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nlmixr2 / rxode2

rxode2
https://nlmixr2.github.io/rxode2/
GNU General Public License v3.0
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issue en web page "Population simulation with rxode2" #709

Closed nsk64 closed 2 months ago

nsk64 commented 2 months ago

Hi

An example is given to "Simulate using variance/standard deviation standard errors"

However, it seems that the simulation used the "Covariance matrix of estimate" but not the "Standard Error" of Estimate. Sorry if I am missing something.

best regards Nicolas

mattfidler commented 2 months ago

Hi @nsk64

I am assuming you mean

https://nlmixr2.github.io/rxode2/articles/rxode2-sim-var.html#simulate-using-variancestandard-deviation-standard-errors

Technically some of the methods of simulation (like the "lkj" and "separation") simulate the covariance matrix and the standard deviations to create the eventual covariance matrix that is sampled with uncertainty.

As you said, this is not how you input parameters into the simulation so it can be misleading.

nsk64 commented 2 months ago

Hi Thanks for your reply. I agree but as you are not using standard error (as said in the title), I am confused. Thanks for your work. Best regards Nicolas

Le 17 juil. 2024 à 02:20, Matthew Fidler @.***> a écrit :

 Hi @nsk64 I am assuming you mean https: //nlmixr2. github. io/rxode2/articles/rxode2-sim-var. html#simulate-using-variancestandard-deviation-standard-errors Technically some of the methods of simulation (like the "lkj" and "separation") simulate

Hi @nsk64https://urldefense.com/v3/__https://github.com/nsk64__;!!JQ5agg!cIIV6-NDSTXB20yPbDE92ubSiuWdDd3njTe6lC4w-JV2BS00VwIMQOA1Q67dL8vL70CrN1QC7T8gBObz67HgrMAEf0nrNA$

I am assuming you mean

https://nlmixr2.github.io/rxode2/articles/rxode2-sim-var.html#simulate-using-variancestandard-deviation-standard-errorshttps://urldefense.com/v3/__https://nlmixr2.github.io/rxode2/articles/rxode2-sim-var.html*simulate-using-variancestandard-deviation-standard-errors__;Iw!!JQ5agg!cIIV6-NDSTXB20yPbDE92ubSiuWdDd3njTe6lC4w-JV2BS00VwIMQOA1Q67dL8vL70CrN1QC7T8gBObz67HgrMA-EbYWDA$

Technically some of the methods of simulation (like the "lkj" and "separation") simulate the covariance matrix and the standard deviations to create the eventual covariance matrix that is sampled with uncertainty.

As you said, this is not how you input parameters into the simulation so it can be misleading.

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