Interpretation of HLA-B and -C alleles isn't working.

nmdp-bioinformatics / pipeline

Consensus assembly and allele interpretation pipeline.

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Interpretation of HLA-B and -C alleles isn't working. #41

Closed ckennedy-nmdp closed 9 years ago

ckennedy-nmdp commented 9 years ago

Field testing with mutlitple data sources validated HLA-A; however, -B and -C alleles aren't being produced even though filtered consensus sequences are there (possible that filtering is incorrect).

ybolon-nmdp commented 9 years ago

Only genes on positive strand are processing and verified. Caleb found that reverse complementing allows the rest to process.

ckennedy-nmdp commented 9 years ago

HLA-B and -C are minus strand genes so their consensus sequences must be reverse complemented before interpretation. The same will be true for class II HLA genes.

ckennedy-nmdp commented 9 years ago

Fixed!