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nlmixr2 / nlmixr2est

nlmixr2 estimation routines
https://nlmixr2.github.io/nlmixr2est/
GNU General Public License v2.0
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Feature Request: Allow Hessian for inner problem to be inferred from the likelihood hessian estimate #294

Open mattfidler opened 1 year ago

mattfidler commented 1 year ago

Currently it is based on the prior hessian, but it could be more accurate (and save more time) to use the NONMEM's or the log-likelihood estimate.

mattfidler commented 1 year ago

As an option (of course)

mattfidler commented 9 months ago

Still not done. Highly technical. Not clear if there is any benefit.