Open jychien opened 7 months ago
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Thank you @jychien, I will investigate this, since I have encountered this classification before.
CL term
fibroblast
is a child ofconnective tissue cell
stromal cell
is a child ofconnective tissue cell
However, there is no relationship between fibroblast and stromal cell. It is the general usage that cells from a tissue are broken up into stromal, immune, endothelial, and epithelial compartments, and fibroblasts are generally accepted as a subset of the stromal cells. So, this would create confusion if users are interested in all stromal cells at CELLxGENE, but then do will not actually be selecting from fibroblasts.
For example, fibroblasts are considered to be stromal cells in the following example, and any cells labeled as stromal cell are non-specific stromal cell: https://cellxgene.cziscience.com/collections/5c868b6f-62c5-4532-9d7f-a346ad4b50a7 (https://doi.org/10.1016/j.immuni.2023.01.002) Fig1:
This publication has a summary:
Suggested revision of class hierarchy
It is unclear the intended cell that is being described by the definition of
stromal cell
:However, because 'stromal cell' is a commonly used cell type and associated with fibroblasts, it would be good to make sure that the hierarchy is reflective of the general understanding. 'stromal cell' sounds as if it potentially could be synonymous with
connective tissue cell
.