Discussion: granularity of hepatocyte-zonation-based subclasses.

[lubianat]

Hello all,

I am in a talk with Prof. Shalev Itzkovitz (https://shalevlab.weizmann.ac.il/) who works with liver spatial transcriptomics.

I've asked the following question:

Given the gradients in the liver, if you really had to split the hepatocytes into zone-based different subtypes, how many would you choose? Cell Ontology currently lists only three: “centrilobular”, “midzonal” and “periportal”.

Ref: https://www.ebi.ac.uk/ols/ontologies/cl/terms?obo_id=CL:0000182

He answered something in the lines of:

"There are definitely more than 3 physiologically relevant cell types. Lobules have from 9-15 layers of hepatocytes, and some genes peak at the second or third layer. I'd say there would be at least 6-8 physiologically relevant divisions."

No action is required for now, but raising the issue to indicate that some modeling there would perhaps be useful in the future.

[ghost]

Hi @lubianat, thank you for your thoughtful contribution. So this ticket does not get lost over time, would you like to assign it to yourself until there is a plan of action? When editing is required, we could continue the discussion and tasks on this ticket, and it can then be reassigned to an editor.

Perhaps we could also start using a new label like "future consideration", "discussion' and/or "pending" to tag issues like this.

[lubianat]

Sure! Also support the new label idea

[github-actions[bot]]

This issue has not seen any activity in the past 6 months; it will be closed automatically in one year from now if no action is taken.

[aleixpuigb]

Hi @lubianat, is there any update or action required for this ticket?

[lubianat]

@aleixpuig thanks for the ping; not really. It was mostly a way of saving this in case anyone worked on hepatocytes in a later moment.