Closed hongzhonglu closed 4 years ago
This is an important question. It is important to stringently filter out paralogous sequences from the alignments to the best that is possible. They have been seen to diminish signals in important correlations. They could also potentially create false positive correlations. Some potential methods to identify strictly orthologous groups are InParanoid and whole genome alignments that use synteny (blastz chain alignments). Best of luck with your analysis!
@nclark-lab Great thanks for your help!
Hi, could I ask a question? In my analysis, I found for some ortholog gene groups, the paralog genes existed for some species, does it affect the evolution rate analysis?