Error: 'rxSolve.default' is not an exported object from 'namespace:RxODE

[sujit541]

fit.1cpt.ode.saem <- nlmixr(model.1cpt.ode, PKdata, est="saem", table=tableControl(cwres=TRUE, npde=TRUE)) Compiling RxODE equations...done. Building SAEM model...done Error: 'rxSolve.default' is not an exported object from 'namespace:RxODE'

[mattfidler]

Hi @sujit541

This would occur on any model, if true; My guess is you have a nlmixr that is not compatible with the version of RxODE you have installed. The new version of nlmixr will not even load if it isn't compiled against the correct version of RxODE.

Can you post your session information?

[sujit541]

sessionInfo() R version 3.6.0 (2019-04-26) Platform: x86_64-w64-mingw32/x64 (64-bit) Running under: Windows 10 x64 (build 18363)

Matrix products: default

locale: [1] LC_COLLATE=English_United States.1252 [2] LC_CTYPE=English_United States.1252
[3] LC_MONETARY=English_United States.1252 [4] LC_NUMERIC=C
[5] LC_TIME=English_United States.1252

attached base packages: [1] stats graphics grDevices utils datasets methods base

loaded via a namespace (and not attached): [1] Rcpp_1.0.5 pillar_1.4.4
[3] compiler_3.6.0 PreciseSums_0.3
[5] tools_3.6.0 mvnfast_0.2.5
[7] digest_0.6.25 nlme_3.1-148
[9] huxtable_5.0.0 memoise_1.1.0
[11] lifecycle_0.2.0 tibble_3.0.1
[13] gtable_0.3.0 lattice_0.20-41
[15] pkgconfig_2.0.3 rlang_0.4.6
[17] cli_2.0.2 rstudioapi_0.11
[19] parallel_3.6.0 xfun_0.14
[21] RcppArmadillo_0.9.900.1.0 n1qn1_6.0.1-7
[23] nlmixr_1.1.1-3 dplyr_1.0.0
[25] knitr_1.28 lbfgs_1.2.1
[27] generics_0.0.2 vctrs_0.3.1
[29] grid_3.6.0 tidyselect_1.1.0
[31] glue_1.4.1 data.table_1.12.8
[33] R6_2.4.1 fansi_0.4.0
[35] ggplot2_3.3.1 purrr_0.3.4
[37] dparser_0.1.8 magrittr_2.0.1
[39] vpc_1.2.1 scales_1.1.1
[41] ellipsis_0.3.1 units_0.6-7
[43] assertthat_0.2.1 RxODE_0.9.2-0
[45] colorspace_1.4-1 brew_1.0-6
[47] lotri_0.2.2 munsell_0.5.0
[49] crayon_1.3.4

[sujit541]

Please let me know the update

[sujit541]

Detail code as follows

> model.1cpt.ode <- function() {
+   ini({
+     tka <- c(-1,0.2,2)
+     tcl <- log(7.57)
+     tv  <- log(40.35)
+     eta.ka ~ 0.1
+     eta.cl ~ 1
+     eta.v ~ 1
+     add.err <- 0.1
+   })
+   model({
+     ka <- exp(tka + eta.ka)
+     cl <- exp(tcl + eta.cl)
+     v <- exp(tv + eta.v)
+     d/dt(depot) = -ka * depot
+     d/dt(center) = ka * depot - cl / v * center
+     cp = center / v
+     cp ~ add(add.err)
+   })
+ }
> fit.1cpt.ode.saem <- nlmixr(model.1cpt.ode, PKdata, est="saem", table=tableControl(cwres=TRUE, npde=TRUE))
Compiling RxODE equations...done.
Building SAEM model...done
Error: 'rxSolve.default' is not an exported object from 'namespace:RxODE'

[mattfidler]

The easiest to fix this in windows is to use the nlmixr installer:

https://github.com/nlmixrdevelopment/nlmixr/releases/tag/v1.1.1-3

Otherwise you can try to re-install from github:

install.packages("remotes") # if needed
remotes::install_github("nlmixrdevelopment/RxODE")
remotes::install_github("nlmixredelopment/nlmixr")

[mattfidler]

This isn't really a bug, so I'm moving this to discussions