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niu-lab / msisensor2

Microsatellite instability (MSI) detection for tumor only data.
GNU General Public License v3.0
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How many Microsatellites (MS) included in a customized panel is accurate when analyzed by msisensor2? #27

Closed biofer closed 2 years ago

biofer commented 2 years ago

Dear author,

How many Microsatellites (MS) included in a customized panel is accurate when analyzed by msisensor2?

Thank you very much for your work！

ZhaoDanOnGitHub commented 2 years ago

您好，您的邮件已收到！

Beifang commented 2 years ago

It's hard to say how many MSs is accurate for msisensor2. We actually test that on TCGA WES samples, and we can get almost 100% AUC using only 10 random sites. As for a customized panel, I think a validation is needed for accurate cutoff.

biofer commented 2 years ago

Thank you for your reply! We will verify the cutoff of our customized panel based on our clinical samples.