Feature Request: Option to change how rate/dur/bioavailibility are inter-related

[mattfidler]

In monolix with tinf it seems that only rate is adjusted with bioavailability changes instead of duration.

[billdenney]

Changing duration seems unusual to me for the definition of bioavailability.

I think of bioavailability affecting the amount that makes it from compartment X to Y (usually depot to central). Amount is usually correlated with rate and not duration. Do you have an example where it affects duration? (The one time I've seen bioavailability affect duration was when an IV infusion had adsorption to the tubing.)

[mattfidler]

rxode2 matches NONMEM (and monolix, and even mrgsolve's behavior). When changing bioavailability with a rate, the rate remains constant, not the duration (ie the duration lengthens or shortens).

I agree with your assessment, and introduced a dur data item where the duration stays the same but the rate changes with bioavailbility.

My mneumonic is that whatever is in the dataset is fixed, whatever is not in the dataset can vary.

This request is again to deal with monolix. Monolix has a similar data item to nlmixr's dur: tinf. Unfortunately according to their documentation only durations change with changes in bioavilability (they use p for bioavailnibility).

So... even though I think what I have done is the "right" thing, to reproduce monolix models, this request was made

[mattfidler]

This was taken care of with babelmixr2 so no for now