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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] Neuroendocrine cell of prostate epithelium #1135

Closed GHAStVHenry closed 2 years ago

GHAStVHenry commented 3 years ago

Note - please check that the term does not already exist (check OLS: https://www.ebi.ac.uk/ols/ontologies/cl)

Preferred term label: Neuroendocrine cell of prostate epithelium

Synonyms

Definition (free text, please give PubMed ID in format PMID:XXXXXX) Neuroendocrine cell (CL:0000165) in the prostate

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols/ontologies/cl): CL:0002231

What is the anatomical structure that the cell is a part of? Please check Uberon: https://www.ebi.ac.uk/ols/ontologies/uberon UBERON:0000428

Your nano-attribution (ORCID) https://orcid.org/0000-0001-7772-9578

Any additional notes or concerns

lubianat commented 3 years ago

@GHAStVHenry PMID:31390564 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6710009/) does not seem to mention neuroendocrine cells. Am I missing anything?

GHAStVHenry commented 3 years ago

Prostate neuroendocrine are rare and sometimes difficult to identify unless you are specifically looking for them. That paper did not identify them as it wasn't important for proving their hypothesis. They are usually referred to in publications in reference to prostate cancer, which can trans-differentiate into neuroendocrine-like prostate cancer... but they are present in the normal prostate and is very well accepted in the urologic field as being present.

The review pmc8023015 describes them as:

NE cells are scattered among the more abundant luminal and basal cells, representing only ∼1% of the epithelial population.11, 13, 21 Because of their rarity in benign prostate and most prostate tumors, they cannot be appreciated on standard H&E stained sections. However, through the use of electron microscopy, they can be identified and differentiated from luminal and basal cells by their elongated cell bodies and intracytoplasmic dense core secretory granules.21 Furthermore, electron microscopy can differentiate between two morphologic subtypes of NE cells: open-type and closed-type.24 Open-type cells possess long microvilli which reach the lumen and can detect changes in pH as well as respond to other chemical stimuli in luminal secretions. Closed-type cells possess dendritic-like processes and receive stimuli from nerve endings, blood vessels, and smooth muscle cells. A more practical way to highlight NE cells in the prostatic epithelium involves the use of immunohistochemistry (IHC) (Fig. 1) and commonly used markers include chromogranin A (CgA),11, 13, 21 synaptophysin (SYP),11, 13, 21 neuron-specific enolase (NSE),11, 13, 21 neural cell adhesion molecule (NCAM or CD56),11, 13, 21 forkhead-box A2 (FOXA2),25 and CXC chemokine receptor 2 (CXCR2).26 In addition to being negative for AR and PSA, they are also negative for Ki67 because they are non-proliferative, post-mitotic cells.11, 13, 21, 26

...as a matter of fact, it even describes two types (open-type and closed-type) which I have never heard about.

lubianat commented 3 years ago

@GHAStVHenry thanks! I am working on this ticket, but it has been a while since my last CL edit. The review might take a while, but it should be moving forward.

GHAStVHenry commented 3 years ago

That's awesome, thanks @lubianat, while this is important...

I'm really would love to have terms #1133 #1134... I have some curation processes that could use terms for them... are you working on those tickets too?

lubianat commented 3 years ago

I've seen them, I plan is to pick up on those two after this one is complete (unless someone happens to work on them first)

GHAStVHenry commented 3 years ago

sounds good... this is the "easiest" one as it is an "old" cell type... the other 2 are "new" so there are fewer references

github-actions[bot] commented 2 years ago

This issue has not seen any activity in the past 6 months; it will be closed automatically in one year from now if no action is taken.

paolaroncaglia commented 2 years ago

@lubianat assigning to you as I see you made a PR. Thanks. As a reminder, I removed the automated assignments; There are 4 NTRs by the same submitter, so it'd make sense to address them all at the same time: https://github.com/obophenotype/cell-ontology/issues/1133 (urethra), https://github.com/obophenotype/cell-ontology/issues/1134 (urethra), https://github.com/obophenotype/cell-ontology/issues/1135 (prostate) and https://github.com/obophenotype/cell-ontology/issues/1171 (bronchiole).