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neurogenomics / rare_disease_celltyping

Code, data and results associated with the "Rare diseases cell-typing" project.
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Find regulator genes #45

Open bschilder opened 1 year ago

bschilder commented 1 year ago

@Al-Murphy MultiEWCE::prioritise_targets could be further extended by identifying key regulators of gene sets. This way, we can target all candidate genes by targeting a single regulator gene:

Useful tools:

@Al-Murphy let me know if you have any other suggestions!

bschilder commented 1 year ago

On a related note, try to find pathway-specificity of each regulator. We want to avoid disrupting other processes/pathways within a celltype by targeting a given regulator.

Al-Murphy commented 1 year ago

Only other one I thought of is Reactome

I don't know if identifying regulator genes is the ideal approach since there would always be off-target effects (by definition these are involved in the regulation of more than one gene). I think the ideal would be finding a gene in the same pathway as a gene of interest that we can't target (for example because of gene length) but that also meets all the other criteria you set out (i.e. specific to the cell type etc).