Nasty perf issues on resolution settings higher than default [i turned it up to 160x160 and it's just about managing 2 frames per second]
lack of setting saving. having to set Literally Everything up every time you start up the program is kind of irritating.
[personal preference but still worth mentioning] the color format setting could probably benefit from being a regular dropdown menu with a few chosen color formats and a "Custom" option at the bottom of the list or a button beneath the dropdown allowing you to insert a custom color format
window resizing should be doable by just dragging the window's borders\corners as opposed to restricting it to a setting. if there is no intention on changing this i highly suggest at the very least disabling the maximize button in the window's title bar as it basically does nothing anyways