ANCOM-BC for differentially abundant taxa

nf-core / ampliseq

Amplicon sequencing analysis workflow using DADA2 and QIIME2

https://nf-co.re/ampliseq

MIT License

188 stars 118 forks source link

ANCOM-BC for differentially abundant taxa #731

Closed enriiquee closed 5 months ago

enriiquee commented 7 months ago

Description of feature

ANCOM-BC has a more robust method for bias correction and controlling FDR by estimating the unknown sampling fractions and correcting the bias induced by their differences among samples. Maybe include it would be nice.

I'd recommend checking out the ANCOM-BC paper to read more on the methods used: https://www.nature.com/articles/s41467-020-17041-7

d4straub commented 7 months ago

Hi there, I agree that would be nice. If you are up to it, make a PR ;)

d4straub commented 5 months ago

This is in dev and will be in the next release, 2.10.0!