Add Regression optimization for time-varying covariates instead of simply mcmc?

nlmixr2 / nlmixr2est

nlmixr2 estimation routines

https://nlmixr2.github.io/nlmixr2est/

GNU General Public License v2.0

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Add Regression optimization for time-varying covariates instead of simply mcmc? #347

Closed mattfidler closed 1 month ago

mattfidler commented 1 year ago

Another option is to do some nealder-meade optimization for these parameters instead of only using the mcmc algorithm. While it is not described in the methodology section of monolix, it could also work a bit better.

_Originally posted by @mattfidler in https://github.com/nlmixr2/nlmixr2est/issues/348

mattfidler commented 1 month ago

This bug was fixed and this is no longer deemed necessary