Genus of Kupffer cell

[dosumis]

definition "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system."^^xsd:string

'tissue-resident macrophage' and ('located in' some 'hepatic sinusoid') and ('has plasma membrane part' some 'adhesion G protein-coupled receptor E1') and ('has plasma membrane part' some 'scavenger receptor cysteine-rich type 1 protein M130') and ('has plasma membrane part' some macrosialin) and ('capable of' some 'erythrocyte clearance') and ('has low plasma membrane amount' some 'integrin alpha-M')

• From text it looks like it should be under mononuclear phagocyte, rather than tissue resident macrophage (although should we have 'tissue resident mononuclear phagocyte' ?
• Possible other things to formalise: has_part Vermiform body (request from GO - or use some more general GO term?
• Question: do we have any idea of the species specificity of these markers?

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