errors from polish_clusters

[Tiezhengyuan]

Hello, I am employing pinfish to analyze Nanopore cDNA data. The tool polish_clusters returned an error:

polish_clusters: 12:56:31 Polishing cluster 70ac1799-5f4b-411b-86be-57459f716c3e of size 101 polish_clusters: 12:56:31 Failed running command: racon -t 40 -q -1 /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reads.fq /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/alignments.sam /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reference.fq > /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/consensus.fq - exit status 1

Here are the commands I used:

alignment

minimap2 -t 24 -a -x splice ref.mmi pass.fq > aln.sam

conversion

samtools sort -@ 24 -o aln_sorted.bam -O bam aln.sam

prepare annotation

spliced_bam2gff -s aln_sorted.bam > raw_transcript.gff

# cluster_gff -a cluster.tsv raw_transcript.gff > clustered_transcript.gff

# polish_clusters -a cluster.tsv -c 50 -o consensus_transcripts.fas -t 40 aln_sorted.bam

[bsipos]

Please check if racon is running properly on your system. If not, please compile the latest version from source.

[Tiezhengyuan]

the racon is v1.3.1 . It works very well on pinfish/polish_clusters/test_data/sirv_e0_sorted.bam. But racon failed when I worked on my data.

[superuser@A4]$ racon --v v1.3.1 [superuser@A4]$ racon -t 40 -q -1 /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reads.fq /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/alignments.sam /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/reference.fq > /tmp/pinfish_70ac1799-5f4b-411b-86be-57459f716c3e_960787481/consensus.fq [racon::Polisher::initialize] loaded target sequences [bioparser::FastqParser] error: invalid file format!

[bsipos]

Could you please paste here the head of reads.fq and reference.fq?

[Tiezhengyuan]

The first coupe lines of reads.fq:

@f82a9341-d2cc-46dd-b19b-c71bb35304c6

+

@361d0257-1be3-44ae-a1b1-5186a01ca67a

+

@25ada1a3-4b67-4d63-991a-e8ce5bf17199 TTGTTGTACTTCGTTCCAGTTGCGTATTGCACAGCACCACAACACACACACCATATCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCCAACCCACTTCACTAACAACACAGTAAGCGCTCTGTGCAGGTAGAAACAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCAAGTATCACATACACACGGTTTAGCCTCATCCACGTTCAGCTGCTTCGCTACTAGCAGAATCATTAAATTTATTTTTCTCACCTCCTGCAGGTACTAAAGATGCTGCTTCCCCACGTACTTAACCCCCACACTGACTATGAATTCATCAGCAGGTACCTACCATAACGGCAGGCGGGTTTCCCCCATTCGGACATCCTGGATCAACGCTCAATTGACAACTCCCCGGGCTTAACGCAGCCTTACGCGTCCTTCATCGGCCCAGCATACCAAGGCATCCACCATGCGCCCTTAAATAAACACACACCCCAACCAACACACAATCAGCTGTGGGGTGACAACCATATTCAAAATACTAAATACACACCAACCAAAGTTGGTATGCGACGTTCTCACCAGAAAAAATAAGAAAAATTACACACACCACACAAAACACTTCAAAAAGCACTCGTGTGGGTAGGATGCTCCGCTTTGCGTCTTCTGCCACAGTTCTCCACACCAACACTACACCACCAACCACACACCCCTTTGCAAACAAAGCGTTTAGTGCGTGTTTCGTGATGCAAGCACGGGACCAGCCCACATAAAGTGGATTGCTGTCCCAGACACCCAACAACCAGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAGCCTCTATAACTGCCGGGGTATGTTTTCCCACTCCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCACCAACACCCACTTTACAACCGTGTGACAGCAAAGATGTTTTAATTTAAAAGCTCGCCCAGAAGGAGTGATCAGCCGCACCTTCCGGTACGGCTACCTTGATACGACTTCGTCCCAATCGCCGATCCACCGACGGCTCCTAACAAGTTTAGGCCACTGGCTTCCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGGAACGTATTCACCGCATTTGCCTGATCTTGCGTTACTGGCGACTCCGGCCATGGGGTCGAGTTGCCGGAGCCAATCGAACTAAGGCCGACTTTCAGGATTCGCTCCACGATGTCGCTGCCCATTTGTATCACGACCATTTGTAGCGTAATGTGAAGCCACGGACATAGAGCATGATGATTTGACGTATCCCCCACCTTCCTCGAGTTAACCTACGCCCAGTTTCTCGCATGAGTCCCCACCATCACGTGCTGGCAGCATAAGACAGAGGTTGCGCTCGTTGGGATAACCCAACATCTCACGACACGAGCTGACGACAACCATGCACCACCCTGTATACAGACCACAAAGGGACGAACTATCTCTAGCCCCAATCCTGTATATGTAAGCCCAGGTAAGGTTCTTCGCGTTGCGTGAATTAATCCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGGAGTTTTAGCCGCGCAGCCCGTACTCAGGCAGGGCGCTTAATACGTTAGCTACGGGCACAGAAGACTGTTGATGGAAGCCCCTACACCTGGCGCCCTCGTTTACGGCATGGACTACTGGGTATCGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCTACACCGGGAGTTCAGTCTCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCGCCCGAAGTTAAGCCCGGAGTTTCACAGACGACGCGACCCGACCACCTACGAGCTCTTTACGCCCAGTAATTCCGGACAACGCTTGCACCCTACGTATTACACCGCGGCTGCTGGCACGTAGTTAGCCGGTGCTTCTTATCTACCGTCACCACCCAAGGTGAAGCTTCGTCGATAGCGAAAGGAGTTTACAGCGAGGCCGTCATCCCCACGCGGCGTCGCTGCATCGGGCTTGCGCCCGGTATTGCAATATTCCCCACTGCTGCCTCCGTAGGGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCCGTACCACTCGGGCCGGATACCCCGTCGCCGCCTTGGTAGGCCACCCCGCAACAAGCTGATAGGCCGCGGAAACATCCCACCGCAAAAGCTTTCCCACCCACAACATCAAGAAGTGGTCCTATATGGTGAAGTAGACCCAGTTTCCCGGGCTTATCCATAGTGGGAACTCACTTGCGTGTTTGCTGCGTTCGCCGCTCAGGTACTGCGGTACGAACGTTCCGACGTGAAATTTGGCGCGCGGCGTTTAAATGCAAAACCGGATCAAACTCTCTAAAAAAAGGCTGTGAAAAGCCCAGAACCTAACCAAAAGACAAACAACACAAAACATCTCTACTAAGTGTGAAGCTGACCAAAGGAGTACTACATAAAGAAATCAACAAATAGCCAACCAAGTAAAAAATGCCAGTTGAGTAAGGTAAAGTGTTTTAACCTGCATCAGCAGACAACAATTACATTCATTCAATATGTACCGTTACAGTATTTAACTATTTTCAATGCCACCCATAACGACAAGTGACATCCGGTACACACCAACAACAAACAAACAACAGTTCATTCAGCCCAACATAATTCTCATCCACACAACACAGACAAAAATAAAAATCTGGTACATTTGGCACACTGGTAGGTTCTCAGACAACAACCACACCCGCAACCCATTACCACATACAGGGCGAAGATAAGTGAATGAAAAGTCTAGAAATAGAGTTTGCTTTACATCAACGGCTGTTTCCCTACCATACTCACCAGAACCCTTGGCTCATGCGGGGGCGTTGTCGGTCTCCTTGGCTATAAAGTTACACCAACCAGAAACAACACAAATCCCCAGCACAAAACCACATTTTCGTTGATCTTGATTGAACTTGGTTTCAGCTCATCGCGACACTGGTGCCATTCCGAACCAACACGCGAGCCCACCAGGGTAGATATTGGTCTTACGAGCCATGCTCAGAGCAACAATGCCAGCGCTATGTATCCACCAAGCGCGGCCAATACTGGAAGCAGGAAGCCACAGGCAATACCGATCATAACATAGACTTCGAGTGCTGCTGCGACGGCGACTACGGGGATGGTTACGGTCCAGCTCAGACGGGTGGTTAGTCCAAATGGTCGATGGCTAGCGGTAGGACAAGGTAGGCGGCGAGGGCACTGAGGTAGTTCCGCGGTACGCCGGCACCTAGGACCACGAGTAGTCCGGGAACGCTGAGTTGATTGACTCGTTAGTTGCGCCCAAAGTTTTGCGCGTTCGCCGAAAGCTACATATTCACGCAACGGCGTCGTAGCTGATGTCTTCATAAACAATGAAGACGATGGGCTGACGGCTTAACCGGTATGAAGGAATAGCCTGAAGCCCAGTGGTTTATTAAACAGGGGCGCTGATTATCAATAGAGCAGGAGACTAGCGCGGCTACGCTGACGATATACATGGCACCAGCGACTTGGGGTCTCATGACGAGCTGGCCTTCGATGGTCACGGGAAATTGGCCGTCATCGGTTCTACCGCTTGTTCCTGCCAAAGGTCGCCCTTCCTAGAGCGATCACTCCTTGGTATACGGGGATTGCGTGCCTAAGTGCCGCGATAACTAGGTAGCCGACGATAAAACCACAATGAAGATCGATTGGTCAGTACAGTAGCCGAAGGCGGTATTGGGGCGGCCGAGACGGCGATTTCACTCCGGCGTTGCAGATTTAATAATCTCGCCTACCAAGTCAGTCGCCGGAACCCAAAGGATCACCGGCGGGTGCCGTCAGCGGATACCGGCCAAGACAGGGAGGTAGAGGTACTGCGAATTTACTTCCCGTGGACAGGCCAGCTGCCAAGACCGCAAAGACGGGCCGAATTGCCCACCGGGGAGTTTATCAACGAGTTCCCGCTGGCTGCGGATTCATGCCGGTCCTTCTCACCGAGCGCTATAGGACTGCTTTCCAGGTTAACCTTCGCTGGCGCGCGAAGGTCGAGAGACACTCGCGGCATCAAAGACATTGTCCGCTCCGGCGCAATCGCATCTACTATGACGCGGTCACCTAAGGCGGTTGGGTTACGGCAGGGTGTTATCTTGCAATCGGTTGAGTGACGGTCAATGTTTTCTGGGTGGCCGGTGACCTCCAAGATTCCATCGATAAGCTCTGCTACCACCCGTGCTTCATGCCATTGAGCATCAGCACGGTATCGAAGATGCCGGATAATTCGTTGAGGTGGGTGGAATAACTATGGTTCGAGCGTGCTCTTCACGCAGCACGTCGCCAGAAACGGCGCTTTTCTGCGTCGGGCCGAGATAGGGTTCATCGAAGCATGGGCTCACAACCTGAAGCTACTGCCATGATGATGCCGCAGCGGTTTGCCCCCGTGATAGAGCAGAGTGGTTCTTGGACGGTAAGCTCAGTCTGCTGCGGCTACTCGGCGCGTGCGCTTCCACGTTGACCAGCGAGCGCACTGCCCAGACGCATGGGCTAGCAATACGTAACTGA + $&%%&')-57:85766'&)4,#),--30*,'&'/1110,(3)((-..0/.+///4:4('$$%',752231//3559676-7-)&/0''+1,(.&/1)$'(5,15,.582+-'')(0&'(..542//%'#0('(')0))0//7-+,''037&-'(%#)+,,1//154748456:4+'+)01)-23)-+..9862/,3878896.,-,140%'+++.//-./265.,+,,.,./456:67:6::..9<<.471((0,),-./1/--1698)+,&$&%.32386+.(2)$)'0)29:7-(-..-223,1,7)+5)22,&1)&1)++0()0:86;:11.-%.0/<9-9;;,,0;85:787:67303.055381122188/..--9.-/44.2,.0202012/,((%##%#',+75073325),42)(+-/3.5,'&-10631'2,9814116)((467.3..67645)6,-'/-42434,0,.+6..,2333,0.-$'+-01)+))+),$057('(067:1#&'-/386+0(77--0101.+(-,04(08143&+&&&498;;0950'17:/3831%.,-0''''1:70,#&$$'+152#/1/3.20,((.(.-/023+1)#%&)&-,-22/2040/.+237,+(&+&*&)%(#)'')016+4245792201,57-)074)11994)5,+,/29/-))'$+/5).61/1%$,&0,1665'+$/5+441:.-037,1.,,1-3340--3:2----1&)#2(2/..71.6,30823:99969;955586786/'"-&.7124630),+-182,()(-2/0287)4+,/224:;/,0)&,5*+5846:+001%7619323778912+++%1+,1997374+-',(2,,,6)('((''(-458/866462,0/393),..6:9$2)7-23/%()'('''.++--',$&&(146%(3(,46:72:'4()$/330%3(%+)),./02724:.462/54:-,,+-$%&))-)(,':(&+-50,/0::-59:8120+/)%'+)+/)+()%%.30

[Tiezhengyuan]

reference.fq (There are only 4 lines) :

@71f61652-7fc8-4901-a511-a16d2ff8f3ff

+

[Tiezhengyuan]

alignments.sam:

@SQ SN:71f61652-7fc8-4901-a511-a16d2ff8f3ff LN:0 @PG ID:minimap2 PN:minimap2 VN:2.12-r829-dirty CL:minimap2 -ax map-ont -t 40 -k14 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq f82a9341-d2cc-46dd-b19b-c71bb35304c6 4 0 0 0 0 361d0257-1be3-44ae-a1b1-5186a01ca67a 4 0 0 0 0 25ada1a3-4b67-4d63-991a-e8ce5bf17199 4 0 0 0 0 TTGTTGTACTTCGTTCCAGTTGCGTATTGCACAGCACCACAACACACACACCATATCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCCAACCCACTTCACTAACAACACAGTAAGCGCTCTGTGCAGGTAGAAACAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCAAGTATCACATACACACGGTTTAGCCTCATCCACGTTCAGCTGCTTCGCTACTAGCAGAATCATTAAATTTATTTTTCTCACCTCCTGCAGGTACTAAAGATGCTGCTTCCCCACGTACTTAACCCCCACACTGACTATGAATTCATCAGCAGGTACCTACCATAACGGCAGGCGGGTTTCCCCCATTCGGACATCCTGGATCAACGCTCAATTGACAACTCCCCGGGCTTAACGCAGCCTTACGCGTCCTTCATCGGCCCAGCATACCAAGGCATCCACCATGCGCCCTTAAATAAACACACACCCCAACCAACACACAATCAGCTGTGGGGTGACAACCATATTCAAAATACTAAATACACACCAACCAAAGTTGGTATGCGACGTTCTCACCAGAAAAAATAAGAAAAATTACACACACCACACAAAACACTTCAAAAAGCACTCGTGTGGGTAGGATGCTCCGCTTTGCGTCTTCTGCCACAGTTCTCCACACCAACACTACACCACCAACCACACACCCCTTTGCAAACAAAGCGTTTAGTGCGTGTTTCGTGATGCAAGCACGGGACCAGCCCACATAAAGTGGATTGCTGTCCCAGACACCCAACAACCAGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAGCCTCTATAACTGCCGGGGTATGTTTTCCCACTCCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCACCAACACCCACTTTACAACCGTGTGACAGCAAAGATGTTTTAATTTAAAAGCTCGCCCAGAAGGAGTGATCAGCCGCACCTTCCGGTACGGCTACCTTGATACGACTTCGTCCCAATCGCCGATCCACCGACGGCTCCTAACAAGTTTAGGCCACTGGCTTCCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGGAACGTATTCACCGCATTTGCCTGATCTTGCGTTACTGGCGACTCCGGCCATGGGGTCGAGTTGCCGGAGCCAATCGAACTAAGGCCGACTTTCAGGATTCGCTCCACGATGTCGCTGCCCATTTGTATCACGACCATTTGTAGCGTAATGTGAAGCCACGGACATAGAGCATGATGATTTGACGTATCCCCCACCTTCCTCGAGTTAACCTACGCCCAGTTTCTCGCATGAGTCCCCACCATCACGTGCTGGCAGCATAAGACAGAGGTTGCGCTCGTTGGGATAACCCAACATCTCACGACACGAGCTGACGACAACCATGCACCACCCTGTATACAGACCACAAAGGGACGAACTATCTCTAGCCCCAATCCTGTATATGTAAGCCCAGGTAAGGTTCTTCGCGTTGCGTGAATTAATCCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGGAGTTTTAGCCGCGCAGCCCGTACTCAGGCAGGGCGCTTAATACGTTAGCTACGGGCACAGAAGACTGTTGATGGAAGCCCCTACACCTGGCGCCCTCGTTTACGGCATGGACTACTGGGTATCGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCTACACCGGGAGTTCAGTCTCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCGCCCGAAGTTAAGCCCGGAGTTTCACAGACGACGCGACCCGACCACCTACGAGCTCTTTACGCCCAGTAATTCCGGACAACGCTTGCACCCTACGTATTACACCGCGGCTGCTGGCACGTAGTTAGCCGGTGCTTCTTATCTACCGTCACCACCCAAGGTGAAGCTTCGTCGATAGCGAAAGGAGTTTACAGCGAGGCCGTCATCCCCACGCGGCGTCGCTGCATCGGGCTTGCGCCCGGTATTGCAATATTCCCCACTGCTGCCTCCGTAGGGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCCGTACCACTCGGGCCGGATACCCCGTCGCCGCCTTGGTAGGCCACCCCGCAACAAGCTGATAGGCCGCGGAAACATCCCACCGCAAAAGCTTTCCCACCCACAACATCAAGAAGTGGTCCTATATGGTGAAGTAGACCCAGTTTCCCGGGCTTATCCATAGTGGGAACTCACTTGCGTGTTTGCTGCGTTCGCCGCTCAGGTACTGCGGTACGAACGTTCCGACGTGAAATTTGGCGCGCGGCGTTTAAATGCAAAACCGGATCAAACTCTCTAAAAAAAGGCTGTGAAAAGCCCAGAACCTAACCAAAAGACAAACAACACAAAACATCTCTACTAAGTGTGAAGCTGACCAAAGGAGTACTACATAAAGAAATCAACAAATAGCCAACCAAGTAAAAAATGCCAGTTGAGTAAGGTAAAGTGTTTTAACCTGCATCAGCAGACAACAATTACATTCATTCAATATGTACCGTTACAGTATTTAACTATTTTCAATGCCACCCATAACGACAAGTGACATCCGGTACACACCAACAACAAACAAACAACAGTTCATTCAGCCCAACATAATTCTCATCCACACAACACAGACAAAAATAAAAATCTGGTACATTTGGCACACTGGTAGGTTCTCAGACAACAACCACACCCGCAACCCATTACCACATACAGGGCGAAGATAAGTGAATGAAAAGTCTAGAAATAGAGTTTGCTTTACATCAACGGCTGTTTCCCTACCATACTCACCAGAACCCTTGGCTCATGCGGGGGCGTTGTCGGTCTCCTTGGCTATAAAGTTACACCAACCAGAAACAACACAAATCCCCAGCACAAAACCACATTTTCGTTGATCTTGATTGAACTTGGTTTCAGCTCATCGCGACACTGGTGCCATTCCGAACCAACACGCGAGCCCACCAGGGTAGATATTGGTCTTACGAGCCATGCTCAGAGCAACAATGCCAGCGCTATGTATCCACCAAGCGCGGCCAATACTGGAAGCAGGAAGCCACAGGCAATACCGATCATAACATAGACTTCGAGTGCTGCTGCGACGGCGACTACGGGGATGGTTACGGTCCAGCTCAGACGGGTGGTTAGTCCAAATGGTCGATGGCTAGCGGTAGGACAAGGTAGGCGGCGAGGGCACTGAGGTAGTTCCGCGGTACGCCGGCACCTAGGACCACGAGTAGTCCGGGAACGCTGAGTTGATTGACTCGTTAGTTGCGCCCAAAGTTTTGCGCGTTCGCCGAAAGCTACATATTCACGCAACGGCGTCGTAGCTGATGTCTTCATAAACAATGAAGACGATGGGCTGACGGCTTAACCGGTATGAAGGAATAGCCTGAAGCCCAGTGGTTTATTAAACAGGGGCGCTGATTATCAATAGAGCAGGAGACTAGCGCGGCTACGCTGACGATATACATGGCACCAGCGACTTGGGGTCTCATGACGAGCTGGCCTTCGATGGTCACGGGAAATTGGCCGTCATCGGTTCTACCGCTTGTTCCTGCCAAAGGTCGCCCTTCCTAGAGCGATCACTCCTTGGTATACGGGGATTGCGTGCCTAAGTGCCGCGATAACTAGGTAGCCGACGATAAAACCACAATGAAGATCGATTGGTCAGTACAGTAGCCGAAGGCGGTATTGGGGCGGCCGAGACGGCGATTTCACTCCGGCGTTGCAGATTTAATAATCTCGCCTACCAAGTCAGTCGCCGGAACCCAAAGGATCACCGGCGGGTGCCGTCAGCGGATACCGGCCAAGACAGGGAGGTAGAGGTACTGCGAATTTACTTCCCGTGGACAGGCCAGCTGCCAAGACCGCAAAGACGGGCCGAATTGCCCACCGGGGAGTTTATCAACGAGTTCCCGCTGGCTGCGGATTCATGCCGGTCCTTCTCACCGAGCGCTATAGGACTGCTTTCCAGGTTAACCTTCGCTGGCGCGCGAAGGTCGAGAGACACTCGCGGCATCAAAGACATTGTCCGCTCCGGCGCAATCGCATCTACTATGACGCGGTCACCTAAGGCGGTTGGGTTACGGCAGGGTGTTATCTTGCAATCGGTTGAGTGACGGTCAATGTTTTCTGGGTGGCCGGTGACCTCCAAGATTCCATCGATAAGCTCTGCTACCACCCGTGCTTCATGCCATTGAGCATCAGCACGGTATCGAAGATGCCGGATAATTCGTTGAGGTGGGTGGAATAACTATGGTTCGAGCGTGCTCTTCACGCAGCACGTCGCCAGAAACGGCGCTTTTCTGCGTCGGGCCGAGATAGGGTTCATCGAAGCATGGGCTCACAACCTGAAGCTACTGCCATGATGATGCCGCAGCGGTTTGCCCCCGTGATAGAGCAGAGTGGTTCTTGGACGGTAAGCTCAGTCTGCTGCGGCTACTCGGCGCGTGCGCTTCCACGTTGACCAGCGAGCGCACTGCCCAGACGCATGGGCTAGCAATACGTAACTGA 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TTCGTGCTTCCGTTCAGTTACGTATTGCTAGGGCTCTCACCTTCTACGGCTGGACATTCAACCCACTTCACCCTAACAACCTGGCGCTCTGTCACGGTAGAAACAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCAAGTATCACATACACACGGTTTACAGCCTCATCCACGTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAAGATGTTTCACTTCCCATTATAACCCCACTGACTATGAATTCATCAGCGGGTACCTACCCATAACGGCAGGCGGGTTTCCCCATTGGACATCCTCGGATCAACGCTCAATTGGCGGCCACAGGGCGCTGGCCTTACACGTCCTTCATCGGCCCAGCATAGAGGCATCCACCATGCGCCCTTAAATAACAAACACACACACCCCACACACCACAAAATAAGCAGGGTGAACAACCATAACTAAAATACTAAACCACACACCAACCAAAGTTGGTAGTAAACGTTCTCACAGAAAAAATAAGAAAAATTACACACACCACACAAACACTTCAAAAGCACTCGTGTGGTGGATGCTCGCGGTCACTATACAGTTCTCACACAACACCCCACACCACCAACCACACACCCACTTCCCGTCTTCGTTTGAGTGCGTGTTTCGTGATGCAAACACGGGGACCAACCCATAACGTGGTGCTGTCAGACACCCAACGGTCTACCAATGTCTAAACCCAGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAAAGCCTCTATAACTGCCGGTGTGTTTCCACTCCGATTCAAACTCAGGCGGCATTACACTCGGGTCATCAACCACCAACACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAGGTTTAAAAGCTCCTTAGAAAGGGAGGTGATCCAGCCGCACCTTCCGGTACAGCTTCTGATACGACTTCGTCCCAATCACCGATCCACCTTCGACAAAGCTCCCTAACAAGTTTAGGCCACTGGCTTCAGGTGTTACCAACTTTCATGACTGACGGGCGGTATGTACAAAGGCCGGGAACGTATTCACCGCAGCATTGCTGATCTGCGATTACTAGCGACTCCGACTTCGCTGGGGTCGAGTTGCAGACAATCGAACTAAGGCCGACTTTCAGGGGATTCGCTCCACCTCACGATGTCGCTGCCGTGGCATGAACCATTGTAGCATGTGTGAAGCCCTGGACATAAGGCGCGGTGACGGCTGATCATCCCACCTTCCTCCGAGTTAACCCGGCAGTTTTCTCATGAGTCCCCACCATCACGTGCGCTGGCAACGCCAGACAAGGGTTGCGCTCGTTGCGGGATAACCCAACATCTCGGCGAGCTGACGGCAACCATGCACCACCTGTACAGACCACAAGGGACGAGCTATCTCCTGGCGTCGCTATGTCAAAGCCAGTGAGTTCTTCGCGTTGCATCGAATTATGCTCCGCCGCTTTGTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCGGCCGTACTCCCCAGGCGGGGCGCTTAATGCGTTAGCTACGGCACGAAGACGTGGAAGCCCACCTAGCGCCCTCGTTTTGGCATGGACTACCAGGGTATCTAATCCTGTTCGCTACCCGTAGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGGACCTGCCAGCGCCGCCATCCCGGTGTTCACTCCTGATATCTGCGCATTTCACCGCTACACGGGAATTCCAGTCTCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCCGGAGTTTCACAGACTGACGCGACAAACCACCTACGAGCTCTTTACGCCCGAAGTAATTCCGGACAACGCTTGCACCCTACGTATTACCGCGGCTGCTGGCGTGGTTAACCGGTGCTTCTTATCTACCTACCGTCACCTGGGCCGTCGATAGCGAAGGTTTAGCCAGGCCGTCATCACCACGCGGCGTGCGCATGGAGCTTGCGCCCGTATTGCAATATTCCCCACTGCTGCCTCCGTAGGAGTCTGGGCCGTATCCTCGGTCCAATGTGATGTGCACCCTCTCAGGGCCGGATGCGTCGCCGCCCCGG 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TTGGTATGCGCTTCGTTCAGTTACGTATTGCTCCTCACCTTCTATAAGCCGGGCATTTCCAGCCCATACCTAACAGCACAATGCGCGCTCTGTCACGAGTAGAGCAGAAAATCATGGCCCCACAACACCGCATGCACAACCTCTACCATTATCACGCCACACGAGTTTTAGCCTCATCCACGTTCGCTCCTTACGCTACCGCCAGAATCGGTATTTGGCCTGCTCCTCCTGCGGAGTACTAAGATGTTTCACTTCCCCACGCTATAACCCCCACCTGGATTCATCAGCGGTACCTACCCATAACGGCAGGCGGAAGGTTTCCCCATTCGGACATCCTCGGATCAGCGCTCAATTGACAACTCCCCGAGGCCAACGCAGGCGCCACGTCCTTCATCAGCAGCATACCAAGGCATCCACCACCTTGCGCCCAGCAAATAACAAACACACACGAAATGCATGGGGGTGAACAACCATAACTAAAATACTAAACCACCAACCAAAGTTGAGTATACGACGTTCTCACAGAAAAATAAGAAAATTACACCACACAAACGCCAAAGCACTCGTGTAGTGGATGCTCGCGTCCACTTCTCACAGTTCTCACACAACTTTTACACCACCAACCACACACCCACTTTTTACCAAATAAAGCCCATTTTAGTACGTGTTTCGTAGGTATTCACAAACACCGGGCCAGCCACGCAACGTAGATTATCCCCAGACACTTAGTGCACCAATGCTCTAAACCCAGATTTAATCTTGCCTGTGTTTATGTCTCAGAATTCATTATTTGTAGCCCTCTATAACTGCCAGTGTGTTTTCACTCAGTTCAAACTCAGTAGCGCCTTGACCACCTCAGGTCATCAACCACCAGCACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTAGCTCCTTAGCAGAAAGGAAGTGATCCAGCCGCACCTTCCAGTACGGCTGCATGACTTCACGTCCCGATAGCGATCCACCTTCGACTGGCTCCTACAACAGTTTAGGCCACTGGCTTCAGGTGTACCTGTAGCTTTCATGACGTGACAGGCGGTGTACAGGCCGGGGAACGTATTCACCGCAACGTGCTGATCTGCGATTACTAGCGACTCCGACTTCATGAGGTCGGGTTACGGATACGAAATCGAACTAAGGCGACTTTCAGAGTTCCTCCACCTCACGATGCTCGCTGCCATTGCTTAGTCGACCATTGTAGCATGTATGAAGCCTGGACGCAGAGCATGATGATTTGACGTCATCCCCACCTTCCTCCGGAATTCACTGGCAGTTTCTCGCGGAGTCCCCACCATCGCATTACTTTGGCAACATAAGACCAAAGGTTGCGCTCGTTGCGGAACCAGCAACATCTCACATTGAGCTGGCGAGCAACCATGCACCACCTGTATACAGACCACAAGGGACCCAGACTATCTCTGGCCAATCCTGTATATATCAAGCCCAGTGGAGTTCTTCGCGTTGCATCAGATTAATCCACATGCTCCGCCATGTGCAGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCAGCCCATGCTCCCGGGCAGAGCAATGCGTGCTTCTGGCGCAGAAGACGTGCGGCCCCACACCTATAGCGCCCGCCGTTTACAGCATGGACACGGGGTATCTAATCCTGTTTCGCCTACGTAGCTTTCGCTCCTCCAGCGTCAGTTTTACTTGAGACCACTGCCTTCGCCATCGGTGTTTCCTCCTGATATCTACGCATTTCACCCGCTGCAGGAATTTCCAGTCTCCTACAGCGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCCGGAGTTTCACAGACGGCGCGACCGACCACCTACAGGCTCTTTACGCCCAGTAATTCCCGGACAACGCCTACGTATTACCGCGGCTGCTGGCGCGTAGTTAGCGGTGCTTCTTCTACCTGCAAATCACCTAGAGTAAGCTTCGTCGATAGCAGAAAGGAGTTTGTAGCCGAAGATACCGTCATCCCCGCGCGGCGTCGCTGCATCAGGCTTGCGCCCGTCCAGTAGTATTCCCCCACTGCTGCCTCCCGTAGGAGTCTGGTACGTATCTCAGTCCCAGTGTGTCCATACGCTCAGGGCCGGATACCCGTCGCGCCGCCTTGGTAGGCCGTACCCCACCAACAAGCTGATGGGCCCGCAGGCTCATCACACCGCAAAGCTTTCCACCCACAGCATCAAGAAGTGGTCCTATAGTAGTCAATGGGCCAGTTCCCAAGCTTATCCCATAGTGCAGGGCCAGATCACCCGTATTTACTCACTTACGTTCGCCCACTCGAGGTACTGTACAAATTTTGGGCCTTTCCGTTCGACTTGCATGTATTGGCGCCGCCAGCGTTCATCCGGGCGGATCAGAACTCTCTCCACCGAGGCTGTGAAAAGCTAAAACCAACCAAAAGAGACAAACCTTTTTACAAAACATCACTTATTAGCCAGGCTGACCAAAGGTACTGCATAGAATCAACAAACCCAACCAACCAAAGTTAGCCAGGTAAGGTAAAAGTGTTTTAACTGCATCAGCAGACAACAATTACATTCAATATGCACCGTTACAGTATTGCTTCTTTTTCAATGCCACCCATAACGACGGTGACATCAGCGGTACGCAACAGCCAAACACACCCCGAAGGAATGCTCAGTCCAACATAATTCCTCATCCACACACAGCACAGACAAAATAAAAAATCTAATTACATTTGGCACTGTGGGTTTCTCAGACGCGGCTTCACACAAGATGAATTCGGCTTCGCCCGGCTGTTTTTAAGCTCTCGGCGCGGAGTTTCTACTATAGACAAACTGTTTGACGTTTGTCAACCGGTAACTTTTATGCCGCACGCTCTCTCGCGGCGGCTTCGATAAAGTTACACAGGACCCAGATCTTTGAAATGATCGCCAGGTAAATCCACGGTTTTAAGATCGGGCAAACAGAGCCCGCGAGCTTTCATTTAAAGACTGCGCTAATGCAAGGTTAATTGCTCAAAGCGCGGACTTCCGATGGAAACTGGCAGAGATGGAAGCCTATGACCTATCTAGGCCTTGGTGCGATGAACGCCGGCGAAGTTAACAACGCGGCGCATCACAAGCCATGCACCGTGGAAGTCATCTTCGGCGGGGTCCAATCATCAGACTCGCTGGTGTGGCGTACGCGCCGCCCAGCTAACTGTAATCGTGCGGCAGGCTGCACCCGCGCCGGAATCAGCGGGCCAGAAGCAGCAGGCAGGTCAACGATTCCGAAAGTCATCATCGCCAAGCTCTGCCACGTTGGTCTCCGACAATGCGCCTTACAAGTCTTTTCATCAGATCCTTTAAGTTCAAGCGCGACCGAAAAGTGCCTGCGCGGCAAGCTCTACTGCACAGGTGGCCTCGTTGCATGTACCCAGAGTTGGTCATCTCTTGCGCGGAAGGACGGCGCTTCGTCAGCGCGAAGGCTCTTCTTCGGCGGCAGCCTTGGCGTACTCAGCGATTTCTTCTGGTTCAAGAAGGTAAGCCAGCGCGGTGATCGATGACCACGGGAGTCACCAGCGTTGAGGAAGTACTGGTACCGGGAATAGGCCGAGGTCTTGTCGGATCCAGCCACGGCTTGCCGCCGCAGTGGACTTGCCAGAGCTTTTGTCCTGCGCGTCGGTCACCCAATGGACAGGTCAGCGCGTGCGCTGGCTACTTCATCAGCACGACGGTTGGGATCACGGAACGATGTACTTACTGATCGCCGCCGCAACCTGCAAGACGCAGTCGATACTTGCGCTGCAGCTGCACAGGTCGGTGGCCTGCAGGAGCATGTAGAAGGGAATTCCGTGTAGGAGATGCCGTCGAGTTTCCAGGCAGCCCGGCGGTATCGCCAGTCCAGCGCTGGTGAGCAACGGAAGTTCTTGCCAACATCCGCGCAAGAGAATCAGCCGGCGGACGCTATTCATCGTCCGATGGCATTGTGTGGCCCGTATGATGGCTGGAGTTTGTCGCCATCAAGTCCACGGGTGGCGGAAGCTGCTTCTTACGATCGCCTCCCGGGTTATTATCGATCTCGTCTTGGCTGGGCATGGAGGCGCTCCCCACATCGTGGTCATCGTCGCCAGTTGCGCCACCCGCCAGTGCAAGTATGGCTGTGCCCCGGCTTCTTGGAAGCGACGCAACATAATCATCGGCACCAAATGCCGGCGTGCGAGAGTCATGGTAGGGAGTCAGAATAACGTAGGGAAGTAATAAGGACTTTCGCCGGCTACACGCCTTGGGGCGTCGATATCAGTGGACTGGTTAATAGAAAGCCCGCGCCATTGCAGTTCATCGATAATGTTCATAGTTTCCTCGTTTAGATTCTAGAAGGGTGCTGAGTAAAAATTTTGGCCGCTGAAATTCAGCTGCGCAGGAGCTTACTGGGCCTTCAGCCATGGCAGCGTCATCCACCAACGTGGCCAGATTCCATCTTCCAATACGGCAATCCCGGGCGCTCGGTGGCTAGGACTTGTTCATCTTTCCAGATAGGCTCAATATTTGTCCTGCGGGCACACAAGTTTCTACTGGCGGGATCTAAACTCATGGTTTCTTATCGTACCTTCTCGCCGGAGTCTCTTCTGCTCCTTGACCCCAGAACTATCACCGCTTGCGCCTTCCTCCATTTTTGGACGAAAGACTGGCGCGGTAAAGTTATGGAAGTAAAGCTACAGACTATACCTGCTGGAAGAGTGTATCAGCTACTGGCGACGACGGGCGACCATTGGGATCTTGCAGGTCCGTAGCACCGGAATTGCCTTATGTGACTGGGTCAGCAGAAGCTAGACCAGCAGCGAATCGGCTGGAACGCCCGCGCTGCTGTAGAGGAACTCCTCATATTCCGCTGGGGTTTGGTTCACGTATTCCACATCCTTTGCCCAGCCGCCGGCCAATCTGCGCCGCAATATCCGGATGGAGTCAGGGCTGGCTGGCGCCGGCGAGCTCAGCTGGAGCCTTTCCGGCATGTCCGTCGGCCCGGTGGTAGCGACAACAGCGGCCGCCTCAGCAAAGTCCGCACGCAGCGCCAGGGGAAACCTTAAGCTTCACCAGCAGCAGAAAGAGACTTGCAGGGACTTACCTGTCTCGGGCCGGAGGCATGGTTGCCAGCCGTTGCGCAGCCTTGCGTGCTCGATGCCGCTATCAGCCAGCAGCTTTTTCCCGTCGCCACGTGTTCAGGGCCAAAACAGTTCTGAGGTCCAGGTTCAACAAGCTGGTGTATATGCAATCCTAGGCAACACCAGCAGATTTCGCCGCATTGACGATATTAGTGTACTGTGAATCAATGCGCTTGCCCACCTCACTGTGGAGACAGACTAGGCCGGTCCACACCATCAAACGCTTTCCTTAACTTGCTGATTCATCTTCATAGGCAGCAGCAGCGTCTTAGTCCCCCTCTTCGCTAGGTCCATAATACCTTTTCTTCATTTGCAGACAACAGCAGCGATATCGGATGGGGGCAGCATGTGAGCGAGCAGCCGATAGTTAGTCCATGAATGACCCGTTACCAGTAACAACTAATGCATGTAAGAACTCCTTGAAGTAAGTGATTGTTGTACTTACACCAGAGCCTAGCGCCTGGAAATAGTTAGTGCAATACTTTCATTAAGTAGCACTCACGGTCTAAAAGGTAGAAAGAACATATCCACCTCTCTCAAGAAAAGTCACTTAAGAATCTTCCCCACGCTGCCGATGTCTTTTTCCGCCCTGTACTCATCCCGGGGCGCTTCAGCACCTCACGGGCCGTTGAGGATCGTTGACCATAGGTGGCGCTGTTAGAAGCTTAATTACTCCCCTACGCTTTGCGGAACTACATCGAAAAAATAGAAGGCATTAGTGACCGGATGATGTCGCAGACTTTGGTAGGATTAAGGCGCGACAGCATGTGGTCAAACTGCGAGGTCCACTGAATCCATTCCCCGCACGTGGACTACTCGCCTCGCTGGGAATCAAGGTTGCCCGACCACCTGCAGACGGTGGCCGGATCAATTTGAGTCACAGTTGGATGGGGTCATCGCGTCGCAAGGGCTTTACGATGCCAACTGGAGCAATAAATGAGAAAAATGCTCTTATCCCACATTCGGGGATAAGAGCATTTTTACTATCGGCTTGAAGTTCTTAGTTCTTAGCTATATCGCACTGGCGTATTTGCCCACGCGCGGGGGAAATCGTCGGTGGAAAAACTATTGTGAGATATACTGTTCAGCCGCGCGCGTACTTGGCAATTGCCGCCCTTGGTGGAACGAGATGCCACCCGCACCATCGATGAGTAGGCACATCTTTGCAGCTGGCTTGGAGCGACTGTCACGTTCTGGGAGTTCTTCATCAGTGGGAGTCTACAGATCCGCACCCACGAGATTCCGCCAAGCGAACGCATTCGCCCGGATGCCTCATGAGCCTCGCGGGAAGGAACGCGCAACTACAGCGCACCATCCACTCTGCCAAGTCAGTAGCGTAAAGCCCTGCGAAGTGTCGAAAGCTCGCGCATGCATCTCAGTGTGGAATTCCAAGGTAGGGGAGACCAGACCCGCATCATAGCCGGTAGCAGCAAGTTGAGCTGCGCGACCAGATCCACGATGGGTTCTTTATCTTCTTGCGGAGTCACGGTTATAGGCCAAGGGCTGTGCCTTTAATGTTGCGAGCAAGCCGACAAGGTTGCCAATAGGGCGTCAGCGGTTTGCACCGCCAGGTCCAGCTCAGCGGCATCAGGTTTTCTTCTGCGGCATGATGGACGAACCTTATCGACCAGGCATCACTGGGGTGACGCCAGATTCAGGTACGCAGTAGATGATTTCTTCGGCAAAGCGCGACATATCCACGGCGATTTGCGCCAAGACGGAATGCCTCGGGGCGAATCACGCGAAGCCCGTGGCATCGAGGGAGTTTTCTGCCTGCGGCATCAAAGCCCGAAGCTCATCGGCGATGGCCTCTGGGTTCAGGCTGCAGGAAAACTACCAGCGCACACCCAGGCCATATGGAGAAATATGAAACGCTTGTCCGAGGTCCTTGGGGCGATCGATATCCTTTGCAGCAAGGGCTGGGCATGAAGCCGAGCAGCGAATGTGCCAGCAAGATCGGCTGTACCCGCTTGGGAGTGCGTCTTGCCCGGCAGTGGCATCCAGGATGCTTTTCAGCCTGGCCGGAGATAAGCTTCGACGGGTCGCTGACCTGCAGCGCAATATAGGGTAGCGCTAGCGCACCCACATACGAAATAAGCGTGGCCACCTGGTCATTGCAGGAACGACCAGCGCGCAGGCGCCCGCCTACTTCAGTCCGACGATGTCAGATTGGCCCACGTTCCATTGCGCCGTGGACATCTTCATCGCTGGCTGCGGGGCCGGTCACCGAAGCCACCCCTGGCGCCAGGCTCGTCAGGGCCATCGAGGCATAGTCTGCAGGTCAGCATCAGAGCAATCAGCGCTGTACAATACCTTGGCGTGGTACCAGCACGTCATAAAGGCCAGCGCAATCAGAAGTGCGTGGATGCAGCAACGCAGCCATGGCCTCTGACGGTCCATGAGAAAAGCGTCCGCCCACAGTGCGCCTTCATTCGTCTTATGTAGGCTGCATATTTAGCTGCTATCCTCCGTTATTTTTTGGACTATATACATTGCGTTATTATCGCGTATAGTCAGCGTACTTACTTACGTTTACTGGCCATTTTCGCTGGATTTAGAGCCGCCATCACGGTCACACGCTGGTTTGGGGGATCTGGGTGGACAGACCAGCTACGAAACGAAGCCCATGGCCGCAGTTTGCGGTCAGAAAGCATCACCAGTGTCGTAGGTGGCCAAGGAGAAATTATACAGCGACTGGCGAACGACGGCCGGGTGACGATGATCTGGCCAGCCTGCAGCGCAAGCCCGGATATCGCCAGTGACATGCTCACGGGACTCAGCCGGTAGAAAGTCCAAGAACGCCTTCAATGGCGAGTACCACAGGCCGTCGTGACCTCTTCGGACCAGCAGGCATCCGTCAAACGCGCCTTGGCGTGCGGGTTCGCGCGCGCTCCATGGTGACATCTTCCAGGCAGCACTGTGTGCGCAGATCAACGTGGTTACTGCGGGTGCCATGAATCTCACGGGACTTAATTCCTGCAGGGCGGTCCTCGACCATATCCAAGTAGCCAATACCTGGGCGCTACACCTGCGACGGTTGAGCTCTTCGGTAAGCTTCAAGCACGCTTACCGGCTTGCCGTCGGAGAGTAGCAACAGGCTTGCCTTATCAGAAGGAGATGACGGCCTCATCGGGAACTTGTGCCCAACGCTGGATCCTCAGTGCTTAAGATGCGGCATCTAAGCTTTGTCAGTGGGTTCCACAGGTCTTCCAAGGAGTAGCCGGTTTTCTACCGCGCACTGACCCCCAGACGTTTTTAGTCAGTAATAGAAAAACGGGTAGGACGCCGACTGCTCAATCAACCCAAGTCGATTTCTTCCGCAAACGCAATGGCCTTATCACTTGGAGTCAGGCGTAGTCACGTACCGCTGATGATGTCAAGATGGATCCAGCGCGCGGAAGGAGACCTCAAAACATTACCTGGTCATTGCCATACCGGTGCAGCCGTAGGGGAGACGTAGGTGCCGCCAGATTCCTGTACGCAGCCTGAACCCGGAGCAGTAATCAGCGGAGCGAGAGTTGCAGAGACCAGTAGGTACTGCTTCATGCGCATGCCGTTGGCCTGGATGGTCGGCAGACAGTACTCGTCCGCGGAATTCATCGCACAGCATCAAGCTGACGATAGATTCCACGGCGCCGCAGTCCAGTGCACGCTGACGTACAGATTCCATATCCTCATACCGCGCCTGAGCACAAGTCGGGGACTGCGACAACGTCACCTCCGGTCATCTTTTGCCAGGTAAGGGATGGCAGCCGAAGTGTATCAGGCCGCCGGAGTAAGCCAGAAGCACAACGCGTGCGTTCATAGTTTTCTCCTCTCCTCTGTCTTAACGTTTTGCTCATTCGCGTA 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TTACTTGTACTCGTTCAGTTACGTATTGCTCACAACAAGGGGCTCTGACGGATTGTAGACACATGGTTTCGGGAATATTTCCTCCCCCTCGGGGTACTTTTCACCATTCCCTCGGTACTCCTTACACTATCGGTCACACTGAGTGTTAGGCTTGGGTGGTCACAAGCAGATTCAGCAGATTCCACGAGCCGCTTTCTCAGGCACCACAACACACACCATGTTTGTCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCAACCCACTTCACTAACAACACAATGCGCGCTCTGTCACGGTAGAAACAGAAAATCATGGCCCCACAACCACCGCATGCACAACCTCTACCAAGTAGCTTATCCCGCATACACGGTTTAGCCTCATCCTTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAGATGTTTCACTTCCCCACGTATAACCCCACACTGACTGAATTCATCAGCAGGTACCTACCCATAACGGCAGGCGGGTTTCCCCATTCGGACATCGATCAGCGCTCAATTGACAACTCCCCGAGGAAACGCGCGGCCTTACACGTCCTTCATCGGCCCCATACCAAGGCATCCACCATGCGCCCTTAAATAACAAACACACACCCCACACACCACAAAATGCGCTGGGGGTGAACAACCATAACTAAAATGCTAAACACCCACACACCAGCTTCGGATTGGTATGCGACGTTCTCACAGAAAAAATAAGAAAAATTACACACCACACAAACACTTCCAAAAGCACTCGTGGATGCTCGCGTCCACTATGCAGTTCTCACACAACACCCCACACCACCAACCACACACCCGCGCAAACAAAGCGTTTTAGTGCGTGTTTCGTGATGCAAGCTTTACGGGACCAACCCACATAACGTGATTGCTGTCCCAGACGCAACAGTGCACCAATGTCTAAACCCGTTGGCTGCCTGTGTTTATGTGTCTCAAAATTCGTGTTAGCAGCCTCTATAGCTGCCGGTGTGTTTCCACTCCGATTCAAACTCGGTGGCGCTGACCACACTCCAGGTCATCAACCACCAACACCCGCGCCACACAACCGTGCTTGACAGCAGATGTTTAATTACAAAGCTCCTTAGAGGAGGTGATCAGCCGCACCTTCCGGTACGGCTACCTTGTTACGACTTCGTCCCAATCGCCGATCCCGCAGCTACGACAGCTCTAACAAGTTTGAGCCCACTGGCTTCAGGTGTTACCAACTTTCGCTGACGTGACGGGCGGTGTGTACAAGGCCGGGAACGTATTATTCACCACACAGCATTGCTGATCTGCGATTACTAACCGACTGCATGGGGTCAGGTTGCAATTAATCCGAACTGAGCCGACTTTCGGGGATTCGCTCCACTCACGATGTCGCTGCCCATTGTATCGACCATTGTAGCATGTGTAAACCCTGGACATAAGAGGCATGATGGTTGACATCATCCCACCTTCCTCCGAGTTAGCCACAAGTTTCTCATGAGTCCCCACCATCACGTGCTGGCAACGCCAAGACAAGGGTTGCGCTCGTTGCGGGACTTAACCAACATCTCACGACACGAGGCTGACGACAACCATGCACCACCTGTATACGGGCTGGGGTTGAGCCTTATCTCGCCCAATCCTGTATGTAAAGCCCGGGTAAGGTTCTTCGCGTTGCATCGGGTAATCCCATGCTCCGCCGCTTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCCTTGCGGCACTCCCCAGGGCAGGGGGCGCTTAATGCGTTAGCTACGGCACAGAAGAAGACGTGGAAACCCCTACACCTAAGCGCCTGGGTTTACGGCATGGACTACCGGGGTATCTAATCCTGTTATTCGCTTCCCCATGCTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCCGCTACACCGGGAATTCCAGTCTCCCTACCAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCGGGATTTCACAGACGACGCGACAAACCACCTACGATGCCTTTACGCCCAGTAATTCGGACAACTTGCACCCCTGCGTATTACCGCGGCTGCTGGCACGTAGTTAACCGGTGCTTCTTATCTACTGCCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGAGTTTACAACCCGAGGCCGTCATCCCCACTGCGGCGTCGCTGCATGGAGCTTGCGCCAGTATTGCAATATTCCCCACTGCCTCCCGTGTGAGTCTGGGCCGTATCTCAGTCCAATGTGTCCGTACACCCTCTCGGAGCCGGATGCCGTCGCGCCGCCTTGGTAGACCATTACCCCCACCAACAAGCTGATGGGCCGCAGGCTCATCCCACACCATAAAGCTTTCCGCCACAACATCCAAAAGTGGTCATAATTATTAGACCCAGTTTCCCAAGCTTATCCCCGCCAATTGCAGGGCGGATCACTTGTGGCATGCCCGTTCGCCACTCGGAGTACCTGTGTACAAGTACAGGCCTTTCCGTTCGACTTTGCATGTGTTAAGCACGCCGCCAGCGATTCATCCTGAGCCGGATCAAACTCTCACAAAACAGCGAAACCCAAGAACCTAACCAAAAGACAAACAACACACAAACATCCTGCAATGTGTGAAGCTGACCAAAGTACTACATGAAATTCAGCAAACCCAACCAACCAAAGTTAGCCGGTAGGTAAAAGTGTTTTAACTGCATCAGCGGACAAACAATTACATTCAATATGCACCGTTACAGTATTTAACTATTTTTCAATGCCACCCATAACGACAAGTGACATCCAGTACGCAACAGCCAAACACACCCGAAGGAATGAAGTCAACATAATTCTCATCCACACAACACAGACAAAATAAAAATCTAGTACATTGGCACACTATTGAGTTCTCAGACAACAATCGCACACTTGATTGGAGCTTTTACATCTTTAGCCCCGCCGCCAAGCGGCTTTATTGAACTTACGCTATCGATTCGGCCGTGTCAAATCCTTGCTTTGAAGTTCTTCGTTGTCGCTTTGCGTTACGCGGCAACCTCTCGGCGACGGCATCCGCCGTCATTCGTCATCCATCTATATCCCATCTTTCGCGTGCTCGGCATACCGCAGCATGGGTGATAATAAATTACCGTTTCAAATGATAGTACGGCGAAACTGCTCAACGCTTCTTTCAGAAATGCCCTCATTTCCACCGAAGTATTACGTGTCCGGGTATTTAATAGCTCATCCAAAAGTACATAGTCTGTTTCCTGACATAGCACCCATGGCGACATAGGCACGTTAGCGCTGGCCGCGAGATTGATCAAGTAGCGGTCTTCCAAGGCCCCAGTGAAGGAAGTCGATATGCGAAATAATCTCTTCGTCTTCATCGGTCAGACGACCCTTGGAATGAGGAAAGCGACCGAAGCCTACGAGCTGACGGACGGTAGCTTGGTAATGAAAGTAGTTCTCGGCGGAGGACGGAAATTATCTTTGCCAAGTCTTTGGACTTGGGTCGCAATATCCATTTCGGCGACGCGGTTTCGCCACAGCATCCATGCCGAGCAAGCGACCGACCATCGTCAGCATCGACTTGCTACAGCACCGTAGAACCAATCAGCGCGGTATTACCGCCAGCTGGGATTTCAAAGTTGACGGGACCAATTTTCAGTTTCTGATGAATACGCCTTTGTGACGTCAGTCAGAGTAATCACAGTCGTCCCTAGCAAGATGACATTGCAGGAACACAGAACCGCCTACTAGCACTCAAGCTGTATTAGTGCGACGCCCTGTGCATAAAACACGTGCCGCATGATGAAGTATGCGCCGGTAAAGGCACCGTAAAGCCAGTTACCGCGGCCATCAGGAAGAGATAGCGGTGGTCATAAGTATCAGCAAATTGATAAGCCAAGGTGGCAACGAGAAGCCCGGGAGGTCATCGGACCGACAAGTGCGTCGTTATTTGCCATTAAAATGGAGACCAAACCAAGGTGTATATCGCATTGACTGCCTTGGATTTAACACCAAGCTGATCGGGCATCCCGCCCGAGCGCCAGCACATTGAGGCGGCGCGAGTTTAGATCCCCATCAACACCGTGGCACCGATGATGGACGGAATGGCGATGGGATGAGTACTCCAGTATCGGCATTGGTAACCGAACCGAAAAGCCGAGCGGTTAAGACATCGAATTTCACTGGGGTCGGCAGACGCTGCATAAACGTCGAGATGGAGCCTAGTCCGCCACCGATGACGATGCCGACGAGCAACATGGCGATGCATGTTTTTGCTTCCGGTGAGCGGCAGTGCAGCAGCGACGAGAGAAAGACCATGAGGACAGGCTGCGACGAACATCTCACGGTGCGGGCATTGTTCAGACTACTACGCGCCGAAGAAATAATTGGCGTGAATTACTCGATAGAGCGATTCGAAGCCCATGATTGGCAACGTCAAAATTCGAACGTGGTTACCGTTTGAAATGCCACGGTGGCCACGGCGGCAGACTGCCACCAAGGCCATGGCGATTACCCCCATCGAGGCGACGATTGGCGATGAGCCAAAAGCCGCGGGTGCCAAATTGCATCCGGGTTTTCATGGGTGCAAGACCGAAGGAAAATAGCGCCGCCAAAATGGACGCTATGGCGATAATCGCGATCGGTATTTGCGGGTACTGTCGCCGACTGGAAAGCGCCGACGTGGCGCGGGTATCTTTCATCAGACCTGCCACTGCAGCGCGTTCTTTATTTGCCACGAGAGTCGACCTCACAATCAAACTTGAAGACGATGGCTCCGGCGATTCCCCAAAATAACCGACACCGGCATTTCAAATGGGGAAATAATCCGCGGCTGGCAGGTCACAGACGGTGACATTAGCGTGCCGAGCAGCAAGACCCACACGGCAGGTTGGAGCCGCAGGTCATCACCGCGGAACATGCGGCAAATGTAGGGGGACGGAAATCAAAGCTAAAAAGTAAGCCAGAGGCCAAACGGCCACGGTAGCCACACCAGTGGCGATGGACACAGATGCAGTTCCCAGCAGCAAACTTTCTGGTTGTAGTTCAAACCAATGGCCAGGTGGCGATATCTTCGCCCAATCCTGCATTGTGAGCTTATCCGCGAAGAAAAGACGGCGATTACGACAACAGGCACAACCCACAGAACTTCGTGGCCTTTGGCCGGAAGTAAACGAACCGCCAGACCAGATGCCAGCTGTTGCAGCGAATCTGTAGCCGAAAATGCAAAGAAGGAAGAATGCAGGCAATGACTGCGCCGAGCATGATGCCGACGATGGGCACGACCATGGACGAGCGCAGTGTTACTCGGCGTAGGAAGAAGAAGATCATGGTGCCGATGAAGGAAAAATCACGCGGCAACAATCATCTTGACCAGTACTGATGACTGCGAGACGGATCAAACACATCAACAGCGAGCCCGGCCCACTCGGTGGTACCGGTGGTGGTCGGTTCGGCAGAAGCGGTTTGCGTCAGCTGCATGGCCGGGCCTGCAAATAGCCATGGCGGCACCGGCGAGAACCCAGTGCGATGGTGCGCGGAACGCGGGTGATCCCGAACATTTCCCATCCGAAGTCATCGGAAAGAATGCTGTATTCGCCTACGGACAACGGCGCAATCAATAATAAGATAGCGACGCGGTAGCTAAGCTTCCAGTTCCATAACGCGGGATCGGCGCTGGTGTCGCCAACTCAGAACGCTCAGCATATGCGCCGTAGGCATCGAGTTCGAAGTTGTCCGTAATCACTTATTCTTTCAAACCAGGCTCAGTTGAGGCCTTGAGGTCTCTCATTCCCCAAGGTCAACCGGCGTTCGTAAAGCACTGTGCACCTAGCTTTTATCTTGCAAAGTGTACATCCTGGCTAAGTATTCTGTGCCTCAAATGCGTCAGCGATGAGGTTGAGAATCTCGGTGTAGGTCACGATGTTCTCATTGGA 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ACTTATCGGTAGCCTTCGATTTGCATTATTGCTGATTTAATCTTGCCTGTGTTTATGTGTCTCAAGAATTCGTGTTAGCAGCCTCTCTATAACTTTGCCGGTGTGTTTCCCTCCGATTCAAACTCGGTGCTTTACTCGGTCATCAACCACCAACACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTGCAAAGCTCCTTAGAGGAGGTGATCCAGCCGCACCTTCCGGTACGGCTACCTTATTACGACTTCGTCCCAATCGCCGATCCACCTTCGACAGCTCCCTAACAAGTTTAGGCCACTGGCTTCGAGATTATTTACCAACTCATGACGTGATGACGGGCGGTGTGTACAAGGCCGGGAACGTATTCACCGCAGCATTGCTACGATCTGCGATTACTATAGCGACTCCGACTTCATGGGGTCGAGTTGCAGACCCCAATGGCCAATCCGAACTAAGGCCGACTTTTCGGGATTCAGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTGTAGCGTAATGTGAAGCCCTGGACGCAAGAGGCATGATGATTTGACGTCATCCCCACACCTTCCTCCAGGTTAACCACAGAAGAGTTTCTCATGAGTCCCCACCATCACGTGCTGGCAACATAAGACAAGGGTTGCGCTCGTTTGCGGGACTTAACCCAACATCACGACACGAGCTGACGACAGCCATGCACCACCTGTATACAGACCACAAGGGACGAACTATCTCTAGCCCAATCCTGTATATGTCAAGCCCGGGTAAGGTTCTTCGCGTTGCATCGAATTAATCCACATGCTCCGCCCGCTTGTGCGGGCCCCGTCGAAAATTCCTTTGAGTTTAGCCTTGCGGCCGTACTCCCCAGGCAGGGGCGCTTAATGCGTTAGCTACGGCACAGAAGACGTGGAAGCCCTACACCTAGCGCCCCTGCGTTTTACGGCATGGACTACCAGGGGTATCTAATCCTGTTCGCTACCCATGCTGGCTCCTCAGCGTGATTACTGCCCAGAGACCTGCCTTCGCCATCGGGTGATTTCCTCCTGATATCTGCGCATTTCACCGCTACACGGGAATTCCAGTCTCCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCGCCCGAAGTTAAGCCCGAGTTCTGAACGACGCGACAAACCACCTACGAGCTCTTTACGCCCAGTAATTCGGACAACGCTTGCACCCTACGTATTACCGCGGCTGCTGGCACGTAGTTAGCCGGTGCTTCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGAGTTTACAACCCGAAGGCCGTCATCCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCCATCAGTGCAATATTCCCCACTGCTGCCTCCCGTAGGAGTCTGGGCCATCTCAGTCCCAATGTGTCCGTACACCCTCAGGCCGGATACCGTCGCCGCAGGCCATTACCCCACCAACAAGCTGATAGGCCGCAGGCTCATCCCACACCACAAAGCTTTCCACCACAACATCAAGAAGTGGTCCTATATGGTATTAGACCCAGTTTCCCAAGCTTATCCCATAGTGCAGGGCGGATCACTTACGATGTTACTCACCCGTTCGCCACTCGGTACCTGTACAAATTACAGGCCTTTCCGTTCGACTTGCATGTATTTAAGCACGCCGCCAGCGATTCATCCTGAGCCGGGATCAAACTCTCCACAAAAGGCTGTAGAAGAAGCCCAAAACCTAACCAAAAGACAAACAACGCACAAACTATCACTGCAATGTGAAGCTGACCAAAATTACTACATAAAGAAATCAAACTAAACCCAACCAACCAAAGTTAGCCCGGGTAAAAGTGTTTTAACTGCATCAGCAGACAACAATTACATTCAATATGCACCGTTACAGTATTTAACTATTTTCAGTACACCCTCAACGACAAAAGTGACATCGGTACACACACCAACAACCAAACACACCCGAAGGAATGCTCAGTCAACATAATTCTCATCCACACAACACAGACAAAATAAAAATCTAGTACATTGGCACACTATTGGGTTCTCAGACAACAACCACACAAGATGAATTCGAAGCACAACCCAGAAGCTGTTTTTCGCTCTCGGCTGGGTTCTACCTTAGACAAACTGTTTTGACGTTTGTCAGCCAGGTCAGTAACTTTTTGTGCGCACGCTCTCTCGCGGCGACTTCGATAAAGGATTACACGGGACCCAGATCTTTTGACAAATCGCCAGGTAAATCACGGTTTTAAAGATCGGGCAAACAACAGAGCCCCGCGAGCTTTCATTTAAGAAGACTGCGCTAATGCAAAGTTAATTGCTCCAGCGCGGACTTCCGATGGAAGCTAGCAGAGGTAAACCTATATTATCTAGGCCTTGGTGCGATGAACGCCGGCAGAAGTTCTTCTTGCTGCGGCGCATCACAAGCCATGCACCGTGGAGGAAGTCATCTTCGGCGGGGTCAATCATCAGACTCGATGCGCTGGTTATTGACGTACGCGCCGCTAACAATCGTGCGGCGGGCTGCACCCCGCTGGAATCAGCAGTACGAAGCAACGAGCAGGTCAACGATTCGAAGTCGTCATCGCCAAGCTCTGCCGGTCTCCGACAATGCGCCTTCAGGTCTTTTCATCCAGATCGCTAAGTTCAGCGCGACCGAAAAGTGCCTGCGCGGCAAGCTCTACTGCCTGGGTGGCCTCGTTGCCGTAGCACCAAGTTGGTCATCTCTTGCGCGAGACGGCGCTGGGCGGCACGCGAAGGCTCTTCTTCGACGGCCTTGGCGTACTCGGCGATTTCTTCACGGTTCAAGAGGTAAACCAGCGCGGGTAGTCGATGACCACGGAGTCACCAGCGTTGAGGAAGTACTGGTGCCGGAATAGGCCGAGGTCTTGTCGGATCAGCCACAGCTTGCCGCCACCGGTGGACTTGCCAAACTTTGTCCTGCGCGTCGGTCACCAATGGACGGAGTCAGCGCGTGCGCTTTGGCGCCATCAGCACGACGGTTGGGATCCGCACCGGAACGATATTGCCCACTGATCGCCGCCACCAACCGCAAGACGCAGTCGTGCTTGCGCTGCAGCTGCACAAAGTCATTGGCCTGCAGGAGCATGTGAGAAAATTCCGTGTAGGAGATGCCGTCGGTTTCCAAACGGCGCTTGACGGTATCGCGGTCCAGCATGGTGTTCAGCAGAAGTTCTTGCCAACATCACGCAAGAAATCAATGACGGACATCGTCCAGTCGGCATTGTTGACCATGATGGCTGGGTTGTCGCCAGCCAGTCCACGAATTGGCAGAGGCACCAGCTGATCGCCTCGGGTTGATATCTCGTCTTGGCTGAGCATGGGCGCTCCCCACATCCTGGGTCGCGATAAAACCAGTTGCGCCACCCGCCAGTGCAAGTGGCTTGTGCTAGCTATGGAAGCGACGCAACATAATCATCGGCGCAAGTGTCCGGCGTGCAAGAGTCGCCGGTGGGGTCGAAGCCAGCGTAGAGAGTAATGGGCTGCTCACAAGCTTCACGCAGGGCGTCGATATCAGTGGACTGGTTAATAAGCCCGCGCCATTGCAGTTCATCGATAATGTTCATGGTTTCCTCGTTTAGATTCTAGAAGGGGTGCTGGGTAAAATTTTGGCCGCTGAAAATTCAGCTGCGCAGGAGCTTACTGAGCCTTCGGCCATGGCAGCGTCATCCACCAACGCGACCGGAATTCCATCTTCAATAGGATAGGCAATCCCAGGGCGCTCATTGACTGGACTTGTTCATCTTCAGATAGCTCAATGGCCCCTTGTCCTTACTGGGCACACAGGATTTCTACTAGCGCAGGATCTAGAAGGTTTCTTATCGTACCTTCTCATGTGGTCTCTTCTTCTCTGCTCGCACTGACCCCAGAAACAACTCACCGCGCGCCTTCCTCCATTTTGGACGAAAAAGACGCGCGGTAAAGTTGTAGGTAAAGCCACAGACTATGCCTGCTGGAAAGTGTCAACTACGGCGACGACGGGCGACCGATGAGGATCTTGCAGGTCCGTGCTTTCGGAGTACAGTGCACTGCTGCTCAATGACTGGGTCAGCAGAAGCTAGACCAGCAGCGGGAAATCGGCTGGGAACGCCCGCGCGCTGCTGCAGAGACTCCTCGCTATTCCGCTGGGGTTTGGTTCGCATTCACATCCTTGCCCAGCACTTGACCAATCTGCGCCGCAATATCCGGATAGGTCAGGGGCTGGCGCGCCGGCGAGCTCATAGACCTTTTCCGGCATGTCCGTCGGTGGTAGCGACAACAGCGGCCGCCTCAGCAAAGTCCGCACGCGCGGCGCCAGAAACCTTAAGCTACACCAGCGGCAGAAAGAACTTACCCGGGACACCTGTCTCGGGCCGGGCATAGTTTTTCCCAGTACCAACCGTTGCGCAGCAGTGCTCGATGCCGCTATCAGCCAGCAGCTTTTCCGTCGCCACGTGTTCCAGGGCCAAAACAGTTCTGGGAGTCCGGGTTCAACAAGCTGGTGTATGCAATCTGGGCAACGCAAGCAGATTTCGCCACATTGACGATATTGGGTATTAGCGGTCGTACGCTTGCCCACCTCACTGGCGGAGACAAAGATTCGACGGTCCACACCGTAAACGCTTTCGCCAACGCTGATTCTCTTCGCCAGGCAGCAACGGCGATATTGATCCCCCTGCTTCGCTAGGTCCTGTGCCTTTTCTTCATTGCGAACAACGGCAGCGATATCGGATGGGGCAACATCGCGAGCGAGCAGCTTGTCGATGATTAGTCGCCCAGATGACCCGTTGCACCGGTAACAGCAATACGCGTATAGGAAGCCAGGGATGATTGTTGTACTTACACGCAAACCCTAGCGCACTTACAAATAGTTAATTCGCAATACTTTCATTGTCGCGCTCACACGTCTAAGGTAAACATGTATCCACCTCTCAAGAAAAGTCGCAGAATCTTCCCGCTGCCGATGTCTTTTCCGCCCTGTGCTCATCCGGGGCCTTCAACCTCACGGGCCGTTGGGGATGTTGACCATGGTGGCGCTGTTAAAGCAGTACTCCCCTACGCTTTGCGGAACTTCGTCAGAAAAATAGAAGGCATTAGTGACCGGATGATGTCGCAGACTTTGGGCCGGATTAGGCGCGACGGCATGGTCAAACGCGAAGTCCTGGATCCATTCCCCGCACGTGGACTACTCGCTTACTCCGCTGGGAATCAAGGTTGCCCGACCACTGCAGACATTGACCGGGATCATTTGAGTCACAGTTGGATGAGGTCATCGCGTCATAAGAGCTACGATGCCAACACGGAGCAATAAATAGAAAAATGCTCTTATCCACATTCAGGGATAAGAGCATTTTCTATCGAAACGAAGTTCTTAGTTCTTAGCTTCTCTCGCACTGGCGTATTTGCCCACGCGCGGGAAATCGTCGTTGAGCTTATTGACGGTCTCGCGCTGTTCAGTAACGCGTGCCAGCGGTACCGCCCTTGGTGGAACGAGATGCCACCGCACCATCGATAGTGAGCACGTCGCGCACGGCTGGCTTGAGGCGACTGTCCACGTTCTGGAGTTCTTCATCGGTGAGGTCTGCAAGATCCGCACCACGAGATTCCGCCAAGCGGAACGCATTCGCCGGATGCCTCGTGAGCCTCGCGGAAAGGAACGCCTTCGCGCACCATCCACTCTGCCAAGTCAGTAGCCAGCGTAAAGCCCTGCGGGGTAAGCTCGCGCATGCGCTTCTCGTTAATGGAATTCCAGGTAGAGACCAGACCCGTCGCAGCCGGTAGCAGCAAGTTGAGCTGCGCGACCGAATCCACGATGGGTTCTTTATCTTCTTGCAGGTCACGGTTATAGGCCAAGGGCTGTGCCTTTAATGTTGCGAGCAAGCCGTGGGTTGCCAATGAGGCGTCGGTTTTACCGCGGGTCAGCTCGGCAACATCCGGGTTTTTCTTCTGCGGCGCGATGGACGAACTGTCGACCGGGCATCACTGAGGGGTGAAGCGTAGCCGAATTCCGGAGTACACCAGTAGATGATTTCTTCGGCAAAGCGCGACATATCCACGGCGATTTGCGCCAAGACGAATGCTACCGTCTCGGAGGCGAAATCACGCGAAGCCGTGGCATCGAGGAGTTTTTCTGCTGCGGCATCAAAGCCCAGCTCATCGGCGATGGCCTCTGGGTTGAGCTGCAAGGAAGAACCTGCCAGCGCACAGAGCCATATGGAGGAAATAGCCAAACCTTGTCGAGGTCAGCAGGGCGATCGATATCGCGCAGCAGGGCTGGGCATGAGCGAAGCAGCCCGAATGTGCCAACAAGATCGGCTGTGTGCCGCTTGGGAGTGCGTCTTGCCCGGCATGATGGCATCGGGATGCTTTTCAGCCTGGCCGGAGATAGCTTCGACGGGGTCGCTGACCTGCAGCGCAATATCGCCCGATGGCATCGCGCACCCACATGCGAAATAGCGTGGCTTTTTGGTCATTGCGGAACGACCAGCAGGCGCCCGCCTACTTCGGTCCGACGATGTCGAATTAGCCCACGTTCCATTGCGCCGTGGACATCTTCATCGCTGGCTGCGGGGCCAAATTCACCCGAAGCCACCCTGGCGCCGAAGCTCGTCGAGGGCCATCGAGCTATGGTCTGCAGGTCGGCATCGGAAAGCAATCCGGCGCTGTGCAATGCCTTGGCGTGCGCTTTCCGTGCCAGCACGTGGAGCCAGCGCAATCGAAGTGCGTGGATGCGGCAACGCAGCCATGGCCTCTGACAGTCCGCCAGAAAAGCGTCCGCCCCACAGTGCGCCTTCATTCGTCTTATGTGGCTGCATATTGGCTAACTATCCTCCGTTATTTTGGACTATACGTGCGTTATTATCGCGTATAGTCGCGTACTTACTTTTACTGGCCGTTTTCGCTGGTTGGGAAACCGCCATCACGGTCACACTGGTTGGAGATCTGTTGGACAGACCATGCAGCTGCACGAAGCCCTTGGCCGCAGTTTGGTCGAAAGCATCACCCGGTGTCGTAGGTGGCCGGGAGAAGTCATACTGGCGACTGTGGCGAGCGACCGTTGACGATGATCTGACCAGCCTGCGGCACCAAGCGGATATCGCCAGTGACATGCTCACGGGACTCGGCGATGAAGCGTCAAGAACGCTTCAATGGCGAGTACCACAAGCCCGTCGTAGACCTCTTCGGACCAACGAGCATCCGTCAAACGCTTGTAGCGTGCGAGTTCGCGCTCCATGGTGACATCTTCAGGCGCGCTTCGTGTGCTGAATCAACGTGATTGCACCAGGTGCTTCATAGATCTCACGGGACTTAATTCCTACGGGCGGTCCTCGGCCATGTCAAGCGGCCAATACCTGAGCGCCTGCACGACGGTTAGGCTCTTCGATAGCTTCAAGCACGCTACCGGCTTGCCGTCGATAGCAACAGGCTTGCCCATCGAAGGAGATGACGCGACGACCTCATCGGGAGCATTGCCCAACGCTGGATCCTCGGTGTAGGGTAAACGTCAGCTGTCGGTGGGTTCCACAGATTCAGGGTAGCAGTTTCTACCGCGCGCGGCCCCGAACGTTTTGGTCAATAGAAAAACGGTGGGGACGCCGACTGCTCAATCGGCAAGTCGATTTCTTCCGCAAACGCAATGGCCTTATCGGGTCAGGCGTAGTCACGTGCCGGCGCGATGATGTCCAAAGATGGATCCAGCGCGCGGAGACCTCAAAACGTACCTGGTCATTTGCCCTTACCGGTGCAATACCGTGGGAGACGTGGGTGCCGCCGAATTCCTGTGCAGCCTGAACCAGGTCTTGGTAATCAGCGGGCGAGATTTGCGAGACCAGTGGGTACTGCTTCATGTACATACCGTTGGCCTGGATGGTCGGCAGACGGTATGTCCGCGAATTCATCTTTGGCATCAATGACGATAGATTCACGGCGCCGCAGTCAGTGCACGCTGACGTACAGATTCCATATCCTCGCCGCCCTGACCTAGGTCCGGGGAGACTGCGACAACGTCCTCCGGTCATCTTTGCCCGGGTAAGGGATGGCAGCCGGTATCAGGCGCCGGAGTAAGCCGAAGCGCAACGCGTGCGTTCATAGTTTCCTCTGTCTTAACGTTTCTCATTGCTTGACATTTTATTTCCACAGCTGTACGTCAGGCCTATTGGAAATATACACGAAGTTACGCAATATACAAACTCGTCGTGCATAATCTGAGCTGTGTTTATTCAATCTCACCTCGACGCGAGCCAGCTGAGGCGTTCGGCCAGCTCTGCCCAGTAATTGATTCGCGACTGGCACAAAAATCATAAGTCCGCGGCAATACGGCCATATCTTCCAAGCCCACGCGATCAGTGAAGCTGGCAAGATACTGCGCGGCACCGGCTGGGGTGCGCAACAGCGATATTGCCGGAGCTATCCACAGAGACCACCAATTCATCAATCATTCGGCGCAGCTTCTCGTGGACCATTGACGGTCAACGGGCGATCCATTTCACCGACGGAGATAAAAAGGACCGCCCACCATCACGCCCGGCCTTTTTGGCACCGGGACATCTAAGTCGCGACAAGGTCGCTTGGGTGATATCGATGCCTTCATCAAGCAGCAAATCAAGCTGCACACGGCTGGTCACGCGGGTTTTTCCTAAAATTTCCAAGATTTTCGCTTGGGCATTGCGAGTCTTAGGCATGGTCATAGTATTTACCTTAAACCCAGCATACTTGCCCAGCCTCAGCTGCCTTATGCCGCTAACCGCACCCATCAAAGCCTTCTGCCGCGTGCGGGCGGTTTTTCAGCTTCGTCAAATGGGCAGGAGCCGTCGGTAACTTCCGCAGTAACTTCACGTGCCGCCGGTAGGCCGGCAGGCGGTGCGAAGATGCGTTCACCATAGGCGCAGCCGCCATCGAATCTGGTTGACCTGGCGCGGCATAAAGGGCGTGCGACGGTCTTTGCCGTCATCTTTGCTTGGCCCCATAGATACCCAGGTATCAGTGATGATGATGTCAGCCCCATCAACCACACTCGTATCATCTGTGATTGTAATGGGTGGCACCGGTGTGTTCAGCGCGGTCAGCGCACGGTCGACAAAGTGCTGCTCCGGCTGGGAAATCATCAGGCGCGCAGATGGCAATATCTACCGGCGGTATGAAGCCGATGAGGTAAGAATTGGCCATATTATTAGCACCATCGCGCCCAAAATGGAGCAGCCTTTTTGCGCTGGCTTGTCGATGCCCCAAATTCCTCCGCGCAGGTGAGCAAATCCGCCAAATCGGCACGGATGCAAATCATCCGTGGCGAATTCGATAATCAATTTACGGTCGACGTCTGCCATCAATGAGGTTTTGGTGCCTTGTGAAAGGTACGCCAGATGATCATTTCGGTAAACCGTGACAACACCGCCGCGGTATCCTGCAAGCTTTCGCCTTTGCCCAACTTTGGGAGCTTTGATCCGTGGACATGATGGCGCATCATCCGTCGCCGCGATACCGGCTGAAAACCGGGTACGTGTGGACGTCTTCGAAAACAACAACGCCACCGACGGGCCCTTCAGCGGGCGGTATACAAGGTTCTTTCTTTGGCTCGAGTGCCAGCGCTAGAACTTCCTGCTGTTCTTTCGGGGGTAGGATCATCGTCAGCTAAGAATGCCGGATGCCGCCAGACCTACTTCTAGCTTGTGAGGAATGGACACCAACTTCGCGGGTGGGTTGGCCACTCATGTGCAAGTTTCGCCAATTGTCGGTCTTAGTGACCCAGTGGCAAGACGGTGGTGATTTTTCTCAATCGCCGCATCGATATCTTCTTCGGTGATAACCAGTGGTGAACCAATACGCACAACATCGGCGCTTGGTGCGTTGACAATGAGCCCATTGTTTAAGCCCTCAGCAACTGCTTCCTTAGCAACGGGCTGGTTGAGCACAACGCCAAGGAGCAGGCCCTGACCGCGCATGATCCACCAACGACAGCTTGTTGAGCTCCGCGGCGAACTTCTCACCCTTGGGCGCACACCAGCGATAAATTCATCATCGATGACATCTAGCACCGCATTGGCTGCGGCGCATACGGGACAGCTGCCGCCAAGGTGGTGCCGTGGCTGCCGGTTCAAAAAGCTCTGCCTTGCCGGTACCAATGCACGCACCGATGGGAAGACCGCGGGCCGCTGGCCATGGTGATGACATCCGGGAGTAATTCAGCCTTTTTAAAGGCAAAGAACGTTCGGTACGCCCCACGGTTTGGACTTCATCCACCACCACATCAAAATCGTACTCATCGCACGGTGCGCGGATGTCTTGGAGGAACTTCTTGCGTGGCTGGGATAACGCCGGTTTCACCTGGGATGGGCTCGAGGAAAATAGCCGCAGTGTCGATGGGATTAACTTCTACAAGCTTGCGCGGTAGTGTCATCATATAGGGATAAACTCCACGCCCCGGGCAGCGGGGCAAGATCGCGTTTGGAAGGCTGGCCTGTCAGCGCTAAAGGCCATGGTGCGGCCATAGAGTATGGTCGGCTGCGAGGTATCCGGCGGCGCCCAGTCAAGCGTGCCGGCAGGCTACTTCATTTGCCTCCGCGCCGGGTTGGAAAAGATGGCGCGTGCGGAGTCATCGCCGACTTTTCTTGCAAACGCTGCGCGAGTTTCACCGCGGGTGGCGATGCAAAAAGTTTTCACGTGGCTCAGCGTCGATACTTGCGTTGACGGCCTTCACCACAGCAAATTTGGTTGGTGCCCAAAATTCGCACGATTCCGGCCAAAGGTCCGGTACTCGGTGCCGTGTTCATCAACCAAGTAGGCCCCGTGCTGGGAGACGGTCCCGAAGGTGCCATAGTTATTCATCATGGCTGATTGCAGGAACTGGTTAGTGATGTTTGTGGTGCTCACTGTGAATCGTCCTTCCTAAGAGCAGATTGCCTTCGGGGTAGCGGGAACGCTCAAAATTATCGGGCAAGACCATGATTGCCAATACCGCCCATGGTCAACAAGCTCAAACAAGACGAGTGCGCTAAGCGGCCATCGATAACATGGGATGCTGCACCGCAGCGTGACGGCGTTGAGGGCAGATTCCATCTTCAGGGATCATACCGGCATCTAATTGCCAACATCGCTTCAAGCTGCGTTGCTTCAATCTTGGACACCAAAGATTCCTTGTTTGGCCAATCGGTGTAGAGACCTTCCACGGTAGTCAACGCGGCCAAGAAGCGTTCAGCACCTAAGGAAGCGAGCTAAAGCACGGCGCAGTCGGCGTTAATGTTATAGACCTCGCCATCAGTGCCAGGGGCAATGCCGGAGACCAGGGATGCGGCCAGCTTCGATAATACATCACGGCTGAAGGGTTGACGTCAGTAATATCGCCAACCAGGCCAATATCAGTCAGTTCGCCGTGACGTTGACCATGCGCTTGGTGGCAGTAAAAGCCCAGCGTCTTCCCCGGAGGTGCCCACCGCATATGGACCATGGGAATTGATGAGATTGGCCCGAGGTCGCGGCCAACAGCCAGAGCACCATTCGAACGACGTCCGCCGATCTCAGGGCTGGTTACCCGAAAACCACCTTTAAATTCGCCTTCGATGCCAATTTTGCCCAGCATTTCATTAATCTGCGGTCCGCCGCCGTGCACGACAACGGGCTTCGCACCGACGGTGCGCAAAGATCAGCGGCAAAGCGCGCTTGGTCTTCATCAACCATGGCGTTCCGCCATATTTCACCACCACAATTTTGTTGCGGTAGTGCTGCAGCCAGCGCCTCGGCGATATGGCGCGGTCATGTTCGACGTCGTATACGTATCACAAGGCTGCCGCGGTGTTTCACGGTCAGGCGTTTTGAAATGCCGCGTACGCGTTGCTGATGCCGGCATCAGCGTAAGGTACGTTAAACATGGGGCGGGGCGCCAGAGTTGGTTCACCGTTTGCGCTTTGGTCGTGAAAGGTCGTGGATTACGTATGGGCATGGGCGCGCAGCGGCTGGTTTGGATCAGGGCGGCGGCTGGCGGTTATTAAGATTTCAAAACGTTGGGGCGTCGTCGGGCCGGGTGCGGCAGCGTTGCATTACTCCGGCATCGAAGCGGGCGATCAAGCTGGGATAAACGGTGCTGGATGACATGGCTCGTCCTGTGAGGTTCGATGCCCGGGCACCATTGGCTAATGCGATGACGGTGTCATTAGTCGGTAGAGCCATCAACATCAAAGTATTAAGGTGATCGCGGGCCTTGCGCAAGGCTTCATCAAGGCGGCAGGGCTTGCTTGAGGCATCAGTAGTAATGCATGCAACATGGTGGTAACGTGGCGCCATCGTACTTACGCATAGCCTGCCCATGCCACCGACAGACCAGCCTTGCCCGTGCACAGCGGTTTAGCCCAGCAACGGTATCGGTCGTCATGATCGCTCGCGCTTCAGCGCCGTGGTCAGGTCGGATCCTGGAGTCTTTCGCTGAAGCTTGTCGATGCCCCCATGCACCTGCTCCATCATCAACTCCCCGATAAGCCCCGTGGGCACACAGCGATCTGGTCGCATCGAGACCGAGCGCAAGGCGGTATCTTCCGCCATCTTTTGCGCATCGGTCATTCCTTGACACCATTGCAGGGCAGTAGCATTGCCGGCGTTATTCACTACGCGGTGGGTTGGGCTCACCGTTTTTCCAGGGCGGCCTGGGTAATTTTACCGGTGCTGCGACAACGCGGTTGCGGGTAAACACCGCTGCCGCGTCAAAGTTCAAGACTGGTTTGTTGACCGGGGCCATATCAGGATGCCGGGCTTAATGCCAGCGATGGTCGATGCCGCAAGAAGCCCTGCGGAACAGTGCACCACTGGCTGGAGTTCGGACGTTGTCATGGCTTGTATCCTTCTTTCCGTGCGAGTTTATGGTGCGACTGCGGCCTGTGGCAGGCCAGCGGTTTCGTCAGACCTAAGGCTAGGTTCATGCACTGTACGGCAGCGCCGCGGGGTGCCCATGGTCCGGAATTGTCTAAGGCGGGAAGTGATCCGCGACTGTGTGCTCCAGCGTCCACGTGGGCTTGAATCTGGCACATATTAGATCCACCACGTGCTGGGTTTGTGGCTGCTGTCGCTACTACTGGCGGCACCCCGGCAAAATGGCTCGTCGGCGTAAAGTTTTGGAAGACTTTGGTGACCTGATGCTTGCGTCACTTTCAGCGGTGCCGTAATCGTGGCGAGGATACTGAGGCATCGGGTACCAACGCGGCGTGACTGACGACGGCGGGTGGTTGCCAAACGGGCTGAGGGTTTTTGTACCGCTTCTGGGGTGTGGCCGGTGGGTACCACACGGTGAATAGGCTTTCACGCTGCCCGCATGGTCTCAGCTCCAGCAGCAGGTGCGGCGGCCTTCTTTGCCGGCACCTGCGACCACCGGTAGCTGCCACAACAGACAAATCGGGCTCAATTAGTTTGCCATGCAGTGCTGGCGAGGCACTTCAGCGTCATGGTGGTTGGGAAGCAACCAGGTACCGCTACCCTTTTCGCGCCTTGGAGTTCTTCGCGGTTGCCGGGTAACAGAATGCCATAGGGCCAGCTTCCGGCATGTTCTGGAGCCATAGAAGTTTTCCCAGTCCTTGGAATCTTTCAAACGGAAATCCGCGGCGCAGTCAATAACGACGACATCATGGTGCCTTAGCGATGGGACCCGAATACTGTGTAGCGAAGTCAAGGAAGACCACGTCATGGCCGAATTATCCACGGTGGTATCGATGGTGCGGCCTGCCGGTTGGTAGCGGAATTATGCGGCAGCTCTGCTACGGTGCGGCGTTGGAGTGGCCGGTGAGTGCGCCAATTTCTAAGTCGCCAGGAGCGCCCAATGCCCGA 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TTGATGTGCTTCGTTCAGTTACGTATTGCTATCACCCACACACAACCAGGGGCTCTGATTGTAGACACATGGTTTCAGGAACTGGCCCTCCCCTCCCGGGGTACTTTTCACCATTCCTCACGGTACTCATACACTATCGGTCACACTGGGTATTTGGAAACACCAGGGTGGTCAGAAGCAGATTCACAGCAGATTCCACGAGCCACTTTGCTACTCGGGCACCACAACACACACACCATCTTATCTTCACCTACAGGGCTCTCACCTTCTACGGCCGGGCATTCCAGCCCACTTCACTAACAACACAATGCGCGCTCTGTCACGGTAGAAACAGAAAATCATGGCCCCTGACACCGCATGCACAACCTCTACCAGAGTATCACATACACACGGTTTAGCCTCATCCACGTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAAGTCACTTCCCCACGTATAACCCCCCACACTGACTATGAATTCATCAGCAGGTACCTACCGCCAACGGCAGGCGGGTTTCCCCATTCCGGACATCCCTCGGATCAACGCTCAATTGACAGCTCCCCGGGAAGCAACGCGGCCCAACTTACACGTCCTTCATCGGCCCAGCATACCCAAGGCACATCCACCATGCGCCCTTAAATAACAAACACACACCCCACACACCTACGGAAATGCATGGGGTGAACAACCATAACTAAAATGCTAAACCACACACCAACCAAAGTTGGTATGCGACGTTCTCACAGAAAATAAGAAATTACACACACCACAAACACTTCAAAAGCACTCGTGTGGTGGATTATACGTCCACTATACTCACACAACACCACACCACCAACCACACACCCACTTTTGCAAACCAGCGTTTAGTGCGTGTTTCGTGATGCAAGCACCGGGACCAACCCACATAATGAATTGCTGTCCCAGACGCAACAGTGCACAATGTCTAAACCCAGTTTAATCTTGCCTGTGTTTTATGTGTCTCAGAATTCGTGTTAGCAGCCTCTATAACTGCGGTGTGTTTCACTCCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCAGCACCCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTAAAAGCTCCTTAGAGGTGATCAGCCGCACCTTCAGTACGGCTACCTTATTACGACTTCGTCCCAATCGCCGATCCACCTTCGACTCCTAACAAGTTTACAGGCCACTGGCTTCGATTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGAACGTATTCACCGCAGCGCGGTTGCTGATCTGCGATTACTAGCGACTCCGACTTCATAGGGTCGAGTTGCAGACCCCAATCGAACTAAGATGGCCGACTTTCAGGGATTCGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTTGTAGCGTAATGTGAAGCCACGGACGCCAAGGGCATGATGATTTGACGTCATCCCACCTTCCTCCCAGTTAACCCCAGCGGTTTCTCGCGGTCCCCACCATCACGTGCTGGCAACGCCAAGACAAGGGTTGCGCTCGTTGCGGGACAACCCAACATCTCGGCGAGCTGACGGCTAGCCGCCACCACCTGTATACAGACCACAAGGGACGAACTATCTCTAGCCCAATCCTGTATATGTCAAGCCCGGTGGGTTCTTCGCGTTGCATCAGGTGAATCCACATGCTCCGCCGCTTGTGCGGCCCCGTCAATTCCTTTGAGGTTTTAGCCTTGCGGCCGTACTCCCCGGGCGGGCGCTTAATGCGTTAGCTACGGCGCAGGGCAGTGGAAGCCCCTACACCTAGCGCCTGCGTTTACGGCATGGACTACGGTATCTAATCCTGTTCGCTGCCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTTCCTCCTGATATCTGCGCATTTCACCGCTACACGGAATTCAGTCTCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCGAAGTTAAGCCCGGAGTTTTCACAGACGACGCGACAAACCACCTACAGGCTCTTTACGCCCAGTAATTCGGACAACGCTTGCACCCTACGTATTACCGCGGCTGCTGGCGTAGTTAGCCAGTGCTTCTTATCTACCTACCGTCGTCACACAAAATTGAAGCCGTCGATAGCGAAAGAGTTTACAACCCGAAGGCCGTCATCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCGTATTGCAATATTCCCCTGCTGCCTCCCGTAGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCCGTATTACACCCTCTCAGGCCGGATACCCGTCGCCGCCTTGGTAGGCCATTACCCCACCAACAAGCTGATGGGCCGCAGGCTCATCCCACACCACAAAAGCTTTCCACCACAACATCCAGAAGTGGTCCTGCAATTAGACCCAGTTTCCCAAGCATCCCATAGTGCAGGGCAGATCACCCACGTGTTACTCACCCGTTCGCCACTCGGGGTACCTTGTGCAAGCACAAGGCCTTTCCGTTCTTGCATGTGTTAAGCGCACCGCCAGCGTTCATCCCTGAGCGGGATCAAATATCCACAAAAGGCTGTAGAGCCCAAACCTAACCAAAAGACAAACAACACACAAACATCACTGCAATGTGTGAAGCTGGCCAAAAATTACTACGCAAAGAAATCAACAAACCCAACCAAACAATGCCAGTTGGTAAGGTAAAAGTGTTTTAACCTGCATCAGCAGACAACAATTATTCATTCAATATGTACCGTTAAAATATTTGGCTTCCTTTTCCAGTACCACCCATAACGATGAAGTGACATCCGGTACACCAACAACCAAACACACGCGAAGAATGCTCAGTCCAACATGAATTCCCATCCGCACAACACAGAACTAAAAATATAAAATCTATTACATTGGTACTGAGTTCTCAGACGTAGCCACACCACCACAACCAACCCGCATTACACGAGGCAGAAGATAGGTGAATGAAAAGTCACAAATAAATTTTTGCTTGTCAACGGCTGTTTTCCTACCGCCATACTCACCCAGAACCACGCCAGCTCTGTGCGGGGCGTTGTCGGTCTCGCTGACTCACATAAAGTTACACACCAACCAGAAACAACACCGTCTACGGCACCCAAACTACGTTTCTGCGATTCGTACTGGGGTTCATTTTTTCGATGATGTGAAGTTATTGGACGATTTCCTCTTGTCCGCGCTCAATCGTGGCACCAAGCGCACGGGTTTTCCACGAGATTCTCGGGTATCCGCAGTCAATATGGAAGACATCATGCACAGTGGTTGCTTCGCGCAAAATGCGGGAGGCACTAAATCCTGCACCCGCACGGATATCGGATGACCAAACGTGCGTGGAGGAAAGCTTCTCTTGCCCACGAAGAACAACATGGTGGCCATCGGCTTGAGCGTCTGCACCGAGTCAGAAGCATCTCGTCAACAAAGGCAGGCGCGGCTCAAGGCATTCTCTGTAATGGCAGCAGTTCCTTCAGCGCTGGCTGCAGAGGCCCAATAGCCATTGGCTGCAGGTCAGTAGGAAAGCCGATAGCAGGATTTGATAATCCACTGACTTTTGGTCGGCCGTCCATGCGAACACGGAATCCGTTTCATGGGTCTCAATGTCTGCACCGGCAGAGCAGCTTCGATAGCCCGGAAGGTGCAAGTGCCGTGAGCAACCACCGCTAGTGATGTCACCTTGGGTCATCACCGCGGCTTATAAGCCAGTGCCTGCAACAATGCGGTCGCCGATAACTTCATGGTTAGTGGGATGAGAGCTTGTCCACACCATTATTAGTGATAGTTACATTTAGCGCGGAGATATCACCCATCTCAAGAGCATGCGCTGAATCCAGCAATTTCTGGCTCGCGCGCAGCATTACATCAAACACGGTCGTGCCCGCCCGGCCAGCACTGCGGCGGTCAAAATATTTTCCGGTAGCTCCACGGATGGAAAATCCGAGGCTTAATCTTTGCATAACAAGCTCCGGAGGCTTCGGTTACTACCGCGCGCCATGCTCAATGTGGGTTGTTGCGCAAGCACTGCAATCAGACTGGTGCATGTCAGAGGGCGGGAGCCAATGGCGTCACCGCACGGAAGGGCTACGGGCTTTGCCACAGCGACGCAGTTAGCGGACCCAAGACACAAACGGATGCGCGGAGATTGACGAACAGCATCAAAGTCAGCATCACTTCGGGGCACCGCTGGGGTGTCAATGGTGACGGTCGTACCGTCAATGTCCACCGATGCAGCCGTCCCTCGGTACCTTTTGCATCAAAGGGACATCGAGGATCTCTAGACAATTAGTTAGCGTTGTAGATCCTTCAGCCAGCAATGCGTATCGGTTAAGAACCGAGTTCTTTAGCGCCGTCTACTTTCACAGCGCCTTGCAGGCGCGCTCCACCGAAACAGTAAATAGATCTTTTTCACGCCTAACTATCTTACGGCAATGCACCAATTCGGCTGGCGATAACCGCCTCATGGCAGTATGTGCTCCCAAAGCTTGCGCATTACGAGGCAGAAGATACGATTTGACGGTCTCGGCTGCGCCGATGCCCATTTCTTCTGCCGCTTCCACATTTTGTGTGGCCCAATGCGACGCAGCTCAGCACGTCAATTCTCGTGCCGACAACTTCGCGTAGATTATGACACGAACTGGTGAGACCATCTGATCATAAAGTGCGCTACAAGCTCCGCGCGCAGATTCATCTTCGACACGGTTAGCAAGCATGCGCATAGAACGTGCGCCCCTCCGCGCCGTTCATTACGTGACCGCGACCGGCACCAGCGGGTGCCATCGCTGCGACGGCGCAAGTTACGCAGTCCTATTCCGACTGCGCGCAATCATCGTGACTTCTTCAATCACTTTGTCGCCGAGGCGGGCAGGTGGAGTGCACTCCAACACCAGATGACTCCACGAATTTCGCGTTGCACAATCCCGGGAACTTACGATCAGATGCAGTCCTTCATCTTGAATGCCAGCGGTCATTCTCGTGCGAGGATCGTATTCGCGCGAATATAGTCAGACACGCCAACTGCGGCGGGTAGAACTACGCGTCCACCAACACCAACACGGTTTAACGTTGAGATTCTGCGGTGCCGGGTACGTAAGCCGACCCACTGCGTAATTTGCGGTTATCCGGCAACAGAGTTCGTACATGGTGACCCGGAATGCCTGTAGCCGACTTCAAAAGAGACTAACGCGGTACGGACGGCTTCATCGTCGTCTTTTATCCGATGCGAGTCCATTAGCCGACTCCTTAAAGCCCGTAAAACAGGGGTATTCCAACACGGTTATCCACAGTTTAACCGTTATTCGGGGGTAATCTAACCCACTGCTACGGAAACTCCAATCTGACATCGGGTTCCGTAAATCTAGGGACGCGAACAGGTGCCCCGCTTACTGCAACAACGCGCACCCACCCCAAATCTGCCAACCTTTCGGTCTAGAATAAATATACCGTCGGTCTAAATTGTCGTAGTACACTAGCGATGAACCAACAAGTTGTCTACAAAGGAATATATCGCGGCTAAAAGATTCACGATTAAATTCTTGACACCATCGGTAGATTTACTGGTTCGACTCAACTTAGCTGACCAGGATCTCGGCGCAGGAGTCACGGTTAGGTCGAAGTCCTTCAACCCAGCTAACTCGGTCAAAGACCGCATCGGTAGGCAATCGTGGGCGCGCCGGGGCATCCTGGCGAGCTCAAGCCAGGCGGCACCATCGTAGAGGCCACCTCAGGCAACACCGGTATCGCACTGGCTGACGAAAGGCGCATCCCGTGGCTACAAAGGTTGTGACCATGGGAAACCATGTCTGCTGAGCGCCGCGTCTTGCTGCCGCGCATACGGTGCGGAAATCGTCTTGACCCGGGTGCTGCTGGCATGCAGGGCGCTGTCGACAAGGCAAATGAGGGTTCTGGCGCAGCAGGACAAACGCGTCCTTGCCCGTCAGTTCTCCAACAGAAACCGACGCAGATCCACTACAGGACCACTGGTCCGCAGAGACCTGGGAAGACTCCGGCGAGAACGTGGGCGCATTCGTCGCTGGTGTGGGCACAGGCGGCACTGTCACGCGCTGGCCGCTACCTGAAGGAAAGAACGCCGACCTGCACCTGGTTACCATCGAGGCCTGCTGATTCCCAGTACTGACCGAAGGCAAGGCTGGCCCACACAAAGATTCAGGACCTTGGCGCCAGCTTCCTGTGAGGTTCTGGATCGCGAGCTTCTCGATGAGGTTCTTACCGCAACCAGCAGAAGATCCATCGCTATGGCCTGTGGCTACCGATGAGGGCCTACTGGTTGGTATCTCATCTCCGGTGCAAACGTCCGCTGGCGCTGGCGCTGAGCTTGCTGAGCGTGGGGAATTCAAGGCGAATGCATCGTCGTTGTTGCTCCAGACTTTTGGTAGGCGCTACGTCTCCACTGTCTCTTCGAAGACATCCGCGACTAATTAATTCTCGGCTGCGCGAAGACTTTAATTCATCAGCGTCATTCCCGGCTATCAATGTTGTTGGGCAGCCGGGTCTTTATAATTGGCGACTTAAAGGTTTAACGGTAGAATCCGGGGGCATGAACCTTTCTGATAATCATTTCTCGGATTCGGGAAGACTAGCCGCCCAATGCTCGCATGATCCTGCTGCTCGTGGCGAAAATGCGGTCATTTACTCCGGATTGCACGCCATTTGGGTCCACCGCATTTGCCACTGGCACAATGGGCCGCAACATTAAAAAGGACCGGCGCGGATTTTATCCCAATTAAACCGCTTCCTTACCGGCATTTGAAATCCACCACAATTTTTGGTCGCCGGTTCTTTATCGACCACGGCATAGGCATCGTTATTGGCGAAACCGCCGAGATTGGCGACAGCGTCATGCTTTATCACGGCGTGACTTTGCCAGGTTCTGGCCCCAACTAAGCGCCACCCACGCTCAAAGACAACGTCGTGGTTGGTGCGGGTGCTAAGAATGCTAGTCCCATCACCATCGGCGAAGGCTCCGCTGTAGGGGCGAATGCTGTAGTAACCAAGACGTTCCTGATACACCGCGACGGCATTCCGGCTAAAATCGCCCTGCCAAAAAGGACCAGCAAATCAAACTGGTCGACCCTGATTATTTTATTTAATTGCCTACTAATTACTCAACGAAGTCGCTGCACAATGTCATTTTGTGTGCAGCGACTTTACGGATTTAGAACAGTGAGACTAGCTTTCTCGGAATCGTCTTTCTTTGACGTCGGAGGCACGGCGATGATGTCGCCTTAGTCGCCGGTAAGTACGCGCAATTTACGCACTGCAGGACACGTGGCAACGACTTTGACCCCCATCGTCCGCGATTGGTCCAAGGCGCTAGTAATCAACGGTTTAGATAGCCCTTGGCCGCGCGGAATGCATCATCAACGACTGGTGAAATTCGCGCACACCATCAACCCAATATTGAGGGTAATGCGATGCCCCAGCTTCGTCGCCATCGACGGTTCATTTTATATTTAAGGTTTCAGGATCATGCGTGACTTGAATGTCTTTATCTTCTGAGCTCATCTTCTTCTCCTTCAACGCATCTGCTCATTCCCCGGTGGTTGTGGCATCAGCTTGAGGGAATGGACAGATCGTGCAGGCTTTTTGCTTATCGACGAATGAGGATCTTCGTATTCTGGATTCTTGTTCACAAAGTGCTGTACAGCCCGGAGCTGAGGCAACTGCCTTGAGCCCGACTTCACAGTATCATCAACTGCCTTCACCAATGGTGAGGACAGGCCTTGTCCTGAAATCTGGGTTAATAACCGTGTGGTTGAAGTCTACGGACATCCTCAGTGACGTAGTCAACCGCAAATCCAGCAGGTTCGCCATCGACGAGTGAGGACGAAACGCTTGCGGTCAGTGTTATTGAGTTACTTCATTAGTCATGGTTCCCAGTCTACGCGGGAACAACAAAGCCCCTAATGTTTTTCACACTAGGAGCTTTATGGTATGTAGAGCGGGGATCGAACTACGGCGACCCCCACACTTTCAGGCGTGTACTCCACCGACTGGGCTATCTATTAAAAGATTGCCGCAAGGACAATCTTGCGACCCTAAGGACTTGAACCTGACCTCCGCCGTGACAGGGCGGCGCGCTAATAACTGCATGGGCCTTATTTAATTTATCTGTGCCTTAGGCACGATATGTTACTTTACATAACGCGCGCTCAGCAATACAAATCCGCAGTTCAAGCGCCAGTTTAGCCGACCTTTGCCCGAGCTTCTCCTCGCAAGTACTTAGCAGCAGCTTAGAAAAGAAGCCCGAAAAGATTAGGCGCGAGACGAATCAGCGGTCATCTTACTGCTTGTTACGCAGCCGCAGCACGATGACCACAGCAGCCGCCAGAAGCCCCAGTACCACGTGCCTACCACTTTTTAGACAGCGCCGTTGGATACACCGTTGGACTTACTTTACGCCGCCGCGTTGGAGACATCTGTACGGTCGCCTGCATCTTCGGGGGCGGTCTCCACCGCCGATGGTATTACCACTTCGGCTCAAGGTCGTGTAGCGAATCCGGGCTCCGGACCTGGTTCACGTACGTCGGACGCCGTCGCTTGCCTTCATCAGGCCCGTTGACATCTACCGCGAGCTCATGAAATCCTGGTCGTGTTTCTCAGACTCTTCATCCCACGGCACCGCCAGTAATACCGCAATGGAAATGATCACCGGCAATGGAAACGCGCTCATCACCCGCGTTCACATTCCTGTTGTCGTGGCAGCCTGTCCACCATAAGCTGGGACATTTTGAGCTTTCTGAGTCTCTGCTGGAGACGAATGCGTATCATCCACAGATTTCACGGGATTGACCAGTGGAAGTGACAACCAAGCGGAATCAATATTTTCGTTCAGTCGGTTTGCGGATGGCCATCTCAGGAACTGGCCCCACTCGACGGGAATCTTGCTTAGTAATGAGTTTCGCCAGCCACGATGGAGTTCTTAAAGGTTCTGGCTCAATCTCAGGCGCGCCAGTAGCTGTGTTCAAATATGGGCATTTTCAAACTTCACCGGGAGACTCCTGCGCCAAAGACCGGGGTCGCCCTCTTCATGAATTGCATTTCCGGAGGAACTGGCTTATGGCAGATGTTGACTTCTACGCCAAGCTCTTCACCAACAAGTTCTCGATCCCATCCCGGCGGTAAAGGTGTGTCCGACAATCCACTCTTCCATGTCGCAATTGCCCTTCTTCCCGTGATGAAAGATGTCCTTTCATGGGTTCAGTGGGAAAAGATTCCTCATGTCGACTTTTCCTTTCCACACCGTCGGTGACTCATCCGCCCGGCAGTCAGACCCGTAAGCGCGATTTGACACCTCCAGCAGCATCTACTTGCACGCTGCCATCGCTTCCTGAAGCTACGCTTCCGGTTAGTCTCGCAGTGCTGTTCGGTTGCAGGATCATCGCGTTGTGCAGGGACAGCTACGCGGAAGTAATTGATGTCGCTCTCGGTACCGGACGCATGACTGGGTCTGGTACTTGGCCTCGTCGAGCCATTTGGCGTCGTCGATATTGTCGGCGTATTCAAATTCAGTTACCGCTCATGTCGTAGCCGACGGTGTCACGCTGAACCGGGGAACTCAGGCTGGTTGCCCAGTTCCTCAGCGTTTTCGGCTTCAACGTAGGTACCGCCACAAGGGCTCAGGATACATTCCAACTCCGCCTGTGCGGCTTCATCACTTTAAACCCACGGTGTGGATGCGGCGAGGAGTCGAAACCGTCGCGAGTTCTTCCGCCACCTCACAGACCGGTGGCGGTGCGCACATATCAATGCCATCAGGACCAAGATGATGGAGCGGTCCCCTCCTGCCCAGTTCATCGGCAGCGCTGGCCTGCCATTTTCCCATCGGGGTATAACCCTGCGCGCCTCCAAGGCACCAATCTCACTTTGAGCTCTTCTTTGTCAATACGCTCAACCGGTGCCAGCGTCGATGTCTGGCACCCTCGCTCCCGGTTGTGGGCATTGGACTCCGCAGGGCCCCGTAGGCCAAGCATGCCCATCACGGCTGTCTCCGGAGGAATTCACAAGCTGATTAGCCGCCTGCTTCGCTGCATCCAGTCGCGTTTCCCCATCAACGTCTTCGGCGAGCATCGAATCCGAGGCATCCATGATGAGCGCAGCGCGCGAGTCCACCACCGAATTTTCGGCGCTTCCCGGG 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TTCGGTATGCTTCGTTCAGTTGCATACCACAGCTCAGCCAGTATTAAATGACATCACCGCAGTGGGTCCCCTTCTTCCGAAGTTACGGGGCAATTTGCCGAATTCCTTAACCACAGTTATCCCGAACGCCTTAGTATTTTCAACCTGACTACCTGTGTCGGTTTTAGGGTACAGGCCATATACACATCGCTAGAGGCTTTCTCGGCAATTTACCAGGATCACCAACTTCACCAAAGGGCTCCGCATCACGCCTTAACCATATGGTGACGGATTTACCTATCACTCGAGCACACGCTTACACCAACAATCCACTAAGTGGCATGGCTACCTCCCTGTATCACCCCATCGGACCACATTTCAGATTTACGCACGCACACACAATCACATCATCCGAAAGAATCAATAGCCATTAACTTGTGGGTGGTTTAAGTATCAATCACTTTACCACGGGCGCGCCACGGGTACCAGAATATCAACTGGTTATCCATCGACTACGCCTGTCGGCCTCGCCTTAGGTCGACTCACCTGGGAGAGACAGACTTGACCCGGGGAACCCCTTAGTCATCCGGACGATTCTCACTGTCAATTCGTTACTCATGCCTGCATTCTCTCCCGCTCGCACACAGTCCGACTCCTTACAGTACCGCCATACCATTTTGACGCTCCCCTGCAATACGCAAAATATATTTGCCGCGGCTTCGGCGGTGTAGCAGGCCCACTACATTGTCGGCGCCGTTTCACTCGACCAGTGAGCTATTACGCACTCTTTCAGGATGGCTGCTTCTAAGCCAACCTCACGGCTATCTTCGCGATCTTACATCCTTTTCACTTAGCACACCCTTAGGGGCCTTAACCGGCTTGATCTGGGCTGTTTCCTCTCGACTATAGGCTTATCCCCACAGACTGCTGCGTAGAACACAATTGAAGTGGCATTCGGAGTTTGGCTGATGTTGCTAAGATGATGGTCCGCTCAACCAACCAGTAAATACCTCCACCAAGCCTACTACGACGCTGCACCTAAATGCATTTCGGGAGAACCAGCTATCACGGAGTTTGGTGGCCTTTCACCCCTACCCACAACTCATCCTGATTTTCAACCTACGTGGGTTCGCGCCTCCCACGACGTCTTACCATCGCTTCACACTGGCCATGGGTGAATCACCCCCGCTTCCGGGACGTACCACTACCACCCTCGTTGGGATTCGGTTTCCCTACGGCTACCCCACGCGGGTTAACCTCGCGACATGCCGCTGACTCGCAGGCTCATTCTTCAAAAGGCGCGCCATCACCCACAACAAGGGGCTCTGACGGATTGTAGACACATGGTTTCAGGGTTTCTTCACTCTCCCCTCCAGGGTGCTTTCACCATTCCCTCACGGTACTCATACACTATCGGTCACTGAGTATTTGGAAGCACCGGGTGGTCTGCGGCAGATTCACAGCAGATTCCACAGGCCCGCTGCTACTCGGGCACCACAACACACACCATGTTATCTTCACCTGGGGCTCTCACCTTCTACGGCCGGGTTGTTCCAGCCCCACTTCACCTAACAACACAATGCGCGCTCTCTTGGTAGAAACAGAAAATCCATGGCCCCACAACACCGCGTACACAACCTCTACCAAGTATCACATACACACAGTTTAGCCTCATCCACATTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTCTCCTCCTGCAGGTACTAAGATGTTTCACTTCCCCACGTATAACCCCACACTGACTATGAATTCATCAGCAGGTACCTACCCATAACAGCGAGCGGGTTTCCCCATTCGGACATCCCTCGGATCAACGCTCAGTGAGCGCTCCCCGAGGCTTAACGCAGCCTTACACGTCCTTCATCGGCCCAGCAGCAAGGCATCCACCATGCGCCCGCCAAATAACAAACACACACCCCACACACCACAAAATGCATGGGGTGAACAGCCATAACTAAAAATACTAAACCACACACCAACCAAAGTTGGTATGCGACGTTCTCACAGAAAAAATAAGAAAAATTACGCACACCACACAAACACTTCAAAAGCACTCGTGTGGTGGATGCTCGCGTCCACTAACCACAGTTCTCACACAACACCCCACACCACCAACCCACACACCCACTTTTGCAAAAGTAAGCGTTTGGTGTTTCGTGATGCAAGCACCGGGACCAACCCACATAACGTGAATTGCTGTCCCAGACGCAACAGTGCACCAATGTCTAAACCCAGATTTAATCACGCACCCAATGTTTATGTCTCCAAGAATTCGTGTTAGCAGCCTCTATAACTGCCAGTGTGTTTCCACTCCGATTCAAACTCGGTGGCGCGGCCACACTCGGGTCATCAACCACCAACACCGCGCCACACAACCGTGTGACAGCAAAGATGTTTAATTTAGCTCGCGCCAGAAGGTGATCAGCCGCACCTTCCGAGGTACGGCCTACCTTATTACGACTTCGTCCCAATCGCCGATCCACCTTCGACAGCTCCCCTGCTCAAGTTTAGGCCACTGGCTTCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGAACGTATTCACCGCAGCATTGCTGATCTGCGATTACTAGCGACTCCGACTTCATGGGGTCGAGTTGCAGATTAATCGAACTAAGGCCGACTTTGAGTTCGCTCCACCTCACGATGTCGCTGCCATTGTATCGACCATTGTAGCGTAATGGCGAAGCCCTGGACGCGGGCATGATGATTTGACGTCATCCCACCTCCGGGAAGTTAACCCCGGCAGTTTCTCATGGAGTCCCCACCATCACGTGCTGGCAGCATAAGACAAGGAGTTGCGCTCGTTTGCAGGACTTAACCAACATCTCACGACACGAGCTGACGACAACCATACCACCTGTATACAGACCACAAGGGACGAACTATCTCTAGCCCAATCCTGTATATATCAAGCCCAGGTAAGGTTCTTGCGTTGCATCCAGATTAATCCACATGCTCCGCCGCTTGTGCGGGCCCCGTCAATTCCTTTGAGTTTTAGCACTTGCGTATTACTCCCAGGGCAGGGGCGCTTGGCCGTTAGCTACGGCACAGAAGGCAGTGGAAGCCTACACCTAGCGCCCTGCGGCATGGACTACCAAGTGCTCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTGTCGCCATCGGTGTTCCTCCTGATATCTGCGCATTTCACCGCTACACGAGGAATTCCAGTCTCCCACAGCACTCAAGTTATGCTGCCCCGTATCGCCTGCACGCCCGAAGTTAAGCCCGGGTTCACAGACTTGACGCGACAAACCACCTACAGAGCTCTTTACGCCCAAGTAATTCCGGACAACACTACGTATTACCGCGGCTGCTGGCGTGGTTAGCCAGTGCTTCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGTTTACAACCCGAAGGCCGTCATCCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCCATTGGCTGGCAATATTCCCCACTGCTGCCTCCCGTAGAGGTCTGGGCCGTATCTCAGTCAATGTGTCCGTACACCCCTCAGGGCCGGATACCCGTCGCCGCCTTGGTAGGCCATTACCCCACCAACAAGCTGATAGGGCCGCAGGCTCATCCACACCGCAAAGCTTTCCCACCACAACATCAAGAGTGGTCCTATATGATGTGAACCCAGTTTTCCCAAGCTTATCCCATAGCGTGCAGGGCTACTTACGTGTTTACTCACCCGTTCGCCACTCGGGGTACCTGGCGCAGTACAGGCCTTTTCCCGTTCGACTTGCATGTGGTGAACGCCGCCAGCGAATTCATCCTGAGCGGATCAAACTCTCCACAAAAGGCTGCAGAAAGAAGCCCAAACCTAACCAAAAGACAAACAACACACAAACATCCTGCAATGTGTGAAGCTGACCAAAATTACTACATAAAGAAATCAACAAACCCAACCAACCAAAGTTAGCCAGGTAAGGTAAAAGTGTTTTAACTGCATCCAGCAGACGCTCATTCATTCAATATGCACCGTTACAGTATTTAACTATTTTCAATTACCACCCACTTAACGACAAGTGACATCCGAGGTACACACAACAACCAAACACACCCAGAAGATGCTCAGTCAACATAATTCCTCATCCACACAACACAGACAAAAATAAAAATCTAGGTACATTGGCACACTATTGAGTTCTCAGACAGCAGCCACACAAGATGGGTCGGCTTCCTTAGAGCTGTTTTCGCTCTCGGCTGGAGTTTCTACCTTAAGACAAACTGTTTGACGTTTGTCAACCAGGTCGGTAACTTTTATTGCCGCACGCTCTCTCGCGGCGACTTCGATAAGTTACACGGGACCCAGATCTTTGACAAATCGCCAAGGTAAATCACGGTTTTAAAGATCGGGCAAACAGAACCCCGCGAGCTTTCATTTTAAAGACTGCGCTAATGCAAGGTTAATTGCTCAAAGCGCGGACTTCCGGTGGAAGCTAGCGGGGTAAAATATGACCTATCTAGGCCTTGGTGCGATGAACGCCGGCGAAGTTCTTCTTGCCGCGCGGCGCATCACAAACCATGCACCGTGGAGGAAGTCATCTTCGGCGGGGTCAATCATCGCTCGATGCGCTGGTTATTGACGTACGCGCCTTCTTTAATCGTGCGGCGGGGCTGCACCCCTTGGAATCAGCGAGGCCGAAGCAACGAAGGCAGGTCAACATTCCGAAAGAGTCGTCATCGCCAAGCTCTGCCACGTTGGTCTCCGACAATGCGCCTTCTAGGGTCTTTTCATCCGGAATCCTTTAAGTTCAGCGCGACCGAAAGTGCCTGCGGCGGCTCTACTGCCTGGAATTGGCCTCATTTGCCGTGTACCAAGTTGGTCATCTCTTGCGCGAGACGGCGCTGGGCGGCACAGCGAAGAGCTCTTCTTCGACGGCCTTAGCGTACTCAGCGATTTCTTCACGGTTCAAAGAAGGTAAACCAGCGCAGGTAGTCGATGACCACGGAGTCACCAGCGTTGAGGAAGTACTGGTACCAGGAATAGGCCGGAGTCTTGTCCGGATCCAGCCACGGCGCGCCACCGGTGGACGCAAACTTTTGTCCCTGCGCGTCGGTCACCAATGGACCGGCGGTGCTTTGTGCGCTTTGACGCCATCAGCGACGGTTGAGATCCACACCAGGAATGTCATTTGCCCCCACTGATCGCCGCCACCAACCTGCAAGACGCAGTCGTACTTGCGCTACAGCTGCACAGAAATCATTGGCCTGCAGGGCATGTAGGGAGAAAATTCCGTGGGAGGAGATGCCGTCGGTTTCCGGCGTAACTGA 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c499d028-472b-4274-9208-95b4523ca5d9 4 0 0 0 0 4d69c521-b119-4a88-b62c-38d4f643485d 4 0 0 0 0 02d43f73-befa-4888-b616-67646fd9d434 4 0 0 0 0 6a185a9f-1b0b-4a28-88ea-dd43e6aa10e4 4 0 0 0 0 db5d9021-7925-4654-8845-b574f9f748fa 4 0 0 0 0 90786119-4789-4e4e-ab3b-8871f4082756 4 0 0 0 0 86c19dd3-d5f2-4487-95ab-b56e13dfb7e6 4 0 0 0 0 1e98192f-6bd5-49e5-a2d3-1db3e57c80a2 4 0 0 0 0 TGGTAATACTTCGTTCAGTTACATTATTGCTAGCTATCACGGAGTTTGATTGGCCTTTCACCCCTACCCCAACTCATCCCGCAGTTTTCAACCTACATTGGGTTCGCGCCTCCACGACGTCTTACCATCGCTTCACACTGGCCATGGGTAGATCACCCCGCTTCGGGTCGGGACATGCCACTACCACCCTCGTTAGGATTCGGTTTCCTACGGCTACCCCACGGGTTAACCTCGCGACATGCCGCTGACTCGCAGGCTCATTCTTCGCGCCATCACCCACACAACAAGGGGCTCTGACGGATTGTAGACACATGGTTTCAGGAACTATTCCTCTCCCCTCCCGGGGTACTTTTCACCATTCCCTCACGGTACTCATACACTATCGGTCACACTACAATTATTTAGGCTTACCGGGTGGTCCCGGCAATTCACAGCAGATTCACGAGCCCGCTGCCTCGGGCACCACAACACACACCATGTTATCTTCACCTACAGAATCTCACCTTCTACGGCCGGGCATTCCAACCACTTCACCTAACAACACAATGCGCGCTCTACAATGCGGTAGAAACAGAAATCGCGGCCCCACAACACCCGCATGCACAACCTCTGCGTATCATACACGGTTTTAGCCTCCACGTTCGCTCGCCGCTACTAGCAGAATCATTATTTATTTTTCTCCTCCTGCAGGTACTAAGATGTTTCACTTCCCCACGTATAACCCCACGCGACTATGAATTCATCAGCAGGTACCTACCATAACGGCAGGCGGGTTTCCCCATTCCGGACATCCTCGGATCAACGCGCTCAATTGACAACTCCCGAAGCAACGCAGCCTTACGTCCTTCATCGGCCCAGCATACCAAGGCATCCACCATGCGCCCATAAATAACAAACACACACACCGAAATGCATGGGGGTGAACAACCATAACTTAAAAATACTAAACACACACCAACCAAGTTGGTATGCGACGTTCTCCACAGAAAAATAAGAAAAATTACACACACCACACCGACTTACTTCAAAGCACTCGTGTGGTGGATGCGTCCACTATACAGTTCTCACACAACACCCCACACACCACCAACCACACACCCACTTTTGCCAAACCGGCGTTTTAGTGCGTGTTTCGTGATGCAAGCACGGGACCAACCCACATAACGTGGTGCTGTCACAGACGCAACGGTACCAATGTCTAAGCAGATTTAATCTTGCCTGTGTTTATATTGTCTCCAGAATTCGTGTTAGCAGCCTCTATAACTGCCGGTGTGTTTCCTCGATTCAAACTCGGTGGCATGACCACACTCGGGTCATCAACCACCAGCACCGCGCCACACAACCGTGTGACGCTTAAAGATGTTTAATTAAAGCTCCTTAGAAGTGATCCATGCGCACCTTCCGGTGCGGCTACCTTATTACGACTTCGTCCCAATCATACGATCCACCTTCGACAGCTCCTAACAAGTTTAGGCCACTGGCTTCGGGTGTTACCAACTTTCATGACGTGACGGGCGGTGTGTACAAGGCCGGGAACGTATTCACCGCAGCATTGCTGATCTGCGATTACCTAGCGACTCCGACTTCATGGGGTCGAGTTGCGGGTAATCGAACTAAGGCCGACTTTCAGAGTTCGCTCCACCTCACGATGTCGCTGCCCATTGTATCGACCATTTGTAGCGTAGTGTGAAACTTATTACGGACATAAGGGGCATGATGATTTGACGTCATCCCCACCTTCCTCCGAGTTAACCCGGCAGTTTCTCGCGAGTCCCCACCATCACGTGCTGGCAACGCCAAGACAAGGGTTGCGCTCGTTGCGGGACTTAACCCAACATCTCGACACGGCGGCGGCAACCATACGCCGCACCTGGCCACAGACGGACGAACTATCTCTGGCCAATCCTGTATATGCTTCAGGCGGGTAAGTTCTTCGCGTTGCATCAGATTAATCCATGCTCCGCCGCTGTGCGGGCCCCGTCAATTCCTTTGAGTTTAGCCTTGCGGCCGTACTCCCCGGGCGGGGCGCTTAATGCGTTAAGCTACGGCACAGAAGACGGTCGGAAGCCCCTACACCTGCCGCGCCTGTTTGTGGACTACCAGGGTATCTAATCCTGTTCGCTACCCATGCTTTCGCTCCTCAGCGTCAGTTACTGCCCAGAGACCTGCCTTCGCCATCGGTGTTCCTCTCCTGATATCTGCGCATTTCACCGCTACACCGGGAATTCCAGTCTCCCCTACAGCACTCAAGTTATGCCCGTATCGCCTGCACGCCCAAGCGGGATTTCTGAACGACGACAAACCACCTACGAAGCTCTTTGCGCCCGAAGTAATTCCGGACAACGCGCACCTACGTATTACCGCGGCTGCTGGCGCATGGATATGGTCTTCTTATCTACCTACCGTCACCACAAGTGGCTTCGTCGATAGCGAAAGGAGTTTACAACCCGAAGGCCGTCATCCCCCCACGCGGCGTCGCTGCATCAGGCTTGCGCCCATGTGCAATATTCCCCACTGCCTCCGTGGAGTCTGGGCCGTATCTCAGTCCCAATGTGTCGTACACCTCTCGGGCCGGATACCCGTCGCCGCCTTGGTAGTATTACCCCACCAACAAGCTGATAGGCCGCAGGCTCATCCCCACACCGCAAAAAGCTTTCCACCACAACATCCAAGAAGTGGTCTATATGGTATTAGTTCCCAAGCTTATCCCGCCAATTGCAGGGCGAGATCACTTACGATATTTACTCACCCGTTCTCGCCATCGAGTACCTGTACAAGTACCAGGCCTTTCCGTTCGGCTTGCATGTGGTAAGCACACGCCGCCAGCGTTCATCCCTGTGAGCGGGGATCAAACTCTCACAAAGGCTGTAGAAAGCCCAAAACCACAACCAAAAGACAAACAACACAAACTATCCTGCAATGTGTGGAAGCTGACCAAAATTACTACATAAAGAAATCAACAAACCCAACCAACCAAAGTTAGCGGTAAGGTAAAAGTGTTTTAACTGCATCAGCAGACAACAATTACATTCAATATGCACCGTTACAGTATTTAACTATTTTCAATGCCACCCGCGACAAGTGACATCCGGTACACCACCAACAACCAAACACACCCGAAGGAATGCTCAGTCAACATAATTCTCATCCACAGCACAGACAAAATAAAAATCTAGTACATTGGCACACTATTGAGTTCTCAGACAACAATCGCACACTTGATTTGGAGCTTTTTATCTTTAGCCCACGCCCATGGCTTTATTGAACTTACGCTATCGATTCGACCGTGTCCGTCCTTGCTTTTAGTTCTTCGTTGTGTCGCTTTGCGTTTACCTTGCGGCAACCTCTCGGCGACATCCGCATAAAGGTAGTTGATCTTCGATGAGGAAGGCAAATCGCCATCTTCACCTCCCTATTTCCACCAGGATATCTAGTTTCTGTCCCTCGTTCAACAATCGCGTGGTTTTGTGTTGTCGTGAAAAGACACAACGCCCGCTACGGAAGTTGGTAGCGGGCGTTAATGTGAATCAAGGTAGGTTTCTGGATACTCGCCATTTGCTAGTTAGTGATATAGCAAGCAAGTAGTCCACGGGACCATCAATGGCTTGGATTTGCGTATTAAGATTGGCGACAAGGATTTCTTCCCGCATGATTTCATCTGGAGTACCAGAATGCGACGATTTGTCCATCTTTCACGGCGCAGATGTACTCGGCGTACCGCGCGGCGTAGTTGATGTCGTGCAAAACAACGATGATGGTGCGGCCGAGCTGCTCGGCAGCTTCTTTCAAGATGCCGCATCATTTCCACCGAGTGTGCGATGTCCAGATTGTTTAATGGCTCATCAAGAGGTATGGTCTGTTTCTGACATAGCACCATGGCGGCATAGGCACGTTGGCGCTGACCGCCCGAAAGTTGATCAAGTAGCGGTCAAGGCTAGGTGAAGGAAGTCGATGCTTGGTAATAATCTCTTCGTCTTCATCGGTCAGACGACCTTGGAATAGGGAAAGCGACCAGAAGCCTACGAGCTGACGGACGGTCAGCTTGGTAATAAGTGGTTCTCGGCGGAGGACGGAGATTATCTTTGCCAAGTCTTTGGACGGAGGTCACCTTAATATCCATTTCGGCGACCTTGATTTCGCCAGCATCCATGCCGAGCAAACGGCCGACAACCATCGTCAGCAGCGTCGACTTGCCGGCACCATTGGGGCCAATCAGCGCGGTGATACCGCCAGCTGGGATTTCAGGTTGACGGGACCAATTTCAGTTTCTGATGAATGCGCCTTTGTGACGTCAGTCAGGTAATCACAGTCGTCCTTTCTTAAGATGACGTACAGGAACACAGAACCGCCTACTAACTCAATAATGATAGTCACGACGCCCTGTGCATAAAACACGTGCCGCATGATGAAGTATGCGCCGGTGAGCACCGTAAACCAGTTACCGCGGCCATCGGAAGAGATAGCGGTGGTCATAAGTATCCAGCAATTGATAAGCCAAGGTGGCAACTTGAGAAAGCCGGGAAGGTCATCGGACCGACAAGTGCGGTCGTTATTTACCATTAAAATGGAGACCGTCAAGGTGTATATCGCATTGACCTTGTAGTTAACGCAAGCTGATCGGGCATCCCGCCCGAGCGCCAGCGCACATTGGCGGCGCGAGTTTAGATCATCAACACCACCGTGGCACCGATGATGAGCAGATAGCGATGGGATAGTACTCAGTATCGGCATTGGTAACCGAACCGAAAAGCCGAGCAGTTAAGACATCAGATTCACTGAGGGGTCAGCAGACGCTGCATAAACGTCGAGATGGAGCCTAGTCGCCACCGATGACGATGCCGACGAAACAACGCCAATGTTTTTGGCATTTCCGGTGAGCAGCCGAGAATTGCAGCGGCAGCGGAGAAGACCATGAGGACGAGCTGCACGACGAACATCTCTACGGTGCGGGCATTGTTCAGACCTACCGCGCCGAAAAAGAAATGGTGGCGGTGTGAATTACTCGATAGGCGATTCCGAAGCCCATGATTGGCAGCGTCAAAATTCGGTGTGGTTACCGTTTGAAATGCCACGGTGGCCACGGCTTGGCAGACTGCCACCAAGGCCATGGCGATTACCCCATCGAGGGCGACGTTGGCGATGGGCAAAGCCGCGGAGTGCCAAATTCCATCGGGTTTTCATAGGCCAAAAGACCGAAGGAAAATAGCGCCGCCAAAATGGACATGGCGATAATCATGATCCAGTATTTGCGGGCCGCTGTCGCCGACTGAAGCGCCGACGTGGCGCGAATCTTTTCATCGGGCCTGCCACTGCGGCGCGTTCTTTATTTGCCACGAGTCGACCTCACAATCAAACCAGCTTGAAGACGATGGCTCCGACGATTCCCAAAATAACCGACACACCGGCATTTCAAATGGGAAATAATCACGCGGCCCAACGGGTCACAGACGGTGACGATGGCGATGCCGAGCAGCAAGACCCACGGCAGGTTGGGCCTGAGTCGTCACCGCGGAACATGCTGACGATATTGGGGACAATCAAGCCCAAAATGGCGGGGGCCAACGACCGCAGTGACCACACCAGTGGCGATGGACACCAGTGCGTTTCCCAGCAGCAAACACGGTTGTAGTTCAAACCAATATTGGTGGCGATATCTTCGCCCAATCCTGCGGCTGTGAAGGCTTATCCGCGAAGAAAAAAGGCGGCGATACGACAACAGCGAGCACAACCCACAGAACTTTCGTATTGGCCTTTGTACACGGAAATGAACCATGAACCAGATGCCAAGCTGTTGCAGCGAATCTGTAGCCAATGCAAGAAGGAAGATACTGGGCAATGGCTGCGCCGAGCATGATGCCGACGATGGGCACGACCATGGACGAGCACAGTGTTACTCGGCGTAGGAAGAGGAAGAAGATCTCATGGTGCCGATGAAGGAAAAATGCAGCAACAATCATCTTGGCCAGTACTGATGACTGCGGGAACAAGATCAAACACATCAACAGCGAGGCCAGCCCACTCGGTGGTACCGGTGGTGGTCGGTTCGACGAAGCGGTTTTGCGTCAATAGCTGCATGACCGGTTACAAATAGCCATGGCGGCACCGGCGAGAACCAGTGCGATGGTGGAACGCTGGTGATCCCGAACTTTCCCATCGAAGTCATCGGAAAGAATGCTGTATTCGCCTGGACAACGACGCAATCAATAAGATAAGCGACGCCAAGCGTGGCTAAGCTTCCAGTTCCATAACTTGCCGCGGGATCGGCGCTGGGGTATCATAACTCAGAACCCGCTCCCAGCGCGCATATGCTTGTAGGCGTCGAGTTCGAGGATTGTCGCATCACTTATTCTTTTCAAACCGAAGAACTCGGTTGAGGCCTTAGGGTCTCATTCCCAAGGTCAACCGGCGTTCGTAATCCGGC 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f6eec407-71f7-46a8-b7ff-94dbb3970353 4 0 0 0 0 b2906001-8b8f-4186-a388-2d05a9ea87a4 4 0 0 0 0 1babd196-9ff1-4563-9b73-44661a9bfd23 4 0 0 0 0 dc75275d-f254-45f1-81c1-ef9ea43d2b00 4 0 0 0 0 31cae1c1-e10c-4fb1-9af9-ec6707a8eada 4 0 0 0 0 223b4e3a-005f-46e6-bc7a-5c6bef9f80e3 4 0 0 0 0 9e3822ea-7fca-4f83-9703-98b235e63cc3 4 0 0 0 0 17970e66-6f8c-4f28-8fad-934b22014ec4 4 0 0 0 0 *

[Tiezhengyuan]

There are the lines of the three files for racon: [superuser@A]$ wc -l /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/* 75 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/alignments.sam 0 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/consensus.fq 292 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq 4 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq 371 total

[Tiezhengyuan]

Hi Botond, The attached files are the temporary files generated by polish_clusters.

[superuser@ALCAZIDCQ01 2018_fastq]$ /mnt/rdedata12/yuan/github/pinfish/polish_clusters/polish_clusters -a cluster.tsv -c 50 -o consensus_transcripts.fas -t 40 aln_filter_sorted.bam polish_clusters: 17:33:46 Polishing cluster 71f61652-7fc8-4901-a511-a16d2ff8f3ff of size 73 polish_clusters: 17:33:46 Failed running command: racon -t 40 -q -1 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/alignments.sam /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq > /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/consensus.fq - exit status 1 [superuser@ALCAZIDCQ01 2018_fastq]$ racon -t 40 -q -1 /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reads.fq /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/alignments.sam /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/reference.fq > /tmp/pinfish_71f61652-7fc8-4901-a511-a16d2ff8f3ff_880040499/consensus.fq [bioparser::FastqParser] error: invalid file format!

---

发件人: Botond Sipos notifications@github.com 发送时间: 2019年3月26日 0:08 收件人: nanoporetech/pinfish 抄送: Tiezhengyuan; Author 主题: Re: [nanoporetech/pinfish] errors from polish_clusters (#5)

Could you please paste here the head of reads.fq and reference.fq?

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[bsipos]

The problem is that you did not filter out the secondary and supplementary alignments. Please run pinfish using the pipeline, which will do that for you.

[MartinTes]

Hi @bsipos ,

I also running polish_cluster with my own data (spliced_bam2gff and cluster_gff worked fine): and I am getting the following error which has something to do with the wrong input format for racon. Besides commands, I am also including pieces of input/ output files.

1) Splice bam2gf spliced_bam2gff -M Pool4_merged_trimmed_BC.bam -t 24 > Pool4_merged_trimmed_BC_raw_transcripts.gff

2) cluster_gff cluster_gff -t 24 -a Pool4_merged_trimmed_BC_raw_transcripts_clusters.tsv Pool4_merged_trimmed_BC_raw_transcripts.gff > Pool4_merged_trimmed_BC_raw_transcripts_clustered_transcripts.gff

3) My command polish_clusters line: (pinfish) martin.tesicky@turbacz:~/Medaka_parrots/Pool4/pinfish$ polish_clusters -a Pool4_merged_trimmed_BC_raw_transcripts_clusters.tsv -c 50 -o Pool4_merged_t_rimmed_BCconsensus_transcripts.fas -t 24 Pool4_merged_trimmed_BC.bam polish_clusters: 15:55:52 Polishing cluster 02e3c0c0-b1b5-4f5f-8bf5-05f83f97fbd3 of size 330 polish_clusters: 15:55:53 Polishing cluster c7a0033e-8bd3-4ea8-8539-8cfe406f915f of size 85 polish_clusters: 15:55:53 Polishing cluster e3b5ea34-f86a-42d8-9e2d-9c86a8d29b5c of size 53 polish_clusters: 15:55:54 Polishing cluster 8f8b2b1d-54d3-4b18-8dc5-3fc9b7eef4f9 of size 96 polish_clusters: 15:55:54 Polishing cluster f786d9ec-ecc0-4b5f-8862-2b4d1b72a8e1 of size 26109 polish_clusters: 15:59:42 Polishing cluster bb6413a0-83dd-452f-8e70-94e848c88720 of size 99 polish_clusters: 15:59:42 Polishing cluster 8db24705-3c4c-4e5a-b8bd-300688ff0bdc of size 50 polish_clusters: 15:59:43 Polishing cluster d28805d8-6cae-42fe-8138-a0d64a998608 of size 1345 polish_clusters: 15:59:50 Polishing cluster 46a7098b-2dd1-4f1b-966e-869613dfa32b of size 53 polish_clusters: 15:59:50 Polishing cluster 34c16ef3-891f-47aa-8946-32b963fb6812 of size 58 polish_clusters: 15:59:50 Polishing cluster d49642c2-0fd4-4c0c-8319-59d1863f57f8 of size 70 polish_clusters: 15:59:50 Polishing cluster 441903e3-5769-43cf-8043-bfb1df57c90e of size 2829 polish_clusters: 16:00:04 Polishing cluster 971c2378-3d77-43de-89ee-fd6c28e1947f of size 107 polish_clusters: 16:00:05 Polishing cluster e4bee383-39e1-494d-968e-ed129b7c4fc5 of size 147 polish_clusters: 16:00:06 Polishing cluster 0523fa67-f3a0-4343-8ecc-6cb957f5c26c of size 188 polish_clusters: 16:00:07 Polishing cluster cdbe623e-17c5-431a-93ea-a79e978eb475 of size 2260 polish_clusters: 16:00:20 Polishing cluster 6b535889-7107-48c3-9eab-5cb0aa6d1092 of size 258 polish_clusters: 16:00:22 Polishing cluster ca60e86e-f2cc-4ab8-ad13-d8727c344461 of size 202 polish_clusters: 16:00:23 Polishing cluster 70ed3672-75d2-4580-b9a8-8c0d79491f98 of size 306 polish_clusters: 16:00:24 Polishing cluster 53d2a843-bff9-4258-8b8b-701c4d47cd46 of size 61 polish_clusters: 16:00:24 Polishing cluster c40639a3-c3bb-4fec-8662-0e963f47d6db of size 99 polish_clusters: 16:00:25 Polishing cluster b788ec37-d32d-4f0a-baa8-5d3ec18af775 of size 130 polish_clusters: 16:00:25 Failed running command: racon -t 24 -q -1 /tmp/pinfish_b788ec37-d32d-4f0a-baa8-5d3ec18af 775_916745013/reads.fq /tmp/pinfish_b788ec37-d32d-4f0a-baa8-5d3ec18af775_916745013/alignments.sam /tmp/pinfish_b788 ec37-d32d-4f0a-baa8-5d3ec18af775_916745013/reference.fq > /tmp/pinfish_b788ec37-d32d-4f0a-baa8-5d3ec18af775_9167450 13/consensus.fq - exit status 134

And when I type only specific command that doesn´t work: racon -t 24 -q -1 /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/reads.fq /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/alignments.sam /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/reference.fq > /tmp/pinfish_30b0c438-8629-4a99-bc51-d09beba70aaf_205375420/consensus.fq terminate called after throwing an instance of 'std::invalid_argument' what(): [bioparser::FastqParser] error: invalid file format! Aborted (core dumped)

Few lines from input/ output files: Pool4_merged_trimmed_BC_raw_transcripts_clusters.tsv Read Cluster 1b27018c-7eb5-4359-8a0f-95d7265a1c28 640b1d2d-8a92-46a8-ac64-03fec213591b 135a6032-2c24-4f62-9948-8edae6dbd8a4 640b1d2d-8a92-46a8-ac64-03fec213591b b1faf377-9151-48c0-9dd4-c8d8900117ba 640b1d2d-8a92-46a8-ac64-03fec213591b 5b6b8a04-bf6d-4e32-b3fa-728e582569f9 640b1d2d-8a92-46a8-ac64-03fec213591b 7046ff83-4301-4694-80a1-4d5d8596a371 640b1d2d-8a92-46a8-ac64-03fec213591b 3e1928ba-06cf-4c04-9cf3-8510bcc318d2 640b1d2d-8a92-46a8-ac64-03fec213591b a2c4f0b8-f6ff-4fa0-9a04-9147bbcbf2ac 640b1d2d-8a92-46a8-ac64-03fec213591b dea24b20-4eb7-478a-97df-4052a7ab435c 640b1d2d-8a92-46a8-ac64-03fec213591b 1e0226c9-2774-4475-b679-100dc3c45f65 640b1d2d-8a92-46a8-ac64-03fec213591b

Pool4_merged_trimmed_BC.bam (pinfish) martin.tesicky@turbacz:~/Medaka_parrots/Pool4/pinfish$ samtools view Pool4_merged_trimmed_BC.bam | head -n 5 14a0e3a4-795f-4986-9975-0547ff81815d 0 ENSMUNG00000000050|ENSMUNG00000000050.1|testis 587 60 41S54M2I70M1D29M34S *0 0 GGGGACGCCGGGGCCAAGCGGTAGCAGTGCCATGAGCTGCGAGACTCTGACACGTCTCTGGGACCTGCAATGACAAGTCAGAACAGTAGCCATGCAGAGAGAAAACTGGTGAAATGTCACCAAAGCAGTCAACACCAAAAGTGCAGGTCCAGCAGTCTGTCTCCCGAAAACCATCACTATTCATTTCTCTGCATTTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA D:/.;=>;;&(2+---$''%)(%%&$9@/9=100%()))$3,5/..,0+)&693?3;=<96231/4?=E=.)BA=4+#$(/2:;9''+))#4%21>922'7-$83''()##569&888%@538%>>IC72GA99=4--<>&$$$37.)+?>80)'1/:9418,-1745=BKMFF>A?7>?;961,)A9E?766555556566766789::;===?@> NM:i:7 ms:i:134 AS:i:134 nn:i:0 ts:A:+ tp:A:P cm:i:28 s1:i:127 s2:i:0 de:f:0.0387 rl:i:33 c9c5990c-ad71-4ee1-a7d6-0fe05e9a2947 0 ENSMUNG00000000050|ENSMUNG00000000050.1|testis 587 60 44S54M2D30M1I7M1D8M1D19M2D38M1D5M1I4M1I2M1I85M1D8M2I10M1D10M1I18M3I25M1D34M3I89M2I98M1D15M2I5M3I7M1I36M1I24M1D90M1D61M1D7M2D42M4D35M1D14M1I29M1I25M1I17M2I12M6I8M1I39M1D22M3D19M1D69M1I11M1D51M1D3M1I3M1I1M1I13M1D18M2D19M1I14M2D22M3D1M1I25M2D6M2D9M4I3M1D11M1D3M2I2M1I14M1I38M2D51M1D27M1I2M1I5M1D31M4D34M5D26M1I35M1I25M1D5M1D27M1D22M2D23M6D15M1D7M1D22M2D56M1D20M2D5M1I3M2D39M1I28M1I10M1D21M3I1M1D20M1D2M1D7M1I33M1I14M1D5M1D44M1I5M1D11M1I3M1D3M1D21M1I107M1S 0 0 GGGGGACGCCGAGACCTGACAGGCAGTGCCATGAGCTGCAGGTAAGACTCTGACACGTCTCTGGGACCTGCAATGACAAGTCAGAACAGTAGCCATGCAGAAAACTGGTGAAATGTCCTCAAAGCAGTCCAGCACCAAAGTGCAGTCCGGCGATCTGTCTCCCGAAACCATCACTATTCATTTCTCTGCATTTGGGAAGGAGAAGAGAGGGAGAGGGAAGAAGAGTTTAAGGAATTCCTTGATGAGGAACTAGATGACCAAAGCATTGTAACAGCACTTGAAATAAAGGAAGACCTCTGCTTGAGCATGCACTGGCCATGGTACTCTGGTCCCAGCTACCTCGCTTAACATAATGGCCAACTCTGCATCACTACTGTCTCATCACCTGCAGTTCTGCCAACTGCAGAGACTACAATAAACCTGTTGGATTCTCCTTCCACATCCCAAGTATTCAGTGCAGTGCCACTAGTCCTGTCTCCTTCATCACACTCATGTAATACAGTTGTAGCTCATCAGGTGCACCACCTGTGAGTCAGAAATCCAGCCTGTCATCCTCCCCATCCTCATCCCCTTCCAGATCAGTTGTCTGCTCTAGTGGATCATCACAGTTTCTAGTTCAGAAAACTTATTTTTAAGGGGTTTAGTCAAGTCCCTTTCAGCAGATGTGGAACCAAAAAGAACCCACCCCACCGATGAGCGCAGACAGCTAGTGAAAACCTTAGTGAAATCTCTGTCTACAGACACTTCCAAACAAGAATCTGAAACTGTGTCTTACGGGCCACCTGACCCAAACTGAACTTGCATCTGTTCAAACAGTTCACTCAACCTCGAGCTACAGGTGGTGATTCAAAACTGCCCTCGTCTCCATTAACATCTCCCTCTGACACCCGTTCCTTTAAGTACCTGAAATGGAGGCTAAAATTGAAGATACTAAAGACGCCTTTCTGGAAGTAATCTGTGAGCCTTTCCAGCTGCTCCAGTAAAATAATGGGTGATGAAAGTGACCAGCCACAGACCCAAAGAGCCTTATCTTCAGGGAGAAGTGCTTCCAGAACTCTCAAACCTTTCCAGTTTGAATGGCCATTTTGAAGCAATAACAACTACAGCATTGAAGAAGAATGTGATTCAGAGAGGACTTCTATGGAAGTGACTCCAACCTGAGCAAGAACGATCAGTCAAAAGTGGCTGAGGAGCATACAAAAAGAGACAGGGCCCAAAGCTCTCAGTCTGCAAGCACAAAGGACGTGAGTTCCAAAACGTCCTCATTAGCGAGGAAAAATGTTCGTGTCTGCATTAGCAAGCAGAGGATGAGGAGTTTTGTGGAACTTTATTCTGAACTTTTCCTTGCTGGAGGATGACTAAAACTGATAAACCTGCTGAAACTTCATGATCGAGATCACCAAAGGAGAAAATGGTACTGGCACTCCAGTAGTGGAGATGAAAAATAATTCCTATGAGCAACAGCCTAAAATACCAGTGAGCTTTATGCTTCTTAACGCTGTTAGTCTATGCTTACCTTAATATCCCTCTCCTAGCTACCAAAGTGGACTTTTATTTAGGAAATGGCCTTGGATTTATGATAGCTGTCTGTGTGATTTAATAACCTCACGTACTCATGAATATCTCAAATTAAAGTGTGAAAAAGCAATGGAATACAGGGAGCTCTAGACATCAAAGAACCTGAAATACTGAAGGGGATGGATGAATGAAATCTATAACACGATCAGAAACATACCATGCTACATTGACTCCTCTGTCTATGTGCGACTTGAAAAGCACCTTACGACTTTCAAAACAAAATATCTCTAGAAGAATATCACAATGAGCCAAAGCCTGAAGTCATATGTCAGCCAGAAAATCTATGGACTTACAGAGCAAAAGATTTCCCTGGTTCCTAAAGTCTGGCACGAAAACGGTTGGAGATAAAGTACCCTATTTGCATTGAACTCGCTAAACAGGATGACTTTTATGGCTAAGGCCCAGGCTGATAAAGAAGAATGCAGAGAAAAGTTATCTGCGGAAAAAAACGAGACGTGAGCAACGAAGAATCAGAAATCTCCAGGGTGGAGCAAAGTACACTAGCCAAAAGGATCCCAGTGCTTTATCTTTTGGAGGACCGGTAGGGAGAAGGAGGAATGGTTCAGAAGGTTTCTTCTCCGCATCAAGCTGAAGTCCTGAGCAAGAAGCTATCCAGTCTATGTGGGGAACAAGCCAGGGATCTTGCCAACACAGAGTAGAGCCGATAGTCAATCTGGAGTTCTCACACACAGCCGAAGCAGCAGCAAGGGAAGTGCAGAAGAGATTGCATCC 8+414)&&'''/)-)$&%%%6>8;=D/5@4(($&"#%$#285D:4992=70335496A>D=)M<FHIABKE9=;=3/7?FEF=9:18:'>>BDE;A=@653,31=>3-13+-23:-4350('+)$$?=&(-(29802H7.1+((8&336>:BA8=A(33'#,168>/1/:>E?F8<JFF-CG4?=>>?3)/:4@=421/80(,$//5.(%0')-1(*::/CBL=:;63);(A-6/197<;<7;0?<4//H48=<@K9<7==:,/;5992//)),++(&&00&4,14;5>928''&'','&''$$"(=A6CB>64&%#"&'*.30154.*454(**2%$'*.-*$#$#$%-%%42??G=+).BGC-3B>4-*38G@@*:=<9358@D<9,354A26;@;BA*+&--'((%(0612:8;=03.;68-.1671-9G<=ID<1-.-@@9?3-1>&,,-:>(767A;;>:I7D@B/;67&)%6C8$$#$#%'14:670-3/-B<*'9***''#&02')(('$%$$%"&)(/4++92$*+7,:<9++1507;7>//26-:&&;;-,<2:)%($A8DAB=<7;7&);(.($48:<A.+1%()1)@B96?*B3'>>41(('$'),-.99@=B5EMF/,(@=13:;D1(5<7&%/4G89,2N95(4==>=+''9768=;<CA?:'%%&$&$$$)*')*0'&%(/.00/.,.*,,12*((+33&&106@;2///.)'$$72=;85:DH:C58EBEC83:=;>43D'&%'9A;C716<8?:9;/46<;8FDD1'/)'8;:>1BA61:;AD.:2$+CJ:9<*<//9.,/01//C0C<8;D?8DC=6??1@<7*4$+)&&.)&('%#%-,63-.BF?>;-/32,AC110;5((#30;?8))9>%%(#'16;D8/..((E?ABBGFI5/3%&/11=D:1+'+*(/>I/*A4&$.76<878/%1.;=?83;)D7,124=>=?@;<4=B)9111'''3$$%'6'94*,,4$5//,,,(+,GHE59>0,65.%%$#+637&@C=:295A/FPJ30'&&&)2/CLKF?8@@A+B@>BGI7/)('(?58>(:?$8>>7=79;:5$#(63/5=7/'%)(&&/),)3??=168899+-&).3?>,@C188=512>&;5=7241?-(4GPE?8.A>802827((&)+$$DQLA=97)43)/(&&++1.,%'()5$.,:80.+0,12<=;:?E@/-53,,/;+5A23966%%.+<((&$),&&-0FE@6@=I8>$39;=D@:<>3-->:'18956=223$&#:+@C7+$$--10KRGBB?6-28B<ERVC)1-+48=6-<>,0/2##6>I?</03AII?B@@<31-.8701,.$&+/4'-67?541,,($.(08@511/+))2/.+;1.+,3>O87A92.*)-+$&'&46<<;33.,69*56?CA<??C833IF5AD)%$&&+//$$%(*)),@503.2=11%16:49/.*+,---,&)&&5//A*023*:-)0*+(%&66&4=::E33MB<0/1/()&*-,--+378714056G@=@3)?8@@;7CB9)586993+%'''$##%*+$$0,+,/4100?520*5050&(+C21+<*-+?@;@,2<PH5588<8,:?21#1?:D1026E.'AB>5#$-())+132657=0-:34:4ABFF>&)?=&&%'75:+04)'&&+)%D:8B9-9612=CHD?;@D89@;$$$1$.994=::9??83).>//.(%&%$'(()))%%45++@+BA56'(&;DBDB@A5;85602$##.)),.::?<992:A=D8JCA>4.-<,245;<9B7;>BC::=E<9<558FK@??E8<;,/7=940/4=??=B>=25<C54TC;;;-21)&'&,/?>5&$'=6::0$)*+,1&&663:794-+,,-1/>:13,-1@>/11>K@;>1$TUN?=BDAADK>93+)$621A@@M?2.1)0//;FE66'>>C;>Q::BD;2,=.IE::%%%)..,-/2;<685236;6;5->9%1@67=$@6:1.?:6/)9>4)/38?@*);3ANAA<=;9((-*1*+/3=B@/@UX.?-:BF?CI@9B?96)+8;85+-)D''';1=**6.B7>E6-**&)&98C<3:AD:C@?@;A##*$%%.=D8&+,0--/''C>?9;BC../:&$%3G@.:2E<>8?=A3611D>B6<:7)<89:''.62,%&&'5R=<F@(($,@6<B482145415,+'234:9:,.--8:.05<KC@941/32?8==-&E<=A NM:i:217 ms:i:1655 AS:i:1655 nn:i:0 ts:A:+ tp:A:P cm:i:322 s1:i:1541 s2:i:0 de:f:0.0718 rl:i:0 4caf762c-9527-47b6-aaea-5c0d324eda2f 0 ENSMUNG00000000050|ENSMUNG00000000050.1|testis 587 41 19S27M1I8M1D19M1D37M1I63M27S 0 0 GAAGTACCATGAAGCTCAGAGACTCTGACACGTCTCTGAGACCTTCTAATGACAATCAGAACGGTAGCCATGCAAGAAGCTTGGTGAAATAATCTCAAAGCAGTCAGCACCAAAAAGTGCAGGTCCAGCGATCTGTCTCCCGAGAAACCATCACTATTCATTTCTCTGCATTTGGAAAAAAAAAAAAAAAAAAAAAAAAAAA 9-C52=3+++)%((($%%',5;64&++.2$$783&($+52)%)%&.,217;<&&>4DC@2288C9<@<41//#$'$#%'897:2@+$$$$.;><+(%%%>9$.0%9IC,45/7502>;I@583-.((77B2>52%&&-(9>B@E@;2522;IGD4<5/':=A@<45+@@877655555667889987766777 NM:i:14 ms:i:112 AS:i:112 nn:i:0 ts:A:+ tp:A:P cm:i:16 s1:i:73 s2:i:0 de:f:0.0886 rl:i:28

The output: Pool4_merged_t_rimmed_BCconsensus_transcripts.fas:

02e3c0c0-b1b5-4f5f-8bf5-05f83f97fbd3|330 TTTTTTTTTTTTTCACAGTTAACAAATATTCTTTATTGTCAGGTCTCAAGACATTATCATAATGGACATTTTTGGACTGTATAAAAACTACTTTTAACTC AGTGTAAAAGCTCCGTTGAATGTATGAATGATAGCTTAAGAAAGTTTAGAGTAGCAGTTATGGAATTCATTCACTTATTTATGAATAAGGTATAACAGGT ACCATTCATGCTTTGATCCAAGAGCATTTACAGCTTTGTTTTTGACACTGGTTGTGCCTACAGCTTCTGTATCAGAATTGCAGAAGCACCTCCTCCACTC CATTGCAAATTCCTGCAAGGCCGTATTGTCCTTGTTTCAATGCATGGGCCATGTGAACAACGATTCTGGCTCCAGACATTCCTATAGGATGTCCAAGAGA GACACACCTCCATTCATGTTTACTTTTTGTGGATCAATACC c7a0033e-8bd3-4ea8-8539-8cfe406f915f|85 TTTTTTTTTTTTTTCAAGAACAACTGTTCTTTATTTTATTGACTGGTTGAAGCAGGACTATAAGCCAGGTATATTTCAATCAAGTGTTGGTCCACTCTTA CCATCAAAAAGAATTTTTTTTTTTTTTTATAATAACATCAACACAAATGGAAGGAATATAAAGCGTCATAATAGGAACTTTCAACTGTACATGATATGAG ACCATGATCAGACTGGTGCTACTTCAGTATTTATAGACTCTCCACTGTACAGTCCAGCCACACTAGTGTTATTTACCTCCAATCATTCAAGTTCTAGGTA AAGGATCCTTCTGACTACAGCTCACATCTGAGCCACCAACATGAAATCAAAATGCCATTTGTGCCACTAGCATTGTAGTCTTGTAGAAATATTTCTATAT TTAGCATATTACTAAAGAATAATTACTATCCTCTCTGAAGTTACATATAGCCATTATAAATATTTACATCAAACATTTACAACTGGTTCATAATATACAA CACAAGAATTTAGCTATAGTTTCTAATCTTCCAGTGTAAAAGTTTCAAACAACATGTTGCTATCATAATTTCATCTGGTTTGCACACAGTCACAGGCAGT ACAGGGTATTTCAAAAACTCATGTCACATAAAAAAAAAGGAATGATGTTACTTTAATAACAATTACCTTGGGGATTGATTGTTGTTGGTTTTTGTTGGGG TTTTTAACAAGCAGTTTTCAATTTCTAAACCCCATCTGATGCTACTACTGACATTTAAAATAAGCTTAAGAGGGAAAAAAATACTTAAAAATAAATACAC CTTTAAAAAATTCCACAATTAACCATGTCAGAATATTTGTTTTCCAGACAGCTGAAAGGAGACCTTACTCTTCATCATTTCCTTGCACTGAAACAGAGTG CAGTTCAATCCATTCTTATCTTCTGATTTGTCATCCTATAAATAATGCTGTCGTAGCCAGGATCCATGTTCCAGAGGTTGTAGGAGATAACTATCACAGC TAAAGCAAGACCTATCATCATCCACAAAATAATGTTGAAGATTACAGAGTAGTTGTAGTTATATGGGTAGGCAAGGTTATATGGATTGTCTGATTCACTC TGTGAGATTGGAGAATGAGCGAGTCTTCCTTATGTTGGGAGAAATAAACGCCTTTACAGCTACCACTTCTACTACTGCATTCCCACTATACAGATTAAAC ATCTCATCTGCAAACTTTTGCAAAGAGTCTACAAAATTTGAGAAGCATCCTTGAACTGCTGAGAGTCTTCCCCATATCGTTTTCCAACCTCTTCCAAACC AGACAGTTCAGAGAATACAGGTCTGGAGAGTGATCTTTGGCTAAGTGCTTGTGTCGAGACAGCAGGCTTGCAATATCATGTAGGACTTGTAGTTCTGACA GAAAAAGCAAGTCAACCTCATTGTTTCTGCTGAGGGAGTTGAGAGGAAGGGAGCCAAGAATAGAGTTGTCCTGGAATAAGCGGTTTCGCAGTTGGCGCAG TGTGACAGACAGATCTTCAAATACAGAGTTTGCCTTACCCACCATGTATACCCTTTCCTCACTGGGGGCCAGCTGCAAGACCACAGGAGTCTCCTCAGAG AACAAAGTATGAATAGCATTTGCAACACTGTCAAGACTGAAAGGAACAGCATTCTCAATAGGGTAAGAAACCCCTTTCACAGGCAGTGCCAGCTTGTCCA CTCCCTTCACAGTTACCAGCACAGTAGCTCGTGGTCTGTGAAACAGATCACCCACTGCAAGGCCAGGCCAGGAAAGGTCCTCTTCAACAGAAAAGCCCAT AGACAATGCAGCTACATCTGGGATCCGCTCACCAGGAATGGGCCAACTTCCATCTCGAAAAACAACTGACTGAGGTGATCGTAAGACACTAAATTCATCT CCACTTACACTGGCAAGACAAGCCGATGTAACCAGCACCGCCACCTCCAGGGACCAGAGCACCCCGCCACGGCACCCCATGTCCGCCGCAGTCCCGGACA CCGCCGCGCTAAGAGACGCCGCTGGGAAGACGCCGGGCCGCACCGTCAGACCGAGACCACC

I would be very grateful for any help.