obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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Obsolete absorptive cell ? #2271

Open dosumis opened 10 months ago

dosumis commented 10 months ago

'absorptive cell' - now appears to be childless under the root. Aleix to look into what edits lead to this. Look at any use on CxG and HubMap and in CL bridge files on the Uberon repo.

emquardokus commented 10 months ago

gut absorptive cell which now exists with all the enterocytes would be under absorptive cell? CL:0000677

emquardokus commented 10 months ago

@dosumis Based on pubmed search of literature "absorptive cell" is only associated with intestinal epithelium and is equated with enterocytes true for human, rat, mouse etc.

aleixpuigb commented 9 months ago

absorptive cell is being used in CCF and HCAO. It is used by the Small intestine ASCT+B table (Large intestine uses 'enterocyte of epithelium of large intestine' for absorptive) gut absorptive cell is used by GO, HCAO, OBA and MP

Both of them are used in cellXgene. However, the marker genes are identical. image

I would recommend the merge the terms, being 'gut absorptive cell' the winning term and 'absorptive cell' an exact synonym.

cmungall commented 9 months ago

I think it's much cleaner to obsolete+consider rather than merge. The definition is (incredibly) broad and encompasses skin cells, placental cells, salivary cells. Following proper practice we should not merge this into a more specific class.

However, there is the practical argument that no one ever read the definition and annotated to the label (despite us urging people to always annotate to the definition and not the label).

Whether it's a merge or consider either way it would be good to get this term out of there as it's doubly confusing how it's not grouping anything right now

What is our strategy for syncing with ZFA and XAO?

@cerivs looks like you wrote the def for the general term, what are your thoughts? Or perhaps you just tweaked the old definition "A cell that takes up stuff and metabolizes it."

github-actions[bot] commented 3 months ago

This issue has not seen any activity in the past 6 months; it will be closed automatically in one year from now if no action is taken.