Hi,
yes, this is because you try to convert iced normalized matrix.
Two solutions :
either you convert raw matrix, asking cooler to normalize the data (-norm) option. Basically, it uses the same approach than HiC-Pro, so the maps should be very similar.
Or you will have to update your cooler package. This small bug was fixed in the latest version of cooler
Best
Hi, yes, this is because you try to convert iced normalized matrix. Two solutions :
-norm
) option. Basically, it uses the same approach than HiC-Pro, so the maps should be very similar.