nodrogluap / pokay

Report salient qPCR primer/probe or immune epitope mismatches info against a set of pathogen isolate genomes
GNU General Public License v3.0
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need a "viral replication" category #20

Open miseminger opened 4 months ago

miseminger commented 4 months ago

Currently in S_convalescent_plasma_escape.txt, we have:

# Mutant found after in passage in plasma pool of 26 convalescents mean 1.5 post symptom onset, but also
# in cell culture without plasma, therefore likely a replication cycle fitness rather than polyclonal iummnuity escape variant.
# Schmidt et al. (2021) https://doi.org/10.1101/2021.08.06.455491 [Preprint (BioRxiv); Now published at: https://doi.org/10.1038/s41586-021-04005-0]
W64R

Since this is probably not an escape variant, I suggest moving it out of "convalescent plasma escape" and into something about "viral replication" (TBA).

miseminger commented 4 months ago

See also, on the same page:

# Mutant found after in passage in plasma pool of 26 convalescents mean 1.5 post symptom onset, but also
# in cell culture without plasma, therefore likely a replication cycle fitness rather than polyclonal iummnuity escape variant.
# Schmidt et al. (2021) https://doi.org/10.1101/2021.08.06.455491 [Preprint (BioRxiv); Now published at: https://doi.org/10.1038/s41586-021-04005-0]
T604I