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Workflow 4: What are the drugs that target hypoglycemic coma? #29

Open jaredroach opened 5 years ago

jaredroach commented 5 years ago

Can any of the translator modules or teams currently answer this question?

Currently, RTX focuses mainly on proteins. The gold standard answer to this question is "glucose".

If I ask RTX, "What are the drugs that target hypoglycemic coma?" I get:

_Your question has been interpreted and is restated as follows: What drugs target proteins associated with hypoglycemic coma? Please ensure that this is an accurate restatement of the intended question.

Sorry, the disease DOID:1607 is not connected to any protein._

cmungall commented 5 years ago

You may have more luck with the phenotypic feature Hypoglycemic coma:

https://monarchinitiative.org/phenotype/HP:0001325

the OWL should have an axiomatization of the concept (coma and arising from hypoglycemia) as well as disease/gene annotations

cbizon commented 5 years ago

So maybe I don't know where to look, but I don't think that this term has a logical definition, or anything pointing to hypoglycemia. It does descend from coma.

There is MONDO:0004946, which is hypoglycemia, but there's nothing in monarchapi that connects hypoglycemia (disease) to hypoglycemic coma (phenotype).

Anyway, it's pretty easy to get glucose from hypoglycemia, but not from hypoglycemic coma. Here's a notebook:

https://github.com/ncats/translator-workflows/blob/master/greengamma/examples/Hypoglycemia.ipynb