[NTR] valve interstitial cell (heart)

[emquardokus]

Note - please check that the term does not already exist (check OLS: https://www.ebi.ac.uk/ols/ontologies/cl)

Preferred term label valve interstitial cell

Synonyms (add reference(s), please) VIC cardiac valve interstitial cell

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

Ayoub, Salma, Chung-Hao Lee, Kathryn H. Driesbaugh, Wanda Anselmo, Connor T. Hughes, Giovanni Ferrari, Robert C. Gorman, Joseph H. Gorman, and Michael S. Sacks. “Regulation of Valve Interstitial Cell Homeostasis by Mechanical Deformation: Implications for Heart Valve Disease and Surgical Repair.” Journal of The Royal Society Interface 14, no. 135 (October 31, 2017): 20170580. https://doi.org/10.1098/rsif.2017.0580. (Table 1. Key Studies With Original Methodology Revealing Important Properties of Isolated, Cultured VICs)

Liu, Amber C, Vineet R Joag, and Avrum I Gotlieb. “The Emerging Role of Valve Interstitial Cell Phenotypes in Regulating Heart Valve Pathobiology.” The American Journal of Pathology 171, no. 5 (November 2007): 1407–18. https://doi.org/10.2353/ajpath.2007.070251.

Rutkovskiy, Arkady, Anna Malashicheva, Gareth Sullivan, Maria Bogdanova, Anna Kostareva, Kåre‐Olav Stensløkken, Arnt Fiane, and Jarle Vaage. “Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification.” Journal of the American Heart Association 6, no. 9 (n.d.): e006339. https://doi.org/10.1161/JAHA.117.006339.

This paper refers to them as "fibroblast-like" Xu, Kang, Shangbo Xie, Yuming Huang, Tingwen Zhou, Ming Liu, Peng Zhu, Chunli Wang, et al. “Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease.” Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 12 (December 1, 2020): 2910–21. https://doi.org/10.1161/ATVBAHA.120.314789.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols/ontologies/cl) It's unclear where this should live exactly. There is no "interstitial cell" in CL; there are some types of interstitial cells specific to some organs under "columnar/cuboidal epithelial cell" CL:0000075 http://purl.obolibrary.org/obo/CL_0000075 ; however, I'm not certain of the histology yet for valve interstitial cell of heart. See above reference "This paper https://doi.org/10.1161/ATVBAHA.120.314789 refers to them as "fibroblast-like"

What is the anatomical structure that the cell is a part of? (check Uberon: https://www.ebi.ac.uk/ols/ontologies/uberon) aortic valve of heart

Your ORCID https://orcid.org/0000-0001-7655-4833

Additional notes or concerns Unsure of parent term in CL; cardiac valve interstitial cells referred to as "fibroblast-like"- CL does not have "interstitial cell" per se.

[dosumis]

There is no "interstitial cell" in CL;

There probably should be. I think 'mesenchymal cell' is often used for this.

there are some types of interstitial cells specific to some organs under "columnar/cuboidal epithelial cell"

That sounds wrong to me.

[ghost]

There is no "interstitial cell" in CL;

[Draft] [NTR] interstitial cell #1654 has been sitting in the drafts, but I will prioritise adding this general class to CL.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols/ontologies/cl) It's unclear where this should live exactly.

There currently exists a problematic class (see valve cell #726): CL:1000147 'heart valve cell'. If it seems reasonable, I could refine CL:1000147 and make it the parent cell class for 'valve interstitial cell' (this request) and 'valve endothelial cell' (a new request; see PMID:25311230).

What is the anatomical structure that the cell is a part of? (check Uberon: https://www.ebi.ac.uk/ols/ontologies/uberon) aortic valve of heart

Based on your references, this cell type is not limited to the aortic valve. I also do not see this class in Uberon. Does UBERON:0000946 'cardial valve' work as an appropriate anatomical structure? (Side note, I think the preferred label for this Uberon class should be 'cardiac valve', which I believe is a much more common name for this structure.)

I also propose adding 'valvular interstitial cell' as an exact synonym to this new term (PMID:25311230).

[ghost]

Proposed modelling, fyi @emquardokus ....

Preferred term label
 valve interstitial cell

Synonyms 
VIC (PMID:25311230, PMID:30796046) valvular interstitial cell (PMID:25311230) cardiac valve interstitial cell (PMID:16456103)

Definition A cardiac valve cell that resides in a valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes. PMID:25311230 https://doi.org/10.1098/rsif.2017.0580 https://doi.org/10.2353/ajpath.2007.070251 https://doi.org/10.1161/JAHA.117.006339 https://doi.org/10.1161/ATVBAHA.120.314789

Comment Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis). PMID:25311230

Parent cell type term 
CL:1000147 'cardiac valve cell' CL:4030031 ‘interstitial cell’

What is the anatomical structure that the cell is a part of? UBERON:0000946 'cardiac valve'

Your ORCID
 https://orcid.org/0000-0001-7655-4833

[dosumis]

Looks good. I would infer classification under 
CL:1000147 'cardiac valve cell' from logical definition of 'cardiac valve cell' (cell and part_of some cardiac valve)

Also consider adding capable_of some extracellular matrix constituent secretion (GO)

[ghost]

@emquardokus, thank you again for the new term.

The following has been added to CL and will be available in the next release:

CL:4030032 'valve interstitial cell'