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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
Creative Commons Attribution 4.0 International
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adult cardiomyocyte #2418

Open anna-anagnostop opened 3 months ago

anna-anagnostop commented 3 months ago

During cardiomyocyte maturation, cardiomyocytes become polyploid in most mammals, either via DNA synthesis and nuclear division without cytokinesis to form binucleated cells, as occurs in rodents, or via DNA synthesis without nuclear division to make polyploid nuclei, as observed in humans (see PMID: 32015528).

Consider adding a new term for "adult cardiomyocyte" to clearly distinguish it from the existing term "fetal cardiomyocyte" CL:0002495.

Preferred term label: adult cardiomyocyte

Synonyms: adult heart muscle cell PMID: 34897388; adult cardiac muscle cell PMID: 7004954; adult cardiac myocyte PMID: 29374152; adult cardiac muscle fiber BTO:0002320

Definition: a terminally differentiated cardiomyocyte that has lost the ability to proliferate and is bi- or multi-nucleated, or has polyploid nuclei

References: PMID: 24184431, PMID: 34897388, PMID: 32015528

Parent cell type term: cardiac muscle cell CL:0000746

Anatomical structure where the cell type is found: cardiac muscle tissue UBERON:0001133

Anna V. Anagnostopoulos: https://orcid.org/0000-0002-6490-7723

Thank you,

Anna

lubianat commented 3 months ago

Pinging @aleixpuigb so this doesn't get lost :)

@anna-anagnostop thanks for the request!

By the way, in CL, each synonym is connect to one supporting reference; could you kindly sort out which reference supports which synonym, if possible? Thanks!

anna-anagnostop commented 2 months ago

I have added additional references supporting each synonym in the synonym section.