ntustison / PaperANTsX

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Inquiry on Data Handling and Disease Group Mapping in ADNI Dataset #1

Open GayanSamuditha opened 6 months ago

GayanSamuditha commented 6 months ago

@ntustison I am reaching out to seek clarification regarding the data handling and mapping of disease groups within the ADNI dataset available in your GitHub repository, specifically within the PaperANTsX project (https://github.com/ntustison/PaperANTsX/tree/master/Data/ADNI). This dataset lists thickness extraction data for 4422 subjects and has been integral to our research.

Our team has delved into the data and we have a few questions that would greatly enhance our understanding and the accuracy of our analysis:

Data Aggregation across ADNI Phases:

Does this dataset aggregate data from all phases of the ADNI study (1, 2, and 3)? If so, could you provide insights into the criteria used for thickness data extraction, especially concerning the ADNI 1 phase data? Correlation with Disease Groups:

We are particularly interested in understanding how the antsxnetThickness data correlates with specific disease groups within the ADNI study (namely AD, CN, MCI). Could you elaborate on the methodology used to map the extracted thickness data to these specific disease groups? These questions stem from our intent to ensure the precision of our data analysis and interpretation within our ongoing research. Clarification on these points would not only benefit our understanding but also contribute to the accuracy of our findings and their potential applications.

ntustison commented 6 months ago

Does this dataset aggregate data from all phases of the ADNI study (1, 2, and 3)? If so, could you provide insights into the criteria used for thickness data extraction, especially concerning the ADNI 1 phase data?

I don't believe the data was from all phases---perhaps just ADNI1.

We are particularly interested in understanding how the antsxnetThickness data correlates with specific disease groups within the ADNI study (namely AD, CN, MCI). Could you elaborate on the methodology used to map the extracted thickness data to these specific disease groups? These questions stem from our intent to ensure the precision of our data analysis and interpretation within our ongoing research. Clarification on these points would not only benefit our understanding but also contribute to the accuracy of our findings and their potential applications.

If you're referring to our paper, what specifically do you have questions about? All the analysis scripts should be located in this repository.

GayanSamuditha commented 6 months ago

@ntustison

There are so many different versions of ADNI 1 data in the repository. So what specific dataset you choose?

image

ntustison commented 6 months ago

There are so many different versions of ADNI 1 data in the repository. So what specific dataset you choose?

In the .csv file that you reference, there's the Subject ID and Image ID number which points to a specific image.