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nodrogluap / pokay

Report salient qPCR primer/probe or immune epitope mismatches info against a set of pathogen isolate genomes
GNU General Public License v3.0
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Check category for Zhou et al. (2022) #33

Open miseminger opened 2 months ago

miseminger commented 2 months ago

Currently in 3CL_pharmaceutical_effectiveness.txt


# [Data suggests that observed A173V and E166V mutations have a fitness cost, and that L50F is compensatory.]
# Zhou et al. (2022) https://doi.org/10.1101/2022.06.06.494921 [Preprint (BioRxiv); Now published at: https://doi.org/10.1126/sciadv.add7197]
L50F
miseminger commented 2 months ago

And, in the same file:

# This mutation in mouse hepatitis virus subsitution residue emerges in cell culture resistance assay. This resulted in 4-5x fold higher EC50 values.
# FDA (2021) https://www.fda.gov/media/155050/download [Grey literature]
S144A;E55L