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NEURON Simulator
http://nrn.readthedocs.io
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Modelling myelinated axon (Question) #988

Closed subash774 closed 3 years ago

subash774 commented 4 years ago

Hi @ramcdougal , Thanks for a great tutorial, really helped me a lot!

I'm a master's student in Computer Science. My project is to model a HH cell (nodes of Ranvier) with myelinated axon and observe the effects of length of the myelinated axon.

As I am completely new to neuroscience, I'm having some problems understanding the mechanisms of extracellular. If I want a myelinated axon with the following paramters, how would I set this up in Python using NEURON? 

Params : {
    Myelin resistance (R_m): MOhms/mm
    Myelin capacitance: F/mm
    longitudinal resistance: MOhms/mm
    resting potential
}

Your help would be greatly appreciated. Thanks in advance!

ramcdougal commented 4 years ago

Thank you so much.

You should talk to Nooshin Abdollahi. Her poster (P168) modeled the axon including the myelin with NEURON to investigate axonal response to stimuli.

One of my colleagues here is more familiar with using the extracellular mechanism, and can give you a better answer, so I'm going to defer to him, besides to caution you that those are not NEURON's default units.

By the way, in the future, consider asking questions like this on the NEURON forum.

neuroman314 commented 4 years ago

Good question, subash774. Actually two questions in one (first is usage of extracellular, second is dealing with units). The NEURON Forum https://www.neuron.yale.edu/phpBB/ would be a perfect venue for this, since the answers will probably be seen by a wider audience. You seem not to be a Forum member, so I set up an account for you with the user name and email address that GitHub lists for you. I'll email the password to you; be sure to log in and change the pwd to something that only you will know. And then post your question in the Forum's "Getting started" discussion area. --Ted Carnevale, aka neuroman314

subash774 commented 4 years ago

@ramcdougal Thank you for the referral. Is there a way I can contact Nooshin Abdollahi? Would be very helpful if I could chat with her given my backgroud in Comp Sci and illiteracy in Neuroscience.

@neuroman314 Thanks a lot! I'll post the question there.

Thank you both!