ea8-8539-8cfe406f915f of size 85 polish_clusters: 15:55:53 Polishing cluster e3b5ea34-f86a-42d8-9e2d-9c86a8d29b5c of size 53 polish_clusters: 15:55:54 Polishing cluster 8f8b2b1d-54d3-4b18-8dc5-3fc9b7eef4f9 of size 96 polish_clusters: 15:55:54 Polishing cluster f786d9ec-ecc0-4b5f-8862-2b4d1b72a8e1 of size 26109 polish_clusters: 15:59:42 Polishing cluster bb6413a0-83dd-452f-8e70-94e848c88720 of size 99 polish_clusters: 15:59:42 Polishing cluster 8db24705-3c4c-4e5a-b8bd-300688ff0bdc of size 50 polish_clusters: 15:59:43 Polishing cluster d28805d8-6cae-42fe-8138-a0d64a998608 of size 1345 polish_clusters: 15:59:50 Polishing cluster 46a7098b-2dd1-4f1b-966e-869613dfa32b of size 53 polish_clusters: 15:59:50 Polishing cluster 34c16ef3-891f-47aa-8946-32b963fb6812 of size 58 polish_clusters: 15:59:50 Polishing cluster d49642c2-0fd4-4c0c-8319-59d1863f57f8 of size 70 polish_clusters: 15:59:50 Polishing cluster 441903e3-5769-43cf-8043-bfb1df57c90e of size 2829 polish_clusters: 16:00:04 Polishing cluster 971c2378-3d77-43de-89ee-fd6c28e1947f of size 107 polish_clusters: 16:00:05 Polishing cluster e4bee383-39e1-494d-968e-ed129b7c4fc5 of size 147 polish_clusters: 16:00:06 Polishing cluster 0523fa67-f3a0-4343-8ecc-6cb957f5c26c of size 188 polish_clusters: 16:00:07 Polishing cluster cdbe623e-17c5-431a-93ea-a79e978eb475 of size 2260 polish_clusters: 16:00:20 Polishing cluster 6b535889-7107-48c3-9eab-5cb0aa6d1092 of size 258 polish_clusters: 16:00:22 Polishing cluster ca60e86e-f2cc-4ab8-ad13-d8727c344461 of size 202 polish_clusters: 16:00:23 Polishing cluster 70ed3672-75d2-4580-b9a8-8c0d79491f98 of size 306 polish_clusters: 16:00:24 Polishing cluster 53d2a843-bff9-4258-8b8b-701c4d47cd46 of size 61 polish_clusters: 16:00:24 Polishing cluster c40639a3-c3bb-4fec-8662-0e963f47d6db of size 99 polish_clusters: 16:00:25 Polishing cluster b788ec37-d32d-4f0a-baa8-5d3ec18af775 of size 130 polish_clusters: 16:00:25 Failed running command: racon -t 24 -q -1 /tmp/pinfish_b788ec37-d32d-4f0a-baa8-5d3ec18af 775_916745013/reads.fq /tmp/pinfish_b788ec37-d32d-4f0a-baa8-5d3ec18af775_916745013/alignments.sam /tmp/pinfish_b788 ec37-d32d-4f0a-baa8-5d3ec18af775_916745013/reference.fq > /tmp/pinfish_b788ec37-d32d-4f0a-baa8-5d3ec18af775_9167450 13/consensus.fq - exit status 134
And when I type only specific command that doesn´t work: racon -t 24 -q -1 /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/reads.fq /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/alignments.sam /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/reference.fq > /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/consensus.fq terminate called after throwing an instance of 'std::invalid_argument' what(): [bioparser::FastqParser] error: invalid file format! Aborted (core dumped)
Few lines from input/ output files: Pool4_merged_trimmed_BC_raw_transcripts_clusters.tsv Read Cluster 1b27018c-7eb5-4359-8a0f-95d7265a1c28 640b1d2d-8a92-46a8-ac64-03fec213591b 135a6032-2c24-4f62-9948-8edae6dbd8a4 640b1d2d-8a92-46a8-ac64-03fec213591b b1faf377-9151-48c0-9dd4-c8d8900117ba 640b1d2d-8a92-46a8-ac64-03fec213591b 5b6b8a04-bf6d-4e32-b3fa-728e582569f9 640b1d2d-8a92-46a8-ac64-03fec213591b 7046ff83-4301-4694-80a1-4d5d8596a371 640b1d2d-8a92-46a8-ac64-03fec213591b 3e1928ba-06cf-4c04-9cf3-8510bcc318d2 640b1d2d-8a92-46a8-ac64-03fec213591b a2c4f0b8-f6ff-4fa0-9a04-9147bbcbf2ac 640b1d2d-8a92-46a8-ac64-03fec213591b dea24b20-4eb7-478a-97df-4052a7ab435c 640b1d2d-8a92-46a8-ac64-03fec213591b 1e0226c9-2774-4475-b679-100dc3c45f65 640b1d2d-8a92-46a8-ac64-03fec213591b
Pool4_merged_trimmed_BC.bam (pinfish) martin.tesicky@turbacz:~/Medaka_parrots/Pool4/pinfish$ samtools view Pool4_merged_trimmed_BC.bam | head -n 5 14a0e3a4-795f-4986-9975-0547ff81815d 0 ENSMUNG00000000050|ENSMUNG00000000050.1|testis 587 60 41S54M2I70M1D29M34S *0 0 GGGGACGCCGGGGCCAAGCGGTAGCAGTGCCATGAGCTGCGAGACTCTGACACGTCTCTGGGACCTGCAATGACAAGTCAGAACAGTAGCCATGCAGAGAGAAAACTGGTGAAATGTCACCAAAGCAGTCAACACCAAAAGTGCAGGTCCAGCAGTCTGTCTCCCGAAAACCATCACTATTCATTTCTCTGCATTTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA D:/.;=>;;&(2+---$''%)(%%&$9@/9=100%()))$3,5/..,0+)&693?3;=<96231/4?=E=.)BA=4+#$(/2:;9''+))#4%21>922'7-$83''()##569&888%@538%>>IC72GA99=4--<>&$$$37.)+?>80)'1/:9418,-1745=BKMFF>A?7>?;961,)A9E?766555556566766789::;===?@> NM:i:7 ms:i:134 AS:i:134 nn:i:0 ts:A:+ tp:A:P cm:i:28 s1:i:127 s2:i:0 de:f:0.0387 rl:i:33 c9c5990c-ad71-4ee1-a7d6-0fe05e9a2947 0 ENSMUNG00000000050|ENSMUNG00000000050.1|testis 587 60 44S54M2D30M1I7M1D8M1D19M2D38M1D5M1I4M1I2M1I85M1D8M2I10M1D10M1I18M3I25M1D34M3I89M2I98M1D15M2I5M3I7M1I36M1I24M1D90M1D61M1D7M2D42M4D35M1D14M1I29M1I25M1I17M2I12M6I8M1I39M1D22M3D19M1D69M1I11M1D51M1D3M1I3M1I1M1I13M1D18M2D19M1I14M2D22M3D1M1I25M2D6M2D9M4I3M1D11M1D3M2I2M1I14M1I38M2D51M1D27M1I2M1I5M1D31M4D34M5D26M1I35M1I25M1D5M1D27M1D22M2D23M6D15M1D7M1D22M2D56M1D20M2D5M1I3M2D39M1I28M1I10M1D21M3I1M1D20M1D2M1D7M1I33M1I14M1D5M1D44M1I5M1D11M1I3M1D3M1D21M1I107M1S 0 0 GGGGGACGCCGAGACCTGACAGGCAGTGCCATGAGCTGCAGGTAAGACTCTGACACGTCTCTGGGACCTGCAATGACAAGTCAGAACAGTAGCCATGCAGAAAACTGGTGAAATGTCCTCAAAGCAGTCCAGCACCAAAGTGCAGTCCGGCGATCTGTCTCCCGAAACCATCACTATTCATTTCTCTGCATTTGGGAAGGAGAAGAGAGGGAGAGGGAAGAAGAGTTTAAGGAATTCCTTGATGAGGAACTAGATGACCAAAGCATTGTAACAGCACTTGAAATAAAGGAAGACCTCTGCTTGAGCATGCACTGGCCATGGTACTCTGGTCCCAGCTACCTCGCTTAACATAATGGCCAACTCTGCATCACTACTGTCTCATCACCTGCAGTTCTGCCAACTGCAGAGACTACAATAAACCTGTTGGATTCTCCTTCCACATCCCAAGTATTCAGTGCAGTGCCACTAGTCCTGTCTCCTTCATCACACTCATGTAATACAGTTGTAGCTCATCAGGTGCACCACCTGTGAGTCAGAAATCCAGCCTGTCATCCTCCCCATCCTCATCCCCTTCCAGATCAGTTGTCTGCTCTAGTGGATCATCACAGTTTCTAGTTCAGAAAACTTATTTTTAAGGGGTTTAGTCAAGTCCCTTTCAGCAGATGTGGAACCAAAAAGAACCCACCCCACCGATGAGCGCAGACAGCTAGTGAAAACCTTAGTGAAATCTCTGTCTACAGACACTTCCAAACAAGAATCTGAAACTGTGTCTTACGGGCCACCTGACCCAAACTGAACTTGCATCTGTTCAAACAGTTCACTCAACCTCGAGCTACAGGTGGTGATTCAAAACTGCCCTCGTCTCCATTAACATCTCCCTCTGACACCCGTTCCTTTAAGTACCTGAAATGGAGGCTAAAATTGAAGATACTAAAGACGCCTTTCTGGAAGTAATCTGTGAGCCTTTCCAGCTGCTCCAGTAAAATAATGGGTGATGAAAGTGACCAGCCACAGACCCAAAGAGCCTTATCTTCAGGGAGAAGTGCTTCCAGAACTCTCAAACCTTTCCAGTTTGAATGGCCATTTTGAAGCAATAACAACTACAGCATTGAAGAAGAATGTGATTCAGAGAGGACTTCTATGGAAGTGACTCCAACCTGAGCAAGAACGATCAGTCAAAAGTGGCTGAGGAGCATACAAAAAGAGACAGGGCCCAAAGCTCTCAGTCTGCAAGCACAAAGGACGTGAGTTCCAAAACGTCCTCATTAGCGAGGAAAAATGTTCGTGTCTGCATTAGCAAGCAGAGGATGAGGAGTTTTGTGGAACTTTATTCTGAACTTTTCCTTGCTGGAGGATGACTAAAACTGATAAACCTGCTGAAACTTCATGATCGAGATCACCAAAGGAGAAAATGGTACTGGCACTCCAGTAGTGGAGATGAAAAATAATTCCTATGAGCAACAGCCTAAAATACCAGTGAGCTTTATGCTTCTTAACGCTGTTAGTCTATGCTTACCTTAATATCCCTCTCCTAGCTACCAAAGTGGACTTTTATTTAGGAAATGGCCTTGGATTTATGATAGCTGTCTGTGTGATTTAATAACCTCACGTACTCATGAATATCTCAAATTAAAGTGTGAAAAAGCAATGGAATACAGGGAGCTCTAGACATCAAAGAACCTGAAATACTGAAGGGGATGGATGAATGAAATCTATAACACGATCAGAAACATACCATGCTACATTGACTCCTCTGTCTATGTGCGACTTGAAAAGCACCTTACGACTTTCAAAACAAAATATCTCTAGAAGAATATCACAATGAGCCAAAGCCTGAAGTCATATGTCAGCCAGAAAATCTATGGACTTACAGAGCAAAAGATTTCCCTGGTTCCTAAAGTCTGGCACGAAAACGGTTGGAGATAAAGTACCCTATTTGCATTGAACTCGCTAAACAGGATGACTTTTATGGCTAAGGCCCAGGCTGATAAAGAAGAATGCAGAGAAAAGTTATCTGCGGAAAAAAACGAGACGTGAGCAACGAAGAATCAGAAATCTCCAGGGTGGAGCAAAGTACACTAGCCAAAAGGATCCCAGTGCTTTATCTTTTGGAGGACCGGTAGGGAGAAGGAGGAATGGTTCAGAAGGTTTCTTCTCCGCATCAAGCTGAAGTCCTGAGCAAGAAGCTATCCAGTCTATGTGGGGAACAAGCCAGGGATCTTGCCAACACAGAGTAGAGCCGATAGTCAATCTGGAGTTCTCACACACAGCCGAAGCAGCAGCAAGGGAAGTGCAGAAGAGATTGCATCC 8+414)&&'''/)-)$&%%%6>8;=D/5@4(($&"#%$#285D:4992=70335496A>D=)M<FHIABKE9=;=3/7?FEF=9:18:'>>BDE;A=@653,31=>3-13+-23:-4350('+)$$?=&(-(29802H7.1+((8&336>:BA8=A(33'#,168>/1/:>E?F8<JFF-CG4?=>>?3)/:4@=421/80(,$//5.(%0')-1(*::/CBL=:;63);(A-6/197<;<7;0?<4//H48=<@K9<7==:,/;5992//)),++(&&00&4,14;5>928''&'','&''$$"(=A6CB>64&%#"&'*.30154.*454(**2%$'*.-*$#$#$%-%%42??G=+).BGC-3B>4-*38G@@*:=<9358@D<9,354A26;@;BA*+&--'((%(0612:8;=03.;68-.1671-9G<=ID<1-.-@@9?3-1>&,,-:>(767A;;>:I7D@B/;67&)%6C8$$#$#%'14:670-3/-B<*'9***''#&02')(('$%$$%"&)(/4++92$*+7,:<9++1507;7>//26-:&&;;-,<2:)%($A8DAB=<7;7&);(.($48:<A.+1%()1)@B96?*B3'>>41(('$'),-.99@=B5EMF/,(@=13:;D1(5<7&%/4G89,2N95(4==>=+''9768=;<CA?:'%%&$&$$$)*')*0'&%(/.00/.,.*,,12*((+33&&106@;2///.)'$$72=;85:DH:C58EBEC83:=;>43D'&%'9A;C716<8?:9;/46<;8FDD1'/)'8;:>1BA61:;AD.:2$+CJ:9<*<//9.,/01//C0C<8;D?8DC=6??1@<7*4$+)&&.)&('%#%-,63-.BF?>;-/32,AC110;5((#30;?8))9>%%(#'16;D8/..((E?ABBGFI5/3%&/11=D:1+'+*(/>I/*A4&$.76<878/%1.;=?83;)D7,124=>=?@;<4=B)9111'''3$$%'6'94*,,4$5//,,,(+,GHE59>0,65.%%$#+637&@C=:295A/FPJ30'&&&)2/CLKF?8@@A+B@>BGI7/)('(?58>(:?$8>>7=79;:5$#(63/5=7/'%)(&&/),)3??=168899+-&).3?>,@C188=512>&;5=7241?-(4GPE?8.A>802827((&)+$$DQLA=97)43)/(&&++1.,%'()5$.,:80.+0,12<=;:?E@/-53,,/;+5A23966%%.+<((&$),&&-0FE@6@=I8>$39;=D@:<>3-->:'18956=223$&#:+@C7+$$--10KRGBB?6-28B<ERVC)1-+48=6-<>,0/2##6>I?</03AII?B@@<31-.8701,.$&+/4'-67?541,,($.(08@511/+))2/.+;1.+,3>O87A92.*)-+$&'&46<<;33.,69*56?CA<??C833IF5AD)%$&&+//$$%(*)),@503.2=11%16:49/.*+,---,&)&&5//A*023*:-)0*+(%&66&4=::E33MB<0/1/()&*-,--+378714056G@=@3)?8@@;7CB9)586993+%'''$##%*+$$0,+,/4100?520*5050&(+C21+<*-+?@;@,2<PH5588<8,:?21#1?:D1026E.'AB>5#$-())+132657=0-:34:4ABFF>&)?=&&%'75:+04)'&&+)%D:8B9-9612=CHD?;@D89@;$$$1$.994=::9??83).>//.(%&%$'(()))%%45++@+BA56'(&;DBDB@A5;85602$##.)),.::?<992:A=D8JCA>4.-<,245;<9B7;>BC::=E<9<558FK@??E8<;,/7=940/4=??=B>=25<C54TC;;;-21)&'&,/?>5&$'=6::0$)*+,1&&663:794-+,,-1/>:13,-1@>/11>K@;>1$TUN?=BDAADK>93+)$621A@@M?2.1)0//;FE66'>>C;>Q::BD;2,=.IE::%%%)..,-/2;<685236;6;5->9%1@67=$@6:1.?:6/)9>4)/38?@*);3ANAA<=;9((-*1*+/3=B@/@UX.?-:BF?CI@9B?96)+8;85+-)D''';1=**6.B7>E6-**&)&98C<3:AD:C@?@;A##*$%%.=D8&+,0--/''C>?9;BC../:&$%3G@.:2E<>8?=A3611D>B6<:7)<89:''.62,%&&'5R=<F@(($,@6<B482145415,+'234:9:,.--8:.05<KC@941/32?8==-&E<=A NM:i:217 ms:i:1655 AS:i:1655 nn:i:0 ts:A:+ tp:A:P cm:i:322 s1:i:1541 s2:i:0 de:f:0.0718 rl:i:0 4caf762c-9527-47b6-aaea-5c0d324eda2f 0 ENSMUNG00000000050|ENSMUNG00000000050.1|testis 587 41 19S27M1I8M1D19M1D37M1I63M27S 0 0 GAAGTACCATGAAGCTCAGAGACTCTGACACGTCTCTGAGACCTTCTAATGACAATCAGAACGGTAGCCATGCAAGAAGCTTGGTGAAATAATCTCAAAGCAGTCAGCACCAAAAAGTGCAGGTCCAGCGATCTGTCTCCCGAGAAACCATCACTATTCATTTCTCTGCATTTGGAAAAAAAAAAAAAAAAAAAAAAAAAAA 9-C52=3+++)%((($%%',5;64&++.2$$783&($+52)%)%&.,217;<&&>4DC@2288C9<@<41//#$'$#%'897:2@+$$$$.;><+(%%%>9$.0%9IC,45/7502>;I@583-.((77B2>52%&&-(9>B@E@;2522;IGD4<5/':=A@<45+@@877655555667889987766777 NM:i:14 ms:i:112 AS:i:112 nn:i:0 ts:A:+ tp:A:P cm:i:16 s1:i:73 s2:i:0 de:f:0.0886 rl:i:28
The output: Pool4_merged_t_rimmed_BCconsensus_transcripts.fas:
02e3c0c0-b1b5-4f5f-8bf5-05f83f97fbd3|330 TTTTTTTTTTTTTCACAGTTAACAAATATTCTTTATTGTCAGGTCTCAAGACATTATCATAATGGACATTTTTGGACTGTATAAAAACTACTTTTAACTC AGTGTAAAAGCTCCGTTGAATGTATGAATGATAGCTTAAGAAAGTTTAGAGTAGCAGTTATGGAATTCATTCACTTATTTATGAATAAGGTATAACAGGT ACCATTCATGCTTTGATCCAAGAGCATTTACAGCTTTGTTTTTGACACTGGTTGTGCCTACAGCTTCTGTATCAGAATTGCAGAAGCACCTCCTCCACTC CATTGCAAATTCCTGCAAGGCCGTATTGTCCTTGTTTCAATGCATGGGCCATGTGAACAACGATTCTGGCTCCAGACATTCCTATAGGATGTCCAAGAGA GACACACCTCCATTCATGTTTACTTTTTGTGGATCAATACC c7a0033e-8bd3-4ea8-8539-8cfe406f915f|85 TTTTTTTTTTTTTTCAAGAACAACTGTTCTTTATTTTATTGACTGGTTGAAGCAGGACTATAAGCCAGGTATATTTCAATCAAGTGTTGGTCCACTCTTA CCATCAAAAAGAATTTTTTTTTTTTTTTATAATAACATCAACACAAATGGAAGGAATATAAAGCGTCATAATAGGAACTTTCAACTGTACATGATATGAG ACCATGATCAGACTGGTGCTACTTCAGTATTTATAGACTCTCCACTGTACAGTCCAGCCACACTAGTGTTATTTACCTCCAATCATTCAAGTTCTAGGTA AAGGATCCTTCTGACTACAGCTCACATCTGAGCCACCAACATGAAATCAAAATGCCATTTGTGCCACTAGCATTGTAGTCTTGTAGAAATATTTCTATAT TTAGCATATTACTAAAGAATAATTACTATCCTCTCTGAAGTTACATATAGCCATTATAAATATTTACATCAAACATTTACAACTGGTTCATAATATACAA CACAAGAATTTAGCTATAGTTTCTAATCTTCCAGTGTAAAAGTTTCAAACAACATGTTGCTATCATAATTTCATCTGGTTTGCACACAGTCACAGGCAGT ACAGGGTATTTCAAAAACTCATGTCACATAAAAAAAAAGGAATGATGTTACTTTAATAACAATTACCTTGGGGATTGATTGTTGTTGGTTTTTGTTGGGG TTTTTAACAAGCAGTTTTCAATTTCTAAACCCCATCTGATGCTACTACTGACATTTAAAATAAGCTTAAGAGGGAAAAAAATACTTAAAAATAAATACAC CTTTAAAAAATTCCACAATTAACCATGTCAGAATATTTGTTTTCCAGACAGCTGAAAGGAGACCTTACTCTTCATCATTTCCTTGCACTGAAACAGAGTG CAGTTCAATCCATTCTTATCTTCTGATTTGTCATCCTATAAATAATGCTGTCGTAGCCAGGATCCATGTTCCAGAGGTTGTAGGAGATAACTATCACAGC TAAAGCAAGACCTATCATCATCCACAAAATAATGTTGAAGATTACAGAGTAGTTGTAGTTATATGGGTAGGCAAGGTTATATGGATTGTCTGATTCACTC TGTGAGATTGGAGAATGAGCGAGTCTTCCTTATGTTGGGAGAAATAAACGCCTTTACAGCTACCACTTCTACTACTGCATTCCCACTATACAGATTAAAC ATCTCATCTGCAAACTTTTGCAAAGAGTCTACAAAATTTGAGAAGCATCCTTGAACTGCTGAGAGTCTTCCCCATATCGTTTTCCAACCTCTTCCAAACC AGACAGTTCAGAGAATACAGGTCTGGAGAGTGATCTTTGGCTAAGTGCTTGTGTCGAGACAGCAGGCTTGCAATATCATGTAGGACTTGTAGTTCTGACA GAAAAAGCAAGTCAACCTCATTGTTTCTGCTGAGGGAGTTGAGAGGAAGGGAGCCAAGAATAGAGTTGTCCTGGAATAAGCGGTTTCGCAGTTGGCGCAG TGTGACAGACAGATCTTCAAATACAGAGTTTGCCTTACCCACCATGTATACCCTTTCCTCACTGGGGGCCAGCTGCAAGACCACAGGAGTCTCCTCAGAG AACAAAGTATGAATAGCATTTGCAACACTGTCAAGACTGAAAGGAACAGCATTCTCAATAGGGTAAGAAACCCCTTTCACAGGCAGTGCCAGCTTGTCCA CTCCCTTCACAGTTACCAGCACAGTAGCTCGTGGTCTGTGAAACAGATCACCCACTGCAAGGCCAGGCCAGGAAAGGTCCTCTTCAACAGAAAAGCCCAT AGACAATGCAGCTACATCTGGGATCCGCTCACCAGGAATGGGCCAACTTCCATCTCGAAAAACAACTGACTGAGGTGATCGTAAGACACTAAATTCATCT CCACTTACACTGGCAAGACAAGCCGATGTAACCAGCACCGCCACCTCCAGGGACCAGAGCACCCCGCCACGGCACCCCATGTCCGCCGCAGTCCCGGACA CCGCCGCGCTAAGAGACGCCGCTGGGAAGACGCCGGGCCGCACCGTCAGACCGAGACCACC
I would be very grateful for any help.
Hello, I am employing pinfish to analyze Nanopore cDNA data. The tool polish_clusters returned an error:
polish_clusters: 12:56:31 Polishing cluster 70ac1799-5f4b-411b-86be-57459f716c3e of size 101 polish_clusters: 12:56:31 Failed running command: racon -t 40 -q -1 /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reads.fq /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/alignments.sam /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reference.fq > /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/consensus.fq - exit status 1
Here are the commands I used:
alignment
minimap2 -t 24 -a -x splice ref.mmi pass.fq > aln.sam
conversion
samtools sort -@ 24 -o aln_sorted.bam -O bam aln.sam
prepare annotation
spliced_bam2gff -s aln_sorted.bam > raw_transcript.gff
# cluster_gff -a cluster.tsv raw_transcript.gff > clustered_transcript.gff
# polish_clusters -a cluster.tsv -c 50 -o consensus_transcripts.fas -t 40 aln_sorted.bam