Nion Swift is open source scientific image processing software integrating hardware control, data acquisition, visualization, processing, and analysis using Python. Nion Swift is easily extended using Python. It runs on Windows, Linux, and macOS.
If you put a graphic (ellipse in my example) in the center of a data item containing 4D data, and switch the displayed coordinates of the graphic to either "Pixels (centered)" or "Fractional (centered)", the position of the graphic in the inspector will not be (0, 0), but almost the same as with "top left" coordinates. It doesn't show the exact same position as in top-left display mode, but definitely not the correct centered one.
On a 2D data item it works as expected.
If you put a graphic (ellipse in my example) in the center of a data item containing 4D data, and switch the displayed coordinates of the graphic to either "Pixels (centered)" or "Fractional (centered)", the position of the graphic in the inspector will not be (0, 0), but almost the same as with "top left" coordinates. It doesn't show the exact same position as in top-left display mode, but definitely not the correct centered one. On a 2D data item it works as expected.