neurorestore / Libra

MIT License
153 stars 25 forks source link

Genes with same adj p-val, p-val and log FC? #10

Open anjkris opened 2 years ago

anjkris commented 2 years ago

Thanks for your great package!

While doing some enrichment analyses with the differentially expressed genes generated from run_de with de_method = "edgeR", and de_type = "LRT", I realized that I get some genes that have exactly the same p-val, adjusted p-val and logFC (none have adj p-val < 0.05, so they're all non statistically significant). Is this normal?

jordansquair commented 2 years ago

Hmmm.. can you elaborate? Is it that the effect size is so small so everything is 1?