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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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NTR: Segmented neutrophil in Bone marrow #152

Open GoogleCodeExporter opened 9 years ago

GoogleCodeExporter commented 9 years ago 
Label: Segmented neutrophil in Bone marrow

Synonyms: Segmented neutrophil

Text definition: A Bone marrow reserve pool segmented neutrophilic cells with 
the phenotype CD11b+/CD16++

Definition source: PMID: 11138622, PMID: 15514007

Other relationships:
Develops from: band form neutrophil (http://purl.obolibrary.org/obo/CL_0000560)

Original issue reported on code.google.com by reach4a...@gmail.com on 12 Sep 2014 at 10:24

GoogleCodeExporter commented 9 years ago

Original comment by dosu...@gmail.com on 17 Nov 2014 at 2:12

GoogleCodeExporter commented 9 years ago 
Draft term:

label: segmented neutrophil of bone marrow
def: "A segmented neutrophilic cell of the bone marrow reserve pool that 
expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity 
immunoglobulin gamma Fc region receptor III) on its cell surface."

subClassOf: mature neutrophil
subClassOf: part_of some bone marrow
subClassOf: has_plasma_membrane_part some 'integrin alpha-M'
subClassOf: has_plasma_membrane_part some 'low affinity immunoglobulin gamma Fc 
region receptor III'

Questions: is it correct to classify this under 'mature neutrophil' or is it 
still immature.  
Also wondering if we should include markers in the name.
(NOte - not clear to me that we have enough info for necessary and sufficient 
conditions here - so have kept axiomatisation as subclasses.

Alex: any comments?

Original comment by dosu...@gmail.com on 17 Nov 2014 at 2:37

GoogleCodeExporter commented 9 years ago 
Hi David,

The segmented form of the neutrophil is the mature form, so the placement is 
correct.

As a side issue, currently it appears that the term 'band form neutrophil' is 
mistakenly asserted as both an 'immature neutrophil' and a 'mature neutrophil'. 
 It should only be asserted as an 'immature neutrophil'.  This needs to be 
fixed.  If you are finished editing, I will do this, or you can if you are not 
done yet.

Thanks,
Alex

Original comment by addi...@buffalo.edu on 17 Nov 2014 at 2:57

GoogleCodeExporter commented 9 years ago 
Committed term (and moved 'band form neurotrophil' to under mature only).  Have 
left markers out of name for now.  Will be in next release.

Original comment by dosu...@gmail.com on 17 Nov 2014 at 3:09

addiehl commented 2 years ago

'band form neutrophil' should be a type of immature neutrophil, not a mature neutrophil; my mistake. Will fix after further review.