Open mshadbolt opened 4 years ago
We already have this: http://purl.obolibrary.org/obo/CL_0017000
definition "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice."
We could potentially add markers - although not directly to a species neutral term. I assume these are for human.
That was actually my first CL cell type :) The original articles characterized the cell type both in mice and humans. In the original articles, they kind of mention the "CFTR gene" in a semi species neutral way, but I was not sure how to add the markers.
I did not put "lung ionocyte" as a synonym, though, that could be readily updated (I think)
Yeah I knew it was already in the ontology, I was just practicing adding a request for the training session. Though I do think it might be cool to add the marker genes if the evidence in the paper is considered good enough to do this.
I have kind of skimmed the paper and I think this cell type has specifically only been found in mice and human, but seems similar to the ionocytes in gills of fish. I wonder if there is any way of characterising that kind of relationship in the ontology?
I did not put "lung ionocyte" as a synonym, though, that could be readily updated (I think)
I also kind of made that up as a synonym, just to practice, I don't know if anyone uses that as a synonym...
Note - please check that the term does not already exist (check OLS: https://www.ebi.ac.uk/ols/ontologies/cl)
Preferred term label: pulmonary ionocyte
Synonyms lung ionocyte
Definition (free text, please give PubMed ID in format PMID:XXXXXX) An ionocyte that is part of a lung which co-expresses FOXI1, multiple subunits of the vacuolar-type H+-ATPase (V-ATPase) and CFTR PMID:30069046
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols/ontologies/cl): epithelial cell of lung http://purl.obolibrary.org/obo/CL_0000082
What is the anatomical structure that the cell is a part of? Please check Uberon: https://www.ebi.ac.uk/ols/ontologies/uberon part of lung epithelium http://purl.obolibrary.org/obo/UBERON_0000115
Your nano-attribution (ORCID) https://orcid.org/0000-0001-7505-5418
Any additional notes or concerns I would like to add links to the genes expressed in the paper i.e. FOXI1 V-ATPase CFTR