neurorestore / Augur

Cell type prioritization in single-cell data
MIT License
100 stars 11 forks source link

Input the raw matrix or HVG matrix? #8

Closed storytc closed 3 years ago

storytc commented 3 years ago

Hi, Thanks for your brilliant tool! I try to understand the methods and I wondered should I input the raw matrix or the matrix that only keep HVGs? I noticed that you will filter 50% features per cell types. By the way, my dataset is scRNA-seq data. If I have two treatment samples(also two control samples) under two conditions, can I regard the two treatment samples just as one treatment sample? I'm sorry for my poor understanding and appreciate for your answer or any advice!

Best, Ariel