[NTR] multliciliated cell of nasal epithelium

[dosumis]

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label nasal ciliated cell

Synonyms (add reference(s), please) multiciliated cell of nasal epithelium

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX) A multiciliated epithelial cell of the nasal epithelium... { add some more relevant content from references }

refs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245175/ + primary refs working back from this paper.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

multi-ciliated epithelial cell CL:0005012

But see also the rather horrifically names: nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa CL_2000094 - I think this should be inferred from correct part relationships. Probably should be renamed while we're at it.

Consider adding a grouping term 'multi-ciliated cell of airway epithelium" - that covers this term and "ciliated columnar cell of tracheobronchial tree" - as there is evidence that these are transcriptomically related - see https://www.nature.com/articles/s41591-023-02327-2

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245175/

"nasal cavity respiratory epithelium" UBERON:0005385 (or would plain - nasal cavity epithelium be sufficient? & what is the relationship to nasal mucosa?)

Your ORCID

Additional notes or concerns

We should really have a standard pattern for representing multiciliated cells. There are certainly more than are classified under this term - it's possible we have others just not classified correctly.

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