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nlmixrdevelopment / nlmixr

nlmixr: an R package for population PKPD modeling
https://nlmixrdevelopment.github.io/nlmixr/
GNU General Public License v2.0
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Linearize models #366

Open mattfidler opened 4 years ago

mattfidler commented 4 years ago

Like PsN. Since sensitivites are calculated it may not be as hard as I originally thought (with the exception of keeping track of f/dur/ etc)

mattfidler commented 4 years ago
Variable Meaning
OPRED Original Individual predictions of model (ie eps=0, eta=ebeEta)
DETA# Sensitivity of ETA with respect to PRED
OETA# Original ETA value
D_EPSETA#_x Sensitivity of ETA with respect to R2

nlmixr sets err to 1 for all situations and estimates theta based error parameters for these values. Hence these error values would still need to be estimated (and on the same scale).

mattfidler commented 4 years ago

In nlmixr a linearized model would be addivitive with fixed component fixed to 1.