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niu-lab / msisensor2

Microsatellite instability (MSI) detection for tumor only data.
GNU General Public License v3.0
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We have downloaded two version software in November 2019 and 2020 respectively.However,the results of tumor only from these two versions were inconsistent.Is it normal? #17

Closed biofer closed 1 year ago

biofer commented 3 years ago

The first version: Software downloaded on November 12, 2019 Result

loading bed regions ...
loading homopolymer and microsatellite sites ...
Total loading windows:  61 
Total loading homopolymer and microsatellites:  71 
......
......
......
*** Summary information ***

Number of total sites: 71
Number of sites with enough coverage: 68
Number of MSI sites: 1
MSI score(%): 1.47059

Total time consumed:  11 secs

The second version: Software downloaded on August 28, 2020 Result

loading bed regions ...
loading homopolymer and microsatellite sites ...
Total loading windows:  61 
Total loading homopolymer and microsatellites:  71 
......
......
......
*** Summary information ***

Number of total sites: 71
Number of sites with enough coverage: 0
Number of MSI sites: 0
MSI score(%): 0

Total time consumed:  3 secs

The results from these two versions were inconsistent. No site was covered from the second version. Is it normal?

additional information： The pair sample Result

loading bed regions ...
loading homopolymer and microsatellite sites ...
Total loading windows:  285 
Total loading homopolymer and microsatellites:  844 
*** Summary information ***

Number of total sites: 844
Number of sites with enough coverage: 709
Number of MSI sites: 45
MSI score(%): 6.34697

Total time consumed:  188 secs