search

nvaldivi / ogms

Automatically exported from code.google.com/p/ogms
0 stars 0 forks source link

genetic disorder #4

Closed GoogleCodeExporter closed 8 years ago

GoogleCodeExporter commented 8 years ago 
Peter Robinson says:
>3) Genetic Disorder =def. A disorder whose etiology
>involves an abnormality in the nucleotide sequence of
>an organisms genome.
>==>> There are genetic disorders that involve only methylation of
>DNA such as Prader-Willi syndrome, in some forms of which the
>nucleotide sequence is not altered.

Original issue reported on code.google.com by albertgo...@gmail.com on 27 Jul 2009 at 3:38

GoogleCodeExporter commented 8 years ago 
Does the addition of epigenetic disorder address this issue?  If so, then we 
could
close it.

Original comment by hoga...@gmail.com on 22 Aug 2009 at 12:17

GoogleCodeExporter commented 8 years ago 
During 11/19/09 teleconference, it was determined that epigenetic disorder 
covers
this case, and that this is not an issue with 'genetic disorder'.  If possible, 
we
should strive to eliminate the negative clause (2) in 'epigenetic disorder'=def 
A
disorder whose etiology involves (1) a modification to the patient's genomic DNA
which leads to alterations in the normal expression pattern of the genome, but 
is (2)
NOT a change in the nucleotide sequence.  Methylation is not a change in 
nucleotide
sequence...are there others?

Original comment by albertgo...@gmail.com on 20 Nov 2009 at 8:29

GoogleCodeExporter commented 8 years ago

Original comment by albertgo...@gmail.com on 20 Nov 2009 at 8:31