Workflow 3B, Module 1: Experiment

[karafecho]

Major histocompatibility complex (MHC) refers to a large group of genes that code for proteins that play an essential role in which of the following? a. Antigen presentation to T lymphocytes b. Phagocytosis by neutrophils c. Antigen presentation to B lymphocytes d. Phagocytosis by macrophages

	n2 - id	n2 - name	score
GO:0006955	immune response	2.722759
GO:0060333	interferon-gamma-mediated signaling pathway	2.334938
GO:0042605	peptide antigen binding	2.030128
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	1.945948
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	1.686622
GO:0050852	T cell receptor signaling pathway	1.470677
GO:0032395	MHC class II receptor activity	1.167969
GO:0002376	immune system process	1.101306
GO:0005102	signaling receptor binding	1.014048
GO:0050776	regulation of immune response	0.992633
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	0.908642
GO:0060337	type I interferon signaling pathway	0.908642
GO:0001916	positive regulation of T cell mediated cytotoxicity	0.908642
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	0.908642
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	0.908642
GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	0.908642
GO:0023026	MHC class II protein complex binding	0.778979
GO:0043312	neutrophil degranulation	0.519653
GO:0030881	beta-2-microglobulin binding	0.389990
GO:0002503	peptide antigen assembly with MHC class II protein complex	0.389990
GO:0042102	positive regulation of T cell proliferation	0.389990
GO:0045087	innate immune response	0.302486
GO:0002455	humoral immune response mediated by circulating immunoglobulin	0.260326
GO:0032729	positive regulation of interferon-gamma production	0.260326
GO:0002729	positive regulation of natural killer cell cytokine production	0.260326
GO:0042270	protection from natural killer cell mediated cytotoxicity	0.260326
GO:0002506	polysaccharide assembly with MHC class II protein complex	0.260326
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	0.260326
GO:0050870	positive regulation of T cell activation	0.260326
GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	0.260326
...	...	...
GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	0.130663
GO:0071346	cellular response to interferon-gamma	0.130663
GO:0046979	TAP2 binding	0.130663
GO:0002666	positive regulation of T cell tolerance induction	0.130663
GO:2000774	positive regulation of cellular senescence	0.130663
GO:0042608	T cell receptor binding	0.130663
GO:0006968	cellular defense response	0.130663
GO:0046703	natural killer cell lectin-like receptor binding	0.130663
GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	0.130663
GO:0042803	protein homodimerization activity	0.130663
GO:0051898	negative regulation of protein kinase B signaling	0.130663
GO:2001199	negative regulation of dendritic cell differentiation	0.130663
GO:0002717	positive regulation of natural killer cell mediated immunity	0.130663
GO:0042288	MHC class I protein binding	0.130663
GO:0007165	signal transduction	0.130663
GO:0002645	positive regulation of tolerance induction	0.130663
GO:0002715	regulation of natural killer cell mediated immunity	0.130663
GO:0070317	negative regulation of G0 to G1 transition	0.130663
GO:0070207	protein homotrimerization	0.130663
GO:0001915	negative regulation of T cell mediated cytotoxicity	0.130663
GO:0032736	positive regulation of interleukin-13 production	0.130663
GO:0050830	defense response to Gram-positive bacterium	0.130663
GO:2000353	positive regulation of endothelial cell apoptotic process	0.130663
GO:0045591	positive regulation of regulatory T cell differentiation	0.130663
GO:0042802	identical protein binding	0.130663
GO:0002451	peripheral B cell tolerance induction	0.130663
GO:0045580	regulation of T cell differentiation	0.130663
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	0.130663
GO:0032759	positive regulation of TRAIL production	0.130663
GO:0060907	positive regulation of macrophage cytokine production	0.130663

[jaredroach]

All four of these answers are correct, as a fairly quick researcher/immunologist guided Google search can validate. As an undergrad taking the MCAT, I would definitely pick (a). But I am not so sure Translator shouldn't be reporting back all of these as correct. I suppose the best case for (a) is made by inclusion of the word "essential". Maybe (b,c,d) functions are not essential. But ( c) is absolutely essential IMHO in training B-lymphocytes (https://www.cell.com/trends/immunology/comments/S1471-4906(16)30151-X).